Review
Infectious Diseases
Neil Powell, Jennie Stephens, Declan Kohl, Rhys Owens, Shadia Ahmed, Crispin Musicha, Mathew Upton, Bridie Kent, Sarah Tonkin-Crine, Jonathan Sandoe
Summary: This systematic review examined the effectiveness and safety of nonallergist health care worker delivery of penicillin allergy delabeling. The results showed that delabeling by nonallergists is effective and safe, with different testing methods leading to varying proportions of patients being delabeled.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Infectious Diseases
Daniel Hearsey, Shuayb Elkhalifa, Jonathan Sandoe, Michael Wilcock, Rhys Owens, Bethan Gay, Charlotte Wildblood, Jane Mendonca, Nicola Leigh, Neil Powell
Summary: A pharmacist-led multidisciplinary penicillin allergy de-labelling ward round was conducted in a UK hospital, aiming to identify patients with incorrect penicillin allergy records and provide appropriate treatment options. The results showed that the pathway was safe, effective, and well accepted by patients and clinical teams, resulting in reduced alternative antibiotic use.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Infectious Diseases
Hiroyuki Suzuki, Eli Perencevich, Michihiko Goto, Bruce Alexander, Rajeshwari Nair, Mireia Puig-Asensio, Erika Ernst, Daniel J. Livorsi
Summary: In this study, comparing different hospital strategies, prospective audit and feedback (PAF) strategies were associated with less carbapenem use and better carbapenem appropriateness, while restrictive policies (RP) were associated with more appropriate carbapenem prescribing. Infectious disease (ID) consultations were common in hospitals with PAF/RP strategies and were associated with better assessment scores.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2021)
Article
Immunology
Kyra Y. L. Chua, Sara Vogrin, Susan Bury, Abby Douglas, Natasha E. Holmes, Nixon Tan, Natasha K. Brusco, Rebecca Hall, Belinda Lambros, Jacinta Lean, Wendy Stevenson, Misha Devchand, Kent Garrett, Karin Thursky, M. Lindsay Grayson, Monica A. Slavin, Elizabeth J. Phillips, Jason A. Trubiano
Summary: This study showed that the program of inpatient delabeling for low-risk penicillin allergies using a combination of direct delabeling and oral penicillin challenge led to increased usage of narrow-spectrum penicillins, improved appropriate antibiotic prescribing, and reduced usage of restricted antibiotics.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Public, Environmental & Occupational Health
N. Powell, R. West, J. A. T. Sandoe
Summary: The study found that penicillin allergy records are associated with non-Access antibiotic prescribing, and delabelling penicillin allergies has the potential to reduce non-Access antibiotic use.
JOURNAL OF HOSPITAL INFECTION
(2021)
Article
Immunology
Laila Carolina Abu Esba, Faisal Aqeel Al Sehli
Summary: The estimated incidence of antimicrobial-associated anaphylaxis is around 18.6 cases per 100,000 exposures, with hospitalization required in 23.8% of cases and ICU admission in 19% of cases. The implications of these episodes may extend beyond the event itself and be associated with poor clinical outcomes such as infection-related mortality and hospitalization.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Bernardo Sousa-Pinto, Kimberly G. Blumenthal, Eric Macy, Ana Margarida Pereira, Luis Filipe Azevedo, Luis Delgado, Joao Almeida Fonseca
Summary: The study projected that penicillin allergy testing is cost-saving in both inpatient and outpatient settings, with potential average savings in United States dollars for patients. Probabilistic sensitivity analysis showed that testing was the less costly option in 75% of simulations, supporting policies promoting widespread testing of patients with a penicillin allergy label.
CLINICAL INFECTIOUS DISEASES
(2021)
Editorial Material
Immunology
Jason Anthony Trubiano, Sara Vogrin, Elise Mitri, Rebecca Hall, Ana Copaescu, Jamie Waldron, Joseph De Luca, Morgan Rose, Geoff Mackay, Belinda Lambros, Abby P. Douglas, Natasha E. Holmes, Kyra Y. L. Chua
Summary: Inpatient direct oral challenge programs are being used more and more to reduce the impact of penicillin allergy labels on antibiotic prescribing. Data from a multicenter cohort study in an inpatient penicillin allergy program help identify key targets for delabeling to aid implementation of these initiatives.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Timothy J. Savage, Shun Rao, Jill Joerger, Al Ozonoff, Alexander J. McAdam, Thomas J. Sandora
Summary: The study has identified that direct disk diffusion testing is highly predictive of susceptibility for many common organism-antibiotic combinations and provides actionable information one day earlier than standard susceptibility approaches. However, the negative predictive value of dDD is variable and frequently lower than the positive predictive value. Antibiotics were narrowed in 30% of cases after a dDD result and a further 25% of cases after AST result.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)
Article
Allergy
Zihan Jiang, Hongting Zhang, Hao Xiao, Xiong Xiao, Juan Meng
Summary: This retrospective study in Chinese hospitalized patients found a prevalence of 4.00% for penicillin allergy labels. Patients with penicillin allergy labels had significantly different antibiotic prescription patterns compared to control group, resulting in potentially irrational antibiotic prescribing, prolonged hospital stays, and greater need for consultation with infection specialists.
WORLD ALLERGY ORGANIZATION JOURNAL
(2022)
Article
Allergy
Nick K. Jones, Bethan Morris, Reem Santos, Shuaib Nasser, Theodore Gouliouris
Summary: This study investigated the prevalence and characteristics of antibiotic allergy labels in a large UK hospital setting and estimated the proportion of penicillin allergy labels that would be suitable for point-of-care (POC) delabeling assessment. Results showed that 11.8% of all patients had recorded reactions to antibiotics, with penicillin allergy being the most common. Retrospective analysis identified that 10.7% of penicillin allergy labels could be removed, 74.5% could undergo oral penicillin challenge, and 14.8% were unsuitable for any form of POC assessment.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Infectious Diseases
Torsten Joerger, Margaret G. Taylor, Yun Li, Debra L. Palazzi, Jeffrey S. Gerber
Summary: Penicillin allergy labels (PALs) lead to increased use of broad-spectrum and second-line antibiotics in children with respiratory tract infections, as well as an increased risk of adverse events. Efforts should be made to prevent unnecessary PALs and promote de-labeling of inaccurate allergies to improve care for children with common bacterial infections.
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
(2023)
Review
Allergy
Neil Powell, Shuayb Elkhalifa, Autumn Guyer, Tomaz Garcez, Jonathan Sandoe, Li Zhou
Summary: Allergy labels are common, often incorrect, and potentially harmful. Clinical decision support (CDS) tools integrated in electronic health records (EHR) and mobile apps can provide solutions for drug allergy management, including penicillin allergy delabeling (PADL). Improving the infrastructure and relevance of drug allergy alerts is important to reduce alert fatigue and facilitate appropriate antibiotic use.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Immunology
Joanna M. Kimball, Connor R. Deri, Whitney J. Nesbitt, George E. Nelson, Milner B. Staub
Summary: This study investigated successful antimicrobial stewardship interventions at Vanderbilt University Medical Center, identifying key strategies such as continuous provider-level education and the implementation of division and department algorithms to reduce the use of concomitant vancomycin and piperacillin-tazobactam. The TASE framework and ASIR analysis were effective in identifying pivotal interventions for achieving and sustaining change, suggesting potential for wider application in similar settings.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Microbiology
Brian R. Lee, Anjana Sasidharan, Chris J. Harrison, Rangaraj Selvarangan
Summary: The study found that conducting CSF RT-PCR testing for enterovirus and parechovirus can significantly reduce the length of hospitalization for children, decreasing the likelihood of antibiotic usage. This helps to improve the quality of care for pediatric patients.
JOURNAL OF CLINICAL MICROBIOLOGY
(2021)