Article
Biology
Jian-He Lu, Yi-Hsuan Wu, Tai-Jui Juan, Hung-Yu Lin, Rong-Jyh Lin, Kuang-Shun Chueh, Yi-Chen Lee, Chao-Yuan Chang, Yung-Shun Juan
Summary: Long-term ketamine abuse can lead to various bladder issues, and this study found that autophagy plays a crucial role in improving bladder function in ketamine-induced cystitis patients.
Article
Biochemistry & Molecular Biology
Kuang-Shun Chueh, Kuan-Hua Huang, Jian-He Lu, Tai-Jui Juan, Shu-Mien Chuang, Rong-Jyh Lin, Yi-Chen Lee, Cheng-Yu Long, Mei-Chen Shen, Ting-Wei Sun, Yung-Shun Juan
Summary: This study demonstrates that intravesical instillation of platelet-rich plasma (PRP) can decrease bladder inflammation and ameliorate bladder hyperactivity in a ketamine ulcerative cystitis (KIC) rat model. PRP treatment reduces inflammatory fibrosis, attenuates oxidative stress, promotes urothelial cell regeneration, and enhances angiogenesis and neurogenesis, thereby recovering bladder dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Emergency Medicine
David M. Vu, Katerina Freyre, Oleg Opsha, Yekaterina Opsha
Summary: Ketamine, a versatile analgesic, has become a popular recreational drug, with its chronic use linked to biliary duct damage and bladder dysfunction. The rare co-presentation of ketamine-induced cholangiopathy and ulcerative cystitis poses diagnostic challenges for emergency physicians. As knowledge and awareness of these conditions increase, cases of ketamine-induced cholangiopathy and ulcerative cystitis are expected to rise.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Quan Zhu, Kaixuan Li, Haozhen Li, Feng Han, Zhengyan Tang, Zhao Wang
Summary: This study investigated the molecular mechanism of ketamine-induced bladder fibrosis and found that ketamine abuse had fibrotic effects on both rat bladders and SV-HUC-1 cells. The study also revealed that Metadherin (MTDH) regulated the process of epithelial-mesenchymal transition (EMT) through the P38 mitogen-activated protein kinase (MAPK) pathway, contributing to bladder fibrosis progression.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Hsueh-Hui Yang, Jia-Fong Jhang, Yung-Hsiang Hsu, Yuan-Hong Jiang, Wei-Jun Zhai, Hann-Chorng Kuo
Summary: This study found that smaller bladder capacity and stronger contractility in ketamine cystitis are associated with elevated expression levels of TRPV1 and TRPV4, respectively.
SCIENTIFIC REPORTS
(2021)
Article
Environmental Sciences
Chung-Hsin Yeh, Bo-He Chen, Xiao-Wen Tseng, Chun-Hou Liao, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu
Summary: This study found that intravesical administration of ketamine and norketamine can induce different types of cystitis, with norketamine treatment causing more severe bladder dysfunction than ketamine treatment. Detailed studies of cellular mechanisms are needed to determine the pathogenesis of ketamine cystitis.
Article
Multidisciplinary Sciences
Jo-Chuan Liu, Yi-Ting Chen, Ya-Ju Hsieh, Chia-Chun Wu, Ming-Chyi Huang, Yu-Chao Hsu, Chun-Te Wu, Chih-Ken Chen, Srinivas Dash, Jau-Song Yu
Summary: Chronic ketamine abuse is found to be associated with bladder dysfunction and cystitis, with significant changes in urinary protein profiles, particularly an increase in APOA1 levels. Furthermore, urinary ketamine and metabolites are positively correlated with symptoms of overactive bladder syndrome, urinary RBC/WBC, and pain rating scale in ketamine abusers, providing potential insights for new molecular tools to manage ketamine-induced bladder dysfunction.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Xiang Xie, Jiayu Liang, Run Huang, Chuang Luo, Jiali Yang, Hongming Xing, Le Zhou, Han Qiao, Erti Ergu, Huan Chen
Summary: Ketamine cystitis is a chronic bladder inflammation caused by multiple tissue injuries in the bladder, including urothelium disruption, lamina propria fibrosis and inflammation, microvascular injury, neuropathological alterations, and bladder smooth muscle abnormalities. Ketamine induces these tissue injuries by regulating different signaling pathways, contributing to the pathogenesis of ketamine cystitis.
Article
Biochemistry & Molecular Biology
Simona Cavalu, Hossam Sharaf, Sameh Saber, Mahmoud E. Youssef, Amir Mohamed Abdelhamid, Ahmed A. E. Mourad, Samar Ibrahim, Shady Allam, Rehab Mohamed Elgharabawy, Eman El-Ahwany, Noha A. Amin, Ahmed Shata, Mai Eldegla, Marina Atef, Maii Aboraya, Mayar Mohamed, Niera Anz, Dina Abd Elmotelb, Fayrouz Gabr, Dalia Elzablawy, Menna Hamada, Amr Yehia, Dalia Osama, Osama A. Mohammed
Summary: The study investigates the potential application of ambroxol in modifying the progression of ulcerative colitis (UC) by its anti-inflammatory, antioxidant, and antiapoptotic properties. The findings suggest that high doses of oral ambroxol improved the features of the injured colon, reduced disease activity, and enhanced antioxidant defense against oxidative damage by boosting Nrf2 activity. Ambroxol also inactivated NF-kappa B signaling and suppressed pro-inflammatory mediators, while upregulating IL-10. The study highlights the need for new therapies with better efficacy and safety profiles for UC patients.
Article
Food Science & Technology
Lan Pang, Ting Wang, Qian Liao, Yanfen Cheng, Di Wang, Jingjing Li, Chaomei Fu, Chen Zhang, Jinming Zhang
Summary: This study extracted sulfur-containing amino acid EGT from P. ostreatus and demonstrated its potential therapeutic benefit against ulcerative colitis. EGT exhibited strong antioxidant activity and could alleviate colonic pathological damage induced by ulcerative colitis in rats by inhibiting inflammation and signaling pathways.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Yu Yin, Kunjian Liu, Guofeng Li
Summary: In this study, the role of Prim-O-glucosylcimifugin (POG) in the treatment of ulcerative colitis (UC) and its underlying mechanisms were discussed. The results from animal studies and in vitro experiments showed that POG could protect against UC by regulating intestinal flora, repairing the intestinal barrier, and suppressing inflammatory responses.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Andrology
Shuo Tan, Xuan Zhu, Zhihuan Zheng, Long Zheng, Ye Kang, Zhengyan Tang
Summary: This study compared the efficacy and safety of BATV and BH for managing KC, indicating that BATV is superior in improving bladder capacity and urodynamic outcomes compared to BH.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Article
Chemistry, Medicinal
Yishan Zhou, Bingling Zhong, Xiangjing Min, Ying Hou, Ligen Lin, Qin Wu, Jingshan Shi, Xiuping Chen
Summary: This study demonstrated that isobavachalcone (IBC) could ameliorate colitis in mice possibly through inhibition of NF-kappa B p65.
PHYTOTHERAPY RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Shiu-Dong Chung, Chellappan Praveen Rajneesh, Kuo-Chiang Chen, Huai-Ching Tai, Meng-Lin Chang, Xiao-Wen Tseng, Jai-Hong Cheng, Wei-Kung Tsai, Han-Sun Chiang, Yi-No Wu
Summary: This study investigated the effects of ketamine on bladder function and observed histological changes in rats over a fixed time course. The results showed that exposure to ketamine led to progressive bladder dysfunction and hyperactive bladder conditions. Histological analysis revealed inflammation, edema, fibrosis, and detrusor hypertrophy in rats at different time points. These findings provide valuable insights into the prognosis and pathophysiology of the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jie Fu, Chaobo Ni, Hua-Dong Ni, Long-Sheng Xu, Qiu-Li He, Huan Pan, Dong-Dong Huang, Yan-Bao Sun, Ge Luo, Ming-Juan Liu, Ming Yao
Summary: Bone cancer pain (BCP) is a clinical issue that requires urgent attention, but research on the underlying mechanisms has been limited. This study investigated the role of Nrf2 in BCP and found that increased nuclear expression of Nrf2 can help alleviate hyperalgesia by activating HO-1 and inhibiting NF-κB signaling, ultimately reducing neuroinflammation and providing an anti-nociceptive effect.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Cheng-Yu Long, Kun-Ling Lin, Yung-Chin Lee, Shu-Mien Chuang, Jian-He Lu, Bin-Nan Wu, Kuang-Shun Chueh, Chin-Ru Ker, Mei-Chen Shen, Yung-Shun Juan
SCIENTIFIC REPORTS
(2020)
Article
Endocrinology & Metabolism
Ju-Yu Yen, Huang-Chi Lin, Pai-Cheng Lin, Tai-Ling Liu, Cheng-Yu Long, Chih-Hung Ko
PSYCHONEUROENDOCRINOLOGY
(2020)
Article
Obstetrics & Gynecology
Chin-Ru Ker, Kae-Ying Ou, Cheng-Yu Long, Linus Chuang, Cherng-Jye Jeng
TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY
(2020)
Letter
Obstetrics & Gynecology
Yu-Wei Lin, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2021)
Article
Biology
Jian-He Lu, Kuang-Shun Chueh, Shu-Mien Chuang, Yi-Hsuan Wu, Kun-Ling Lin, Cheng-Yu Long, Yung-Chin Lee, Mei-Chen Shen, Ting-Wei Sun, Yung-Shun Juan
Summary: This study investigated the therapeutic effect and duration of low intensity extracorporeal shock wave therapy (LiESWT) on overactive bladder (OAB) symptoms. The results showed significant improvements in urinary frequency, urgency, nocturia, and post-voided residual volume after 8 weeks of LiESWT treatment. Furthermore, the treatment also led to meaningful improvements in social activity and quality of life for OAB patients.
Letter
Obstetrics & Gynecology
I-Chieh Sung, Ching-Ju Shen, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Engineering, Biomedical
Kun-Ling Lin, Shih-Hsiang Chou, Zi-Xi Loo, Yi-Yin Liu, Jung-Chien Cheng, Cheng-Yu Long
Summary: This study investigated the effects of vulvovaginal erbium laser on the genitourinary syndrome of menopause (GSM) and sexual function of post-menopausal women. The results showed a significant improvement in GSM and sexual function after vulvovaginal laser treatment, with no serious adverse effects observed up to 1 year post-treatment.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Kuang-Shun Chueh, Kuan-Hua Huang, Jian-He Lu, Tai-Jui Juan, Shu-Mien Chuang, Rong-Jyh Lin, Yi-Chen Lee, Cheng-Yu Long, Mei-Chen Shen, Ting-Wei Sun, Yung-Shun Juan
Summary: This study demonstrates that intravesical instillation of platelet-rich plasma (PRP) can decrease bladder inflammation and ameliorate bladder hyperactivity in a ketamine ulcerative cystitis (KIC) rat model. PRP treatment reduces inflammatory fibrosis, attenuates oxidative stress, promotes urothelial cell regeneration, and enhances angiogenesis and neurogenesis, thereby recovering bladder dysfunction.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Letter
Obstetrics & Gynecology
Chun-Hsiang Yang, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Letter
Obstetrics & Gynecology
Jian-Ling Yeh, Cheng-Yu Long
INTERNATIONAL UROGYNECOLOGY JOURNAL
(2022)
Article
Medicine, General & Internal
Yu-Chen Chen, Yin-Chi Liang, Shuo-Jung Ho, Hao-Wei Chen, Yung-Shun Juan, Wei-Chung Tsai, Shu-Pin Huang, Jung-Ting Lee, Yu-Peng Liu, Chung-Yao Kao, Yen-Ko Lin, Cheng-Yu Long, Meng-Ni Wu, Chao-Ju Chen, Wen-Jeng Wu
Summary: The study found that storage lower urinary tract symptoms may deteriorate after COVID-19 vaccination, with individuals pre-existing overactive bladder being more susceptible to worsening of storage LUTS post-vaccination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Cheng-Yu Long, Jennifer Po-Ning Lee, Zi-Xi Loo, Yi-Yin Liu, Chang-Lin Yeh, Chien-Wei Feng, Kun-Ling Lin
Summary: This study assessed the efficacy of Pixel CO2 laser for female stress urinary incontinence (SUI). The results showed significant improvement in SUI symptoms with vaginal Pixel CO2 laser treatment, indicating its effectiveness and safety.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Ching-Hu Wu, Chien-Wei Feng, Chiu-Lin Wang, Zhi-Hong Wen, Cheng-Yu Long, Feng-Hsiang Tang
Summary: Our data showed that cisplatin treatment induces production of reactive oxygen species (ROS) that regulate apoptotic protein expression and stimulate anti-oxidative signal, inhibiting cell migration. The intervention of Zfp90 enhanced apoptosis pathway and inhibited migrative pathway, thus regulating the sensitivity of ovarian cancer cells to cisplatin. This study suggests that loss of Zfp90 function promotes cisplatin sensitization in ovarian cancer cells through the regulation of Nrf2/HO-1 pathway, enhancing cell apoptosis and inhibiting migration.
Article
Clinical Neurology
Ching-Hu Wu, Kun-Ling Lin, Cheng-Yu Long, Chien-Wei Feng
Summary: Parkinson's disease is a highly influential disease worldwide, and current medications only provide relief for symptoms without slowing down disease progression. However, the plant-derived compound isotetrandrine (ITD) has been found to possess neuroprotective activity both in vitro and in vivo. ITD inhibits inflammatory-related protein and mRNA expression, improves locomotor deficiency, and reduces apoptosis in zebrafish models of PD. The neuroprotective effects of ITD may be mediated through anti-neuroinflammation and antiapoptosis pathways involving PI3K, ERK, and HO-1.
PARKINSONS DISEASE
(2023)
Article
Medicine, General & Internal
Cheng-Yu Long, Zi-Xi Loo, Ching-Hu Wu, Kun-Ling Lin, Chang-Lin Yeh, Chien-Wei Feng, Pei-Chi Wu
Summary: This study aimed to evaluate the correlation between the overall rest-stress distance measured by transperineal ultrasound (TPUS) and Q-tip test angle in women with urodynamic stress incontinence (USI), and determine the optimal cut-off value for predicting urethral hypermobility (UH). The results showed a strong correlation between the overall rest-stress distance in TPUS and Q-tip test angle, and a rest-stress distance of more than 13.3 mm was found to be an optimal cut-off value for predicting UH in women with USI.
JOURNAL OF CLINICAL MEDICINE
(2023)