期刊
FRONTIERS IN IMMUNOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2018.00716
关键词
Dr. William E. Paul; T helper type 2 cell differentiation; interleukin-4; interleukin-18; natural killer T cell
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology (MEXT) in Japan
- Japan Society for the Promotion of Science (JSPS)
Interleukin (IL)-4 plays a central role in determining the phenotype of naive CD4+T cells by promoting their differentiation into IL-4-producing T helper type 2 (Th2) cells, which are crucial for the induction of allergic inflammation. However, to date, the potential sources of primary IL-4 in vivo, as distinguished from IL-4 produced by Th2 cells, remain unclear. Here, I describe the research I carried out in collaboration with Dr. William E. Paul to identify primary IL-4-producing cells and Th2 cell differentiation in vivo.
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