Article
Cardiac & Cardiovascular Systems
Dirk H. van Dalen, Johannes A. Kragten, Mireille E. Emans, Clara E. E. Van Ofwegen-Hanekamp, Claudia C. R. Klaarwater, Mireille H. A. Spanjers, Remond Hendrick, Cees Th B. M. van Deursen, Hans-Peter Brunner-La Rocca
Summary: The prevalence of iron deficiency in patients with acute heart failure is high, but some patients show improvement during treatment even without iron supplementation. Absolute iron deficiency is more likely to persist, while functional iron deficiency often resolves during treatment, possibly indicating reduced iron availability rather than a true deficiency.
Article
Hematology
Li Xuan, Yu Wang, Kaibo Yang, Ruoyang Shao, Fen Huang, Zhiping Fan, Peiru Chi, Yajing Xu, Na Xu, Lan Deng, Xudong Li, Xinquan Liang, Xiaodan Luo, Pengcheng Shi, Hui Liu, Zhixiang Wang, Ling Jiang, Ren Lin, Yan Chen, Sanfang Tu, Yu Zhang, Jing Sun, Xiaojun Huang, Qifa Liu
Summary: This study is a Phase 3 trial that showed sorafenib maintenance after HSCT can improve overall survival and reduce relapse rates for FLT3-ITD AML patients. The 5-year follow-up data demonstrated the long-term benefits of sorafenib maintenance in terms of overall survival, leukemia-free survival, and GRFS.
LANCET HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Joshua A. Hill, Michael J. Martens, Jo-Anne H. Young, Kavita Bhavsar, Jianqun Kou, Min Chen, Lik Wee Lee, Aliyah Baluch, Madhav Dhodapkar, Ryotaro Nakamura, Kristin Peyton, Zainab Shahid, Paul Armistead, Peter Westervelt, John McCarty, Joseph McGuirk, Mehdi Hamadani, Susan DeWolf, Kinga Hosszu, Elad Sharon, Ashley Spahn, Amir A. Toor, Stephanie Waldvogel, Lee M. Greenberger, Jeffery J. Auletta, Mary M. Horowitz, Marcie L. Riches, Miguel-Angel Perales
Summary: The optimal timing for SARS-CoV-2 vaccines in allogeneic hematopoietic cell transplant (HCT) recipients within the first year after HCT remains uncertain. This prospective study enrolled participants who initiated SARS-CoV-2 vaccinations within 12 months of HCT and found no significant differences in antibody levels and T-cell responses between those who started vaccinations <4 months versus 4-12 months after HCT.
Article
Respiratory System
Thomas Sonnweber, Sabina Sahanic, Alex Pizzini, Anna Luger, Christoph Schwabl, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstatter, David Haschka, Verena Petzer, Anna Boehm, Magdalena Aichner, Piotr Tymoszuk, Daniela Lener, Markus Theurl, Almut Lorsbach-Koehler, Amra Tancevski, Anna Schapfl, Marc Schaber, Richard Hilbe, Manfred Nairz, Bernhard Puchner, Doris Huettenberger, Christoph Tschurtschenthaler, Malte Asshoff, Andreas Peer, Frank Hartig, Romuald Bellmann, Michael Joannidis, Can Gollmann-Tepekoylu, Johannes Holfeld, Gudrun Feuchtner, Alexander Egger, Gregor Hoermann, Andrea Schroll, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Rudolf Kirchmair, Raimund Helbok, Helmut Prosch, Dietmar Rieder, Zlatko Trajanoski, Florian Kronenberg, Ewald Woell, Gunter Weiss, Gerlig Widmann, Judith Loeffler-Ragg, Ivan Tancevski
Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Hematology
Justin Loke, Vinit Upasani, Charlotte Gaskell, Sonia Fox, Rachel Fletcher, Catherine Thomas, Louise Hopkins, Anita Kumari, Tina Tang, Emily Yafai, Rebecca Boucher, Victoria Homer, Arpad Toth, Y. L. Tracey Chan, Katie Randall, Tom Rider, Jenny O'Nions, Victoria Drew, Arvind Pillai, Moez Dungarwalla, Duncan Murray, Anjum Khan, Farooq Wandroo, Sally Moore, Pramila Krishnamurthy, Ya-Wen Jessica Huang, Steve Knapper, Jenny Byrne, Rui Zhao, Charles Craddock, Helen Parry, Paul Moss, Simon J. Stanworth, David M. Lowe
Summary: Limited data exist on the efficacy of COVID-19 vaccination in patients with AML/MDS-EB2. A prospective study found detectable antibodies against SARS-COV-2 spike antigen in all post-vaccine samples. T-cell reactivity to SARS-COV-2 spike protein was only seen in a subset of patients, and disease response and age were predictors of poor T-cell response.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Review
Immunology
Sarah Weber, Anastasia Parmon, Nina Kurrle, Frank Schnuetgen, Hubert Serve
Summary: MDS and AML patients often experience systemic iron overload issues, iron is closely associated with the pathogenesis and potential treatment strategies of the diseases, imbalances in iron homeostasis may lead to various cell death.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Melissa F. Djodikromo, Rosella P. M. G. Hermens, Bart J. F. van den Bemt, Yolba Smit, Tim M. Govers, Charlotte L. Bekker, Nicole M. A. Blijlevens
Summary: This study aims to evaluate the effectiveness of patient-guided dose reduction of tyrosine kinase inhibitors (TKI) in patients with chronic myeloid leukaemia (CML) who have reached a major or deep molecular response. The study includes 147 CML patients who will use an online patient decision aid and receive a shared decision making consultation before choosing to receive a personalised, lower TKI dose. The primary outcome is the proportion of patients with intervention failure at 12 months after dose reduction.
Article
Pathology
Charlotte F. M. Hughes, Paolo Gallipoli, Rishu Agarwal
Summary: NGS technology plays a vital role in the understanding and management of myeloid malignancies such as AML and MDS. However, there are technical and biological challenges in the design, analysis, and interpretation of NGS results, highlighting the importance of expert guidance.
Article
Biophysics
Gaelle Rey, Elisabeth Daguenet, Paul Bonjean, Raynier Devillier, Nathalie Fegueux, Edouard Forcade, Micha Srour, Patrice Chevallier, Marie Robin, Felipe Suarez, Jean-Baptiste Micol, Helene Labussiere-Wallet, Karin Bilger, Etienne Daguindau, Jacques-Olivier Bay, Amandine Fayard, Claude-Eric Bulabois, Stephanie Nguyen-Quoc, Alexis Genthon, Corentin Orvain, Pascal Turlure, Michael Loschi, Xavier Poire, Gaelle Guillerm, Yves Beguin, Natacha Maillard, Jean-Baptiste Mear, Emilie Chalayer, Jerome Cornillon, Emmanuelle Tavernier
Summary: We conducted a retrospective study on 220 adult patients who underwent alloHSCT for t-AML, and found that approximately 20% of patients had measurable residual disease at transplantation, and 3% of patients were not in complete remission. The survival rates at 12 months were 60.7% for OS, 52.8% for EFS, and 44.1% for GRFS. At 5 years, the survival rates were 44.1% for OS, 40.4% for EFS, and 35.3% for GRFS. Uncontrolled t-AML at transplant was associated with lower EFS.
BONE MARROW TRANSPLANTATION
(2023)
Article
Anesthesiology
A. Cumberworth, H. Lewith, A. Sud, H. Jefferson, V Athanassoglou, J. J. Pandit
Summary: This observational study in four hospitals in the UK found that the incidence of serious airway complications is similar to previous research, despite the use of airway prediction not affecting subsequent management.
Article
Anesthesiology
J. Gibson, T. Leckie, J. Hayward, L. Hodgson, South East Anaesthet Res Chain
Summary: This study reports the incidence and nature of non-theatre emergency airway management events in eight acute NHS hospitals in southeast England. The study found that these events are common, unpredictable, and associated with high complication rates. Senior personnel were often present during advanced airway management episodes, and videolaryngoscopy and capnography were frequently used. However, adverse outcomes such as hypoxia and hypotension still occurred.
Review
Hematology
Elizabeth Herrity, Mariana Pinto Pereira, Dennis Dong Hwan Kim
Summary: This study describes the mechanistic diversity of relapse after hematopoietic stem cell transplantation and emphasizes the importance of these mechanisms in treatment selection and future research inspiration.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Medicine, General & Internal
Rory J. Piper, Fardad T. Afshari, Wai Cheong Soon, Angelos G. Kolias, Edward W. Dyson, Laurence Watkins, Rodney Laing, William B. Lo, Jayaratnam Jayamohan
Summary: The UK Chiari 1 Study (UKC1S) aims to investigate the health-related quality of life and complications in patients with Chiari 1 malformation (CM1) in the UK, as well as to compare the outcomes of conservative and surgical management. It also seeks to determine the variation within UK practice in referral patterns, patient pathways, investigations, and surgical decisions.
Article
Surgery
Federica Branchi, Rolf Klingenberg-Noftz, Kristina Friedrich, Nataly Burgel, Severin Daum, Juliane Buchkremer, Elena Sonnenberg, Michael Schumann, Christoph Treese, Hanno Troger, Donata Lissner, Hans-Jorg Epple, Britta Siegmund, Andrea Stroux, Andreas Adler, Winfried Veltzke-Schlieker, Daniel Autenrieth, Silke Leonhardt, Andreas Fischer, Christian Jurgensen, Ulrich-Frank Pape, Bertram Wiedenmann, Oliver Moschler, Maximilian Schreiner, Mathias Z. Strowski, Volkmar Hempel, Yvonne Huber, Helmut Neumann, Christian Bojarski
Summary: PuraStat gel is an effective tool for treating gastrointestinal bleeding, safely applicable as both primary and secondary therapy, and can serve as a bridge to surgery for temporary haemostasis. It shows high efficacy with low rebleeding rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Critical Care Medicine
Florian Reizine, Sarah Le Marec, Anthony Le Meur, Maelys Consigny, Florian Berteau, Laetitia Bodenes, Marie Geslain, Zoe McQuilten, Catherine Le Niger, Julien Huntzinger, Philippe Seguin, Jean-Baptiste Thibert, David Simon, Jean Reignier, Pierre-Yves Egreteau, Jean-Marc Tadie, Olivier Huet, Pierre Asfar, Stephan Ehrmann, Cecile Aubron
Summary: This study aimed to investigate the response of prophylactic platelet transfusion in critically ill patients and to identify factors associated with a poor response. The results showed that nearly two-thirds of prophylactic platelet transfusions led to suboptimal platelet increment, which was associated with the storage duration of platelets.
Article
Hematology
Jan-Niklas Eckardt, Christoph Rillig, Klaus Metzeler, Michael Kramer, Sebastian Stasik, Julia-Annabell Georgi, Peter Heisig, Karsten Spiekermann, Utz Krug, Jan Braess, Dennis Girlich, Cristina M. Sauerland, Bernhard Woermann, Tobias Herold, Wolfgang E. Berdel, Wolfgang Hiddemann, Frank Kroschinsky, Johannes Schetelig, Uwe Platzbecker, Carsten Mueller-Tidow, Tim Sauer, Hubert Serve, Claudia Baldus, Kerstin Schaefer-Eckart, Martin Kaufmann, Stefan Krause, Mathias Haenel, Christoph Schliemann, Maher Hanoun, Christian Thiede, Martin Bornhaeuser, Karsten Wendt, Jan Moritz Middeke
Summary: This study used machine learning models to predict complete remission and 2-year overall survival in AML patients, incorporating clinical, laboratory, cytogenetic and molecular genetic data. The predictive features for complete remission included gene mutations such as CEBPA, NPM1, FLT3-ITD, etc., as well as certain clinical indicators. Predictive markers for 2-year overall survival included gene mutations such as CEBPA, FLT3-ITD, white blood cell count, etc.
Article
Biophysics
Donata Backhaus, Dominic Brauer, Rosmarie Pointner, Lara Bischof, Vladan Vucinic, Georg-Nikolaus Franke, Dietger Niederwieser, Uwe Platzbecker, Madlen Jentzsch, Sebastian Schwind
Summary: The impact of higher HCT-CI risk on NMA-HSCT outcomes in older AML patients is not significant, suggesting that age and comorbidities should not prevent the use of this treatment option.
BONE MARROW TRANSPLANTATION
(2023)
Article
Hematology
Ulrich Germing, Pierre Fenaux, Uwe Platzbecker, Rena Buckstein, Valeria Santini, Maria Diez-Campelo, Aylin Yucel, Derek Tang, Shannon Fabre, George Zhang, Roberto Zoffoli, Xianwei Ha, Dimana Miteva, Christina Hughes, Rami S. S. Komrokji, Amer M. M. Zeidan, Guillermo Garcia-Manero
Summary: Red blood cell transfusion independence (RBC-TI) can be achieved more effectively with luspatercept compared to placebo in the first 24 weeks of treatment for lower-risk myelodysplastic syndromes with ring sideroblasts. Long-term analysis also suggests that continuing luspatercept treatment beyond week 25 can provide additional clinical benefits for initial nonresponders.
ANNALS OF HEMATOLOGY
(2023)
Article
Hematology
Steffen Koschmieder, Susanne Isfort, Dominik Wolf, Florian H. Heidel, Andreas Hochhaus, Philippe Schafhausen, Martin Griesshammer, Denise Wolleschak, Uwe Platzbecker, Konstanze Doehner, Philipp J. Jost, Stefani Parmentier, Markus Schaich, Nikolas von Bubnoff, Frank Stegelmann, Angela Maurer, Martina Crysandt, Deniz Gezer, Maike Kortmann, Jeremy Franklin, Julia Frank, Martin Hellmich, Tim H. Bruemmendorf
Summary: This study found that treatment with ruxolitinib is effective, well-tolerated, and efficient for previously untreated patients with polycythemia vera, with significant reduction in symptoms and improvement in hematological parameters.
ANNALS OF HEMATOLOGY
(2023)
Article
Oncology
Yi Han, Pascal Drobisch, Alexander Krueger, Doreen William, Konrad Gruetzmann, Lukas Boethig, Heike Polster, Lena Seifert, Adrian M. Seifert, Marius Distler, Mathieu Pecqueux, Carina Riediger, Verena Plodeck, Heiner Nebelung, Georg F. Weber, Christian Pilarsky, Ulf Kahlert, Ulf Hinz, Susanne Roth, Thilo Hackert, Juergen Weitz, Fang Cheng Wong, Christoph Kahlert
Summary: This study identified a non-invasive prognostic EV mRNA signature for risk stratification and survival prediction of PDAC patients by isolating plasma-derived extracellular vesicles. The signature, consisting of PPP1R12A, SCN7A, and SGCD, demonstrated its potential as a biomarker for PDAC patient prognosis.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2023)
Article
Oncology
Felix Merboth, Heiner Nebelung, Natalie Wotschel, Hendrik Liebscher, Franziska Eckert, Janusz von Renesse, Jasmin Hasanovic, Thilo Welsch, Johannes Fritzmann, Daniel E. Stange, Verena Plodeck, Ralf-Thorsten Hoffmann, Marius Distler, Juergen Weitz, Johanna Kirchberg
Summary: This study found that robot-assisted minimally invasive esophagectomy (RAMIE) is associated with a lower risk of developing sarcopenia after surgery compared to open esophagectomy (OE) for esophageal cancer. These findings provide new evidence to support the use of robotic surgery in the multimodal therapy of EC.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Jan-Niklas Eckardt, Sebastian Stasik, Christoph Rollig, Tim Sauer, Sebastian Scholl, Andreas Hochhaus, Martina Crysandt, Tim H. Bruemmendorf, Ralph Naumann, Bjoern Steffen, Volker Kunzmann, Hermann Einsele, Markus Schaich, Andreas Burchert, Andreas Neubauer, Kerstin Schaefer-Eckart, Christoph Schliemann, Stefan W. Krause, Regina Herbst, Mathias Haenel, Maher Hanoun, Ulrich Kaiser, Martin Kaufmann, Zdenek Racil, Jiri Mayer, Tiago Cerqueira, Frank Kroschinsky, Wolfgang E. Berdel, Hubert Serve, Carsten Mueller-Tidow, Uwe Platzbecker, Claudia D. Baldus, Johannes Schetelig, Timo Siepmann, Martin Bornhaeuser, Jan Moritz Middeke, Christian Thiede
Summary: Functional perturbations of the cohesin complex with subsequent changes in chromatin structure and replication are reported in various cancers, including AML. Mutations of its STAG2 subunit were found to be associated with unfavorable risk in AML patients, but limited evidence and conflicting observations exist regarding their clinical outcomes. We analyzed data from 1615 AML patients and identified distinct co-mutational patterns for STAG2 mutations. We also found mutual exclusivity of genetic alterations in individual cohesin subunits, suggesting potential therapeutic strategies for cohesin mutated AML.
BLOOD CANCER JOURNAL
(2023)
Article
Biophysics
Gesine Bug, Myriam Labopin, Riitta Niittyvuopio, Matthias Stelljes, Hans Christian Reinhardt, Inken Hilgendorf, Nicolaus Kroeger, Ain Kaare, Wolfgang Bethge, Kerstin Schaefer-Eckart, Mareike Verbeek, Stephan Mielke, Kristina Carlson, Ali Bazarbachi, Alexandros Spyridonidis, Bipin N. Savani, Arnon Nagler, Mohamad Mohty
Summary: Retrospective analysis compared two different conditioning regimens for AML patients undergoing HSCT and found that using FluTBI resulted in lower relapse probability but higher non-relapse mortality. There were no significant differences in overall survival and GRFS between the two groups. Therefore, FluTBI may be more suitable for younger patients below the age of 55.
BONE MARROW TRANSPLANTATION
(2023)
Article
Oncology
Elisabetta Sauta, Marie Robin, Matteo Bersanelli, Erica Travaglino, Manja Meggendorfer, Lin-Pierre Zhao, Juan Carlos Caballero Berrocal, Claudia Sala, Giulia Maggioni, Massimo Bernardi, Carmen Di Grazia, Luca Vago, Giulia Rivoli, Lorenza Borin, Saverio D'Amico, Cristina Astrid Tentori, Marta Ubezio, Alessia Campagna, Antonio Russo, Daniele Mannina, Luca Lanino, Patrizia Chiusolo, Luisa Giaccone, Maria Teresa Voso, Marta Riva, Esther Natalie Oliva, Matteo Zampini, Elena Riva, Olivier Nibourel, Marilena Bicchieri, Niccolo' Bolli, Alessandro Rambaldi, Francesco Passamonti, Victor Savevski, Armando Santoro, Ulrich Germing, Shahram Kordasti, Valeria Santini, Maria Diez-Campelo, Guillermo Sanz, Francesc Sole, Wolfgang Kern, Uwe Platzbecker, Lionel Ades, Pierre Fenaux, Torsten Haferlach, Gastone Castellani, Matteo Giovanni Della Porta
Summary: The study validates the effectiveness of the Molecular International Prognostic Scoring System (IPSS-M) in predicting clinical outcomes of patients with myelodysplastic syndromes (MDS). IPSS-M improves the prognostic discrimination of the Revised International Prognostic Scoring System (IPSS-R) and enhances the accuracy of selecting candidates for hematopoietic stem cell transplantation (HSCT).
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Madlen Jentzsch, Lara Bischof, Dominic Brauer, Donata Backhaus, Jule Ussmann, Georg-Nikolaus Franke, Vladan Vucinic, Uwe Platzbecker, Sebastian Schwind
Summary: The presence and allelic ratio of FLT3-ITD have been recognized as prognostic factors in acute myeloid leukemia (AML), but their impact on patient outcomes after allogeneic hematopoietic stem cell transplantation (HSCT) is not well understood. This study found that the FLT3-ITD allelic ratio did not significantly affect survival in patients undergoing HSCT, but highlighted the importance of pre-HSCT measurable residual disease (MRD) as a prognostic factor.
Article
Chemistry, Physical
Ralf Zimmermann, Mirko Nitschke, Valentina Magno, Uwe Freudenberg, Katja Sockel, Friedrich Stoelzel, Manja Wobus, Uwe Platzbecker, Carsten Werner
Summary: The reported study demonstrates the potential of ToF-SIMS in detecting characteristic ECM variants and disease-associated alterations. DPCA analysis of ToF-SIMS spectra enables the identification of compositional differences in MSC-secreted ECM induced by exogenous stimulation or pathology. The results are verified by immunostaining, confirming the accuracy of the novel methodology.
Letter
Hematology
Marie Robin, Liesbeth C. de Wreede, Thomas Schroeder, Friedrich Stoelzel, Nicolaus Kroeger, Linda Koster, Uwe Platzbecker, Juergen Finke, Arnold Ganser, Didier Blaise, Fabio Ciceri, Johan Maertens, Helene Labussiere Wallet, Junfeng Wang, Patrice Chevallier, Jakob Passweg, Jan J. Cornelissen, Stephanie Nguyen, Edouard Forcade, Amandine Charbonnier, Francesca Bonifazi, Patrick Hayden, Donal P. McLornan, Ibrahim Yakoub-Agha
Article
Biophysics
Enrico Maffini, Maud Ngoya, Jacques-Emmanuel Galimard, Samia Harbi, Nicolaus Kroeger, Uwe Platzbecker, Henrik Sengeloev, Charles Craddock, Victoria Potter, Goda Choi, Patrice Chevallier, Friedrich Stolzel, Eleni Tholouli, Johan Maertens, Fabio Ciceri, Jan Cornelissen, Jaime Sanz, Alexandros Spyridonidis, Francesco Lanza, Arnon Nagler, Mohamad Mohty
Summary: Allogeneic HCT programs are becoming accessible for older AML patients. Patients aged ≥70 years who received HCT from matched sibling, unrelated, or haploidentical donors showed good clinical outcomes, with reduced relapse rates and improved leukemia-free survival in haploidentical and unrelated donor transplantations compared to matched sibling transplantation.
BONE MARROW TRANSPLANTATION
(2023)
Letter
Oncology
Uwe Platzbecker, Valeria Santini, Rami S. Komrokji, Amer M. Zeidan, Guillermo Garcia-Manero, Rena Buckstein, Dimana Miteva, Karen Keeperman, Natalia Holot, Jose Alberto Nadal, Yinzhi Lai, Sadanand Vodala, Barbara Rosettani, Ana Carolina Giuseppi, Aylin Yucel, Pierre Fenaux
Article
Radiology, Nuclear Medicine & Medical Imaging
Heiner Nebelung, Willi Troeger, Ivan Platzek, Ralf-Thorsten Hoffmann, Verena Plodeck
Summary: The effect of contrast timing, volume, and flow rate on the image quality of pulmonary arteries in CTA was evaluated. It was found that when using 60 mL or more contrast volume and less than 4 mL/s flow rate, ROI positioning in the left atrium, which is used in triple-rule-out CTA, is sufficient for the assessment of pulmonary arteries.
RADIOLOGIC TECHNOLOGY
(2023)