Article
Allergy
Antonino Romano, Rocco Luigi Valluzzi, Cristiano Caruso, Alessandra Zaffiro, Donato Quaratino, Francesco Gaeta
Summary: This study evaluated the usefulness of skin tests and challenges in 236 subjects with immediate reactions to cephalosporins, finding that most of these reactions are IgE-mediated. Cephalosporin skin testing is a useful tool for evaluating these reactions, and IgE-mediated cephalosporin hypersensitivity may be a transient condition.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Antonino Romano, Rocco Luigi Valluzzi, Francesco Gaeta, Cristiano Caruso, Alessandra Zaffiro, Donato Quaratino, Didier Ebo, Vito Sabato
Summary: The timing of a reaction in response to the last dose of a penicillin can predict the results of diagnostic testing. IgE-mediated hypersensitivity can be diagnosed by skin tests in about 70% of subjects who react within 1 hour. However, this hypersensitivity can be lost over time.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Review
Allergy
Cristiano Caruso, Rocco Luigi Valluzzi, Stefania Colantuono, Francesco Gaeta, Antonino Romano
Summary: Beta-lactams are the most common antibiotics causing allergic reactions, with cross-reactivity usually due to similarities in side-chain structures. While positive responses to all beta-lactams are infrequent in patients with IgE-mediated allergies, they are anecdotal in those with T-cell-mediated allergies.
JOURNAL OF ASTHMA AND ALLERGY
(2021)
Article
Surgery
Spencer Fosnot, Katelyn Currier, Jay Pendell, Meghan N. Jeffres
Summary: This study showed that hypersensitivity reactions are uncommon in patients labeled as penicillin allergic. The frequency of immediate hypersensitivity reactions did not differ significantly among patients receiving cefazolin, clindamycin, or vancomycin. Avoiding cefazolin in patients labeled as penicillin allergic may not be necessary.
Article
Allergy
Cosby A. Stone, Jason A. Trubiano, Elizabeth J. Phillips
Summary: This study found that cross-reactivity of cephalosporins is based on shared R1 groupings, and increasing time since the original reaction and having a penicillin allergy label (PAL) with unknown cephalosporin tolerance predicted a lower likelihood of positive skin testing.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Allergy
Ellen Minaldi, Elizabeth J. Phillips, Allison Norton
Summary: Beta-lactam antibiotics are the most commonly reported drug allergy, but over 95% of reported allergies are not confirmed upon testing. Immediate and delayed hypersensitivity reactions are associated with beta-lactams, and risk stratification based on diagnosis and timing guides appropriate management. Different evaluation methods are used for immediate and delayed reactions, and cross-reactivity is commonly driven by shared R1 side-chains.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2022)
Review
Immunology
Rakesh D. Bansie, A. Faiz Karim, Maurits S. van Maaren, Maud A. W. Hermans, Paul L. A. van Daele, Roy Gerth van Wijk, Saskia M. Rombach
Summary: Skin tests and provocation tests are recommended for evaluating hypersensitivity reactions to contrast agents, showing a high risk of immediate repeat hypersensitivity reactions for skin-test-positive patients. However, provocation tests are not common in clinical practice.
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY
(2021)
Article
Allergy
Paola Nicoletti, Daniel F. Carr, Sarah Barrett, Laurence McEvoy, Peter S. Friedmann, Neil H. Shear, Matthew R. Nelson, Anca M. Chiriac, Natalia Blanca-Lopez, Jose A. Cornejo-Garcia, Francesco Gaeta, Alla Nakonechna, Maria J. Torres, Cristiano Caruso, Rocco L. Valluzzi, Aris Floratos, Yufeng Shen, Rebecca K. Pavlos, Elizabeth J. Phillips, Pascal Demoly, Antonino Romano, Miguel Blanca, Munir Pirmohamed
Summary: This study identified HLA-DRB1*10:01 as a genetic predisposing factor for immediate hypersensitivity reactions to beta-lactam antibiotics, particularly penicillins. Further research is needed to identify other predisposing HLA and non-HLA loci.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Article
Allergy
Juliette Caron, Sahara Graf, Christine Delebarre-Sauvage
Summary: Among patients with immediate hypersensitivity reactions to iodinated contrast media, the rate of confirmed allergic patients by positive skin tests was 8.1%. Despite negative skin test results, 12.5% of re-exposed patients experienced recurrent hypersensitivity reactions. Additional investigations on pure intradermal tests to contrast media and development of drug provocation tests could provide a safety net for detecting recurrent reactors. Agreement among allergists is necessary to standardize practices.
CLINICAL AND TRANSLATIONAL ALLERGY
(2022)
Article
Chemistry, Organic
Lukas V. Hoff, Joana M. Hauser, Karl Gademann
Summary: An efficient method utilizing Pd catalysis for cross-coupling of 5-bromo-1,2,3-triazine is described. Optimization of reaction conditions enables the preparation of a diverse range of (hetero)aryl-1,2,3-triazines in high yields (up to 97%). Assessment of the reaction scope using data science techniques and subsequent diversification of products allows for the efficient synthesis of pyrimidines and pyridines.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Immunology
Grace Thompson, Andrew McLean-Tooke, Michaela Lucas
Summary: Current understanding of cross-reactivity in severe cutaneous adverse reactions to beta-lactam antibiotics is limited, and the underlying immunopathogenesis of these reactions is not completely understood. Research has shown that cross-reactivity or co-reactivity commonly occurred among the beta-lactam antibiotic class, but further investigation is needed to understand and investigate patterns of cross-reactivity.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Dermatology
Antonios Tsimpidakis, Alexandros Katoulis, Electra Nicolaidou, Dimitrios Rigopoulos, Alexander Stratigos, Stamatis Gregoriou
Summary: The widespread use of oxidative hair dyes has raised concerns about potential allergy reactions, management, and prevention measures for professionals and consumers. Allergic contact dermatitis can be caused by various hair dye-related allergens, with p-phenylenediamine and related aromatic amines being the main culprits. Patch testing is recommended to identify the responsible allergen, and individuals sensitized to specific hair dye substances should avoid exposure to these chemicals and be aware of potential cross-sensitization. The efficacy of an open application hair dye allergy self-test is doubtful due to the lack of standardized conditions.
Article
Allergy
Pedro Gamboa, Javier Sanchez de Vicente, Cristina Galan, Ignacio Jauregui, Aritza Segurola, Eduardo Garcia-Lirio, Yolanda Seras, Ma Dolores Martinez-Anton, Angel Arrien de Lecea
Summary: Skin tests had a sensitivity of less than 50% for patients with NIHRs due to iomeprol, while the negative predictive value of skin tests in patients who tolerated challenges with alternative contrasts (mainly iopamidol) was 53%. The cross-reactivity between iomeprol and iopamidol is high.
Article
Pharmacology & Pharmacy
Khadija Mansour, Najah Ben Fadhel, Nadia Ben Fredj, Haifa Ben Romdhane, Amel Chaabane, Zohra Chadli, Karim Aouam
Summary: Drug reaction with eosinophilia and systemic symptom (DRESS) is a severe adverse drug-induced reaction. This article reports a case of cefotaxime-induced DRESS in a child and emphasizes the importance of allergological work-up to identify the culprit drug and explore cross-reactivity and potential cosensitization.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Immunology
Toon Ieven, Martijn Vandebotermet, Lisa Nuyttens, David Devolder, Peter Vandenberghe, Dominique Bullens, Rik Schrijvers
Summary: This study analyzed the tolerability of adenoviral vector and mRNA-based COVID-19 vaccines in high-risk patient groups. The results showed that these vaccines were safe and well-tolerated in patients with pMCD, HAE, and IA, with no cases of anaphylaxis observed. Some patients with pMCD may experience mild flare-ups of mast cell activation-like symptoms after vaccination.
Review
Allergy
S. Voltolini, V Cofini, F. Murzilli, D. Bignardi, M. Borro, M. Calamari, C. Caruso, G. Cittadini, M. Contatore, G. Cortellini, G. Desideri, C. Di Paolo, D. Lippolis, M. Lobene, G. Manzotti, E. Meucci, S. Necozione, G. A. Ramirez, G. A. Rollandi, M. R. Yacoub, M. B. Bilo
Summary: This study describes the characteristics of Italian patients experiencing hypersensitivity reactions to iodinated contrast media and investigates potential risk factors. Male gender and age over 65 were identified as protective factors, while cardiovascular disease, respiratory allergy, and adverse drug reactions were identified as risk factors for these reactions.
EUROPEAN ANNALS OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Allergy
Ioana Agache, Dario Antolin-Amerigo, Frederic de Blay, Cristina Boccabella, Cristiano Caruso, Pascal Chanez, Mariana Couto, Ronina Covar, Serge Doan, Jean-Luc Fauquert, Gail Gauvreau, Alina Gherasim, Ludger Klimek, Catherine Lemiere, Parameswaran Nair, Inigo Ojanguren, David Peden, Luis Perez-de-Llano, Oliver Pfaar, Carmen Rondon, Maia Rukhazde, Joaquin Sastre, Johannes Schulze, Diana Silva, Susan Tarlo, Sanna Toppila-Salmi, Jolanta Walusiak-Skorupa, Stefan Zielen, Ibon Eguiluz-Gracia
Summary: Allergic asthma is a common asthma phenotype that requires IgE sensitization to aeroallergens for diagnosis. However, current protocols for bronchial allergen challenge are not suitable for moderate-to-severe asthmatics or clinical practice. Correct diagnosis of allergic asthma can aid in selecting patients for immunomodulatory therapies, such as allergen sublingual immunotherapy.
Article
Dermatology
Andrea Chiricozzi, Niccolo Gori, Lucia Di Nardo, Flaminia Antonelli, Cristiano Caruso, Giacomo Caldarola, Laura Calabrese, Cristina Guerriero, Clara De Simone, Ketty Peris
Summary: Atopic dermatitis localization in exposed areas and persistence in head/neck may have a negative impact on certain treatment response parameters to dupilumab therapy.
Letter
Medicine, General & Internal
Maurizio Gabrielli, Giulia Pignataro, Marcello Candelli, Marta Sacco Fernandez, Martina Bizzarri, Alessandra Esperide, Francesco Franceschi
INTERNAL AND EMERGENCY MEDICINE
(2022)
Article
Allergy
Cristiano Caruso, Colantuono Stefania, Gabriele Ciasca, Umberto Basile, Riccardo Di Santo, Diego Bagnasco, Giovanni Passalacqua, Marco Caminati, Schiappoli Michele, Gianenrico Senna, Enrico Heffler, G. Walter Canonica, Nunzio Crimi, Rossella Intravaia, Corso De Eugenio, Davide Firinu, Antonio Gasbarrini, Stefano R. Del Giacco
Summary: This retrospective study evaluated the prevalence of SE-IgE sensitization in a multicentric Italian cohort of severe asthmatic patients. SEB-IgE sensitization was found to be associated with female gender and comorbidities such as CRS and CRSwNP. No significant associations were observed between SEB-IgE sensitization and atopy, exacerbations, and corticosteroid dosages. Patients with SEB-IgE sensitization were younger and had an earlier disease onset, suggesting that it may be an independent risk factor for developing asthma.
Article
Medicine, General & Internal
Vitaliano Nicola Quaranta, Silvano Dragonieri, Maria Rosaria Vulpi, Nunzio Crimi, Claudia Crimi, Pierachille Santus, Francesco Menzella, Corrado Pelaia, Giulia Scioscia, Cristiano Caruso, Elena Bargagli, Nicola Scichilone, Giovanna Elisiana Carpagnano
Summary: This study found a correlation between eosinophilic inflammation and the localization of bronchiectasis in a population with severe asthma and bronchiectasis. Patients with eosinophil counts > 1000 cells/μL were more likely to have lower pulmonary bronchiectasis compared to upper lobes.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Allergy
Gianenrico Senna, Maria Aliani, Elena Altieri, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Cristiano Caruso, Maria D'Amato, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Jan Walter Schroeder, Alessandra Vultaggio, Sara Rizzoli, Alessandro Zullo, Silvia Boarino, Marilena Palmisano, Alessandra Rossi, Gianfranco Vitiello, Stefano Centanni
Summary: The post hoc analysis from the Italian study ANANKE aimed to define the clinical features and effectiveness of benralizumab in the BEC 300-450 cells/mm3 subset of patients. Results showed that patients in this subset had similar improvements in exacerbation rate, asthma control, lung function, and corticosteroid use after 48 weeks of benralizumab treatment compared to the total population.
JOURNAL OF ASTHMA AND ALLERGY
(2022)
Review
Biochemistry & Molecular Biology
Giulia Scioscia, Santi Nolasco, Raffaele Campisi, Carla Maria Irene Quarato, Cristiano Caruso, Corrado Pelaia, Andrea Portacci, Claudia Crimi
Summary: Currently, Italy offers three classes of monoclonal antibodies for severe asthma treatment: anti-IgE (Omalizumab), anti-IL-5/anti-IL-5Ra (Mepolizumab and Benralizumab), and anti-IL-4Ra (Dupilumab). Studies have been conducted to determine their efficacy and identify predictors of treatment outcomes. Switching to another monoclonal antibody is recommended if there are no benefits. The choice of treatment should consider the patient's clinical history, biomarkers, and comorbidities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Allergy
Antonino Romano, Francesco Gaeta, Cristiano Caruso, Alessandro Fiocchi, Rocco Luigi Valluzzi
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Biology
Andrea Giovanni Ledda, Giulia Costanzo, Giada Sambugaro, Cristiano Caruso, Martina Bullita, Maria Luisa Di Martino, Paolo Serra, Davide Firinu, Stefano Del Giacco
Summary: This study investigated the effects of dupilumab on inflammatory biomarkers in patients with asthma and chronic rhinosinusitis with nasal polyps (CRSwNP). The results showed that after treatment with dupilumab, levels of eosinophils and eosinophil cationic protein initially increased and then gradually declined, returning to baseline levels. Additionally, serum total IgE and fractional exhaled nitric oxide levels decreased over time, while FEV1 and FEV1% improved significantly.
Article
Respiratory System
Alessandra Vultaggio, Maria Aliani, Elena Altieri, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Paolo Cameli, Giorgio Walter Canonica, Cristiano Caruso, Stefano Centanni, Maria D'Amato, Fausto De Michele, Stefano Del Giacco, Fabiano Di Marco, Francesco Menzella, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Gianenrico Senna, Marco Benci, Silvia Boarino, Jan Walter Schroeder
Summary: In this study, the long-term effects of benralizumab in patients with severe eosinophilic asthma (SEA) were evaluated. The results showed that treatment with benralizumab for up to 96 weeks resulted in significant improvements in asthma symptoms, lung function, and reduced exacerbations and oral corticosteroid use in SEA patients. Overall, benralizumab demonstrated remarkable efficacy in treating SEA.
RESPIRATORY RESEARCH
(2023)
Meeting Abstract
Allergy
Adriana Ariza Veguillas, Gador Bogas Herrera, Francesco Gaeta, Maria Salas, Rocco Valluzzi, Marina Labella, Natalia Perez-Sanchez, Cristiano Caruso, Ana Molina Bueno, Tahia Fernandez, Cristobalina Mayorga, Maria Jose Torres, Antonino Romano
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2022)
Review
Allergy
Cristiano Caruso, Rossana Giancaspro, Giuseppe Guida, Alberto Macchi, Massimo Landi, Enrico Heffler, Matteo Gelardi
Summary: Nasal cytology is a non-invasive and repeatable diagnostic tool that can be used to evaluate biomarkers in non-allergic rhinitis and chronic rhinosinusitis forms, and predict the prognostic index of recurrence of nasal polyposis.
FRONTIERS IN ALLERGY
(2022)
Article
Otorhinolaryngology
Matteo Gelardi, Corso Bocciolini, Mario Notargiacomo, Irene Schiavetti, Cristiano Lingua, Pietro Pecoraro, Lucia Iannuzzi, Vitaliano Antonio Quaranta, Rossana Giancaspro, Gianluca Ronca, Michele Cassano, Giorgio Ciprandi
Summary: This study compared three severity measures for chronic rhinosinusitis with nasal polyps and found that the combined use of nasal polyp score, sinonasal outcome test, and clinical-cytological grading is preferable for identifying patients eligible for biological therapy.
ACTA OTORHINOLARYNGOLOGICA ITALICA
(2022)
Article
Respiratory System
Francesco Menzella, Elena Bargagli, Maria Aliani, Pietro Bracciale, Luisa Brussino, Maria Filomena Caiaffa, Cristiano Caruso, Stefano Centanni, Maria D'Amato, Stefano Del Giacco, Fausto De Michele, Fabiano Di Marco, Elide Anna Pastorello, Girolamo Pelaia, Paola Rogliani, Micaela Romagnoli, Pietro Schino, Gianenrico Senna, Alessandra Vultaggio, Lucia Simoni, Alessandra Ori, Silvia Boarino, Gianfranco Vitiello, Elena Altieri, Giorgio Walter Canonica
Summary: This study examined the baseline characteristics and therapy effectiveness of patients with severe eosinophilic asthma (SEA) treated with benralizumab in a real-world setting. The results showed that benralizumab treatment significantly reduced exacerbations and the use of oral corticosteroids, and improved lung function and asthma control.
RESPIRATORY RESEARCH
(2022)