Article
Multidisciplinary Sciences
Yen-Fu Chen, Ao-Ho Hsieh, Lian-Chin Wang, Yun-Ju Huang, Yun-Chen Tsai, Wen-Yi Tseng, Yu-Lun Kuo, Shue-Fen Luo, Kuang-Hui Yu, Chang-Fu Kuo
Summary: The study revealed alterations in the gut microbiota of mice induced with lupus-like effects through immunization with HCMVpp65 peptide, showing increased abundances of certain families and genera correlated with lupus symptoms.
SCIENTIFIC REPORTS
(2021)
Article
Gastroenterology & Hepatology
Eun Soo Kim, Leonid Tarassishin, Caroline Eisele, Amelie Barre, Nilendra Nair, Alexa Rendon, Kelly Hawkins, Anketse Debebe, Sierra White, Anne Thjomoe, Einar Mork, Mario Bento-Miranda, Hinaben Panchal, Manasi Agrawal, Anish Patel, Ching-Lynn Chen, Asher Kornbluth, James George, Peter Legnani, Elana Maser, Holly Loudon, Maria-Teresa Mella, Joanne Stone, Marla Dubinsky, Joao Sabino, Joana Torres, Jean-Frederic Colombel, Inga Peter, Jianzhong Hu
Summary: Pregnancy is associated with reduced inflammatory activity in mothers with IBD, however, babies born to mothers with IBD show subclinical inflammation in early life. The study findings suggest a correlation between maternal FC levels and bacterial abundance.
Article
Veterinary Sciences
Xiaopeng Tang, Kai Zhang, Kangning Xiong
Summary: The present study found that fermented complete feed (FCF) had a significant impact on the diversity of fecal microbiota in pigs, increasing the biodiversity and altering the abundance of certain phyla and genera. Additionally, there were significant differences in the relative abundance of disease-associated and metabolism-associated genes between the FCF group and the basal diet group.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Microbiology
Kristen S. Smith, Molly M. Morris, Casey D. Morrow, Josh R. Novak, Michael D. Roberts, Andrew Dandridge Fruge
Summary: This study explored the effects of a 10-week resistance training regimen with or without peanut protein supplementation on gut microbiota and mood disturbance in untrained young adults. The results showed that exercise and protein supplementation had an impact on gut microbial composition and mood, and mood states were associated with changes in microbial taxa and body composition.
Article
Multidisciplinary Sciences
Luca Laghi, Sara Zagonari, Giulia Patuelli, Chenglin Zhu, Claudio Foschi, Sara Morselli, Maria Federica Pedna, Vittorio Sambri, Antonella Marangoni
Summary: During pregnancy, the vaginal microbiome undergoes significant changes in composition, with a decrease in overall diversity and enrichment with Lactobacillus spp. These modifications are associated with shifts in the composition of vaginal metabolites, with a reduction in BV-associated metabolites and an increase in metabolites typically found in healthy vaginal conditions. This study suggests a relationship between vaginal microbiota, metabolites, and pregnancy outcomes.
Article
Agriculture, Dairy & Animal Science
Brooke E. McAnally, Molly S. Smith, Jeffrey G. Wiegert, Vignesh Palanisamy, Sapna Chitlapilly Dass, Rebecca K. Poole
Summary: This study characterized the bacterial communities in fresh extended boar semen samples using 16S rRNA sequencing and associated the prevalence and diversity of the microbial population with sperm quality parameters. Differences in bacterial communities were found between boar studs and over time, and these differences were associated with variations in sperm quality. The findings suggest that the semen microbiome plays a role in sperm cell function and can influence semen quality.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Immunology
Wiwat Chancharoenthana, Supitcha Kamolratanakul, Peerapat Visitchanakun, Supistha Sontidejkul, Thanya Cheibchalard, Naraporn Somboonna, Sarn Settachaimongkon, Asada Leelahavanichkul
Summary: The impacts of metabolomic changes in uremic condition are not fully understood. In a mouse experiment, Candida administration worsened the condition of uremic mice and induced leaky gut, while the administration of SCFA-producing probiotics attenuated these effects. Overall, the use of probiotics in uremia is supported.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Hongjiao Liu, Wodan Ling, Xing Hua, Jee-Young Moon, Jessica S. S. Williams-Nguyen, Xiang Zhan, Anna M. M. Plantinga, Ni Zhao, Angela Zhang, Rob Knight, Qibin Qi, Robert D. D. Burk, Robert C. C. Kaplan, Michael C. C. Wu
Summary: This study proposes a novel approach called the covariate-adjusted KRV framework to map genetic variants associated with microbiome beta-diversity. The framework evaluates the association between genetics and microbes by comparing similarity in genetic profiles to similarity in microbiome profiles across individuals. The study identifies an immunity-related gene IL23R and three other novel genes involved in immune functions or autoimmune disorders. Simulation studies show that the covariate-adjusted KRV has a greater power than other microbiome GWAS methods.
Article
Agriculture, Dairy & Animal Science
Eun-Tae Kim, Sang-Jin Lee, Tae-Yong Kim, Hyo-Gun Lee, Rahman M. Atikur, Bon-Hee Gu, Dong-Hyeon Kim, Beom-Young Park, Jun-Kyu Son, Myung-Hoo Kim
Summary: The study utilized metagenomic analysis to investigate the dynamic changes in the fecal microbiome of pre-weaned dairy calves, revealing significant shifts in gut microbiome composition during diarrheal disease and increased diversity with age. The findings suggest important implications of gut microbiota in the metabolism and health status of neonatal dairy calves.
Article
Dentistry, Oral Surgery & Medicine
William Johnston, Bob T. Rosier, Miguel Carda-Dieguez, Michael Paterson, Paddy Watson, Krystyna Piela, Marilyn Goulding, Gordon Ramage, Divyashri Baranyia, Tsute Chen, Nezar N. Al-Hebshi, Alex Mira, Shauna Culshaw
Summary: This study investigated the early and later changes in subgingival biofilm following periodontal treatment and found that hand and ultrasonic instruments had similar impacts on the composition of the subgingival plaque microbiome. There were marked changes in biofilm composition in the early stages after treatment, but limited evidence of these changes being associated with treatment outcomes.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Immunology
Ylaine Gerardin, Sonia Timberlake, Jessica R. Allegretti, Mark B. Smith, Zain Kassam
Summary: The transfer of live gut microbes may revolutionize the treatment of various diseases, with fecal microbiota transplantation showing early success in certain infections. The development of microbiome drugs is now being driven by these clinical advances, although challenges remain in terms of safety, consistency, and delivery.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Gastroenterology & Hepatology
Laura Grieneisen, Ran Blekhman, Elizabeth Archie
Summary: A crucial aspect of microbiome research is understanding how host genetics influence the composition of gut microbiota. However, it is challenging to establish a direct link between host genetics and gut microbiota composition due to the correlation between host genetic similarity and environmental similarity. Longitudinal microbiome data can offer valuable insights into the relative impact of genetic processes on the microbiome by revealing environmentally contingent host genetic effects and comparing genetic effects in different environments. This article explores four areas in which longitudinal data can provide new knowledge on host genetic effects on the microbiome: microbial heritability, microbial plasticity, microbial stability, and host and microbiome population genetics. Methodological considerations for future studies are also discussed.
Article
Multidisciplinary Sciences
Marina D. Brown, Leila M. Shinn, Ginger Reeser, Matthew Browning, Andiara Schwingel, Naiman A. Khan, Hannah D. Holscher
Summary: This study analyzed the fecal and soil microbiota of gardening families and non-gardening families, and found differences in fecal microbial characteristics, phylogenetic diversity score, fiber intake, and fiber fermenting bacteria abundance between gardening and non-gardening families. The study also revealed detectable changes in the fecal microbial community of gardeners and their family members over the course of the gardening season, with shared microbes between soil and fecal samples.
SCIENTIFIC REPORTS
(2022)
Article
Gastroenterology & Hepatology
Prashant Singh, Eric J. Alm, John M. Kelley, Vivian Cheng, Mark Smith, Zain Kassam, Judy Nee, Johanna Iturrino, Anthony Lembo
Summary: Fecal microbiota transplantation is an effective strategy to correct microbial dysbiosis in diarrhea-predominant irritable bowel syndrome. For patients with IBS-D, FMT with antibiotic pretreatment significantly reduces bacterial engraftment.
Article
Ecology
Elizabeth A. Herder, Austin R. Spence, Morgan W. Tingley, Sarah M. Hird
Summary: The study on the microbial communities in wild Anna's hummingbirds found that individual bird ID and sample elevation are the two main factors influencing the microbiome variation. The environment can shape the abundance of bacteria in the microbiome, but not directly impact the presence or absence of microbes.
FRONTIERS IN ECOLOGY AND EVOLUTION
(2021)
Article
Microbiology
Yuqing He, Francesco Tiezzi, Jeremy Howard, Yijian Huang, Kent Gray, Christian Maltecca
Summary: This study explores the influence of gut microbiota on feeding behavior traits and identifies specific microbes associated with these traits in three commercial swine breeds at different growth stages. The results indicate that the gut microbial composition explains a small to moderate proportion of the variability in feeding behavior. Several archaea and bacteria are found to be significantly correlated with feeding behavior measures. These findings highlight the importance of the gut microbiome in interacting with host feeding behavior and provide insights into swine microbial studies.
Article
Genetics & Heredity
Yuqing He, Francesco Tiezzi, Jicai Jiang, Jeremy T. Howard, Yijian Huang, Kent Gray, Jung-Woo Choi, Christian Maltecca
Summary: This study investigates the use of feeding behavior and gut microbiome in predicting growth and body composition traits of finishing pigs, and finds that they provide non-redundant information for predicting porcine growth.
Article
Agriculture, Dairy & Animal Science
Cristina Sartori, Francesco Tiezzi, Nadia Guzzo, Enrico Mancin, Beniamino Tuliozi, Roberto Mantovani
Summary: This study investigated the impact of environmental factors on the genotype of local dual-purpose cattle and found that genetic variability and response to selection for production traits and conformation traits differed under different environmental conditions.
Review
Agriculture, Dairy & Animal Science
O. Gonzalez-Recio, M. Martinez-Alvaro, Francesco Tiezzi, A. Saborio-Montero, C. Maltecca, R. Roehe
Summary: The rumen microbiome plays a crucial role in methane emission in ruminants and has been the subject of extensive research in the past decade. High-throughput sequencing technologies have greatly expanded our knowledge of rumen microorganisms through metagenomic studies. Evidence shows that the composition of the rumen microbiota is influenced by the host's genotype, making modulation of the microbiota an important tool for breeding animals with lower emissions. This review discusses the challenges of metagenomic studies and proposes solutions, including incorporating metagenomic information into statistical models used in animal breeding. The latest advances in this field are also addressed.
Article
Nutrition & Dietetics
Brandon J. Eudy, Jack Odle, Xi Lin, Christian Maltecca, Kathleen R. Walter, Nathan P. McNulty, Vivek Fellner, Sheila K. Jacobi
Summary: This study evaluated the effects of arachidonate (ARA) and/or prebiotic oligosaccharide (PRE) supplementation in formula on the development of the microbial ecosystem and colonic health parameters. The results showed that PRE supplementation increased the abundance of specific bacterial genera and concentrations of short-chain fatty acids (SCFA), benefiting intestinal development. ARA supplementation increased the ARA content in the colonic mucosa and increased the unsaturation of fatty acids.
JOURNAL OF NUTRITION
(2023)
Article
Biochemistry & Molecular Biology
Feng Wang, Chaolai Man, Xiaoqiu Wang, Jack Odle, Christian Maltecca, Xi Lin
Summary: Maternal undernutrition during pregnancy can lead to severe fetal impairments, but the exact mechanisms are not fully understood. This study investigated the potential impacts of restricted nutrition on metabolic pathways in fetal pigs. The results revealed differential expression of mRNA and miRNA, as well as alterations in metabolic and signaling pathways. These findings provide valuable insights into the negative effects of maternal malnutrition on hepatic metabolism in full-term fetal pigs via miRNA-mRNA interactions.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Ecology
Sahana Kuthyar, Jessica Diaz, Fabiola Avalos-Villatoro, Christian Maltecca, Francesco Tiezzi, Robert R. Dunn, Aspen T. Reese
Summary: Animal domestication affects the gut microbiome and immune state of pig populations. The main differences in the gut microbiome are found between wild and domestic genetic lineages.
JOURNAL OF EVOLUTIONARY BIOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Jay S. Johnson, Hui Wen, Pedro H. F. Freitas, Jacob M. Maskal, Sharlene O. Hartman, MaryKate Byrd, Jason R. Graham, Guadalupe Ceja, Francesco Tiezzi, Christian Maltecca, Yijian Huang, Ashley DeDecker, Allan P. Schinckel, Luiz F. Brito
Summary: Climate change and global warming have a negative impact on swine production, so improving swine heat stress resilience is crucial. Genomic selection for heat stress resilience could be an effective strategy. This study identified environmental conditions for heat stress and determined phenotypes that predict heat stress tolerance in lactating sows. The findings can be applied to develop or refine genomic selection indexes for heat stress resilience in pigs.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Biochemical Research Methods
Jian Cheng, Christian Maltecca, Paul M. VanRaden, Jeffrey R. O'Connell, Li Ma, Jicai Jiang
Summary: SLEMM is a new software tool for large-scale genomic prediction, which can improve prediction accuracy through SNP weighting. Extensive analyses on multiple datasets showed that SLEMM had the best predictive ability and computational performance compared to other genomic prediction methods. Simulation analyses also demonstrated that SLEMM had comparable accuracy to BayesR.
Meeting Abstract
Agriculture, Dairy & Animal Science
MaryKate Byrd, Luiz F. F. Brito, Hui Wen, Pedro H. F. Freitas, Sharlene Hartman, Jacob M. Maskal, Yijian Huang, Francesco Tiezzi, Christian Maltecca, Allan P. Schinckel, Jay S. Johnson
JOURNAL OF ANIMAL SCIENCE
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Christiana O. Obari, Bayode O. Makanjuola, Flavio S. Schenkel, Filippo Miglior, Christian Maltecca, Christine F. Baes
JOURNAL OF ANIMAL SCIENCE
(2023)
Meeting Abstract
Agriculture, Dairy & Animal Science
Junjian Wang, Christian Maltecca, Francesco Tiezzi, Yijian Huang, Jicai Jiang
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Agriculture, Dairy & Animal Science
Vanille Deru, Francesco Tiezzi, Celine Carillier-Jacquin, Benoit Blanchet, Laurent Cauquil, Olivier Zemb, Alban Bouquet, Christian Maltecca, Helene Gilbert
Summary: The study found that the gut microbiota significantly influenced the phenotypic variability of digestive efficiency traits, even more than host genetics. The use of microbiota information could enhance the selection of digestive efficiency traits, and to a lesser extent, growth and feed efficiency traits. Filtering OTU is an important step that influences microbiability.
GENETICS SELECTION EVOLUTION
(2022)
Article
Agriculture, Dairy & Animal Science
Emmanuel Andre Lozada-Soto, Daniela Lourenco, Christian Maltecca, Justin Fix, Clint Schwab, Caleb Shull, Francesco Tiezzi
Summary: The value of using genomic information for genetic improvement in pork production depends on the traits and the source of genomic information. Including genomic information of crossbred individuals is more beneficial than multi-trait prediction for most traits.
GENETICS SELECTION EVOLUTION
(2022)