Review
Immunology
Kevin Schneider, Sanja Arandjelovic
Summary: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects about 1% of the human population. It is characterized by joint swelling and bone erosion, causing disability and even death. Immune dysregulation, including circulating autoantibodies and inflammatory mediators, plays an important role in the development of RA. Studies have shown that inducing cell death through apoptosis can reduce the severity of the disease. Apoptotic cells are cleared by phagocytes through a process called efferocytosis, which has anti-inflammatory properties. Dysfunctions in efferocytosis have been linked to autoimmune diseases, while administration of apoptotic cells in RA models effectively inhibits inflammation. However, the signaling pathways and clearance mediators involved in RA are still not well understood.
IMMUNOLOGICAL REVIEWS
(2023)
Article
Cell Biology
Ana Carolina de Figueiredo Costa, Luane Macedo de Sousa, Joana Maria dos Santos Alves, Paula Goes, Karuza Maria Alves Pereira, Ana Paula Negreiros Nunes Alves, Mariana Lima Vale, Delane Viana Gondim
Summary: The study found that QT and/or MX therapy could alleviate inflammatory symptoms in a rat model of arthritis, and the hepatotoxicity induced by MX could be improved through combination therapy with QT. However, MX had a downregulation effect on IL-10. QT has the potential to support MX therapy and exhibit anti-inflammatory and hepatoprotective effects in this model.
Article
Dermatology
Tamas Nemeth, Lili Balogh, Eszter Kaposztas, Kata P. Szilveszter, Attila Mocsai
Summary: Autoantibodies against C7 trigger skin disease in epidermolysis bullosa acquisita. Syk tyrosine kinase plays a crucial role in the disease process, especially in neutrophils. Inhibitors of Syk effectively block the immune response and reduce the dermal-epidermal separation caused by anti-C7 antibodies. Syk inhibition may be a potential therapeutic strategy for epidermolysis bullosa acquisita.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ammara Saleem, Huma Khalid, Muhammad Furqan Akhtar, Alam Zeb
Summary: This study evaluated the antioxidant, anti-inflammatory, and anti-arthritic activities of Coronopus didymus. The extracts showed significant free radical scavenging activity and inhibited protein denaturation, as well as reducing inflammation and edema in arthritic rats. The extracts also had positive effects on blood parameters and oxidative stress biomarkers. These activities may be attributed to the presence of quercetin, ferulic acid, dihydromyricetin, apigenin, vitexin, and kaempferol in the extracts.
Article
Chemistry, Multidisciplinary
Feng Gao, Ziqi Dai, Tong Zhang, Yuhao Gu, Desheng Cai, Mingjun Lu, Zijie Zhang, Qi Zeng, Bingxian Shang, Bing Xu, Haimin Lei
Summary: In this study, a series of novel sinomenine derivatives were designed and synthesized. Compound 17 exhibited excellent anti-inflammatory and analgesic activities, indicating its potential as a drug.
Article
Biochemistry & Molecular Biology
Scott Scarneo, Philip Hughes, Robert Freeze, Kelly Yang, Juliane Totzke, Timothy Haystead
Summary: Selective targeting of TNF has provided therapeutic benefit in inflammatory diseases like rheumatoid arthritis, but the development of antidrug antibodies limits long-term efficacy, necessitating the development of alternative treatments. Targeting the protein kinase TAKI has shown promise in providing an effective alternative to frontline biologic-based RA therapeutics.
ACS CHEMICAL BIOLOGY
(2022)
Article
Plant Sciences
Yury Maritza Zapata Lopera, Enrique Jimenez-Ferrer, Maribel Herrera-Ruiz, Alejandro Zamilpa, Manases Gonzalez-Cortazar, Gabriela Rosas-Salgado, Mayra Alejandra Santillan-Urquiza, Gabriela Trejo-Tapia, Antonio Ruperto Jimenez-Aparicio
Summary: The extract, fractions, and compounds of Bouvardia ternifolia root were evaluated for their antiarthritic activity. Two new compounds with anti-inflammatory activity and NF-kappa B inhibitory activity were isolated and identified. Changes in joint cytokine levels indicated that B. ternifolia modulated the inflammatory response at the joint and kidney levels.
Article
Pharmacology & Pharmacy
Pusheng Hui, Sicong Zhou, Chunhao Cao, Wenting Zhao, Li Zeng, Xiaofeng Rong
Summary: Using network pharmacology, key targets of emodin against rheumatoid arthritis (RA) were identified, including HMGB1, STAT1, EGR1, NR3C1, EGFR, MAPK14, CASP3, CASP1, IL4, IL13, IKBKB, and FN1. Single-cell RNA sequencing analysis showed that these core target proteins mainly modulate monocytes. Emodin's anti-RA effect was confirmed in MH7A cells, showing inhibition of cell differentiation and reduction of IL-6 and IL-1 levels. Sequencing of synovial fibroblasts from emodin-treated rats further supported the anti-inflammatory effect of emodin.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Rheumatology
Mark C. Genovese, Alberto Spindler, Akira Sagawa, Won Park, Anna Dudek, Alan Kivitz, Jeannie Chao, Lai Shan Melanie Chan, Jennifer Witcher, William Barchuk, Ajay Nirula
Summary: This study evaluated the efficacy and safety of poseltinib in treating RA patients, but was terminated after interim data showed low likelihood of benefit.
JOURNAL OF RHEUMATOLOGY
(2021)
Article
Medicine, Research & Experimental
L. Sakhno, E. Ya Shevela, M. A. Tikhonova, A. A. Maksimova, T. Tyrinova, A. A. Ostanin, E. R. Chernykh
Summary: The study found that the expression of arginase-1 (Arg1) and tyrosine kinase Mer (MerTK) was highest in M2 macrophage populations generated under conditions of growth/serum factor deficiency. Additionally, contact with apoptotic neutrophils significantly increased the percentages of macrophages co-expressing Arg1 and MerTK.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Pharmacology & Pharmacy
Kaja Kasarello, Iwona Koehling, Anna Kosowska, Katarzyna Pucia, Anna Lukasik, Agnieszka Cudnoch-Jedrzejewska, Leszek Paczek, Urszula Zielenkiewicz, Piotr Zielenkiewicz
Summary: Cross-kingdom gene expression regulation by xenomiRs, particularly from plants, has been found to have potential scientific significance. In this study, miR172a derived from Brassica oleracea was shown to decrease the levels of FAN protein in human and mouse cells. Furthermore, treatment with miR172a was found to mitigate inflammation in a mouse model of rheumatoid arthritis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Xuesong Liu, Ruru Guo, Shicheng Huo, Huan Chen, Qingxiang Song, Gan Jiang, Ye Yu, Jialin Huang, Shaowei Xie, Xiaoling Gao, Liangjing Lu
Summary: This study evaluated the potential of HIF-1 alpha siRNA-loaded CaP-rHDL nanoparticles in the treatment of RA. The nanoparticles showed significant anti-inflammatory effects and reduced joint damage and osteoclastogenesis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Pharmacology & Pharmacy
Rudaba Saleem, Mujeeb-ur Rehman, Saadat Hussain, Aqsa Arif, Hira Noor Malik, Farwa Naqvi, Almas Jabeen
Summary: In this study, lipidic prodrugs of celecoxib were successfully synthesized and formulated into nanoparticles. These nanoparticles exhibited small size, stability, high encapsulation efficiency, and maintained the anti-inflammatory activity both in vitro and in vivo. Therefore, these nanoscale prodrugs have significant potential for inflammation therapy.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Minseon Kim, Yongae Kim
Summary: Cytokine imbalance leads to inflammation, which is difficult to treat without side effects. Therefore, we aimed to develop a peptide drug with minimal side effects. Previous research identified three peptides with anti-inflammatory activity based on a truncated IK (tIK) protein. This study optimized the process of expressing, isolating, and purifying the peptides using bacterial strains and analyzed their secondary structure using circular dichroism and nuclear magnetic resonance spectroscopy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
J. Willem M. Nissink, Sana Bazzaz, Carolyn Blackett, Matthew A. Clark, Olga Collingwood, Jeremy S. Disch, Diana Gikunju, Kristin Goldberg, John P. Guilinger, Elizabeth Hardaker, Edward J. Hennessy, Rachael Jetson, Anthony D. Keefe, William McCoull, Lindsay McMurray, Allison Olszewski, Ross Overman, Alexander Pflug, Marian Preston, Philip B. Rawlins, Emma Rivers, Marianne Schimpl, Paul Smith, Caroline Truman, Elizabeth Underwood, Juli Warwicker, Jon Winter-Holt, Simon Woodcock, Ying Zhang
Summary: This study conducted an extensive screening for Mer inhibitors through data mining, high-throughput (HT), and DNA-encoded chemical library (DECL) screens, resulting in the identification of many potent, selective, and novel starting points for inhibitor development.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Nutrition & Dietetics
Marina C. Oliveira, Julia Vullings, Fons A. J. van de Loo
Article
Endocrinology & Metabolism
G. Ascone, I. Di Ceglie, B. Walgreen, A. W. Sloetjes, E. Lindhout, I. Bot, F. A. J. van de Loo, M. I. Koenders, P. M. van der Kraan, A. B. Blom, M. H. J. van den Bosch, P. L. E. M. van Lent
Article
Cell & Tissue Engineering
Juan Fafian-Labora, Miriam Morente-Lopez, Maria Jose Sanchez-Dopico, Onno J. Arntz, Fons A. J. van de Loo, Javier De Toro, Maria C. Arufe
STEM CELL RESEARCH & THERAPY
(2020)
Article
Multidisciplinary Sciences
Onno J. Arntz, Bartijn C. H. Pieters, Peter L. E. M. van Lent, Marije I. Koenders, Peter M. van der Kraan, Fons A. J. van de Loo
Article
Biotechnology & Applied Microbiology
Marina C. Oliveira, Bartijn C. H. Pieters, Polianna B. Guimaraes, Leticia F. Duffles, Joyce E. Heredia, Ana L. M. Silveira, Amanda C. C. Oliveira, Mauro M. Teixeira, Adaliene V. M. Ferreira, Tarcilia A. Silva, Fons A. J. van de Loo, Soraia Macari
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2020)
Article
Multidisciplinary Sciences
Van Thai Ha, Dusko Lainscek, Bernd Gesslbauer, Eva Jarc-Jovicic, Tuulia Hyotylainen, Nejc Ilc, Katja Lakota, Matija Tomsic, Fons A. J. van de Loo, Valery Bochkov, Toni Petan, Roman Jerala, Mateja Mancek-Keber
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Immunology
Julia Vullings, Juliana P. Vago, Claire E. J. Waterborg, Rogier M. Thurlings, Marije I. Koenders, Peter L. E. M. van Lent, Peter M. van der Kraan, Flavio A. Amaral, Fons A. J. van de Loo
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Article
Rheumatology
Arjen B. Blom, Martijn H. van den Bosch, Esmeralda N. Blaney Davidson, Johannes Roth, Thomas Vogl, Fons A. van de Loo, Marije Koenders, Peter M. van der Kraan, Edwin J. Geven, Peter L. van Lent
ARTHRITIS RESEARCH & THERAPY
(2020)
Proceedings Paper
Optics
Kalloor Joseph Francis, Marvin Xavierselvan, Mithun Kuniyil Ajith Singh, Srivalleesha Mallidi, Conny van der Laken, Fons van de Loo, Wiendelt Steenbergen
PHOTONS PLUS ULTRASOUND: IMAGING AND SENSING 2020
(2020)
Meeting Abstract
Rheumatology
J. Aarts, A. Van Caam, M. Helsen, B. Walgreen, E. Vitters, F. Van de Loo, P. Van Lent, P. Van der Kraan, M. Koenders
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Meeting Abstract
Orthopedics
R. Wiegertjes, A. van Caam, P. van der Kraan, F. van de Loo, E. Blaney Davidson
OSTEOARTHRITIS AND CARTILAGE
(2020)
Meeting Abstract
Orthopedics
N. Kruisbergen, Y. van Gemert, A. Blom, F. van de Loo, P. van der Kraan, M. van den Bosch, P. van Lent
OSTEOARTHRITIS AND CARTILAGE
(2020)
Meeting Abstract
Orthopedics
I. Di Ceglie, M. Broeren, C. Waterborg, D. Dorst, R. Thurlings, P. Laverman, F. van de Loo, P. van der Kraan, M. Koenders, P. van Lent
OSTEOARTHRITIS AND CARTILAGE
(2020)