Article
Oncology
Minsuk Kwon, Gahyun Kim, Ryul Kim, Kyu-Tae Kim, Seung Tae Kim, Simon Smith, Peter G. S. Mortimer, Jung Yong Hong, Arsene-Bienvenu Loembe, Itziar Irurzun-Arana, Loumpiana Koulai, Kyoung-Mee Kim, Won Ki Kang, Emma Dean, Woong-Yang Park, Jeeyun Lee
Summary: The combination of Ceralasertib and durvalumab has shown promising clinical activity and tolerability in patients with advanced gastric cancer (AGC). Certain patients showed better clinical responses, which were associated with loss of ATM expression and homologous repair deficiency.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Multidisciplinary Sciences
Kabsoo Shin, Joori Kim, Se Jun Park, Myung Ah Lee, Jae Myung Park, Myung-Gyu Choi, Donghoon Kang, Kyo Young Song, Han Hong Lee, Ho Seok Seo, Sung Hak Lee, Bohyun Kim, Okran Kim, Juyeon Park, Nahyeon Kang, In-Ho Kim
Summary: The study investigated the prognostic significance of soluble PD-L1 (sPD-L1) and exosomal PD-L1 (exoPD-L1) in patients with gastric cancer receiving chemotherapy. It was found that low levels of sPD-L1 and exoPD-L1 were associated with better overall survival and progression-free survival. Pretreatment sPD-L1 could be used as an independent prognostic factor for overall survival, while exoPD-L1 may reflect the immunosuppressive state of patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Yun Gu, Puran Zhang, Jieti Wang, Chao Lin, Hao Liu, He Li, Hongyong He, Ruochen Li, Heng Zhang, Weijuan Zhang
Summary: ARID1A mutation in gastric cancer predicts responsiveness to chemotherapy and immunotherapy, and is associated with DNA damage repair deficiency and immunogenic tumor microenvironment.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Review
Oncology
Tong Xie, Zhening Zhang, Xiaotian Zhang, Changsong Qi, Lin Shen, Zhi Peng
Summary: PD-L1 CPS >= 1 is the cutoff value for ICI monotherapy to gain survival benefit. Combined immunotherapy prolonged PFS and OS in the whole population, but further study is needed to confirm its efficacy.
FRONTIERS IN ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Hiroshi Nakano, Motonobu Saito, Shotaro Nakajima, Katsuharu Saito, Yuko Nakayama, Koji Kase, Leo Yamada, Yasuyuki Kanke, Hiroyuki Hanayama, Hisashi Onozawa, Hirokazu Okayama, Shotaro Fujita, Wataru Sakamoto, Zenichiro Saze, Tomoyuki Momma, Kosaku Mimura, Shinji Ohki, Akiteru Goto, Koji Kono
Summary: Epstein-Barr virus-positive gastric cancer (EBV (+) GC) exhibits overexpression of PD-L1 through a unique dual mechanism: focal amplification of CD274 or IFN-gamma-mediated signaling via activation of IRF3, correlating with CD8 lymphocyte infiltration and IRF3 signature expression in tumor tissue and infiltrating immune cells.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Sweta Sharma Saha, Lucy Gentles, Alice Bradbury, Dominik Brecht, Rebecca Robinson, Rachel O'Donnell, Nicola J. Curtin, Yvette Drew
Summary: This study identified that genomic/transcriptomic and/or functional alterations in DDR pathways can determine therapy response, offering insights into personalized chemotherapy choices for ovarian cancer patients.
Article
Chemistry, Medicinal
Tianyu Wang, Shi Cai, Yao Cheng, Wanheng Zhang, Minmin Wang, Huiyong Sun, Binghua Guo, Zheng Li, Yibei Xiao, Sheng Jiang
Summary: Compound 17 is a bifunctional inhibitor that can block the interactions between PD-1 and PD-L1, promoting internalization and degradation of PD-L1. It effectively suppresses tumor growth in vivo by activating antitumor immunity.
JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Birgid Schoemig-Markiefka, Jana Eschbach, Andreas H. Scheel, Aylin Pamuk, Josef Rueschoff, Thomas Zander, Reinhard Buettner, Wolfgang Schroeder, Christiane J. Bruns, Heike Loeser, Hakan Alakus, Alexander Quaas
Summary: This study optimized PD-L1 assessment in gastric cancer using endoscopically available tissue and found that CPS values from four surface biopsies can accurately reflect the PD-L1 status of the entire tumor. Preoperative biopsies showed lower sensitivity compared to tissue microarrays (TMAs).
Article
Oncology
Ming Lei, Nathan O. Siemers, Dimple Pandya, Han Chang, Teresa Sanchez, Christopher Harbison, Peter M. Szabo, Yelena Janjigian, Patrick A. Ott, Padmanee Sharma, Johanna Bendell, Thomas R. Jeffry Evans, Filippo de Braud, Ian Chau, Zachary Boyd
Summary: This study indicates a stronger association between PD-L1 expression determined by CPS and efficacy of immune checkpoint inhibitors in patients with advanced gastric cancer/gastroesophageal junction cancer (GC/GEJC). Inflammatory signatures are also correlated with response to this therapy, suggesting the need for further investigation.
CLINICAL CANCER RESEARCH
(2021)
Article
Multidisciplinary Sciences
Ji Hyun Park, Hee Jin Cho, Jeonghwa Seo, Ki Bum Park, Yong Hwan Kwon, Han Ik Bae, An Na Seo, Moonsik Kim
Summary: EBVaGC can be classified into different molecular subtypes based on histological patterns, and patients exhibit distinct genetic alterations, PD-L1 expression, and levels of tumor-infiltrating lymphocytes (TILs).
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Lingxi Nan, Changcheng Wang, Jie Wang, Shulong Zhang, Xiaobo Bo, Yueqi Wang, Houbao Liu
Summary: This study reveals the clinical significance of ARID1A in gallbladder cancer patients. Low expression of ARID1A is associated with decreased overall survival and downregulation of immune-evasion related signaling pathways. High expression of ARID1A combined with low PD-L1 expression or low PD1+ TILs count is associated with the best prognosis in patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ericka M. Ebot, Daniel L. Duncan, Khaled Tolba, David Fabrizio, Garrett M. Frampton, Leah A. Comment, Lee A. Albacker
Summary: This study identified genomic predictors of survival after immunotherapy in non-squamous NSCLC patients and found that deletions at 9p21.3 are associated with worse survival in patients treated with pembrolizumab monotherapy but not in those treated with pembrolizumab in combination with chemotherapy. Furthermore, these deletions were found to be a negative predictor of clinical benefit from first-line immune checkpoint inhibitors in multiple tumor types. This information can be useful in guiding treatment decisions between mono-immunotherapy and chemo-immunotherapy regimens in NSCLC.
NPJ PRECISION ONCOLOGY
(2022)
Article
Oncology
Liyu Wang, Ying Feng, Anquan Huang, Jianming Shi, Qinying Zhang, Fan Zhu, Bin Lv, Fen Guo, Tianming Zou, Luyao Zhang
Summary: Alpha-fetoprotein-positive gastric cancer (AFPGC) is a highly malignant type of gastric cancer, and current treatment options are limited. This study describes a case of a young woman with high blood alpha-fetoprotein levels who showed promising results with immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Shenghan Lou, Yufei Wang, Jian Zhang, Xin Yin, Yao Zhang, Yimin Wang, Yingwei Xue
Summary: The role of DNA damage repair (DDR) in gastric cancer remains to be fully understood. This study utilized gene set enrichment analysis to investigate the impact of DDR pathway profiling on clinical outcomes, biological functions, genetic variants, immune heterogeneity, and treatment responses. The results demonstrate distinct differences in DDR pathway activity between tumor and normal tissues, with correlations to patient survival, tumor phenotypes, and genome stability.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Yusuke Matsuno, Mai Hyodo, Mafuka Suzuki, Yosuke Tanaka, Yasunori Horikoshi, Yasufumi Murakami, Hidetaka Torigoe, Hiroyuki Mano, Satoshi Tashiro, Ken-ichi Yoshioka
Summary: Exposure to ionizing radiation increases cancer risk by inducing a state of genomic destabilization in cells repairing double-strand breaks caused by radiation. This accumulation of replication-stress-associated DSBs ultimately leads to clonal evolution and increased risk of single-nucleotide variants and chromosomal structural alterations.
Article
Surgery
Fabio Carboni, Renato Covello, Maria Grazia Diodoro, Enrico Vizza, Mario Valle
Article
Dermatology
Marinella Tedesco, Valentina Garelli, Fulvia Elia, Francesca Sperati, F. Biondi, L. Mosiello, Aldo Morrone, Emilia Migliano
Summary: This preliminary study evaluated the efficacy of injecting Hybrid Cooperative Complexes of Hyaluronic Acid (HCC) for the treatment of vulvar lichen sclerosus (VLS). The results are promising, as most patients showed significant improvement in symptoms after 1 and 6 months of HCC treatment. The study demonstrated the effectiveness of HCC in reducing symptoms and improving sexuality and patient quality of life.
JOURNAL OF COSMETIC DERMATOLOGY
(2023)
Article
Clinical Neurology
Roberto Latina, Giustino Varrassi, Ettore Di Biagio, Diana Giannarelli, Francesco Gravante, Antonella Paladini, Daniela D'Angelo, Laura Iacorossi, Cristina Martella, Rosaria Alvaro, Dhurata Ivziku, Nicola Veronese, Mario Barbagallo, Anna Marchetti, Paolo Notaro, Irene Terrenato, Gianfranco Tarsitani, Maria Grazia De Marinis
Summary: Opioids are effective in managing moderate or severe chronic pain. The use of invasive treatments and complementary therapy is associated with severe or moderate pain. The choice of a pain clinic is influenced by clinical parameters such as the nature of pain, multi-diagnosis, multiple sites of pain, treatments, and general practitioner.
Article
Oncology
Antonello Vidiri, Andrea Ascione, Francesca Piludu, Eleonora Polito, Enzo Gallo, Renato Covello, Paola Nistico, Vittoria Balzano, Barbara Pichi, Raul Pellini, Simona Marzi
Summary: In this study, the correlation between imaging parameters obtained from magnetic resonance imaging (MRI) and pathological factors in oral cavity squamous cell carcinomas (OSCCs) was investigated. The results showed that pathological factors such as inflammatory infiltrate, tumor grading, and desmoplastic reaction affected the MRI parameters. Significant relationships were found between DKI parameters and tumor-infiltrating lymphocytes (TILs). Differences in DCE-MRI parameters were also observed according to tumor grading. These findings contribute to a better understanding of OSCCs and can be used for diagnostic and prognostic purposes.
Article
Computer Science, Interdisciplinary Applications
Martina Betti, Chiara Maria Salzano, Alice Massacci, Mattia D'Antonio, Isabella Grassucci, Benedetta Marcozzi, Marco Canfora, Elisa Melucci, Simonetta Buglioni, Beatrice Casini, Enzo Gallo, Edoardo Pescarmona, Gennaro Ciliberto, Matteo Pallocca
Summary: The biomedical research field is advancing towards developing clinical trials and translational projects based on real-world evidence. To make this transition feasible, clinical centers need to work towards data accessibility and interoperability. This task is particularly challenging when applied to genomics, which has become routine through amplicon-based next-generation sequencing panels. These experiments produce numerous features per patient, and their results are often stored in static clinical reports, making critical information inaccessible to automated access and federated search consortia. This study presents a reanalysis of 4620 solid tumor sequencing samples in different histology settings and describes the bioinformatics and data engineering processes employed to create a somatic variant registry capable of dealing with the large biotechnological variability of routine genomics profiling.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Editorial Material
Oncology
Paolo Visca, Enzo Gallo, Mirella Marino
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medicine, Research & Experimental
Veronica Villani, Beatrice Casini, Antonio Tanzilli, Mario Lecce, Fabrizio Rasile, Stefano Telera, Andrea Pace, Francesca Piludu, Irene Terrenato, Francesca Rollo, Francesca De Nicola, Maurizio Fanciulli, Matteo Pallocca, Gennaro Ciliberto, Mariantonia Carosi
Summary: This study analyzed the genetic profile of 99 glioma patients using next-generation sequencing. Most patients had mutations in genes, such as single nucleotide variants, copy number variants, and gene fusions. The study found that glioblastoma patients had lower overall survival and progression-free survival compared to other glioma patients. However, only a small number of patients could receive targeted treatment based on the detected mutations.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Article
Oncology
Alessia Farneti, Marta Bottero, Adriana Faiella, Diana Giannarelli, Luca Bertini, Valeria Landoni, Patrizia Vici, Pasqualina D'Urso, Giuseppe Sanguineti
Summary: The study investigated the predictive value of dynamic contrast-enhanced-magnetic resonance imaging (DCE-MRI) findings in restaging before salvage radiotherapy (sRT) for prostate cancer. The results showed that DCE-MRI provides both predictive and therapeutic information, especially in patients with biochemical failure after radical prostatectomy. Patients with small lesions in the vesico-urethral anastomosis have an excellent prognosis after sRT.
Article
Medicine, General & Internal
Paolo Bironzo, Francesco Pepe, Gianluca Russo, Pasquale Pisapia, Gianluca Gragnano, Gabriella Aquino, Silvia Bessi, Simonetta Buglioni, Federico Bartoccini, Giuseppina Ferrero, Michela Anna Bresciani, Paola Francia di Celle, Francesca Sibona, Andrea Giusti, Alessandra Movilia, Renata Mariella Farioli, Alessandra Santoro, Domenico Salemi, Stefania Scarpino, Dino Galafate, Stefania Tommasi, Rosanna Lacalamita, Davide Seminati, Elham Sajjadi, Silvia Novello, Fabio Pagni, Giancarlo Troncone, Umberto Malapelle
Summary: Lung cancer is the leading cause of cancer deaths worldwide. The molecular analysis of MET proto-oncogene, receptor tyrosine kinase (MET) exon 14 skipping has been promoted for the stratification of non-small cell lung cancer (NSCLC) patients. Different testing strategies for MET exon 14 skipping were evaluated for their technical performance and reproducibility in various centers. The use of artificial reference slides proved to be a valid tool for harmonizing technical workflows in the evaluation of MET exon 14 skipping molecular alterations in routine practice.
Correction
Clinical Neurology
Roberto Latina, Giustino Varrassi, Ettore Di Biagio, Diana Giannarelli, Francesco Gravante, Antonella Paladini, Daniela D'Angelo, Laura Iacorossi, Cristina Martella, Rosaria Alvaro, Dhurata Ivziku, Nicola Veronese, Mario Barbagallo, Anna Marchetti, Paolo Notaro, Irene Terrenato, Gianfranco Tarsitani, Maria Grazia De Marinis
Article
Oncology
Luana Fianchi, Fabio Guolo, Francesco Marchesi, Chiara Cattaneo, Michele Gottardi, Francesco Restuccia, Anna Candoni, Elettra Ortu La Barbera, Rita Fazzi, Crescenza Pasciolla, Olimpia Finizio, Nicola Fracchiolla, Mario Delia, Federica Lessi, Michelina Dargenio, Valentina Bonuomo, Maria Ilaria Del Principe, Patrizia Zappasodi, Marco Picardi, Claudia Basilico, Monica Piedimonte, Paola Minetto, Antonio Giordano, Patrizia Chiusolo, Lucia Prezioso, Caterina Buquicchio, Lorella Maria Antonia Melillo, Daniele Zama, Francesca Farina, Valentina Mancini, Irene Terrenato, Michela Rondoni, Irene Urbino, Mario Tumbarello, Alessandro Busca, Livio Pagano
Summary: This study evaluated the absolute infectious risk in 200 AML patients treated with CPX-351 and found it to have a good safety profile, with an incidence of infectious complications comparable to that of pivotal studies. The only factor significantly associated with mortality was a lack of response to CPX-351 treatment.
Article
Oncology
Lauro Bucchi, Alessandra Ravaioli, Luigino Dal Maso, Fabio Falcini, Lucia Mangone, Samuele Massarut, Laura Schirosi, Anna Crispo, Patrizia Vici, Silvia Franceschi
Summary: A study in Italy found that sentinel lymph node biopsy and post-lumpectomy radiotherapy were rarely performed in low-risk breast cancer patients aged >= 70. These findings can serve as a baseline to monitor the impact of future guidelines, but improvements in the recording and storage of hospital-based information are needed.
Article
Medicine, General & Internal
Maria Cecilia Cercato, Concetta Elisa Onesti, Sabrina Vari, Gabriella Maggi, Wioletta Faltyn, Serena Ceddia, Irene Terrenato, Virginia Scarinci, Francesca Servoli, Cristina Cenci, Roberto Biagini, Virginia Ferraresi
Summary: This study aimed to evaluate the feasibility and usefulness of a digital narrative diary in the care pathway of patients with bone sarcoma and limb soft tissue sarcoma. The results showed that the diary provided benefits for both patients and healthcare professionals, including increased awareness, improved communication, and deeper knowledge of patients.
JOURNAL OF CLINICAL MEDICINE
(2023)