Article
Biochemistry & Molecular Biology
Kamylla Fernanda Souza de Souza, Danilo Tofoli, Indiara Correia Pereira, Kelly Juliana Filippin, Ana Tereza Gomes Guerrero, Edgar Julian Paredes-Gamero, Maria de Fatima Cepa Matos, Walmir Silva Garcez, Fernanda Rodrigues Garcez, Renata Trentin Perdomo
Summary: The study isolated three compounds from the leaves of Aniba heringeri, with compound 3 showing strong cytotoxicity against breast cancer cells and a high selective index. This compound exhibited promising apoptosis induction effects on triple-negative breast cancer cells, demonstrating potential as a prototype for targeting TNBC cells that are usually resistant to conventional therapies.
BIOORGANIC & MEDICINAL CHEMISTRY
(2021)
Article
Cell Biology
Marco A. Lacerda-Abreu, Thais Russo-Abrahao, Raissa Leite Tenorio Aguiar, Robson de Queiroz Monteiro, Franklin D. Rumjanek, Jose R. Meyer-Fernandes
Summary: Breast cancer is associated with genetic mutations that lead to uncontrolled growth of breast cells. Tumor cells have rewired energy metabolism compared to normal cells, with inorganic phosphate playing a crucial role in cancer cell proliferation. Understanding the activity of ectophosphatase can provide insights into cancer cell energy requirements and growth mechanisms.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Anil Kumar Kalvala, Ramesh Nimma, Arvind Bagde, Sunil Kumar Surapaneni, Nilkumar Patel, Peggy Arthur, Li Sun, Rakesh Singh, Nagavendra Kommineni, Aakash Nathani, Yan Li, Mandip Singh
Summary: This study demonstrates that the combination of synthetic cannabidiol (CBD) and Tetrahydrocannabivarin (THCV) enhances the cytotoxicity of doxorubicin (DOX) against DOX-resistant MDAMB-231 cells. CBD and THCV regulate the expression of various genes and proteins involved in cell apoptosis, leading to improved sensitivity to DOX in resistant tumors.
Article
Oncology
Tatiana J. Carneiro, Ana L. M. Batista Carvalho, Martin Vojtek, Ines F. Carmo, Maria Paula M. Marques, Carmen Diniz, Ana M. Gil
Summary: This study compared the metabolic profiles of cisplatin-sensitive and cisplatin-resistant breast cancer cell lines, revealing differences in metabolic adaptations and providing insights for the discovery of new therapies for TNBC.
CANCER CELL INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Xiwei Ji, Xiangrui Meng, Qingfeng He, Xiaoqiang Xiang, Yufei Shi, Xiao Zhu
Summary: This study investigated the antitumor effects of foretinib on triple-negative breast cancer cells and its pharmacokinetic characteristics. The results showed that foretinib inhibited tumor growth in a dose-dependent manner and suppressed the expression of p-MET and HGF in both cells and tumors, suggesting that the decrease of p-MET and HGF may play a crucial role in the anti-breast cancer properties of foretinib.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Sebastian Simu, Iasmina Marcovici, Amadeus Dobrescu, Daniel Malita, Cristina Adriana Dehelean, Dorina Coricovac, Flavius Olaru, George Andrei Draghici, Dan Navolan
Summary: Translate: Oral contraceptives (OCs) are widely used for preventing unplanned pregnancies and treating human diseases. Despite their medical benefits, concerns about their toxicity, particularly their potential link to hormone-dependent malignancies such as breast cancer, have been raised. This study found that the active ingredients in modern OCs, 17 beta-Ethinylestradiol and Levonorgestrel, have differential effects on TNBC cells, with 17 beta-Ethinylestradiol showing potential anticancer effects and Levonorgestrel having proliferative effects. Further research is needed to understand the mechanisms of action of these hormones on TNBC cells.
Article
Pharmacology & Pharmacy
Sushma Maharjan, Yun-Suk Kwon, Min-Gu Lee, Kyu-Shik Lee, Kyung-Soo Nam
Summary: In this study, we found that morin inhibited proliferation of MDA-MB-231 cells in a time and concentration-dependent manner. The treatment with morin induced phosphorylation of ERK and p-H2A.X, and decreased the expression of DNA repair markers RAD51 and survivin. Flow cytometry analysis showed S and G2/M arrest by morin, associated with downregulation of cyclin A2 and cyclin B1 and upregulation of p21.
PHARMACOLOGICAL REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Euitaek Jung, Young Han Lee, Sukjin Ou, Tae Yoon Kim, Soon Young Shin
Summary: Vasculogenic mimicry (VM) is the phenomenon where cancer cells organize themselves into capillary-like channels. This study investigated the role of Early Growth Response 1 (EGR1) in regulating VM in aggressive cancer cells. The results showed that EGR1 promotes the formation of capillary-like tubes by cancer cells. Furthermore, the study identified the involvement of ERK1/2 and p38 MAPK pathways in regulating the expression of EGR1 and KLF4, highlighting their crucial role in VM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shiyue Liu, Youhong Dong, Ying Wang, Pengchao Hu, Jing Wang, Robert Yl Wang
Summary: The study demonstrated that pristimerin inhibits tumor growth and reverts EMT by suppressing integrin beta 3, providing important insights into its potential anti-cancer effects.
BIOMEDICAL JOURNAL
(2021)
Article
Chemistry, Medicinal
Sushma Maharjan, Min-Gu Lee, So-Young Kim, Kyu-Shik Lee, Kyung-Soo Nam
Summary: Considerable emphasis is being placed on combinatorial chemotherapeutic/natural treatments for breast cancer. This study reveals the synergistic anti-tumor activity of morin and Doxorubicin (Dox) co-treatment on MDA-MB-231 triple-negative breast cancer (TNBC) cell proliferation. Morin/Dox treatment promoted Dox uptake and induced DNA damage and formation of nuclear foci of p-H2A.X. Furthermore, co-treatment attenuated the expression of DNA repair proteins, cell cycle proteins, and FOXM1, as well as downregulated the phosphorylation of EGFR and STAT3, resulting in suppression of TNBC cell growth.
Article
Biotechnology & Applied Microbiology
Neelam Mishra, Kavita Rana, Siva Deepthi Seelam, Rakesh Kumar, Vijyendra Pandey, Bharathi P. Salimath, Dayanand Agsar
Summary: Pseudomonas aeruginosa DNM50 was identified as a biosurfactant-producing bacterium with 12 different congeners of rhamnolipid identified through structural characterization. The rhamnolipid showed radical scavenging activity with an IC50 value of 101.8 μg/ml and exhibited cytotoxic activity against MDA-MB-231 breast cancer cell line with a low IC50 of 0.05 μg/ml at 72 h of treatment. This suggests that DNM50RL may have potential in breast cancer treatment by targeting inhibition of p38MAPK.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Cell Biology
Marco Antonio Lacerda-Abreu, Thais Russo-Abrahao, Jose Roberto Meyer-Fernandes
Summary: Resveratrol inhibits the Na+-dependent Pi transporter, leading to reduced metastasis in breast cancer and potentially affecting the migration and invasion of cancer cells.
CELL BIOLOGY INTERNATIONAL
(2021)
Article
Environmental Sciences
Chun-Wen Cheng, Gwo-Tarng Sheu, Jing-Shiuan Chou, Pei-Han Wang, Yu-Chun Cheng, Chane-Yu Lai
Summary: The study demonstrated that soluble PM2.5 from building demolition sites can promote the survival and metastasis of triple-negative breast cancer cells, with increased cell viability, migration capacity, and activation of malignant signaling pathways in cancer cells exposed to the particulates.
Article
Biochemistry & Molecular Biology
Raji Sundararajan, Pragatheiswar Giri, S. Madhivanan, Anita Ramesh, N. K. Kishore, M. Manjunatha, Ignacio G. Camarillo
Summary: Heat shock proteins (HSPs) are essential for the survival of all organisms under high temperature stresses, protecting cells against various stresses including thermal, chemical, physical, and others. In cancer treatment, some HSPs can be modulated to induce apoptotic cell death, potentially offering effective therapeutic strategies.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biophysics
Rahman Hallaj, Zhaleh Ghafary, Osama kamal Mohammed, Raheleh Shakeri
Summary: The study developed an electrochemical biosensor for detecting the endogenous protein of breast cancer cells using RNA-cleaving DNAzymes. Thionine-modified gold nanoparticles and modified magnetic nanoparticles were used to prepare a probe, which was then pulled to the electrode surface with the help of a magnetic field. The presence of gold nanoparticle-thionine hybrid as an electroactive label ensured strong detection signals. The biosensor showed a linear range of (1.0E-06 to 1.0E+01) pg/ml for the protein marker and a detection limit of (1.0129E-07 pg/ml) using differential pulse voltammetry and electrochemical impedance spectroscopy (EIS).
BIOSENSORS & BIOELECTRONICS
(2023)
Meeting Abstract
Oncology
Samata Kakkad, Desmond Jacob, Balaji Krishnamachary, Zaver M. Bhujwalla
Article
Oncology
Marie-France Penet, Samata Kakkad, Arvind P. Pathak, Balaji Krishnamachary, Yelena Mironchik, Venu Raman, Meiyappan Solaiyappan, Zaver M. Bhujwalla
CLINICAL CANCER RESEARCH
(2017)
Article
Biophysics
Tariq Shah, Flonne Wildes, Samata Kakkad, Dmitri Artemov, Zaver M. Bhujwalla
NMR IN BIOMEDICINE
(2016)
Article
Multidisciplinary Sciences
Louis Dore-Savard, Esak Lee, Samata Kakkad, Aleksander S. Popel, Zaver M. Bhujwalla
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Balaji Krishnamachary, Ioannis Stasinopoulos, Samata Kakkad, Marie-France Penet, Desmond Jacob, Flonne Wildes, Yelena Mironchik, Arvind P. Pathak, Meiyappan Solaiyappan, Zaver M. Bhujwalla
Article
Biochemical Research Methods
Zaver M. Bhujwalla, Samata Kakkad, Zhihang Chen, Jiefu Jin, Sudath Hapuarachchige, Dmitri Artemov, Marie-France Penet
JOURNAL OF MAGNETIC RESONANCE
(2018)
Meeting Abstract
Oncology
Samata Kakkad, Peng Huang, Malcolm Brock, Balaji Krishnamachary, Zaver M. Bhujwalla
Review
Oncology
Samata Kakkad, Balaji Krishnamachary, Desmond Jacob, Jesus Pacheco-Torres, Eibhlin Goggins, Santosh Kumar Bharti, Marie-France Penet, Zaver M. Bhujwalla
CANCER AND METASTASIS REVIEWS
(2019)
Article
Oncology
Santosh Kumar Bharti, Samata Kakkad, Pierre Danhier, Flonne Wildes, Marie-France Penet, Balaji Krishnamachary, Zaver M. Bhujwalla
Review
Medicine, Research & Experimental
Eibhlin Goggins, Shuhei Mitani, Shinji Tanaka
Summary: This review discusses the current evidence supporting the efficacy of vagus nerve stimulation (VNS) in different diseases and highlights recent advancements in this field. Insights into the mechanism of VNS are also considered.
Letter
Public, Environmental & Occupational Health
Eibhlin Goggins, Binu Sharma, Jennie Z. Ma, Jitendra Gautam, Brendan Bowman
HEALTH SCIENCE REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Eibhlin Goggins, Binu Sharma, Jennie Z. Ma, Jitendra Gautam, Brendan Bowman
Summary: Dialysis patients who received the BNT162b2 vaccine showed a significant decline in long-term immunity. At 6 months post-vaccination, 40% of patients had negative or borderline antibody levels. These findings underscore the urgent need for vaccine boosters in this patient population.
HEALTH SCIENCE REPORTS
(2022)
Meeting Abstract
Oncology
Samata Kakkad, Mikayla Hanna, Desmond Jacob, Balaji Krishnamachary, Zaver M. Bhujwalla