期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01823
关键词
type I interferon; human immunodeficiency virus type 1; innate immunity; intrinsic immunity; interferon-stimulated gene; restriction factor; humanized mouse
类别
资金
- CREST, JST
- Japanese Initiative for Progress of Research on Infectious Disease for global Epidemic (J-PRIDE) [17fm0208006h0001]
- AMED
- JSPS KAKENHI [15K07166, 16KT0111, 16H06429, 16K21723, 17H05813]
- Takeda Science Foundation
- Salt Science Research Foundation
- Smoking Research Foundation
- Chube Ito Foundation
- Fordays Self-Reliance Support in Japan
- Mishima Kaiun Memorial Foundation
- Tobemaki Foundation
- Food Science Institute Foundation (Ryoushoku-kenkyukai)
- JSPS Core-to-Core program, A. Advanced Research Networks
- Research on HIV/AIDS, AMED [16fk0410203h002]
- Grants-in-Aid for Scientific Research [16KT0111, 15K07166, 17H05813] Funding Source: KAKEN
Human immunodeficiency virus type 1 (HIV-1) is the causative agent of acquired immunodeficiency syndrome and its infection leads to the onset of several disorders such as the depletion of peripheral CD4(+) T cells and immune activation. HIV-1 is recognized by innate immune sensors that then trigger the production of type I interferons (IFN-Is). IFN-Is are well-known cytokines eliciting broad anti-viral effects by inducing the expression of anti-viral genes called interferon-stimulated genes (ISGs). Extensive in vitro studies using cell culture systems have elucidated that certain ISGs such as APOBEC3G, tetherin, SAM domain and HD domain-containing protein 1, MX dynamin-like GTPase 2, guanylate-binding protein 5, and schlafen 11 exert robust anti-HIV-1 activity, suggesting that IFN-I responses triggered by HIV-1 infection are detrimental for viral replication and spread. However, recent studies using animal models have demonstrated that at both the acute and chronic phase of infection, the role of IFN-Is produced by HIV or SIV infection in viral replication, spread, and pathogenesis, may not be that straightforward. In this review, we describe the pluses and minuses of HIV-1 infection stimulated IFN-I responses on viral replication and pathogenesis, and further discuss the possibility for therapeutic approaches.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据