Review
Medicine, General & Internal
Sarah L. Boddy, Ilaria Giovannelli, Matilde Sassani, Johnathan Cooper-Knock, Michael P. Snyder, Eran Segal, Eran Elinav, Lynne A. Barker, Pamela J. Shaw, Christopher J. McDermott
Summary: The gut microbiome may play a significant role in the pathogenesis of ALS, with research indicating that microbial changes can affect disease outcomes. Variability in gut microbiota between individuals may explain the different disease outcomes seen in ALS patients.
Article
Nutrition & Dietetics
Liva Aumeistere, Juris Kibilds, Inese Siksna, Lolita Vija Neimane, Mara Kampara, Olga Lubina, Inga Ciprovica
Summary: This study aimed to evaluate the impact of yoghurt intake on the gut microbiome among postmenopausal women and how overall dietary habits modulate the gut microbiome. Although no significant changes in the gut microbiome were related to daily consumption of yoghurt, we report that consumption of food products like grains, grain-based products, milk and milk products, and beverages is associated with differences in the composition of the gut microbiome.
Review
Engineering, Chemical
Takashi Hosaka, Hiroshi Tsuji, Akira Tamaoka
Summary: Reduction-oxidation reactions are essential for cellular homeostasis, and oxidative stress has been suggested to be involved in the pathogenesis of ALS. Promising biomarkers indicating the mechanism between oxidative stress and ALS may have important diagnostic and therapeutic implications.
Article
Biochemistry & Molecular Biology
Xin Yan, Yu Wang, Xue-Yang Ren, Xiao-Yun Liu, Jia-Mu Ma, Ruo-Lan Song, Xiu-Huan Wang, Ying Dong, A-Xiang Yu, Qi-Qi Fan, Jing Wei, Gai-Mei She
Summary: The study showed that Thymus quinquecostatus Celak extract has hepatoprotective effects against ALD by improving gut barrier function, modulating gut microbiota, suppressing inflammatory response, and reducing ROS production in the liver.
Review
Immunology
Sarah Martin, Carolina Battistini, Jun Sun
Summary: Amyotrophic lateral sclerosis (ALS) is a debilitating disease characterized by motor neuron degeneration, and its etiology and pathophysiology remain poorly understood. Recent studies suggest the significant roles of intestinal dysfunction and microbiota in ALS development and progression. However, research on innate immunity and intestinal changes in early disease pathology is lacking.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Belen Proano, Julia Casani-Cubel, Maria Benlloch, Ana Rodriguez-Mateos, Esther Navarro-Illana, Jose Maria Lajara-Romance, Jose Enrique de la Rubia Orti
Summary: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease with no medical cure. Dutasteride, a potential treatment molecule, has shown neuroprotective, antioxidant, and anti-inflammatory effects in ALS.
Article
Biochemistry & Molecular Biology
Acsa Nara de Araujo Brito Barros, Maria Luisa do Nascimento Felipe, Isabelle Ribeiro Barbosa, Lucia Leite-Lais, Lucia Fatima Campos Pedrosa
Summary: This study aimed to evaluate the prevalence of inadequate micronutrient intake in ALS patients, comparing subgroups according to the disease severity. The results showed that patients with higher disease severity had lower intakes of vitamin E, niacin, pantothenic acid, pyridoxine, folate, and selenium. Therefore, monitoring the dietary intake of essential micronutrients in neurological processes is important for ALS patients.
Review
Medicine, General & Internal
Jiangwei Sun, Tingting Huang, Justine W. Debelius, Fang Fang
Summary: ALS is a rare and incurable neurodegenerative disease characterized by a loss of motor neurons in the brain and spinal cord. Contributions from outside the central nervous system to the etiology of ALS, including the gut microbiome, are increasingly recognized. Results from animal studies on altered gut microbiome composition in ALS are relatively consistent, while findings from human studies are largely inconclusive.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Luyang Xiong, Michael McCoy, Hitoshi Komuro, Xiaoxia Z. West, Valentin Yakubenko, Detao Gao, Tejasvi Dudiki, Amanda Milo, Jacqueline Chen, Eugene A. Podrez, Bruce Trapp, Tatiana Byzova
Summary: ALS is a progressive neurodegenerative disease with no cure, where inflammation and oxidative stress may play a significant role, particularly in patients with the SOD1 mutation. The accumulation of CEP, a DHA peroxidation product, in ALS brains may be linked to activated inflammatory cells and reduced antioxidant activity due to the mutation, highlighting its potential as a hallmark of oxidative damage in neurodegenerative diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Elena Obrador, Rosario Salvador-Palmer, Rafael Lopez-Blanch, Ryan W. Dellinger, Jose M. Estrela
Summary: ALS is a degenerative disease with no cure or proven therapy. While some drugs have been approved for treatment, there has been no significant breakthrough in the field.
Article
Nutrition & Dietetics
Kailin Xia, Yajun Wang, Linjing Zhang, Lu Tang, Gan Zhang, Tao Huang, Ninghao Huang, Dongsheng Fan
Summary: This study used Mendelian randomization analysis to investigate the potential causal relationship between essential nutrients and the risk of amyotrophic lateral sclerosis (ALS). The study found a causal association between genetically predicted linoleic acid (LA) and ALS risk, and a negative association between vitamin D/vitamin E and ALS risk. No causal effect was observed for essential amino acids and minerals on ALS risk.
Article
Multidisciplinary Sciences
Paul B. Stege, Joost Hordijk, Sudarshan A. Shetty, Michael Visser, Marco C. Viveen, Malbert R. C. Rogers, Esther Gijsbers, Cindy M. Dierikx, Rozemarijn Q. J. van der Plaats, Engeline van Duijkeren, Eelco Franz, Rob J. L. Willems, Susana Fuentes, Fernanda L. Paganelli
Summary: This study assessed whether long-term dietary habits in the Netherlands impact the human gut resistome. The results showed that different diet groups had similar numbers of antibiotic resistance genes, but vegans had a distinct microbiome composition compared to other diet groups.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
George Anderson
Summary: The article integrates data on the biological underpinnings of ALS, focusing on the mitochondrial melatonergic pathway and systemic factors. Suppression of this pathway leads to changes in muscle brain-derived neurotrophic factor, contributing to a lack of metabolic trophic support at the neuromuscular junction. Activation of astrocytes and microglia is a driver of motor neuron susceptibility in ALS. Gut dysbiosis/permeability and pineal melatonin play important roles in upregulating the melatonergic pathway. The occupational risk of ALS in farmers, gardeners, and sportsmen/women is linked to exposure to glyphosate-based herbicides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Kiyoung Kim
Summary: ALS is a rare neurological disorder characterized by a deficiency in the antioxidant tripeptide glutathione (GSH). Imbalanced GSH homeostasis and its molecular characteristics play crucial roles in ALS development. Studies have shown that GSH metabolism and redox status are associated with neuronal toxicity in ALS.
Review
Biochemistry & Molecular Biology
Giulia Gibiino, Martina De Siena, Monica Sbrancia, Cecilia Binda, Vittorio Sambri, Antonio Gasbarrini, Carlo Fabbri
Summary: Diet plays a crucial role in influencing our intestinal microbiota and ecosystem balance, but a clearly defined dietary regime to ensure its health is still lacking. The Mediterranean diet may potentially have significant benefits for our health through direct interaction with our microbiota.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Bozenna Kuraszkiewicz, Jia-Jin Jason Chen, Hanna Goszczynska, Yu-Lin Wang, Maria Piotrkiewicz
Article
Neurosciences
Mustafa Gorkem Ozyurt, Maria Piotrkiewicz, Betilay Topkara, Hans-Werner Weisskircher, Kemal Sitki Turker
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Clinical Neurology
Kristin Diekmann, Magdalena Kuzma-Kozakiewicz, Maria Piotrkiewicz, Marta Gromicho, Julian Grosskreutz, Peter M. Andersen, Mamede de Carvalho, Hilmi Uysal, Alma Osmanovic, Olivia Schreiber-Katz, Susanne Petri, Sonja Koerner
JOURNAL OF NEUROLOGY
(2020)
Review
Neurosciences
B. Kuraszkiewicz, H. Goszczynska, T. Podsiadly-Marczykowska, M. Piotrkiewicz, P. Andersen, M. Gromicho, J. Grosskreutz, M. Kuzma-Kozakiewicz, S. Petri, B. Stubbendorf, K. Szacka, H. Uysal, M. de Carvalho
FRONTIERS IN NEUROSCIENCE
(2020)
Article
Engineering, Biomedical
M. Piotrkiewicz
Summary: Investigating MN physiology with computer simulations allows evaluation of human MNs' biophysical properties and understanding the role of PICs in shaping MU discharge patterns. Recent MN models focus on PICs and their interaction with synaptic inputs to produce various discharge patterns.
BIOCYBERNETICS AND BIOMEDICAL ENGINEERING
(2021)
Letter
Clinical Neurology
Maria Piotrkiewicz
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Geriatrics & Gerontology
Sonja Korner, Johanna Kammeyer, Antonia Zapf, Magdalena Kuzma-Kozakiewicz, Maria Piotrkiewicz, Boienna Kuraszkiewicz, Hanna Goszczynska, Marta Gromicho, Julian Grosskreutz, Peter M. Andersen, Mamede de Carvalho, Susanne Petri
