Pathogenetic and Clinical Aspects of Anti-Neutrophil Cytoplasmic Autoantibody-Associated Vasculitides

Identification and phenotyping of circulating autoreactive proteinase 3-specific B cells in patients with PR3-ANCA associated vasculitis and healthy controls

(2017) Divi Cornec et al.   JOURNAL OF AUTOIMMUNITY

Environmental factor and inflammation-driven alteration of the total peripheral T-cell compartment in granulomatosis with polyangiitis

(2017) Anja Kerstein et al.   JOURNAL OF AUTOIMMUNITY

Transgenic Mice Expressing Human Proteinase 3 Exhibit Sustained Neutrophil-Associated Peritonitis

(2017) Katherine R. Martin et al.   JOURNAL OF IMMUNOLOGY

Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis

(2017) David R.W. Jayne et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Novel insights into the expression pattern of anaphylatoxin receptors in mice and men

(2017) Yves Laumonnier et al.   MOLECULAR IMMUNOLOGY

Dominant protection from HLA-linked autoimmunity by antigen-specific regulatory T cells

(2017) Joshua D. Ooi et al.   NATURE

Complement in ANCA-associated vasculitis: mechanisms and implications for management

(2017) Min Chen et al.   Nature Reviews Nephrology

Position paper: Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis

(2017) Xavier Bossuyt et al.   Nature Reviews Rheumatology

Complement activation in pauci-immune necrotizing and crescentic glomerulonephritis: results of a proteomic analysis

(2017) Sanjeev Sethi et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis

(2017) Adrian Schreiber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global ethnic and geographic differences in the clinical presentations of anti-neutrophil cytoplasm antibody–associated vasculitis

(2017) Fiona A Pearce et al.   RHEUMATOLOGY

Towards precision medicine in ANCA-associated vasculitis

(2017) Kornelis S M van der Geest et al.   RHEUMATOLOGY

S1-Leitlinie Diagnostik und Therapie der ANCA-assoziierten Vaskulitiden

(2017) Jan Henrik Schirmer et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

Patients with ANCA-associated vasculitis admitted to the intensive care unit with acute vasculitis manifestations: a retrospective and comparative multicentric study

(2017) Julien Demiselle et al.   Annals of Intensive Care

Identification of Functional and Expression Polymorphisms Associated With Risk for Antineutrophil Cytoplasmic Autoantibody-Associated Vasculitis

(2017) Peter A. Merkel et al.   Arthritis & Rheumatology

Effect of Continuous B Cell Depletion With Rituximab on Pathogenic Autoantibodies and Total IgG Levels in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis

(2017) Frank B. Cortazar et al.   Arthritis & Rheumatology

Galactosylation and Sialylation Levels of IgG Predict Relapse in Patients With PR3-ANCA Associated Vasculitis

(2017) Michael J. Kemna et al.   EBioMedicine

Genetic loci of Staphylococcus aureus associated with anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides

(2017) Corinna Glasner et al.   Scientific Reports

EULAR/ERA-EDTA recommendations for the management of ANCA-associated vasculitis

(2016) M Yates et al.   ANNALS OF THE RHEUMATIC DISEASES

Detection of antineutrophil cytoplasmic antibodies (ANCAs): a multicentre European Vasculitis Study Group (EUVAS) evaluation of the value of indirect immunofluorescence (IIF) versus antigen-specific immunoassays

(2016) Jan Damoiseaux et al.   ANNALS OF THE RHEUMATIC DISEASES

Combined Allergic Bronchopulmonary Aspergillosis and Eosinophilic Granulomatosis with Polyangiitis: Three Cases and a Review of the Literature

(2016) Takashi Ishiguro et al.   INTERNAL MEDICINE

Persistent deficiency of circulating mucosal-associated invariant T (MAIT) cells in ANCA-associated vasculitis

(2016) Cécile Braudeau et al.   JOURNAL OF AUTOIMMUNITY

Lessons from a double-transgenic neutrophil approach to induce antiproteinase 3 antibody-mediated vasculitis in mice

(2016) Adrian Schreiber et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Experimentally-induced anti-myeloperoxidase vasculitis does not require properdin, MASP-2 or bone marrow-derived C5

(2016) Simon J Freeley et al.   JOURNAL OF PATHOLOGY

ANCA-associated vasculitis — clinical utility of using ANCA specificity to classify patients

(2016) Divi Cornec et al.   Nature Reviews Rheumatology

The incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK Clinical Practice Research Datalink

(2016) Fiona A. Pearce et al.   RHEUMATOLOGY

Therapiedeeskalation bei ANCA-assoziierten Vaskulitiden

(2016) S. Schinke et al.   ZEITSCHRIFT FUR RHEUMATOLOGIE

HLA-DPB1 as a Risk Factor for Relapse in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Cohort Study

(2016) Marc Hilhorst et al.   Arthritis & Rheumatology

Neutrophil Extracellular Traps in ANCA-Associated Vasculitis

(2016) Daniel Söderberg et al.   Frontiers in Immunology

ANCA-Associated Glomerulonephritis: Risk Factors for Renal Relapse

(2016) Arda Göçeroğlu et al.   PLoS One

Clinical outcomes of treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis based on ANCA type

(2015) Sebastian Unizony et al.   ANNALS OF THE RHEUMATIC DISEASES

Mechanisms of human autoimmunity

(2015) Michael D. Rosenblum et al.   JOURNAL OF CLINICAL INVESTIGATION

Proteinase 3 on apoptotic cells disrupts immune silencing in autoimmune vasculitis

(2015) Arnaud Millet et al.   JOURNAL OF CLINICAL INVESTIGATION

Skewed Fc Glycosylation Profiles of Anti-proteinase 3 Immunoglobulin G1 Autoantibodies from Granulomatosis with Polyangiitis Patients Show Low Levels of Bisection, Galactosylation, and Sialylation

(2015) Manfred Wuhrer et al.   JOURNAL OF PROTEOME RESEARCH

Circulating ADAM17 Level Reflects Disease Activity in Proteinase-3 ANCA-Associated Vasculitis

(2015) A. Bertram et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Complement in ANCA-associated glomerulonephritis

(2015) Marc Hilhorst et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Clinical presentation and long-term outcome of 144 patients with microscopic polyangiitis in a monocentric German cohort

(2015) Jan H. Schirmer et al.   RHEUMATOLOGY

Manifestation of eosinophilic granulomatosis with polyangiitis in head and neck

(2015) H. Petersen et al.   RHINOLOGY

Brief Report: Defining the Nasal Transcriptome in Granulomatosis With Polyangiitis (Wegener's)

(2015) Peter C. Grayson et al.   Arthritis & Rheumatology

SAT0019 Disease-associated micro-RNA profiles in granulomatosis with polyangiitis nasal tissue indicate a regulatory network targeting pathophysiological processes

(2014) S. Schinke et al.   ANNALS OF THE RHEUMATIC DISEASES

The molecular and functional characterization of clonally expanded CD8+ TCR BV T cells in eosinophilic granulomatosis with polyangiitis (EGPA)

(2014) Monica Boita et al.   CLINICAL IMMUNOLOGY

Pathogenesis of antineutrophil cytoplasmic autoantibody-mediated disease

(2014) J. Charles Jennette et al.   Nature Reviews Rheumatology

Key advances in the clinical approach to ANCA-associated vasculitis

(2014) Cees G. M. Kallenberg   Nature Reviews Rheumatology

Altered B cell balance, but unaffected B cell capacity to limit monocyte activation in anti-neutrophil cytoplasmic antibody-associated vasculitis in remission

(2014) N. Lepse et al.   RHEUMATOLOGY

Doubled prevalence rates of ANCA-associated vasculitides and giant cell arteritis between 1994 and 2006 in northern Germany

(2014) K. Herlyn et al.   RHEUMATOLOGY

Regulatory B cells are numerically but not functionally deficient in anti-neutrophil cytoplasm antibody-associated vasculitis

(2014) S. K. Todd et al.   RHEUMATOLOGY

Plasma cells in immunopathology: concepts and therapeutic strategies

(2014) Benjamin Tiburzy et al.   Seminars in Immunopathology

Plasma cells within granulomatous inflammation display signs pointing to autoreactivity and destruction in granulomatosis with polyangiitis

(2014) Antje Mueller et al.   ARTHRITIS RESEARCH & THERAPY

TheSEM6A6Locus Is Not Associated With Granulomatosis With Polyangiitis or Other Forms of Antineutrophil Cytoplasmic Antibody-Associated Vasculitides in Europeans: Comment on the Article by Xie et al

(2014) Stefan Wieczorek et al.   Arthritis & Rheumatology

Eosinophilic Granulomatosis with Polyangiitis: An Overview

(2014) Andrea Gioffredi et al.   Frontiers in Immunology

Genetics of toll like receptor 9 in ANCA associated vasculitides

(2013) C A Husmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulatory B cells in ANCA-associated vasculitis

(2013) B Wilde et al.   ANNALS OF THE RHEUMATIC DISEASES

Patients With Antineutrophil Cytoplasmic Antibody-Associated Vasculitis Have Defective Treg Cell Function Exacerbated by the Presence of a Suppression-Resistant Effector Cell Population

(2013) Meghan E. Free et al.   ARTHRITIS AND RHEUMATISM

A myelopoiesis gene signature during remission in anti-neutrophil cytoplasm antibody-associated vasculitis does not predict relapses but seems to reflect ongoing prednisolone therapy

(2013) T. Kurz et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Vδ2 T cell deficiency in granulomatosis with polyangiitis (Wegener's granulomatosis)

(2013) Juliane Fazio et al.   CLINICAL IMMUNOLOGY

The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies

(2013) Mattias Collin et al.   EXPERIMENTAL DERMATOLOGY

Epitope specificity determines pathogenicity and detectability in ANCA-associated vasculitis

(2013) Aleeza J. Roth et al.   JOURNAL OF CLINICAL INVESTIGATION

Estimating Renal Survival Using the ANCA-Associated GN Classification

(2013) M. Hilhorst et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

C5a Receptor (CD88) Blockade Protects against MPO-ANCA GN

(2013) H. Xiao et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Efficacy of Remission-Induction Regimens for ANCA-Associated Vasculitis

(2013) Ulrich Specks et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Pro-Inflammatory Role of C5L2 in C5a-Primed Neutrophils for ANCA-Induced Activation

(2013) Jian Hao et al.   PLoS One

Increased frequency of circulating IL-21 producing Th-cells in patients with granulomatosis with polyangiitis (GPA)

(2013) Wayel H Abdulahad et al.   ARTHRITIS RESEARCH & THERAPY

Cartilage Destruction in Granulomatosis with Polyangiitis (Wegener's Granulomatosis) Is Mediated by Human Fibroblasts after Transplantation into Immunodeficient Mice

(2012) Nina Kesel et al.   AMERICAN JOURNAL OF PATHOLOGY

2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides

(2012) J. C. Jennette et al.   ARTHRITIS AND RHEUMATISM

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss): Clinical characteristics and long-term followup of the 383 patients enrolled in the French Vasculitis Study Group cohort

(2012) Cloé Comarmond et al.   ARTHRITIS AND RHEUMATISM

How anti-neutrophil cytoplasmic autoantibodies activate neutrophils

(2012) R. Kettritz   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Proteinase 3, the Autoantigen in Granulomatosis with Polyangiitis, Associates with Calreticulin on Apoptotic Neutrophils, Impairs Macrophage Phagocytosis, and Promotes Inflammation

(2012) J. Gabillet et al.   JOURNAL OF IMMUNOLOGY

Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody–associated vasculitis

(2012) Shen-Ju Gou et al.   KIDNEY INTERNATIONAL

Genetically Distinct Subsets within ANCA-Associated Vasculitis

(2012) Paul A. Lyons et al.   NEW ENGLAND JOURNAL OF MEDICINE

Anti-Proteinase 3 Anti-Neutrophil Cytoplasm Autoantibodies Recapitulate Systemic Vasculitis in Mice with a Humanized Immune System

(2012) Mark A. Little et al.   PLoS One

Decreased Neutrophil Apoptosis in Quiescent ANCA-Associated Systemic Vasculitis

(2012) Mohamed Abdgawad et al.   PLoS One

High Basal Activity of the PTPN22 Gain-of-Function Variant Blunts Leukocyte Responsiveness Negatively Affecting IL-10 Production in ANCA Vasculitis

(2012) Yali Cao et al.   PLoS One

The contrasting epidemiology of granulomatosis with polyangiitis (Wegener's) and microscopic polyangiitis

(2012) R. A. Watts et al.   RHEUMATOLOGY

Aberrant cytokine pattern of the nasal mucosa in granulomatosis with polyangiitis

(2012) Janet Wohlers et al.   ARTHRITIS RESEARCH & THERAPY

C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis

(2012) Jun Yuan et al.   ARTHRITIS RESEARCH & THERAPY

Th17 expansion in granulomatosis with polyangiitis (Wegener's): the role of disease activity, immune regulation and therapy

(2012) Benjamin Wilde et al.   ARTHRITIS RESEARCH & THERAPY

Sialylation levels of anti-proteinase 3 antibodies are associated with the activity of granulomatosis with polyangiitis (Wegener's)

(2011) Cécile Espy et al.   ARTHRITIS AND RHEUMATISM

CD4+CD28− T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality

(2011) Matthew D. Morgan et al.   ARTHRITIS AND RHEUMATISM

Pathogenesis of antineutrophil cytoplasmic autoantibody vasculitis

(2011) J Charles Jennette et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Flow cytometric characterization of “early” and “late differentiated” T-cells including PR3-specific cells in granulomatosis with polyangiitis (Wegener's)

(2011) Ursula Fagin et al.   CYTOMETRY PART B-CLINICAL CYTOMETRY

Elevated Soluble Flt1 Inhibits Endothelial Repair in PR3-ANCA-Associated Vasculitis

(2011) S. Le Roux et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular signatures of a disturbed nasal barrier function in the primary tissue of Wegener's granulomatosis

(2011) M Laudien et al.   Mucosal Immunology

Genomics and the Multifactorial Nature of Human Autoimmune Disease

(2011) Judy H. Cho et al.   NEW ENGLAND JOURNAL OF MEDICINE

IgA and IgG antineutrophil cytoplasmic antibody engagement of Fc receptor genetic variants influences granulomatosis with polyangiitis

(2011) J. M. Kelley et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Are there specific genetic risk factors for the different forms of ANCA-associated vasculitis?

(2010) L. Arning et al.   ANNALS OF THE RHEUMATIC DISEASES

Prospective long-term follow-up of patients with localised Wegener's granulomatosis: does it occur as persistent disease stage?

(2010) J. U. Holle et al.   ANNALS OF THE RHEUMATIC DISEASES

Long-term patient survival in ANCA-associated vasculitis

(2010) O. Flossmann et al.   ANNALS OF THE RHEUMATIC DISEASES

Improved outcome in 445 patients with Wegener's granulomatosis in a German vasculitis center over four decades

(2010) Julia U. Holle et al.   ARTHRITIS AND RHEUMATISM

Complement alternative pathway acts as a positive feedback amplification of neutrophil activation

(2010) L. Camous et al.   BLOOD

Molecular characteristics of anti-self antibody fragments against neutrophil cytoplasmic antigens from human V gene phage display libraries

(2010) R. FINNERN et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Wegener’s granuloma harbors B lymphocytes with specificities against a proinflammatory transmembrane protein and a tetraspanin

(2010) Lorenz Thurner et al.   JOURNAL OF AUTOIMMUNITY

IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis

(2010) M. M. van Timmeren et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Histopathologic Classification of ANCA-Associated Glomerulonephritis

(2010) A. E. Berden et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Natural autoantibodies to myeloperoxidase, proteinase 3, and the glomerular basement membrane are present in normal individuals

(2010) Zhao Cui et al.   KIDNEY INTERNATIONAL

The role of defective clearance of apoptotic cells in systemic autoimmunity

(2010) Luis E. Muñoz et al.   Nature Reviews Rheumatology

Urinary CD4+ effector memory T cells reflect renal disease activity in antineutrophil cytoplasmic antibody-associated vasculitis

(2009) Wayel H. Abdulahad et al.   ARTHRITIS AND RHEUMATISM

Cytokine Production Profile of CD4+ T Cells from Patients with Active Churg-Strauss Syndrome Tends Toward Th17

(2009) Hiroshi Saito et al.   INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY

Netting neutrophils in autoimmune small-vessel vasculitis

(2009) Kai Kessenbrock et al.   NATURE MEDICINE

Histopathologie systemischer Vaskulitiden

(2009) K. Holl-Ulrich   PATHOLOGE

Severe impaired respiratory ciliary function in Wegener granulomatosis

(2008) S Ullrich et al.   ANNALS OF THE RHEUMATIC DISEASES

Functionally relevant variations of the interleukin-10 gene associated with antineutrophil cytoplasmic antibody-negative Churg-Strauss syndrome, but not with Wegener's granulomatosis

(2008) S. Wieczorek et al.   ARTHRITIS AND RHEUMATISM

Skewed distribution of Th17 lymphocytes in patients with Wegener's granulomatosis in remission

(2008) Wayel H. Abdulahad et al.   ARTHRITIS AND RHEUMATISM

Differences in regulatory T cells between Churg-Strauss syndrome and chronic eosinophilic pneumonia with asthma

(2008) Naomi Tsurikisawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

C5a Receptor Mediates Neutrophil Activation and ANCA-Induced Glomerulonephritis

(2008) A. Schreiber et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Analysis and classification of B-cell infiltrates in lupus and ANCA-associated nephritis

(2008) Oliver M. Steinmetz et al.   KIDNEY INTERNATIONAL