Review
Biochemistry & Molecular Biology
Sana Hibino, Tetsuro Kawazoe, Hidenori Kasahara, Shinji Itoh, Takatsugu Ishimoto, Mamiko Sakata-Yanagimoto, Koji Taniguchi
Summary: Inflammation plays a pivotal role in tumorigenesis and metastasis by suppressing anti-tumor immunity. Different types of tumors may have diverse responses to inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Nao Nagai, Yotaro Kudo, Daisuke Aki, Hayato Nakagawa, Koji Taniguchi
Summary: This article mainly discusses the effects of chronic inflammation on tumorigenesis and metastasis, as well as how it induces immune-suppressive tumor microenvironment. It also mentions the impact of chronic inflammation on age-related diseases, especially in the liver and colon.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Zhi Huan Chew, Jianzhou Cui, Karishma Sachaphibulkij, Isabelle Tan, Shreya Kar, Kai Kiat Koh, Kritika Singh, Hong Meng Lim, Soo Chin Lee, Alan Prem Kumar, Stephan Gasser, Lina H. K. Lim
Summary: Intracellular recognition of tumor-derived nucleic acids can activate macrophages, leading to inflammasome activation in the tumor microenvironment, which initiates pro-inflammatory and anti-tumorigenic responses.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Wencheng Zhu, Huiying Chu, Yajuan Zhang, Tianhang Luo, Hua Yu, Hongwen Zhu, Ye Liu, Hong Gao, Yun Zhao, Quanlin Li, Xiongjun Wang, Guohui Li, Weiwei Yang
Summary: Emerging evidence suggests that certain metabolic enzymes have the ability to phosphorylate protein substrates in addition to soluble metabolites, playing a role as protein kinases to regulate crucial cellular processes such as cell cycle and apoptosis. This study identifies the metabolic enzyme fructose 1,6-biphosphatase 1 (FBP1) as a protein phosphatase that dephosphorylates the serine (S) 32/36 of I kappa B alpha, inhibiting NF-kappa B activation. The findings also highlight the important role of FBP1-mediated I kappa B alpha dephosphorylation in suppressing colorectal tumorigenesis.
Article
Oncology
Melissa Prat, Kimberley Coulson, Clement Blot, Godefroy Jacquemin, Mathilde Romano, Marie-Laure Renoud, Mohamad AlaEddine, Augustin Le Naour, Helene Authier, Mouna Chirine Rahabi, Khaddouj Benmoussa, Marie Salon, Melissa Parny, Jean-Pierre Delord, Gwenael Ferron, Lise Lefevre, Bettina Couderc, Agnes Coste
Summary: In this study, it was found that activation of PPARγ in treated small peritoneal macrophages can inhibit ovarian adenocarcinoma growth, regulate the proportion of immune cells, and attenuate the immunosuppressive properties of tumor-associated macrophages.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Immunology
Xinyan Xue, Jing Wang, Ke Fu, Shu Dai, Rui Wu, Cheng Peng, Yunxia Li
Summary: The liver is susceptible to external stimuli and its dysfunction leads to liver diseases with increasing morbidity and mortality worldwide. miR-155, a small noncoding RNA molecule, regulates inflammation, immunity, and tumorigenesis in liver diseases and liver cancer. Through a systematic review of 64 articles, miR-155 is shown to be significantly involved in alcoholic liver injury, viral hepatitis, autoimmune hepatitis, infectious liver injury, liver transplantation, and liver cancer. It regulates macrophage polarization, NK cell killing, and Th17 cell differentiation, and participates in the development of liver cancer through cell cycle regulation, invasion, metastasis, and immune escape. miR-155 serves as a biomarker for diagnosis and prognosis, and also has therapeutic potential in liver diseases by modulating immunity, inflammation, and tumorigenesis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Oncology
Michael Chiorazzi, Jan Martinek, Bradley Krasnick, Yunjiang Zheng, Keenan J. Robbins, Rihao Qu, Gabriel Kaufmann, Zachary Skidmore, Melani Juric, Laura A. Henze, Frederic Brosecke, Adam Adonyi, Jun Zhao, Liang Shan, Esen Sefik, Jacqueline Mudd, Ye Bi, S. Peter Goedegebuure, Malachi Griffith, Obi Griffith, Abimbola Oyedeji, Sofia Fertuzinhos, Rolando Garcia-Milian, Daniel Boffa, Frank Detterbeck, Andrew Dhanasopon, Justin Blasberg, Benjamin Judson, Scott Gettinger, Katerina Politi, Yuval Kluger, Karolina Palucka, Ryan C. Fields, Richard A. Flavell
Summary: Researchers developed an autologous system using patient-derived bone marrow cells to establish a genetically matched tumor microenvironment model in mice, which can be used for studying tumor-immune interactions and preclinical drug testing.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Review
Cell Biology
Apeksha Bharatgiri Goswami, Dimitrije Karadarevic, Natalia Castano-Rodriguez
Summary: IRGM plays a crucial role in regulating autophagy and inflammation, impacting inflammatory diseases and cancer development. Its polymorphisms are functionally relevant to autophagic and inflammatory responses.
INFLAMMATION RESEARCH
(2022)
Article
Oncology
Monisankar Ghosh, Suchandrima Saha, Julie Bettke, Rachana Nagar, Alejandro Parrales, Tomoo Iwakuma, Adrianus W. M. van der Velden, Luis A. Martinez
Summary: Mtp53 suppresses innate immune response by interfering with cytoplasmic DNA sensing mechanism, leading to altered cytokine production and immune evasion. Restoring TBK1 signaling bypasses mtp53 and restores immune cell function, potentially eliminating mtp53 tumors.
Article
Oncology
Janani Panneerselvam, Venkateshwar Madka, Rajani Rai, Katherine T. Morris, Courtney W. Houchen, Parthasarathy Chandrakesan, Chinthalapally V. Rao
Summary: The Western-style diet high in fat is a major cause of obesity and increased risk of colon cancer, with inflammatory molecules playing a key role in the connection between obesity and colon tumorigenesis. IL-23 is significant in the impact of a Western-style diet on obesity, gut microbiome, and colon tumorigenesis, suggesting it as a potential target for prevention and treatment. Pro-inflammatory eicosanoids and gut bacterial toxins facilitate IL-23 production, which is crucial in the progression of obesity-associated colon tumors.
Review
Toxicology
Hardeep Singh Tuli, Jagjit Kaur, Kanupriya Vashishth, Katrin Sak, Ujjawal Sharma, Renuka Choudhary, Tapan Behl, Tejveer Singh, Sheetu Sharma, Adesh K. Saini, Kuldeep Dhama, Mehmet Varol, Gautam Sethi
Summary: ROS plays important roles in living organisms, with moderate levels affecting disease development and excessive levels leading to cell death. Current research is focused on using chemotherapy drugs and herbal agents to induce cancer cell death, while maintaining ROS homeostasis is crucial for cell development and survival.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Oncology
Yunsha Zhang, Weiling Pu, Melanie Bousquenaud, Sarah Cattin, Jelena Zaric, Li-kang Sun, Curzio Ruegg
Summary: Emodin has shown to suppress colorectal cancer development and progression by reducing inflammation and key factors in tumor growth, presenting a potential for prevention of colorectal cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Hariprasad Thangavel, Kezia Lizardo, Dhanya Dhanyalayam, Sonia De Assis, Jyothi F. Nagajyothi
Summary: Breast cancer is one of the most diagnosed cancer types, and the association between obesity and breast cancer risk varies by age. A short-term high-fat diet delays tumorigenesis, while a regular diet may increase tumor occurrence and metastasis in young mice. It suggests that the pathogenesis of breast cancer is regulated by diet composition, adipogenesis, and loss of body fat, which differs between young and post-menopausal subjects.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Lujun Chen, Hao Huang, Xiao Zheng, Yuan Li, Junjun Chen, Bo Tan, Yingting Liu, Runzi Sun, Bin Xu, Min Yang, Bin Li, Changping Wu, Binfeng Lu, Jingting Jiang
Summary: This study reveals the critical role of IL1 signaling in inhibiting Treg-mediated tumor immune suppression by modulating the interaction between Tregs and CAFs. These findings provide a theoretical basis for developing new anti-tumor immunotherapy strategies.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Environmental Sciences
Tianyu Guan, Yi Zhang, Qianqian Zhu, Long Wang, Jianbin Feng, Hui Wang, Jiale Li
Summary: In this study, the effects of metamifop on the defense system in Monopterus albus were evaluated. The results showed that metamifop induced oxidative damage and inhibited or damaged the antioxidant, immune, and apoptotic systems in M. albus.