Article
Immunology
K. R. van Straalen, K. Dudink, P. Aarts, H. H. van der Zee, T. P. P. van den Bosch, J. Giang, E. P. Prens, J. Damman
Summary: This study did not find significant local complement deposition in HS patients compared to controls, but the increased presence of C5aR1 positive immune cells in HS lesions suggests the importance of complement in the pathogenesis of HS and supports emerging therapies targeting this pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Laura Macca, Federica Li Pomi, Ylenia Ingrasciotta, Pietro Morrone, Gianluca Trifiro, Claudio Guarneri
Summary: Psoriasis and hidradenitis suppurativa are chronic inflammatory skin diseases that often occur together, with psoriasis usually preceding hidradenitis suppurativa. Paradoxical hidradenitis suppurativa can occur following biological therapy for psoriasis. While there have been significant advancements in the treatment of psoriasis, progress for hidradenitis suppurativa has been limited, highlighting the need for novel therapeutic approaches.
FRONTIERS IN MEDICINE
(2023)
Review
Medicine, General & Internal
Carlo Alberto Maronese, Nicoletta Cassano, Giovanni Genovese, Caterina Foti, Gino Antonio Vena, Angelo Valerio Marzano
Summary: The coexistence of psoriasis with autoimmune bullous diseases, particularly bullous pemphigoid, has been observed in case reports, series, and epidemiological studies. Psoriasis usually precedes the onset of bullous pemphigoid and patients with both conditions typically have a milder presentation of bullous pemphigoid. It has been suggested that some cases of bullous pemphigoid with comorbid psoriasis may actually correspond to a rare form known as anti-laminin gamma-1 pemphigoid. The pathomechanisms of the association between psoriasis and bullous pemphigoid remain unclear, but the epitope spreading hypothesis is the most widely accepted explanation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Divya Chopra, Rachel A. Arens, Watcharee Amornpairoj, Michelle A. Lowes, Marjana Tomic-Canic, Natasa Strbo, Hadar Lev-Tov, Irena Pastar
Summary: Hidradenitis Suppurativa is a chronic inflammatory skin disease with complex mechanisms. It is characterized by abnormal activation of the innate immune system, leading to unresolved inflammation. Imbalance in host immunity and dysbiosis of the microbiome play important roles, as well as the ability of pathogens associated with the disease to overcome host immune response.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Tianmeng Yan, Zhenying Zhang
Summary: Bullous pemphigoid (BP) is an autoimmune blistering disease primarily affecting elderly individuals. It presents with heterogeneous manifestations, typically characterized by microscopically subepidermal separation and mixed inflammatory infiltrate. The development mechanism of BP remains unclear. B cells are involved in pathogenic autoantibody production, and other immune cells such as T cells, type II inflammatory cytokines, eosinophils, mast cells, neutrophils, and keratinocytes also contribute to the pathogenesis of BP. This review focuses on the roles and crosstalk between innate and adaptive immune cells in BP.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Chiara Moltrasio, Rachele Cagliani, Manuela Sironi, Mario Clerici, Chiara Pontremoli, Carlo Alberto Maronese, Paola Maura Tricarico, Sergio Crovella, Angelo Valerio Marzano
Summary: A variant in the AIM2 gene was found in syndromic HS patients, suggesting its involvement in the pathogenesis of the disease. This variant was less common in sporadic HS and PG. These findings suggest a potential role of this variant in susceptibility to develop syndromic HS.
Article
Dermatology
Yukiko Nakahara, Mariko Yamane, Midori Sunada, Yumi Aoyama
Summary: This article reports a case of an SLE patient who developed tense blister lesions after receiving the SARS-CoV-2 vaccine. The patient did not show IgG deposition at the basement membrane before vaccination, but became positive afterwards. Additionally, the results of testing using NaCl split skin were also positive. The findings suggest that the SARS-CoV-2 vaccine may trigger the production of autoantibodies that cause bullous SLE.
JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Khalaf Kridin, Michal Shani, Yochai Schonmann, Shani Fisher, Guy Shalom, Doron Comaneshter, Erez Batat, Arnon D. Cohen
Summary: This study aimed to investigate the association between psoriasis and hidradenitis suppurativa (HS) using a large-scale real-life computerized database. The results showed that the prevalence of HS was higher in patients with psoriasis compared to the control group. Even after adjusting for confounding factors, the association between psoriasis and HS remained.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Review
Medicine, General & Internal
Maria-Angeles Ferrer-Alcala, Manuel Sanchez-Diaz, Salvador Arias-Santiago, Alejandro Molina-Leyva
Summary: Psoriasis and hidradenitis suppurativa have an impact on pregnancy and fertility, including decreased fertility and unpredictable disease evolution during pregnancy. Treatment during pregnancy may change, but biologic therapies do not appear to increase the risk of adverse events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Dermatology
Chang-Yu Hsieh, Tsen-Fang Tsai
Summary: Psoriasis and bullous pemphigoid often coexist and have different optimal treatment strategies. Topical corticosteroids are commonly used for mild cases, while systemic immunosuppressants such as corticosteroids and methotrexate are popular choices for more severe cases. However, tapering of immunosuppressants may lead to flare-ups of both diseases.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Article
Dermatology
A. Lamberts, N. Kotnik, G. F. H. Diercks, J. M. Meijer, G. Di Zenzo, H. H. Pas, M. F. Jonkman, B. F. Gibbs, U. Raap, B. Horvath
Summary: Total IgE levels were elevated in a significant percentage of both NBP and BP patients, with IgE being present in both serum and skin. The study suggests a common IgE-dependent mechanism in both diseases, such as pruritus, but further research is needed to determine if IgE contributes to blister formation in BP.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2021)
Review
Dermatology
Daniel G. W. Johnston, Brian Kirby, Desmond J. Tobin
Summary: The innate immune system of human skin consists of multi-layered barrier cells and soluble effector molecules charged with maintaining homeostasis and responding to insults and infections. These barrier layers are compromised in skin diseases, with significant advancements in understanding occurring in the research of hidradenitis suppurativa.
EXPERIMENTAL DERMATOLOGY
(2021)
Review
Dermatology
Y. Yao, J. W. Frew, S. F. Thomsen, H. C. Ring
Summary: The review highlights the diversity of AMPs in HS, with consistent findings of dysregulation of AMPs in HS skin. The included studies demonstrate an overexpression of certain AMPs in HS, while others show a decreased expression.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Review
Immunology
Shuo-Yan Gau, Ivan Arni C. Preclaro, James Cheng-Chung Wei, Chien-Ying Lee, Yu-Hsiang Kuan, Yu-Ping Hsiao, Sin-Ei Juang, Kevin Sheng-Kai Ma
Summary: This systematic review and meta-analysis found a significant association between hidradenitis suppurativa (HS) and psoriasis. HS patients had a higher risk of having psoriasis, and the risk was even higher in male patients and female patients with HS.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, General & Internal
Faith A. P. Zeng, Dedee F. Murrell
Summary: Further research into inhibitors of eotaxin, IL-4, IL-5, IL-17, IL-23, CCR3, and specific complement factors are warranted as preliminary studies have largely identified success in treating BP with these agents. Learning from novel treatments for other IgG-mediated autoimmune diseases may be beneficial.
FRONTIERS IN MEDICINE
(2022)
Article
Dermatology
M. Rijsbergen, T. Niemeyer-van der Kolk, R. Rijneveld, J. H. F. M. Pinckaers, I Meshcheriakov, J. N. Bouwes Bavinck, M. B. A. van Doorn, G. Hogendoorn, G. Feiss, A. F. Cohen, J. Burggraaf, M. I. E. van Poelgeest, R. Rissmann
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2020)
Article
Pharmacology & Pharmacy
Melanie Rijsbergen, Rianne Rijneveld, Marina Todd, Gary L. Feiss, Stijn T. P. Kouwenhoven, Koen D. Quint, Dirk C. J. G. van Alewijk, Maurits N. C. de Koning, Erica S. Klaassen, Jacobus Burggraaf, Robert Rissmann, Mariette I. E. van Poelgeest
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2020)
Article
Dermatology
Jenny Giang, Asok Biswas, Antien L. Mooyaart, Floris H. Groenendijk, Petra Dikrama, Jeffrey Damman
Summary: This case report presents a rare trichoblastic carcinosarcoma with panfollicular differentiation, with molecular analysis revealing identical molecular aberrations in both epithelial and mesenchymal components. This is the first report of panfollicular carcinosarcoma and the presence of a CTNNB1 mutation in trichoblastic carcinosarcoma.
JOURNAL OF CUTANEOUS PATHOLOGY
(2021)
Article
Pharmacology & Pharmacy
Mahdi Saghari, Pim Gal, Dimitrios Ziagkos, Jacobus Burggraaf, John F. Powell, Nuala Brennan, Robert Rissmann, Martijn B. A. van Doorn, Matthijs Moerland
Summary: The study demonstrated an increase in anti-KLH antibodies after KLH immunization and a delayed-type hypersensitivity response after intradermal KLH administration. This suggests that the KLH model could serve as an objective tool for studying the pharmacodynamics of T-cell-directed immunomodulatory drugs.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Dermatology
Tessa Niemeyer-van der Kolk, Thomas P. Buters, Lara Krouwels, Jiry Boltjes, Marieke L. de Kam, Hein van der Wall, Dirk C. J. G. van Alewijk, Ellen H. A. van den Munckhof, Martin J. Becker, Gary Feiss, Edwin F. Florencia, Errol P. Prens, Matthijs Moerland, Jacobus Burggraaf, Robert Rissmann, Martijn B. A. van Doorn
Summary: Omiganan restored dysbiosis by reducing Staphylococcus abundance and increasing diversity. However, there was no significant clinical improvement observed.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Justin Jacobse, Wouter ten Voorde, Anushka Tandon, Stefan G. Romeijn, Hendrika W. Grievink, Koen van der Maaden, Michiel J. van Esdonk, Dirk Jan A. R. Moes, Floris Loeff, Karien Bloem, Annick de Vries, Theo Rispens, Gertjan Wolbink, Marieke de Kam, Dimitrios Ziagkos, Matthijs Moerland, Wim Jiskoot, Joke Bouwstra, Jacobus Burggraaf, Lenneke Schrier, Robert Rissmann, Rebecca ten Cate
Summary: This study evaluated the feasibility of intradermal administration of adalimumab using hollow microneedles. It was found that intradermal adalimumab injection was perceived as more painful compared to subcutaneous administration, but resulted in higher relative bioavailability and skin reactions. The study also showed similar safety and pharmacokinetic effects between intradermal and subcutaneous administration routes.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Editorial Material
Pharmacology & Pharmacy
Robert Rissmann, Rob Zuiker
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter W. Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter Ten Voorde, Edwin Florencia, Michelle Osse, Marieke L. de Kam, Hendrika W. Grievink, Mascha Schoonakker, Amit A. Patel, Simon Yona, Derek W. Gilroy, Erik Lubberts, Jeffrey Damman, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: This study aimed to characterize the intradermal LPS response in healthy volunteers as a local inflammation model for clinical pharmacology studies. Results showed that intradermal LPS administration induced a visible response, with acute interleukin and tumor necrosis factor protein response followed by different cellular responses. The study suggests that intradermal LPS administration may be a valuable inflammation model for evaluating the pharmacological activity of anti-inflammatory compounds.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Thomas P. Buters, Pieter Hameeteman, Iris M. E. Jansen, Floris C. van Hindevoort, Wouter ten Voorde, Hendrika W. Grievink, Mascha Schoonakker, Marieke L. de Kam, Derek W. Gilroy, Gary Feiss, Robert Rissmann, Manon A. A. Jansen, Jacobus Burggraaf, Matthijs Moerland
Summary: In this study, the inhibitory effects of oral and topical corticosteroid treatment on intradermal lipopolysaccharide (LPS) responses were evaluated. The results showed that corticosteroids significantly suppressed the clinical inflammatory response and reduced the secretion of inflammatory mediators. This experimental model is effective in evaluating the effects of anti-inflammatory drugs.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Pharmacology & Pharmacy
Mahdi Saghari, Pim Gal, Sally Gilbert, Martin Yateman, Ben Porter-Brown, Nuala Brennan, Sonia Quaratino, Rosamund Wilson, Hendrika W. Grievink, Erica S. Klaassen, Kirsten R. Bergmann, Jacobus Burggraaf, Martijn B. A. van Doorn, John Powell, Matthijs Moerland, Robert Rissmann
Summary: The safety, tolerability, immunogenicity, and pharmacokinetic profile of anti-OX40L monoclonal antibody KY1005 were evaluated, and its effects on antibody response and skin response were observed. The study found that KY1005 demonstrated an acceptable safety and tolerability profile, showed pharmacological activity, and had potential as a novel pharmacological treatment for immune-mediated disorders.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Oncology
Bertine W. Huisman, Merve Cankat, Tjalling Bosse, Alexander L. Vahrmeijer, Robert Rissmann, Jacobus Burggraaf, Cornelis F. M. Sier, Mariette I. E. van Poelgeest
Summary: Fluorescence-guided surgery using integrin alpha v beta 6 as a target showed robust discrimination of vulvar tumors and surrounding tissue, suggesting its potential utility in future studies. Immunohistochemistry of membrane proteins identified possible tracers for fluorescence-guided surgery in vulvar (pre)malignancies, emphasizing the need for further evaluation of alpha v beta 6 as a target.
Review
Microbiology
Lisa Pagan, Roos A. M. Ederveen, Bertine W. Huisman, Jan W. Schoones, Romy D. Zwittink, Frank H. J. Schuren, Robert Rissmann, Jurgen M. J. Piek, Mariette I. E. van Poelgeest
Summary: This systematic review explores the relationship between microbiome and vulvar (pre)malignant disease, revealing differences in vulvar microbiome composition between healthy and diseased states. Although promising, there is limited data with low evidence levels.
Review
Pharmacology & Pharmacy
Laura M. de Jong, Sylvia D. Klomp, Nicoline Treijtel, Robert Rissmann, Jesse J. Swen, Martijn L. Manson
Summary: This systematic review aimed to evaluate the risk of disease-drug-drug interactions (DDDIs) caused by immunomodulating drugs and summarize the relevant information in FDA/EMA approved drug labeling. The results showed that the DDDI risk of immunomodulating drugs is specific to target and disease.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2022)
Editorial Material
Dermatology
Deepak M. W. Balak, Robert Rissmann
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Letter
Dermatology
Bertine W. Huisman, Lauren E. H. Nene, Feeke L. L. Linders, Tom K. Gambrah, Tessa Niemeyer van Der Kolk, Marieke L. de Kam, Jan Nico Bouwes Bavinck, Jacobus Burggraaf, Gary Feiss, Robert Rissmann
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)