Review
Biochemistry & Molecular Biology
Maryam Masoumi, Nader Hashemi, Fatemeh Moadab, Mojtaba Didehdar, Rahim Farahani, Hossein Khorramdelazad, Amirhossein Sahebkar, Thomas P. Johnston, Jafar Karami
Summary: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by synovial hyperplasia and joint damage. RA patients face systemic complications and progressive disability, resulting in significant socio-economic costs. Current RA biomarkers have limited success in predicting, diagnosing, and monitoring the disease. Studies suggest that dysregulated immunometabolism could be targeted for RA treatment.
CURRENT MEDICINAL CHEMISTRY
(2023)
Article
Medical Laboratory Technology
Lina Ying, Luping Gong, Sicen Meng, Xiudi Wu, Mingcai Li, Yan Li
Summary: The present study aimed to detect the expression of IL-39 in the sera of patients with RA and investigate its relationship with RA activity. Results showed that serum levels of IL-39 were significantly higher in patients with RA compared with healthy controls, and positively correlated with clinical indicators. Therefore, IL-39 may serve as a biomarker for the diagnosis of RA.
CLINICAL BIOCHEMISTRY
(2023)
Article
Rheumatology
Yu-Hao Xue, Liang-Tian You, Hsin-Fu Ting, Yu-Wen Chen, Zi-Yun Sheng, Yi-Dong Xie, Yu-Hsun Wang, Jeng-Yuan Chiou, James Cheng-Chung Wei
Summary: This retrospective cohort study found that patients with endometriosis have a higher risk of RA, especially in those who are older and have autoimmune diseases. The relationship between endometriosis and RA needs to be considered in the clinical management of patients with RA.
Article
Health Care Sciences & Services
Jing Xu, Jiarui Ou, Chen Li, Zheng Zhu, Jian Li, Hailun Zhang, Junchen Chen, Bin Yi, Wu Zhu, Weiru Zhang, Guanxiong Zhang, Qian Gao, Yehong Kuang, Jiangning Song, Xiang Chen, Hong Liu
Summary: A machine learning model was developed to diagnose Psoriatic arthritis (PsA) and analyze its progression risk using 3961 patients' clinical records. General additive models (GAMs) and the Kaplan-Meier method were applied to analyze the efficacy of various drugs on psoriasis treatment and inhibiting PsA progression. The results showed accurate prediction of PsA and its progression and analysis of drug efficacy.
NPJ DIGITAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Parastou Rahimizadeh, Zahra Rezaieyazdi, Faezeh Behzadi, Abbas Hajizade, Sung In Lim
Summary: Rheumatoid arthritis is a chronic inflammatory autoimmune disease with a prevalence of around 5 per 1000 people, and nanotechnology has emerged as a significant player in efficacious disease management, with applications in joint replacement, photothermal therapy, photodynamic therapy, diagnosis, and treatment monitoring.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Medical Laboratory Technology
Luping Gong, Yinxin Zhou, Shanjun Shi, Lina Ying, Yan Li, Mingcai Li
Summary: IL-41 expression is increased in the serum of RA patients and positively correlated with disease-related parameters. IL-41 may serve as a potential new diagnostic biomarker for RA.
CLINICA CHIMICA ACTA
(2023)
Article
Neurosciences
Jonas Bacelis, Michele Compagno, Sonia George, J. Andrew Pospisilik, Patrik Brundin, Asa Torinsson Naluai, Lena Brundin
Summary: Individuals previously diagnosed with rheumatoid arthritis (RA) had a decreased risk of developing Parkinson's disease (PD) by 30-50%, with the greatest risk reduction in females. These findings should be considered when developing or repurposing therapies aimed at modifying the course of PD.
JOURNAL OF PARKINSONS DISEASE
(2021)
Article
Nanoscience & Nanotechnology
Hanghang Fang, Yongjie Sha, Liang Yang, Jingjing Jiang, Lichen Yin, Jiaying Li, Bin Li, Bert Klumperman, Zhiyuan Zhong, Fenghua Meng
Summary: By nano-formulating hydroxychloroquine and designing it as a macrophage-targeted nanotherapeutic, it is possible to achieve highly effective treatment for rheumatoid arthritis. This therapeutic approach can induce repolarization of macrophages towards an anti-inflammatory phenotype, effectively reducing inflammation, and has shown significant therapeutic effects in mouse models.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Alexander Blagov, Andrey Grechko, Nikita G. Nikiforov, Alexander D. Zhuravlev, Nikolay K. Sadykhov, Alexander N. Orekhov
Summary: This article discusses the connection between metabolism and inflammation in rheumatoid arthritis, exploring the changes in metabolic processes and their immunomodulatory effects, as well as the metabolic features of synovial membrane cells during inflammation and potential targets for the therapy of rheumatoid arthritis.
Review
Clinical Neurology
Michael J. Bradshaw, Siddharama Pawate, Laura L. Koth, Tracey A. Cho, Jeffrey M. Gelfand
Summary: Neurosarcoidosis typically presents as recognizable syndromes that can be diagnosed by considering clinical syndrome, imaging and histopathological findings, and excluding other causes. Recent years have seen significant advancements in understanding and treating neurosarcoidosis, with tumor necrosis factor inhibitors playing an important role in therapy.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Review
Immunology
Sha Wu, Xiao-Feng Li, Yuan-Yuan Wu, Su-Qin Yin, Cheng Huang, Jun Li
Summary: Rheumatoid arthritis is characterized by immune cell infiltration and destruction of cartilage and bone. Studies have shown that m(6)A modification is related to the pathogenesis of RA, providing evidence for the development of new therapies. The relationship between m(6)A enzymes, immune cells, and RA is important for understanding and treating this autoimmune disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Rui-Chen Gao, Ni Sang, Cheng-Zhen Jia, Meng-Yao Zhang, Bo-Han Li, Meng Wei, Guo-Cui Wu
Summary: In this study, the causal association between sleep disorders and rheumatoid arthritis (RA) was investigated using Mendelian randomization analysis. The results showed that short sleep duration was causally linked to an increased risk of RA, while other sleep-related traits were not significantly associated with RA.
FRONTIERS IN PUBLIC HEALTH
(2022)
Review
Environmental Sciences
Jiraporn Chittrakul, Ratana Sapbamrer, Wachiranun Sirikul
Summary: There is some evidence suggesting an association between exposure to pesticides, particularly insecticides, and an increased risk of rheumatoid arthritis (RA). However, the current evidence is limited and further epidemiological studies are needed to confirm this relationship.
Review
Immunology
Desislava (Daisy) Ilchovska, Dr Michelle Barrow
Summary: NF-kB and RANKL play important roles in RA, with potential side effects from long-term non-specific suppression of the NF-kB pathway. Vitamin D supplementation may help to lower RANKL levels, serving as a potential nutrition intervention for RA management.
AUTOIMMUNITY REVIEWS
(2021)
Review
Immunology
Jianan Zhao, Shicheng Guo, Steven J. Schrodi, Dongyi He
Summary: This study explores the link between cuproptosis and the pathological mechanisms of rheumatoid arthritis (RA), as well as its effects on various immune cells. The findings provide a theoretical basis for translating preclinical and experimental results into clinical protocols for RA treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ghulam Md Ashraf, Mohd Rehan, Alhuseen O. Alsayed, Pallavi Somvanshi, Shafiul Haque
Summary: This study examines the possibility of cardiovascular medications inhibiting Galectin-3-related biological activities using bioinformatics techniques. Through clustering, molecular docking, and molecular dynamics simulation, potential chemical compounds were screened and repurposed. The results show that certain compounds have the ability to inhibit Galectin-3. Further experimental validation and animal model-based studies are needed.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Endocrinology & Metabolism
Nobendu Mukerjee, Swastika Maitra, Subhradeep Roy, Shaswata Modak, Mohammad Mehedi Hasan, Biswajit Chakraborty, Arabinda Ghosh, Asmita Ghosh, Mohammad Amjad Kamal, Abhijit Dey, Ghulam Md Ashraf, Sumira Malik, Md Habibur Rahman, Badrah S. Alghamdi, Adel Mohammad Abuzenadah, Athanasios Alexiou
Summary: Glioblastoma is an aggressive tumor that hinders normal brain function, and the inability of the skull to expand results in increased pressure in the brain. Recent studies have found that SNPs play a significant role in the development and spread of glioblastoma, with many GB-related SNPs being highly abundant in the promoter region, creating genetic vulnerability to glioma.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Akhtar Atiya, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Dalia Almaghaslah, Anwar L. Bilgrami, Waleed Al Abdulmonem, Nasser M. Alorfi, Debarati DasGupta, Ghulam Md Ashraf, Anas Shamsi, Moyad Shahwan
Summary: Cardiovascular diseases are a leading cause of premature adult death. This study evaluates the inhibitory potential of lisinopril on MARK4, a protein involved in regulating cardiomyocyte contractility. Molecular docking and molecular dynamics simulations demonstrate the stable binding and therapeutic role of lisinopril in managing cardiovascular diseases.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Correction
Biochemistry & Molecular Biology
Ghulam Md. Ashraf, Debarati DasGupta, Mohammad Zubair Alam, Saleh S. Baeesa, Badrah S. Alghamdi, Firoz Anwar, Thamer M. A. Alqurashi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Mohammed A. Alyousef, Fahad A. Alhumaydhi, Anas Shamsi
Article
Behavioral Sciences
Kholoud M. Al-Otaibi, Badrah S. Alghamdi, Maryam A. Al-Ghamdi, Rasha A. Mansouri, Ghulam Md Ashraf, Ulfat M. Omar
Summary: The combination of vitamin D3 and siponimod can enhance remyelination and modulate microglia phenotypes, leading to improved symptoms and protection of the myelin sheath in multiple sclerosis (MS) patients.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Review
Neurosciences
Mahmoud A. Ebada, Abdalrhman Mostafa, Al-Hussein A. Gadallah, Souad Alkanj, Badrah S. Alghamdi, Ghulam Md Ashraf, Adel M. Abuzenadah, Raed F. Alserihi, Ahmed Wadaa-Allah, Mohamed Salama
Summary: Finding a link between hormones and microRNAs (miRNAs) is valuable for adjusting genetic composition or cellular functions without gene-level interventions. The cleavage of precursor miRNAs by dicer is an interface link between miRNA and its regulators, disruption of which can affect neurogenesis. Hormonal regulation of miRNAs occurs directly through binding to miRNA promoter elements and indirectly through regulation of post-transcriptional processing proteins' signaling effects. Estrogenic hormones play a significant role in regulating miRNAs in the brain, and their relationship with miR-29, miR-9 could be an etiological route for various neurodegenerative disorders.
Review
Medicine, General & Internal
Manisha Singh, Vinayak Agarwal, Divya Jindal, Pranav Pancham, Shriya Agarwal, Shalini Mani, Raj Kumar Tiwari, Koushik Das, Badrah S. Alghamdi, Tukri S. Abujamel, Ghulam Md. Ashraf, Saurabh Kumar Jha
Summary: The widespread use of corticosteroids has led to an increase in corticosteroid-induced neuropsychiatric disorders. These disorders range from depression and insomnia to panic attacks and overt psychosis. This study explores the concerns surrounding these disorders, molecular biology approaches to improve therapy, and potential gene-editing-based therapeutic strategies.
Review
Cell Biology
Ghulam Mehdi Dar, Ejaj Ahmad, Asgar Ali, Bhawna Mahajan, Ghulam Md Ashraf, Sundeep Singh Saluja
Summary: Growing neurological diseases, caused mainly by genetic alterations in genes encoding mitochondrial proteins, present a significant challenge for diagnosis and management. Mitochondrial complex I, composed of 44 subunits encoded by nuclear and mitochondrial genes, is particularly important and frequently mutated, leading to various neurological disorders. This review discusses the genetic origins of neurological diseases related to mitochondrial complex I and highlights recent advances in diagnostic and therapeutic approaches.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Subham Preetam, Swathi Jonnalagadda, Lamha Kumar, Rajeswari Rath, Soham Chattopadhyay, Badrah S. Alghamdi, Adel M. Abuzenadah, Niraj Kumar Jha, Akash Gautam, Sumira Malik, Ghulam Md Ashraf
Summary: Parkinson's disease is the second most common neurodegenerative disorder, and the delivery of therapeutic compounds is hindered by the blood-brain barrier. Lipid nanosystems have been used for the precise delivery of therapeutic compounds in anti-PD therapy. This review discusses the application and clinical significance of lipid nanosystems in delivering therapeutic compounds for anti-PD treatment.
AGEING RESEARCH REVIEWS
(2023)
Review
Neurosciences
Ishfaq Ahmad Ahanger, Ghulam Md. Ashraf, Anurag Sharma, Asimul Islam
Summary: Protein misfolding and aggregation is a generic propensity of proteins that is still not fully understood. It is a major concern in biology and medicine due to its association with various debilitating human proteinopathies and neurodegenerative diseases. The mechanism of protein aggregation, associated diseases, and the development of therapeutic strategies against these diseases present significant challenges.
CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS
(2023)
Review
Neurosciences
Faraz Ahmad, Siva Ramamorthy, Mohammed Y. Areeshi, Ghulam Md. Ashraf, Shafiul Haque
Summary: Mitochondria play important roles in neuronal development, physiology, plasticity, and pathology through their regulation of bioenergetic, calcium, redox, and cell survival/death signaling. However, a comprehensive discussion on the relevance of isolated brain mitochondria in neuroscience research has been lacking. This mini-review explores the commonly used analytical assays for assessing mitochondrial physiology and dysfunction in organello, with a focus on neuroscience research. It also provides protocols for isolating mitochondria, assessing their quality, and preserving them for future use.
CURRENT NEUROPHARMACOLOGY
(2023)
Review
Neurosciences
Md. Mominur Rahman, Mst. Afroza Alam Tumpa, Md. Saidur Rahaman, Fahadul Islam, Popy Rani Sutradhar, Muniruddin Ahmed, Badrah S. S. Alghamdi, Abdul Hafeez, Athanasios Alexiou, Asma Perveen, Ghulam Md. Ashraf
Summary: Mitochondria are crucial for cellular homeostasis and metabolism in eukaryotes, especially in brain functions. Dysfunction of mitochondria is associated with neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, Huntington's disease, and amyotrophic lateral sclerosis. This review focuses on the mitochondrial disturbances in these disorders and discusses the potential use of mitochondrial drugs for their treatment and control, including mitochondrial antioxidants, mitochondrial permeability transition blockade, and mitochondrial gene therapy.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ammara Saleem, Izza Hameed, Muhammad Furqan Akhtar, Ghulam Md Ashraf, Badrah S. Alghamdi, Md. Habibur Rahman, Majed N. Almashjary
Summary: This research validated the folkloric use of Quercus leucotrichophora (QL) leaf extracts against inflammation and arthritis, and determined the chemical composition using HPLC. The study found that QL leaf extracts exhibited significant antioxidant, anti-inflammatory, and anti-arthritic potential, possibly due to the presence of quercetin, gallic acid, sinapic acid, and ferulic acid.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Green & Sustainable Science & Technology
Syed Ali Fazal, Naeem Hayat, Abdullah Al Mamun
Summary: This study investigates the factors influencing the intention and consumption of renewable energy among low-income households in Malaysia. The results suggest that perceived benefits, environmental concerns, motivation, skills, and knowledge all play a role in shaping households' intention and behavior towards renewable energy consumption. The findings provide valuable insights for policymakers in developing nations to prioritize the feasibility of renewable energy projects and design targeted campaigns for low-income households, promoting economic, social, and environmental sustainability.
Review
Environmental Sciences
Rajnish Kumar, Garima Yadav, Mohammed Kuddus, Ghulam Md Ashraf, Rachana Singh
Summary: The metagenomics approach revolutionized the study of genetic information from uncultured microbes and complex microbial communities. In silico research allowed for a better understanding of protein interactions, drug design, and microbial evolution. Artificial intelligence, particularly machine learning and deep learning, has enabled the analysis and utilization of large datasets generated from nucleic acid sequencing and proteomics, leading to breakthroughs in microbiology research.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)