Article
Immunology
Parveen Kumar, Kanchan Saini, Vikram Saini, Tanecia Mitchell
Summary: This study found that oxalate impairs macrophage metabolism, redox homeostasis, and cytokine signaling leading to a reduction in anti-bacterial response and increased infection.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kristell Le Gal, Edward E. Schmidt, Volkan Sayin
Summary: Cellular redox homeostasis is crucial for balancing the reducing and oxidizing reactions within cells, regulating various biological responses and events. Despite the challenges in studying these biochemical reactions, recent advancements in technology have rapidly expanded the redox field, enhancing our understanding of its significance in biology. This short review aims to provide an overview of redox regulation in cellular signaling, development, and disease, as well as introduce some recent discoveries in these areas.
Review
Biochemistry & Molecular Biology
Verena Tretter, Beatrix Hochreiter, Marie Louise Zach, Katharina Krenn, Klaus Ulrich Klein
Summary: The field of redox biology aims to understand the regulation and maintenance of redox homeostasis, as well as the mechanisms involved in the development of diseases with oxidative or reductive stress. Targeting oxidative stress therapeutically is challenging due to the delicate cellular redox systems that vary in concentrations across subcellular compartments and depend on the physiological and pathological status of cells and organelles.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Nnamdi Uche, Qiang Dai, Shuping Lai, Kurt Kolander, Mai Thao, Elizabeth Schibly, Xavier Sendaydiego, Jacek Zielonka, Ivor J. Benjamin
Summary: This study found that pretreatment with carvedilol, a drug used for heart disease, can alleviate the damage caused by doxorubicin and improve mitochondrial function. The results suggest that carvedilol may have a potential role as an antioxidant to prevent oxidative stress. These findings provide new evidence for the use of carvedilol as a preventive treatment for cardiotoxicity.
Article
Environmental Sciences
Macarena Ros, Jose M. Guerra-Garcia, Jehan-Herve Lignot, Georgina A. Rivera-Ingraham
Summary: This study explores the role of ecophysiology in mediating marine biological pollution and predicting invasive species impacts, focusing on two sympatric skeleton shrimps. The research found that decreased seawater salinity and/or oxygen levels can weaken biotic resistance, particularly in females of one shrimp species, leading to increased vulnerability to invasion.
MARINE POLLUTION BULLETIN
(2021)
Article
Biochemistry & Molecular Biology
Leonardo de Moura Alvorcem, Renata Britto, Cristiane Cecatto, Ana Cristina Roginski, Francieli Rohden, Juliete Nathali Scholl, Fatima C. R. Guma, Fabricio Figueiro, Alexandre Umpierrez Amaral, Geancarlo Zanatta, Bianca Seminotti, Moacir Wajner, Guilhian Leipnitz
Summary: The study revealed that EMA inhibits mitochondrial respiration, particularly glutamate oxidation, and induces mitochondrial permeability transition, potentially contributing to the pathogenesis of cerebellar abnormalities in ethylmalonic encephalopathy (EE).
JOURNAL OF NEUROCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Yuh-Cherng Chai, John J. Mieyal
Summary: This Special Issue aims to advance the understanding of the roles of the GSH/Grx system in cellular homeostasis and disease processes. GSH is the most abundant non-enzymatic antioxidant/nucleophilic molecule in cells. The S-glutathionylation of proteins, a reversible post-translational modification, can act as a regulatory switch in cell signaling and redox homeostasis.
Review
Biochemistry & Molecular Biology
Md. Ataur Rahman, Kazi Rejvee Ahmed, Farzana Haque, Moon Nyeo Park, Bonglee Kim
Summary: Autophagy is a fundamental process for maintaining cellular homeostasis and survival. It involves the degradation of cellular components to generate energy and maintain stability. It has been found to play a crucial role in disease progression and maintaining redox equilibrium.
Article
Biotechnology & Applied Microbiology
Marilise Nogueira, Eugenia M. A. Enfissi, Elliott J. Price, Guillaume N. Menard, Eudri Venter, Peter J. Eastmond, Einat Bar, Efraim Lewinsohn, Paul D. Fraser
Summary: Plant cells have a remarkable capacity to adapt to the synthesis and response of non-endogenous substances, involving changes in plastidial membrane, core metabolic pathways, and redox control.
PLANT BIOTECHNOLOGY JOURNAL
(2023)
Review
Cell Biology
Rafael D. Mesquita, Alessandro Gaviraghi, Renata L. S. Goncalves, Marcos A. Vannier-Santos, Julio A. Mignaco, Carlos Frederico L. Fontes, Luciana E. S. F. Machado, Marcus F. Oliveira
Summary: This review discusses the regulation of COX in flying insects and compares the structure models of three COX subunits from different insect species to mammalian counterparts, finding similarities with specific phosphomimetic amino acid substitutions. The results suggest a new regulatory mechanism of COX activity in insects, potentially impacting their biology and dispersal.
Article
Nanoscience & Nanotechnology
Haifeng Lu, Shuxin Xu, Ge Ge, Zhanchen Guo, Menghuan Zhao, Zhen Liu
Summary: This study presents Cu2+-encapsulated and GalNAc-imprinted biodegradable silica nanoparticles for enhancing chemodynamic therapy (CDT). The nanoparticles specifically target tumor cells and release Cu2+/Cu+ to promote GSH depletion and generate hydroxyl radicals, leading to apoptosis of tumor cells. In vitro and in vivo experiments demonstrate excellent cytotoxicity against tumor cells and high efficacy of tumor inhibition.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Multidisciplinary Sciences
Wei Li, Junjie Kou, Zhenxi Zhang, Haoyue Li, Li Li, Wenjing Du
Summary: Research reveals that MYC gene plays an important role in driving T cell lymphomagenesis, and malic enzyme 2 (ME2), an enzyme associated with glutamine metabolism, is essential in this process. By establishing a CD4-Cre; Myc flox/+ transgenic mouse model, it is found that knockout of Me2 significantly suppresses T cell lymphomagenesis. Mechanistically, MYC up-regulates ME2 to maintain redox homeostasis, while ME2 stimulates mTORC1 activity through adjusting glutamine metabolism, promoting MYC translation. Overall, these findings highlight the crucial role of ME2 in MYC-driven T cell lymphomagenesis and suggest the MYC-ME2 circuit as a potential target for TCL therapy.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Ying Wang, Mengwei Li, Lin Chen, Huan Bian, Xiangying Chen, Huilin Zheng, Peiwei Yang, Quan Chen, Hanmei Xu
Summary: Exosomal miR-1249-3p derived from NK cells plays a crucial role in alleviating insulin resistance and inflammation in type 2 diabetes mice, suggesting potential therapeutic targets in this disease.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)
Article
Plant Sciences
Yue Xi, Jiajia Cai, Ganting Li, Haijian Huang, Xinxiang Peng, Guohui Zhu
Summary: The concentration of CO2 has significant effects on plant biological processes, especially the ratio of photosynthesis to photorespiration. Previous studies have shown that high CO2 levels can promote carbon fixation and reduce oxidative damage in plants. However, the impact of high CO2 on fatty acid metabolism and cellular redox balance in FA-deficient plants remains unclear.
Article
Biochemistry & Molecular Biology
Sudipta Biswas, Detao Gao, Jessica B. Altemus, Umar R. Rekhi, Ellen Chang, Maria Febbraio, Tatiana V. Byzova, Eugene A. Podrez
Summary: Recent studies have shown that plasma cCD36 levels are elevated in hyperlipidemic conditions, with endothelial cells making a significant contribution. Oxidized phospholipids known to accumulate in hyperlipidemia induce the release of CD36 from various cell types. This demonstrates a link between cCD36 and oxidized phospholipids associated with oxidative stress and low-grade inflammation in hyperlipidemia.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Genetics & Heredity
Jennifer K. Blakemore, Paxton Voigt, Mindy R. Schiffman, Shelley Lee, Andria G. Besser, M. Elizabeth Fino
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2019)
Article
Multidisciplinary Sciences
Katelyn W. Ahern, Vlad Serbulea, Catherine L. Wingrove, Zachary T. Palas, Norbert Leitinger, Thurl E. Harris
SCIENTIFIC REPORTS
(2019)
Article
Cardiac & Cardiovascular Systems
Nenja Kruger, Lauren A. Biwer, Miranda E. Good, Claire A. Ruddiman, Abigail G. Wolpe, Leon J. DeLalio, Sara Murphy, Edgar H. Macal, Louis Ragolia, Vlad Serbulea, Angela K. Best, Norbert Leitinger, Thurl E. Harris, Swapnil K. Sonkusare, Axel Goedecke, Brant E. Isakson
CIRCULATION RESEARCH
(2020)
Article
Hematology
Gael F. P. Bories, Scott Yeudall, Vlad Serbulea, Todd E. Fox, Brant E. Isakson, Norbert Leitinger
Article
Genetics & Heredity
Paxton E. Voigt, Jennifer K. Blakemore, David McCulloh, M. Elizabeth Fino
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Chemistry, Medicinal
Molly Congdon, Russell G. Fritzemeier, Yugesh Kharel, Anne M. Brown, Vlad Serbulea, David R. Bevan, Kevin R. Lynch, Webster L. Santos
Summary: Elevated levels of Sphingosine 1-phosphate (S1P) and increased expression of Sphingosine kinase iso-forms (SphK1 and SphK2) are associated with various disease states. The development of selective inhibitors for SphK1 and SphK2 has become a focus of drug discovery, with studies focusing on optimizing binding in the SphK2 substrate binding site. The identification of indole-based compounds with 1,5-disubstitution as potent inhibitors highlights the potential for targeting SphK2 with improved potency and selectivity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
Subramanian Senthivinayagam, Vlad Serbulea, Clint M. Upchurch, Renata Polanowska-Grabowska, Suresh K. Mendu, Srabani Sahu, Prathiba Jayaguru, Kevin W. Aylor, Mahendra D. Chordia, Limor Steinberg, Nathaniel Oberholtzer, Seichii Uchiyama, Noriko Inada, Ulrike M. Lorenz, Thurl E. Harris, Susanna R. Keller, Akshaya K. Meher, Alexandra Kadl, Bimal N. Desai, Bijoy K. Kundu, Norbert Leitinger
Summary: By studying the activity of Panx1 channels in brown adipocytes, it was discovered that Panx1 channels play a significant role in regulating thermogenesis induced by beta 3AR, with potential therapeutic implications for thermoregulation.
MOLECULAR METABOLISM
(2021)
Article
Cell Biology
Stephen L. Abrams, Shaw M. Akula, Akshaya K. Meher, Linda S. Steelman, Agnieszka Gizak, Przemyslaw Duda, Dariusz Rakus, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Giuseppe Montalto, Melchiorre Cervello, Peter Ruvolo, Massimo Libra, Luca Falzone, Saverio Candido, James A. McCubrey
Summary: GSK-3 plays diverse roles in pancreatic and breast cancers, altering the levels of GSK-3 can significantly impact cellular sensitivity to drugs and signal transduction inhibitors, which may be influenced by the tumor background.
Article
Pathology
Michael D. Spinosa, William G. Montgomery, Melissa Lempicki, Prasad Srikakulapu, Matthew J. Johnsrude, Coleen A. McNamara, Gilbert R. Upchurch, Gorav Ailawadi, Norbert Leitinger, Akshaya K. Meher
Summary: The study demonstrated that BAFF antagonism can attenuate the formation and development of abdominal aortic aneurysm in mice. In the intervention group, BAFF antagonism reduced mature B-cell subsets, promoting resolution of inflammation in AAA tissues.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Cell Biology
Melissa D. Lempicki, Saikat Paul, Vlad Serbulea, Clint M. Upchurch, Srabani Sahu, Jake A. Gray, Gorav Ailawadi, Brandon L. Garcia, Coleen A. McNamara, Norbert Leitinger, Akshaya K. Meher
Summary: Human recombinant B cell activating factor (BAFF) can form 60-mers or higher order multimers in human plasma, and these multimers play critical roles in hyperactivation of B cells by inducing the transcriptome and activating specific signaling pathways.
CELLULAR IMMUNOLOGY
(2022)
Article
Hematology
Rebecca A. Deaton, Gamze Bulut, Vlad Serbulea, Anita Salamon, Laura S. Shankman, Anh Tram Nguyen, Gary K. Owens
Summary: This study introduces a new Myh11-CreER(T2)-RAD mouse model that can be used for lineage tracing and gene knockout studies of smooth muscle cells (SMCs) in both male and female mice. The innovation of this model is that the Myh11 transgene is inserted into mouse chromosome 2, allowing for study in female mice. Flow cytometric and immunofluorescence analyses of mouse samples confirmed that this model can label vascular and visceral SMCs and pericytes.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2023)
Article
Cell Biology
James A. McCubrey, Akshaya K. Meher, Shaw M. Akula, Stephen L. Abrams, Linda S. Steelman, Michelle M. LaHair, Richard A. Franklin, Alberto M. Martelli, Stefano Ratti, Lucio Cocco, Fulvio Barbaro, Przemyslaw Duda, Agnieszka Gizak
Summary: TP53 plays a crucial role in regulating signaling and apoptotic pathways in pancreatic cancer, impacting drug sensitivity and metabolism.
Article
Biochemistry & Molecular Biology
Scott M. Seki, Kacper Posyniak, Rebecca McCloud, Dorian A. Rosen, Anthony Fernandez-Castaneda, Rebecca M. Beiter, Vlad Serbulea, Sarah C. Nanziri, Nikolas Hayes, Charles Spivey, Lelisa Gemta, Timothy N. J. Bullock, Ku-Lung Hsu, Alban Gaultier
Article
Endocrinology & Metabolism
Alexandra A. C. Newman, Vlad Serbulea, Richard A. Baylis, Laura S. Shankman, Xenia Bradley, Gabriel F. Alencar, Katherine Owsiany, Rebecca A. Deaton, Santosh Karnewar, Sohel Shamsuzzaman, Anita Salamon, Mahima S. Reddy, Liang Guo, Aloke Finn, Renu Virmani, Olga A. Cherepanova, Gary K. Owens
Summary: The study found that stable atherosclerotic plaques are composed of cells from various origins, including smooth muscle cells, endothelial cells, and macrophages that undergo different transitions to produce myofibroblast-like cells. Additionally, it was shown that myofibroblasts derived from endothelial-to-mesenchymal transition and macrophage-to-mesenchymal transition cannot indefinitely compensate for the loss of smooth muscle cell-derived myofibroblasts. Furthermore, the transitions from smooth muscle cells to myofibroblasts are induced by PDGF and TGF-beta, while endothelial-to-mesenchymal transition is induced by interleukin-1 beta and TGF-beta.
Article
Endocrinology & Metabolism
Liujun Chen, Lisha Li, Donghong Cui, Yiheng Huang, Haibin Tong, Haleh Zabihi, Shuxia Wang, Yadan Qi, Ted Lakowski, Lin Leng, Suixin Liu, Hong Wu, Lawrence H. Young, Richard Bucala, Dake Qi
Summary: Attenuation of adipose hormone sensitive lipase (HSL) may impair lipolysis and exacerbate obesity. Cytokine macrophage migration inhibitory factor (MIF) plays a role in regulating adipose HSL and adipocyte hypertrophy. Both intracellular and extracellular MIF have opposing effects on HSL, but extracellular action predominates to downregulate HSL and exacerbate obesity development during high-fat diet (HFD).
MOLECULAR METABOLISM
(2024)
Article
Endocrinology & Metabolism
Mengyang Tang, Yi Zhang, Rong Zhang, Yuemei Zhang, Jiangfei Zheng, Daixi Wang, Xinyu Wang, Jing Yan, Cheng Hu
Summary: This study aimed to explore the role of GPSM1 in POMC neurons and the underlying mechanisms in metabolic homeostasis. Through various molecular, biochemical, immunofluorescent, immunohistochemical analyses, and cell culture studies, the study revealed the pathophysiological role of GPSM1 in POMC neurons and its regulation of POMC neuron activity.
MOLECULAR METABOLISM
(2024)