期刊
CURRENT OPINION IN INSECT SCIENCE
卷 28, 期 -, 页码 66-72出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.cois.2018.05.006
关键词
-
资金
- NIH [DP5 OD023098, 5K22AI113060, 1R21AI123937]
- Defense Advanced Research Project Agency (DARPA) Safe Genes Program [HR0011-17-2-0047]
Initially discovered in bacteria, CRISPR-based genome editing endonucleases have proven remarkably amenable for adaptation to insects. To date, these endonucleases have been utilized in a plethora of both model and non-model insects including diverse flies, bees, beetles, butterflies, moths, and grasshoppers, to name a few, thereby revolutionizing functional genomics of insects. In addition to basic genome editing, they have also been invaluable for advanced genome engineering and synthetic biology applications. Here we explore the recent genome editing advancements in insects for generating site-specific genomic mutations, insertions, deletions, as well as more advanced applications such as Homology Assisted Genome Knock-in (HACK), potential to utilize DNA base editing, generating predictable reciprocal chromosomal translocations, and development gene drives to control the fate of wild populations.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据