Article
Biochemistry & Molecular Biology
Daniel Desaulniers, Gu Zhou, Andrew Stalker, Cathy Cummings-Lorbetskie
Summary: This study compares the in vitro toxicity of nine data-poor chemicals to structurally related chemicals and positive DNA damage inducers, aiming to prioritize chemicals for future study and mitigate chemical hazards.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Neurosciences
Brandon Signal, Thalia Gabriela Perez Suarez, Phillippa C. Taberlay, Adele Woodhouse
Summary: Different cell types in the brain have distinct roles in the progression of Alzheimer's disease (AD). Epigenetic mechanisms can explain the genetic and environmental factors associated with AD, but analyzing purified cell populations or single cells is necessary. Studies have revealed that different cell types contribute and react differently to AD progression through epigenetic alterations.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Biotechnology & Applied Microbiology
Nasrullah, Abrar Hussain, Sagheer Ahmed, Mahmood Rasool, Abdul Jabbar Shah
Summary: DNA methylation is a process of adding methyl groups to the DNA molecule, which can alter the function of DNA. The importance and role of DNA methylation vary across different organisms, with mammals showing a strong relationship between DNA methylation and diseases such as cancer and placental development.
Review
Health Care Sciences & Services
Piotr Czarny, Katarzyna Bialek, Sylwia Ziolkowska, Justyna Strycharz, Gabriela Barszczewska, Tomasz Sliwinski
Summary: Recent studies suggest a strong association between epigenetics and major depressive disorder, with epigenetic modifications being able to impact disease severity and therapy outcomes. The latest literature summarizes the use of histone deacetylases as therapeutic agents and miRNAs/lncRNAs as markers for depression treatment and diagnosis.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Review
Oncology
Yuhao Zhao, Mao Yang, Shijia Wang, Sk Jahir Abbas, Junzhe Zhang, Yongsheng Li, Rong Shao, Yingbin Liu
Summary: This review focuses on the mechanistic insights of DNA, histone, and RNA methylation in regulating the progression of pancreatic cancer. The roles of methylation regulators in modulating gene expression associated with cell proliferation, invasion, and apoptosis are discussed. Recent clinical trials on methylation drug targeting are also explored. Understanding the novel regulatory mechanisms of methylation modification may offer alternative opportunities to improve therapeutic efficacy in combating this devastating disease.
FRONTIERS IN ONCOLOGY
(2022)
Review
Plant Sciences
Rafaqat A. Gill, Federico Scossa, Graham J. King, Agnieszka Golicz, Chaobo Tong, Rod J. Snowdon, Alisdair R. Fernie, Shengyi Liu
Summary: Recent research has shown that TEs play a crucial role in regulating gene expression through generating siRNAs via different RdDM pathways, especially in complex polyploid genomes.
CRITICAL REVIEWS IN PLANT SCIENCES
(2021)
Review
Plant Sciences
Kajal Samantara, Aalok Shiv, Lorenna Lopes de Sousa, Karansher Singh Sandhu, Parichita Priyadarshini, Sourav Ranjan Mohapatra
Summary: Epigenetics is an important mechanism that can help plants cope with various stressors by altering gene expression without involving changes in DNA sequences. It provides diversity to aid plants in responding to the impacts of climate change.
ENVIRONMENTAL AND EXPERIMENTAL BOTANY
(2021)
Review
Cell & Tissue Engineering
Kai Xia, Li-Yuan Yu, Xin-Qi Huang, Zhi-He Zhao, Jun Liu
Summary: This review summarizes the role of long noncoding RNAs (lncRNAs) in the osteo-/adipogenic differentiation of mesenchymal stromal cells (MSCs) and the pathogenesis of degenerative bone diseases. It highlights the potential of lncRNAs as diagnostic and therapeutic targets for bone diseases.
WORLD JOURNAL OF STEM CELLS
(2022)
Review
Cell Biology
Qiuyun Xue, Yurong Huang, Chenglong Cheng, Yuting Wang, Faxue Liao, Qiangjun Duan, Xiao Wang, Chenggui Miao
Summary: Inadequate milk secretion and a lack of nutrients in humans and mammals are serious problems. Epigenetic modification, represented by RNA methylation, is an important way of gene expression regulation that profoundly affects human gene expression and participates in various physiological and pathological mechanisms. This review systematically summarized the research results of epigenetics in the process of lactation and reviewed the effects of epigenetics on human and mammalian lactation, including miRNAs, circRNAs, lncRNAs, DNA methylations, and RNA methylations.
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xiao-Fei Peng, Shi-Feng Huang, Ling-Juan Chen, Lingqing Xu, Wen-Chu Ye
Summary: The early onset and progression of liver diseases can be driven by aberrant transcriptional regulation, with a strong epigenetic component. Inhibitors of different epigenetic regulators are being explored as potential candidates for preventing and treating liver diseases. Current research provides a perspective for identifying therapeutic targets and new hepatic biomarkers, bringing precision research and disease therapy into the modern era of epigenetics.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Bruna Cristine de Almeida, Laura Gonzalez dos Anjos, Andrey Senos Dobroff, Edmund Chada Baracat, Qiwei Yang, Ayman Al-Hendy, Katia Candido Carvalho
Summary: Epigenetic alterations play a key role in cancer initiation and its biology. Studies on DNA methylation, chromatin remodeling patterns, and non-coding RNAs have led to the development of novel therapeutic approaches. However, treatment options for rare uterine sarcomas are still limited.
Review
Clinical Neurology
M. S. Camara, M. Martin Bujanda, M. Mendioroz Iriarte
Summary: The article reviews the potential epigenetic mechanisms involved in headache development, emphasizing the importance of further research in understanding the pathophysiology of headache, identifying biomarkers, and finding more effective therapeutic targets.
Review
Biochemistry & Molecular Biology
Klaudia Dopytalska, Piotr Ciechanowicz, Kacper Wiszniewski, Elzbieta Szymanska, Irena Walecka
Summary: Psoriasis is a chronic immune-mediated disease with approximately 2% incidence. Genetic and environmental factors play significant roles in its pathogenesis. Epigenetic mechanisms, including DNA methylation, histone modifications, and non-coding RNAs, are highlighted for their role in the etiology and pathogenesis of psoriasis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Nivine Srour, Sarah Khan, Stephane Richard
Summary: Exploration in the field of epigenetics has revealed the role of protein arginine methyltransferases (PRMTs) in disease and the development of compounds that inhibit arginine methylation. PRMTs play crucial roles in regulating cellular processes, physiological processes, and are implicated in various diseases. By understanding their functions, we can explore potential treatments for cancer, immune disorders, and inflammatory-related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Alvaro Del Real, Laura Lopez-Delgado, Carolina Sanudo, Carmen Garcia-Ibarbia, Esther Laguna, Flor M. Perez-Campo, Guillermo Menendez, Ana Alfonso, Michel Fakkas, Belen Garcia-Montesinos, Carmen Valero, Maria Isabel Perez-Nunez, Jose A. Riancho
DNA AND CELL BIOLOGY
(2020)
Article
Medicine, Legal
Alvaro del Real, Maria Saenz-Aldea, Ana Santurtun, Maria T. Zarrabeitia
Summary: Scientific and technological progress in forensic genetics is helpful in solving criminal cases, but also requires deep ethical reflection. Prisoners and prison officials generally find the national DNA database useful, but are concerned about its future uses.
Article
Biochemistry & Molecular Biology
Alvaro Del Real, Flor M. Perez-Campo, Maria Isabel Perez-Nunez, Carolina Sanudo, Ana Santurtun, Carmen Garcia-Ibarbia, M. Teresa Garcia-Unzueta, Mario F. Fraga, Agustin F. Fernandez, Maria Carmen Valero, Esther Laguna, Jose A. Riancho
Summary: The study found that the SOST gene promoter methylation levels in serum cfDNA were similar to bone-derived DNA but lower than blood cell DNA. There was a positive correlation between individual's SOST DNA methylation values in serum and bone. No differences in serum sclerostin levels or SOST methylation were found after 6-months of therapy with antiosteoporotic drugs.
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2021)
Article
Cell Biology
Laura Lopez-Delgado, Alvaro del Real, Carolina Sanudo, Carmen Garcia-Ibarbia, Esther Laguna, Guillermo Menendez, Belen Garcia-Montesinos, Ana Santurtun, Jesus Merino, Maria Perez-Nunez, Jose A. Riancho
Summary: The study aimed to investigate whether MSCs from patients with osteoporosis exhibit a senescent phenotype and explore their bone-forming ability in vivo. The results showed that there was no significant difference in the osteogenic capacity of MSCs from osteoporosis patients compared to those from controls with osteoarthritis, indicating potential for the use of autologous MSCs from osteoporosis patients in bone regeneration procedures.
CONNECTIVE TISSUE RESEARCH
(2022)
Review
Environmental Sciences
Alvaro del Real, Ana Santurtun, M. Teresa Zarrabeitia
Summary: The review focuses on the relationship between epigenetic marks, exposure to air pollution, and human health, highlighting how air contaminants lead to changes in the epigenome, increasing susceptibility to diseases. Further analyses derived from particulate matter (PM) exposure are necessary to identify new targets and disease biomarkers, as some epigenetic change mechanisms remain unclear.
ENVIRONMENTAL RESEARCH
(2021)
Article
Public, Environmental & Occupational Health
A. del Real, A. Sanchez-Lorenzo, J-a Lopez-Bustins, M. T. Zarrabeitia, A. Santurtun
Summary: This study analyzed the temporal and geographical distribution of accidental drowning deaths in Spain over 20 years and assessed the relationship between accidental drowning and atmospheric circulation patterns. The results showed a decreasing trend in mortality rate, but highlighted the need for improved prevention strategies.
PERSPECTIVES IN PUBLIC HEALTH
(2023)
Article
Environmental Sciences
Ana Santurtun, Marina L. Colom, Pablo Fdez-Arroyabe, Alvaro Del Real, Ignacio Fernandez-Olmo, Maria T. Zarrabeitia
Summary: Understanding the role of Particulate Matter (PM) in the COVID-19 pandemic is important for preventing outbreaks. Exposure to PM has been linked to new cases and severity of SARS-CoV-2 infection. PM can cause oxidative stress and inflammation in the respiratory system, and it plays a role in the expression of ACE-2 in respiratory cells. SARS-CoV-2 RNA has also been detected in PM samples from indoor and outdoor environments. If PM is confirmed as a transmission vector, prevention strategies may need to be adapted and PM sampling could indicate viral load in specific areas.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Alvaro del Real, Andrea Exposito, Laura Ruiz-Azcona, Miguel Santibanez, Ignacio Fernandez-Olmo
Summary: This study aimed to determine the presence of SARS-CoV-2 RNA in indoor and outdoor size-segregated aerosol samples. The positive detection of SARS-CoV-2 was only found in one PM2.5 sample from an occupancy room where a patient with positive PCR and cough was present. Negative results in other sampling areas may be attributed to the limitation of air sampling volume and good ventilation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Alvaro del Real, Carmen Valero, Jose M. Olmos, Jose L. Hernandez, Jose A. Riancho
Summary: Common genetic variants in the mevalonate and oestrogen pathways are associated with changes in bone mineral density in response to antiresorptive drugs, providing insights for predicting drug responses and making personalized therapeutic choices.
Article
Biochemistry & Molecular Biology
Esther Laguna, Maria Isabel Perez-Nunez, Alvaro del Real, Guillermo Menendez, Jose A. Sainz-Aja, Laura Lopez-Delgado, Carolina Sanudo, Alicia Martin, Remigio Mazorra, Diego Ferreno, Belen Garcia-Montesinos, Jose A. Riancho
Summary: This study analyzed the regenerative capacity of MSCs in the treatment of fractures and found that MSCs from patients with osteoarthritis had an inhibitory effect on consolidation, while MSCs from patients with osteoporosis compared favorably.
Article
Biochemistry & Molecular Biology
Alvaro del Real, Sergio Ciordia, Carolina Sanudo, Carmen Garcia-Ibarbia, Adriel Roa-Bautista, Javier G. Ocejo-Vinals, Fernando Corrales, Jose A. Riancho
Summary: The aim of this study was to explore new markers in serum proteome associated with the response to antiosteoporosis drugs. The results showed significant differences in protein levels, particularly those related to the innate immune system, in the serum after treatment with teriparatide and denosumab.
Article
Biochemistry & Molecular Biology
Ricardo Usategui-Martin, Alvaro Del Real, Jose A. Sainz-Aja, Jesus Prieto-Lloret, Elena Olea, Asuncion Rocher, Ricardo J. Rigual, Jose A. Riancho, Jose Luis Perez-Castrillon
Summary: This study found that hypoxia and obesity can lead to changes in bone remodeling and microarchitecture, increasing the risk of fragility fracture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Health Care Sciences & Services
Zaida Salmon-Gonzalez, Javier Anchuelo, Juan C. Borregan, Alvaro del Real, Carolina Sanudo, Maria Teresa Garcia-Unzueta, Jose A. Riancho, Carmen Valero
Summary: Despite concerns about hyperoxia, the study found no evidence that hyperbaric oxygen therapy has any detrimental effect on bone homeostasis. While there was a significant increase in HIF-1 alpha levels, no significant changes were observed in other serum biomarkers reflecting the status of bone homeostasis.
Article
Oncology
Zaida Salmon-Gonzalez, Javier Anchuelo, Juan C. Borregan, Alvaro Del Real, Jose A. Riancho, Carmen Valero
Summary: This study found that patients with neoplasms and complications of radiotherapy have increased bone remodeling, which may be reduced after HBOT treatment.
REPORTS OF PRACTICAL ONCOLOGY AND RADIOTHERAPY
(2021)
Article
Endocrinology & Metabolism
A. Del Real, L. Lopez-Delgado, C. Sanudo, M. Perez-Nunez, E. Laguna, G. Menendez, C. Garces, B. Garcia-Montesinos, C. Garcia-Ibarbia, A. Santurtun, J. A. Riancho
REVISTA DE OSTEOPOROSIS Y METABOLISMO MINERAL
(2020)