Article
Immunology
Saisai Ren, Xiaorong Zhang, Hongbing Guan, Lihong Wu, Miao Yu, Dan Hou, Yongyong Yan, Xuechun Fang
Summary: The study found that the probiotic Lactobacillus acidipiscis in the intestine can suppress the development of multiple sclerosis by inducing the generation of regulatory T cells. This helps to inhibit the progression of the disease and shows potential for treatment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Dariush Haghmorad, Ali Khaleghian, Majid Eslami, Abdolvahid Sadeghnejad, Mahdieh Tarahomi, Bahman Yousefi
Summary: This study found that mesenchymal stem cells (MSCs) can modulate the progression of multiple sclerosis (MS) and immune system regulation by changing the expression patterns of miRNAs.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Immunology
Zhihui Zhang, Kai Zhang, Mi Zhang, Xiaomin Zhang, Rongxin Zhang
Summary: This study demonstrates the important immunosuppressive effect of parthenolide (PTL) on autoimmune inflammation. PTL can alleviate clinical symptoms by inhibiting inflammatory cell infiltration, reducing inflammation, and demyelination. It also regulates the immune response by inhibiting the reactivation of specific T cells and the differentiation of CD4(+) T cells into pathogenic Th17 cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Jingjing Han, Wei Zhuang, Wanhua Feng, Fuxing Dong, Fang Hua, Ruiqin Yao, Xuebin Qu
Summary: The study identified circINPP4B as a regulator promoting Th17 differentiation and progression of EAE by targeting miR-30a, indicating its potential as a diagnostic and therapeutic target for Th17-mediated MS.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Agnieshka Agasing, James L. Quinn, Gaurav Kumar, Robert C. Axtell
Summary: IFN-beta has differential effects on different stages of TH17 cell development, inhibiting IL-17 production in early stages and synergizing with IL-23 in late stages to promote pathogenic T cell development.
Article
Biochemistry & Molecular Biology
Haishan Li, Yingying Zeng, Shunchang Luo, Zhenhua Li, Fang Huang, Zonghua Liu
Summary: Multiple sclerosis (MS) is a common autoimmune disease of the central nervous system (CNS) that mainly affects young adults. CD4+ T cells play a significant role in the inflammatory processes of MS. Ferroptosis, a newly discovered form of programmed cell death, has been found to be associated with CD4+ T cells, but its impact on MS remains unclear.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Oncology
Bei Liu, Zewei Mao, Na Yin, Qianlan Gu, Yan Qi, Xiaosi Li, Haihao Yang, Zhao Wu, Nanting Zou, Sai Ying, Chunping Wan
Summary: The present study demonstrates that MW-9 can attenuate experimental autoimmune encephalomyelitis (EAE) by suppressing the formation and activities of pathogenic T(H)17 cells. MW-9 slows down infiltration process, inhibits demyelination, blocks anti-MOG(35-55) IgG antibody production, and reduces accumulation of neutrophils. Additionally, MW-9 decreases IL-17A production and IL-17 expression in CD4(+) T-cells.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Immunology
Ping Zhao, Xin Chen, Xudong Han, Yanping Wang, Yu Shi, Jiayu Ji, Yanting Lei, Ying Liu, Qingfei Kong, Lili Mu, Jinghua Wang, Wei Zhao, Guangyou Wang, Xijun Liu, Tongshuai Zhang, Yao Zhang, Bo Sun, Yumei Liu, Hulun Li
Summary: Electroacupuncture (EA) treatment can alleviate clinical symptoms of EAE, reduce spinal cord demyelination, regulate inflammatory cytokine levels, and modulate miR-155 and POMC expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Arezoo Hosseini, Tohid Gharibi, Adel Mohammadzadeh, Abbas Ebrahimi-Kalan, Farhad Jadidi-niaragh, Zohreh Babaloo, Dariush Shanehbandi, Elham Baghbani, Behzad Baradaran
Summary: Ruxolitinib ameliorated the severity of EAE by modulating the balance between Th17 cells and Tregs, reducing inflammatory markers levels and increasing levels of anti-inflammatory cytokines.
Article
Immunology
Jie Lv, Mengyao Han, Guangyu Liu, Wei Zhuang, Chun Wang, Ling Xie, Kaidireya Saimaier, Sanxing Han, Changjie Shi, Qiuhong Hua, Ru Zhang, Changsheng Du
Summary: Apoptosis is important in maintaining the homeostasis of the body and immune system, but its dysfunction can lead to autoimmune diseases like multiple sclerosis (MS). An animal model, experimental autoimmune encephalomyelitis (EAE), is used to study MS. In this study, we found that carboplatin (CA), a platinum anti-tumor drug, reduced inflammation and demyelination in EAE mice. CA also decreased pathogenic T cell numbers and proportions in the spleen and lymph nodes of EAE mice. Additionally, CA induced apoptosis and inhibited T cell proliferation. These findings suggest that CA has potential as a novel drug for MS treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Siying Qu, Shengfeng Hu, Huiting Xu, Yongjian Wu, Siqi Ming, Xiaoxia Zhan, Cheng Wang, Xi Huang
Summary: Multiple sclerosis (MS) is a neuroinflammatory demyelinating disease mediated by pathogenic T helper 17 (Th17) cells. In this study, the key regulator of Th17 differentiation in MS was found to be the triggering receptor expressed on myeloid cells 2 (TREM-2). TREM-2 was highly expressed on pathogenic CD4-positive T lymphocytes in both MS patients and EAE mouse models. Conditional knockout of Trem-2 significantly alleviated disease activity and reduced Th17 cell infiltration, activation, differentiation, and inflammatory cytokine production in EAE mice. The TREM-2/ZAP70/STAT3 signal axis was identified as essential for Th17 activation and differentiation in EAE progression.
NEUROSCIENCE BULLETIN
(2023)
Review
Immunology
Xinzou Fan, Panyin Shu, Ying Wang, Ning Ji, Dunfang Zhang
Summary: Neutrophils are the predominant immune cells in human peripheral circulation that play a crucial role in fighting infections, autoimmune diseases, and cancer. This review discusses the physiological roles of Th17 cells and neutrophils, their interactions, and their involvement in pathological processes. The study also provides a summary of drugs targeting IL-17A and their clinical trials.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Neurosciences
Qianling Jiang, Xin Ma, Gaochen Zhu, Wen Si, Lingyu He, Guan Yang
Summary: This study investigated the effects of EAE induction on thymopoiesis and T cell development, revealing changes such as increased apoptosis, decreased proliferation, and a blockade in the transition from double-negative thymocytes to double-positive cells. It was also found that positive selection was disrupted in the thymus of EAE mice, along with an increased production of regulatory T cells.
EXPERIMENTAL NEUROLOGY
(2024)
Review
Immunology
Jarne Belien, An Goris, Patrick Matthys
Summary: This review highlights the important role of natural killer (NK) cells in the immunopathology of multiple sclerosis (MS). Through studies using animal models, genetics, as well as ex vivo and in vitro research on MS patients, evidence has been found for the contribution of NK cells to the pathogenesis of MS. The discovery of NK cell heterogeneity using modern hypothesis-free technologies such as single-cell transcriptomics has further blurred the boundaries between adaptive and innate immunity. Understanding the heterogeneity of NK cells and the mechanistic link between innate and adaptive immune cell functions may lead to the use of NK cells as prognostic tools and therapeutic targets for MS and other currently incurable autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
