期刊
ONCOIMMUNOLOGY
卷 7, 期 6, 页码 -出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/2162402X.2018.1434468
关键词
Microbiota; immune checkpoint blockers; PD-1/PD-L1; NSCLC; RCC; Biomarkers; Inflammation and cancer; New target
资金
- Gustave Roussy Course of Excellence in Oncology-Fondation Philanthropia
- Ligue contre le Cancer (equipe labelisee)
- Agence Nationale de la Recherche (ANR)
- ANR under the frame of E-Rare-2
- ERA-Net for Research on Rare Diseases
- Association pour la recherche sur le cancer (ARC)
- Canceropole Ile-de-France
- Institut National du Cancer (INCa)
- Institut Universitaire de France
- Fondation pour la Recherche Medicale (FRM)
Cancer immunotherapists have been searching for biomarkers predicting patient responses to PD-1/PD-L1 blockade in neoplastic cells as well as in the immune system. Now, accumulating evidence indicates that the composition of the intestinal microflora has a major impact on patient prognosis. Here, we enumerate the bacterial species that are associated with favorable outcome of immunotherapy.
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