Article
Environmental Sciences
Xufei Zhang, Xianhao Jia, Shengnan Wang, Jinge Xin, Ning Sun, Yanyan Wang, Xingting Zhang, Zhiqiang Wan, Jing Fan, Hao Li, Yang Bai, Xueqin Ni, Yongmei Huang, Hesong Wang, Hailin Ma
Summary: Approximately 400 million people worldwide suffer from memory dysfunction in high-altitude areas. This study investigated the effect of intestinal flora on spatial memory impairment induced by high altitudes and found that antibiotic treatment exacerbated the memory dysfunction and reduced diversity of the gut microbiota.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Health Care Sciences & Services
Maxime Ilzkovitz, Elikyah Esther Kayembe, Caroline Geers, Agnieszka Pozdzik
Summary: This study reported a rare case of kidney stone disease in an Indian woman with a strong association with Sjogren syndrome, highlighting the importance of autoimmune screening in the diagnosis of such conditions.
Review
Food Science & Technology
Dong Han, Justyna Zulewska, Ke Xiong, Zhennai Yang
Summary: This review discusses the concept and current research on synbiotics, which are a dietary mixture of probiotic microorganisms and prebiotic substrates. Studies using microbial cultures, cell lines, animal models, and human subjects have shown that these combinations have metabolic properties that can promote beneficial activities, making them potentially useful for improving human health and for therapeutic purposes. However, there are challenges to the widespread use of these combinations, such as practical application, inconsistent results, unclear mechanisms, and legal hurdles.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Adriana Fodor, Andrada Luciana Lazar, Cristina Buchman, Brandusa Tiperciuc, Olga Hilda Orasan, Angela Cozma
Summary: MetS is a complex entity that increases the risk of various diseases, including type two diabetes, cardiovascular diseases, and certain types of cancer. miRNAs play an important role in cancer genesis, progression, and metastasis, and the altered secretion of miRs in adipose tissue may explain their involvement in oncogenesis. The interaction between miRs expressed in adipose tissue, their dysregulation, and cancer pathogenesis are still intriguing, as miRNAs exhibit both carcinogenic and tumor suppressor effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Immunology
Jiaxing Tan, Ming Chen, Yutong Wang, Yi Tang, Wei Qin
Summary: This study describes the hotspots and evolution of gastrointestinal microbiome and kidney disease research over the past three decades and predicts future trends in the field. The research found a significant increase in the number of studies combining gastrointestinal microbiomes with kidney diseases over the past two decades, with the United States leading in terms of publication quantity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Neurosciences
Ahmed Eltokhi, Iris E. Sommer
Summary: Depression is a severe mental disorder that places a significant economic burden on public health. More research is focusing on the link between the gut microbiota and depression, suggesting that probiotics may be beneficial in alleviating depressive symptoms。
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Medicine, General & Internal
Fabiana Radu, Claudia-Gabriela Potcovaru, Teodor Salmen, Petruta Violeta Filip, Corina Pop, Carmen Fierbinteanu-Braticievici
Summary: Metabolic syndrome (MetS) is characterized by a combination of cardiovascular and diabetes mellitus type 2 risk factors. The main diagnostic criteria include impaired fasting glucose, low HDL-cholesterol, elevated triglycerides levels, and high blood pressure. Insulin resistance is believed to be the main cause of MetS and is connected to the level of visceral adipose tissue.
Article
Gastroenterology & Hepatology
Diana Corina Petrisor, Zlatka Etropolska, Kiril Elenski, Emiliya Dimitrova, Javier Santos
Summary: This study supports the evidence that FABD patients may benefit from a XG + PP-based treatment that acts on etiology and not just the symptoms.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Plant Sciences
Veronica C. Perez, Ru Dai, Breanna Tomiczek, Jorrel Mendoza, Emily S. A. Wolf, Alexander Grenning, Wilfred Vermerris, Anna K. Block, Jeongim Kim
Summary: Identification of an enzyme in sorghum for PAOx production reveals a link between auxin metabolism and defense metabolite production in monocots. This finding may contribute to understanding the trade-off between growth and defense and has important implications for plant adaptation and stress response mechanisms.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Biochemistry & Molecular Biology
Samrein B. M. Ahmed, Nada Radwan, Sara Amer, Narjes Saheb Sharif-Askari, Amena Mahdami, Kamel A. A. Samara, Rabih Halwani, Herbert F. F. Jelinek
Summary: Diabetes mellitus affects cellular functions through altered glucose metabolism and has been linked to cancer development. This study found that hyperglycemia combined with hyperinsulinemia has a potential effect on the progression of breast cancer cells, with differential expression of 45 genes observed. Additionally, 15 genes were found to be upregulated in breast tumor tissues of diabetic patients with breast cancer. These findings emphasize the importance of monitoring diabetes-related metabolic alterations in improving breast cancer outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Microbiology
Yuan Zeng, Yifan Wu, Qian Zhang, Xinhua Xiao
Summary: The gut microbiota and GLP-1 interact with each other, as gut microbiota metabolites stimulate GLP-1 secretion and affect its function and rhythm. The mechanism of action of GLP-1 on gut microbiota involves inflammatory response. Various interventions can affect the interaction between gut microbiota and GLP-1, which is of great significance for the treatment of metabolic diseases.
Review
Nutrition & Dietetics
Georgios Konstantis, Stylianos Efstathiou, Chryssa Pourzitaki, Elisavet Kitsikidou, Georgios Germanidis, Michail Chourdakis
Summary: This meta-analysis evaluated the efficacy and safety of probiotics in IBS-patients. The results showed a significant reduction in abdominal pain and bloating, but no improvement in other parameters. Larger randomized controlled trials are needed to confirm these findings and further investigate the use of specific probiotic strains.
CLINICAL NUTRITION
(2023)
Article
Microbiology
Leonardo Mancabelli, Christian Milani, Federico Fontana, Gabriele Andrea Lugli, Chiara Tarracchini, Alice Viappiani, Tecla Ciociola, Andrea Ticinesi, Antonio Nouvenne, Tiziana Meschi, Francesca Turroni, Marco Ventura
Summary: The recent COVID-19 pandemic has prompted scientists to investigate the underlying causes of this disease. This study conducted a comprehensive meta-analysis of 323 fecal samples and found that the composition of the intestinal microbiota may be correlated with the severity of COVID-19 symptoms. Healthy individuals had a higher abundance of beneficial bacteria, while COVID-19 patients exhibited an increase in potentially pathogenic bacteria. Furthermore, the functional capabilities of the microbiome in COVID-19 patients were unbalanced, which may contribute to disease severity and systemic inflammation.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Review
Endocrinology & Metabolism
Gracia M. Martin-Nunez, Isabel Cornejo-Pareja, Mercedes Clemente-Postigo, Francisco J. Tinahones
Summary: H. pylori infection is associated with various clinical conditions beyond gastric issues, including metabolic diseases like diabetes and obesity. Recent studies have shown that H. pylori can modulate gut microbiota, which in turn affects metabolic regulation and potentially plays a role in diseases like diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Meneerah Abdulrahman Aljafary, Ebtesam Abdullah Al-Suhaimi
Summary: Adiponectin plays a key role in regulating energy generation and storage as well as functioning as an endocrine tissue in the body. It has both pro-inflammatory and anti-inflammatory effects on the cardiovascular system, making it an important biomarker and potential therapeutic tool for metabolic syndromes and cardiovascular diseases. Adiponectin is known for its cardioprotective impact and its ability to regulate various metabolic processes.