Article
Chemistry, Multidisciplinary
Daiki Hara, Wensi Tao, Ryder M. Schmidt, Yu-Ping Yang, Sylvia Daunert, Nesrin Dogan, John Chetley Ford, Alan Pollack, Junwei Shi
Summary: Metal nanoparticles, especially gold nanoparticles (GNPs), can enhance radiation doses in targeted cancer cells. In this study, the effects of active-targeting GNPs on the radiation-induced bystander effect (RIBE) in prostate cancer cells were investigated. The results showed that PGNPs could boost the expression and sensitivity of RIBE in prostate cancer cells.
Review
Oncology
Haoyi Tang, Luwei Cai, Xiangyang He, Zihe Niu, Haitong Huang, Wentao Hu, Huahui Bian, Hao Huang
Summary: For many years, targeted DNA damage caused by radiation has been considered the main cause of various biological effects. However, there is increasing evidence that the linear-non-threshold model is not fully applicable to the biological effects caused by low dose radiation and requires further investigation. Additionally, non-targeted effects, such as bystander effects, genetic instability, etc., are significant effects related to low dose radiation.
FRONTIERS IN ONCOLOGY
(2023)
Review
Biology
Ziqi Zhang, Kui Li, Mei Hong
Summary: Microbeams are useful tools for studying non-target effects and responses to cytoplasmic irradiation. This article summarizes the observations and mechanisms involved in bystander effects and cytoplasmic irradiation-related effects using different types of microbeam irradiators. These non-target effects may contribute to the biological consequences of ionizing radiation exposure, and understanding them can help better evaluate the damage caused by irradiation.
Review
Oncology
Yanan Gao, Hong Ma, Changyin Lv, Fei Lan, Yunfeng Wang, Yulin Deng
Summary: Localized cranial radiotherapy is a key treatment for brain cancers, causing targeted and non-targeted radiation effects in the central nervous system. MicroRNAs play a crucial role in regulating these effects, making them promising biomarkers and therapeutic targets for CNS radiation-induced effects.
Article
Biochemistry & Molecular Biology
Mateusz Smolarz, Lukasz Skoczylas, Marta Gawin, Monika Krzyzowska, Monika Pietrowska, Piotr Widlak
Summary: Exosomes released by irradiated cells mediate the radiation-induced bystander effect, resulting in DNA breaks and replication stress in recipient cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Sharmi Mukherjee, Anindita Dutta, Anindita Chakraborty
Summary: Redox homeostasis is essential for normal physiological and metabolic functions. Radiotherapy disrupts this balance and induces genomic instability in diseased cells, affecting both targeted and non-targeted cells. The use of external modulators with radiation can enhance the therapeutic efficiency.
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH
(2021)
Article
Ecology
David M. Welsch, Matthew W. Winden, David M. Zimmer
Summary: By examining flood mitigation spending and flood damages, researchers found a positive relationship, which complicates policy formulation and analysis. Using a dynamic feedback model, the study revealed that increasing mitigation spending can reduce the financial consequences of flood damages by approximately 9%.
ECOLOGICAL ECONOMICS
(2022)
Article
Multidisciplinary Sciences
Ho Yi Wong, Ruby C. Lee, Sharene Chong, Stuti Kapadia, Michael Freeman, Valentine Murigneux, Susan Brown, H. Peter Soyer, Edwige Roy, Kiarash Khosrotehrani
Summary: This study suggests that mutation burden is strongly associated with the burden of keratinocyte skin cancers (KCs) such as basal and squamous cell carcinomas. Accumulation of mutations and clonal expansion play a key role in the development of KCs. UV radiation, the main carcinogen for KCs, is linked to epidermal mutation load. Epidermal ablation, followed by spontaneous healing, can reduce mutation load and prevent subsequent KCs.
Article
Biochemistry & Molecular Biology
Feng Qin, Guodong Chen, Kwan Ngok Yu, Miaomiao Yang, Wei Cao, Peizhong Kong, Shengjie Peng, Mingyu Sun, Lili Nie, Wei Han
Summary: In this study, Golgi protein GOLPH3 was found to play a crucial role in the transduction of RIBE. Knocking down GOLPH3 blocked RIBE generation, while re-expression of GOLPH3 rescued the effect. The GOLPH3/ERK/EGR1 signaling axis was identified as the mechanism that regulates the transcription of TNF-alpha and determines its release level.
Article
Pharmacology & Pharmacy
Mie Chen, Min Zhang, Xun Lu, Yongfei Li, Cheng Lu
Summary: This study developed a dimeric prodrug nanomedicine with a diselenium bond for TNBC, which disrupts the intracellular redox balance and shows promising potential for effective therapy.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Amparo Olivares, Miguel Alcaraz-Saura, Daniel Gyingiri Achel, Juan de Dios Berna-Mestre, Miguel Alcaraz
Summary: The research investigated the modulation effect of rosmarinic acid on radiation-induced effects and found that it could reduce micronuclei frequency and increase cell survival rate, showing a certain radioprotective capacity.
Article
Mechanics
Mohammad Amin Abazari, M. Soltani, Farshad Moradi Kashkooli
Summary: This study developed a computational framework to evaluate the treatment efficacy of free Doxorubicin (Dox) and immunoliposome at different stages of vascular solid tumors. The results showed that immunoliposomes exhibited higher drug internalization and fusion effect during therapy, leading to more homogeneous drug distribution and a greater fraction of killed cancer cells.
Article
Oncology
Zhen Yang, Qiuning Zhang, Hongtao Luo, Lihua Shao, Ruifeng Liu, Yarong Kong, Xueshan Zhao, Yichao Geng, Chengcheng Li, Xiaohu Wang
Summary: Carbon ion radiation can inhibit A549 cell colony formation, migration, and invasion, and 2 Gy radiation significantly inhibits tumor cell metastasis. LC-MS analysis showed 23 differential metabolites in the cell culture medium after carbon ion 0 and 2 Gy irradiation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Pavel Lobachevsky, Helen B. Forrester, Alesia Ivashkevich, Joel Mason, Andrew W. Stevenson, Chris J. Hall, Carl N. Sprung, Valentin G. Djonov, Olga A. Martin
Summary: Scattered synchrotron radiation influences the DNA damage response in non-irradiated cells, particularly in bystander DNA damage. It significantly impacts DNA damage response, with broad-beam irradiation generating distance-independent bystander DNA damage, while MRT-generated bystander response is minimal. The study also suggests a reduced response to scattered radiation in p53-null cells, but not to bystander signalling.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Paola Montes, Ana Guerra-Librero, Paloma Garcia, Maria Elena Cornejo-Calvo, Maria del Senor Lopez, Tomas de Haro, Laura Martinez-Ruiz, Germaine Escames, Dario Acuna-Castroviejo
Summary: This study investigated the impact of the hypomethylating agent 5-azacitidine on the redox status and inflammation in MDS patients. The results showed that MDS patients had a lower redox status and higher CAT activity compared to healthy subjects. The progression of the disease was associated with increased GPx activity, GSSG/GSH ratio, LPO, and AOPP levels, and decreased CAT activity. The study also found changes in pro-inflammatory cytokines and plasma nitrite plus nitrate levels, but no association between inflammation and oxidative stress was observed.
Review
Biochemistry & Molecular Biology
Masoud Najafi, Shima Tavakol, Ali Zarrabi, Milad Ashrafizadeh
Summary: Chemotherapy is an important treatment for cancer, but the resistance of cancer cells reduces its effectiveness. Quercetin, a flavonoid compound with high anti-tumour activity, can be used with cisplatin to enhance the efficacy of chemotherapy and reduce its side effects.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Hossein Moutabian, Ruhollah Ghahramani-Asl, Tohid Mortezazadeh, Reza Laripour, Asghar Narmani, Hamed Zamani, Gholamreza Ataei, Hamed Bagheri, Bagher Farhood, Thozhukat Sathyapalan, Amirhossein Sahebkar
Summary: Nano-curcumin can alleviate doxorubicin-induced cardiotoxicity and improve treatment efficacy.
Review
Oncology
Shahram Taeb, Milad Ashrafizadeh, Ali Zarrabi, Saeed Rezapoor, Ahmed Eleojo Musa, Bagher Farhood, Masoud Najafi
Summary: Cancer is a complex chronic disorder, and the interaction between the tumor microenvironment and immune cells plays a crucial role in tumor treatment and development. Factors such as cancer-associated fibroblasts, extracellular matrix, and hypoxia-inducible factor can enhance the proliferation capacity of cancer stem cells, leading to resistance to treatments such as radiotherapy. Additionally, radiotherapy can affect the release of cytokines and growth factors in the tumor microenvironment, altering local immune responses.
CURRENT CANCER DRUG TARGETS
(2022)
Article
Chemistry, Physical
Akbar Aliasgharzadeh, Vahid Anaraki, Daryoush Khoramian, Mahdi Ghorbani, Bagher Farhood
Summary: This study evaluates the dosimetric characteristics of PASSAG gel dosimeter for different amounts of components in its formulation. It was found that the optimized PASSAG gel dosimeter showed increased sensitivity and excellent linear dose response, with dose resolution values varying in the 0-10 Gy range. Temporal stability in R-2 values was observed during 15-30 days post-irradiation, with R-2 dose sensitivity varying over the 30-day period.
RADIATION PHYSICS AND CHEMISTRY
(2022)
Review
Immunology
Run Yang, Changming Tan, Masoud Najafi
Summary: Cardiovascular disorders are a major concern among individuals undergoing cancer therapy, with heart diseases being a common cause of mortality in these patients. Inflammatory changes and fibrosis are key mechanisms of cardiac diseases following chemotherapy and radiotherapy. Chronic oxidative stress, cell death, and overproduction of pro-inflammatory and pro-fibrosis cytokines are the underlying mechanisms of cardiovascular diseases following cancer therapy.
INFLAMMOPHARMACOLOGY
(2022)
Review
Cell Biology
Zihong Wu, Caidie Zhang, Masoud Najafi
Summary: This article discusses the interaction between anti-tumor immune cells and immunosuppressive cells in the tumor microenvironment, as well as the modulating effects of metformin on various cells and secretions in TME.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2022)
Review
Biochemistry & Molecular Biology
Jun Huang, Zaoshang Chang, Quzhe Lu, Xuedong Chen, Masoud Najafi
Summary: Cancer resistance to therapy is a significant challenge in cancer treatment, involving reduced induction of cell death and decreased response to anti-tumor immunity. Nobiletin can induce endogenous ROS generation, leading to damage to critical macromolecules and ultimately cell death. Additionally, NOB can induce cancer cell killing by modulating multiple mechanisms of cell death.
Review
Oncology
Hossein Moutabian, Mehrsa Majdaeen, Ruhollah Ghahramani-Asl, Masoumeh Yadollahi, Esmaeil Gharepapagh, Gholamreza Ataei, Zahra Falahatpour, Hamed Bagheri, Bagher Farhood
Summary: This study aimed to review the potential therapeutic effects of resveratrol in combination with 5-fluorouracil (5-FU) against colorectal cancer. The results demonstrated that co-administration of resveratrol could sensitize the colorectal cancer cells to 5-FU treatment via various mechanisms.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Xiao-yu Wu, Wen-Wen Xu, Xiang-kun Huan, Guan-nan Wu, Gang Li, Yu-Hong Zhou, Masoud Najafi
Summary: Resistance of cancer cells to anti-tumour agents is a major challenge in cancer treatment. Metformin, an antidiabetic drug, can enhance cell death mechanisms and play a key role in inducing cell death, thereby increasing the therapeutic efficiency of anti-cancer therapy.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Review
Pharmacology & Pharmacy
Masoud Moslehi, Sepideh Rezaei, Pourya Talebzadeh, Mohammad Javed Ansari, Mohammed Abed Jawad, Abduladheem Turki Jalil, Nima Rastegar-Pouyani, Emad Jafarzadeh, Shahram Taeb, Masoud Najafi
Summary: The incidence of cancer is increasing globally. The long-term adverse effects of cancer therapy and tumor resistance to anticancer agents are major concerns. Apigenin, a plant-derived molecule, has potential as an adjuvant for chemoprevention and overcoming malignancy resistance to cancer therapy. It has promising anti-tumor effects and may reduce genomic instability and risks of second malignancies in normal tissues, as well as improve the efficacy of anticancer modalities.
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
(2023)
Review
Immunology
Mahdie Jafari, Maryam Kadkhodazadeh, Mina Bahrololoumi Shapourabadi, Nasser Hashemi Goradel, Mohammad Ali Shokrgozar, Arash Arashkia, Shahriyar Abdoli, Zahra Sharifzadeh
Summary: Despite the approval of new drugs and targeted therapies, most cancer types remain difficult to treat due to tumor heterogeneity, immune system evasion, and the complex interaction between the tumor microenvironment and immune cells. Oncolytic virus (OV) immunotherapy, which uses viruses to selectively replicate within cancer cells and activate the immune system, has shown promising results. However, challenges such as off-target side effects and non-specific uptake limit its effectiveness as monotherapy. Combining OV with other biotherapeutic agents, such as antibodies and CAR-T cells, has been proposed to enhance the anti-tumor activities of OV.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ehsan Khodamoradi, Shima Afrashi, Karim Khoshgard, Farshid Fathi, Soodeh Shahasavari, Rasool Azmoonfar, Masoud Najafi
Summary: This study aimed to evaluate the effects of simultaneous exposure to Wi-Fi waves and gamma-ray on DNA in peripheral blood lymphocytes. The results showed that simultaneous exposure to Wi-Fi waves and gamma-ray can increase the number of double-strand breaks in DNA in peripheral blood lymphocytes within 72 hours after technetium injection.
BIOCHEMISTRY AND BIOPHYSICS REPORTS
(2022)
Review
Obstetrics & Gynecology
Neda Khanlarkhani, Elham Azizi, Fardin Amidi, Mahshad Khodarahmian, Ensieh Salehi, Azar Pazhohan, Bagher Farhood, Keywan Mortezae, Nasser Hashemi Goradel, Maryam Shabani Nashtaei
Summary: This paper reviews the relationship between obesity, diabetes mellitus (DM), and ovarian cancer, indicating that these metabolic abnormalities are correlated with higher incidence and poorer survival in ovarian cancer patients. Various pathological factors contribute to ovarian cancer risk, development, and survival, making obesity and DM potential intervention targets for preventing ovarian cancer and improving outcomes.
JORNAL BRASILEIRO DE REPRODUCAO ASSISTIDA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daryoush Khoramian, Soroush Sistani, Bagher Farhood
Summary: The study measured systematic and random set-up errors in prostate cancer radiotherapy using EPID and proposed the optimum CTV-to-PTV margin. Results showed population systematic and random errors in different directions, leading to calculated margins based on different formulas, with overall margins averaging at 2.73, 4.98 and 5.86 mm.
JOURNAL OF RADIOTHERAPY IN PRACTICE
(2022)
Correction
Engineering, Biomedical
Pooyan Makvandi, Milad Ashrafizadeh, Matineh Ghomi, Masoud Najafi, Hamid Heydari Sheikh Hossein, Ali Zarrabi, Virgilio Mattoli, Rajender S. Varma
PROGRESS IN BIOMATERIALS
(2022)