Article
Pharmacology & Pharmacy
Marie-Laure Laroche, Sophie Gautier, Elisabeth Polard, Marie-Blanche Rabier, Laurent Chouchana, Benedicte Lebrun-Vignes, Jean-Luc Faillie, Nadine Petitpain, Laurence Lagarce, Annie-Pierre Jonville-Bera
Summary: This study aimed to assess the incidence and characteristics of adverse drug reaction-related hospital admissions (ADR-HAs) in France. The results showed a significant increase in ADR-HA incidence over the past decade. The most common ADRs included hemorrhagic events, hematological disorders, and acute renal failure. A substantial proportion of ADRs were considered preventable due to noncompliance with medication guidelines.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Joanna E. Klopotowska, Jan-Hendrik Leopold, Tinka Bakker, Izak Yasrebi-de Kom, Frouke M. Engelaer, Evert de Jonge, Esther K. Haspels-Hogervorst, Walter M. van den Bergh, Maurits H. Renes, Bas T. Jong, Hans Kieft, Andre Wieringa, Stefaan Hendriks, Cedric Lau, Sjoerd H. W. van Bree, Hendrick J. W. Lammers, Peter C. Wierenga, Rob J. Bosman, Vincent M. de Jong, Mirjam Slijkhuis, Eric J. F. Franssen, Wytze J. Vermeijden, Joost Masselink, Ilse M. Purmer, Liesbeth E. Bosma, Martin Hoeksema, Elsbeth Wesselink, Dylan W. de Lange, Nicolette F. de Keizer, Dave A. Dongelmans, Ameen Abu-Hanna
Summary: Limited knowledge about adverse drug events caused by drug-drug interactions (DDI-ADEs), this study aimed to provide detailed insights about DDI-ADEs related to three frequent, high-risk potential DDIs in critical care settings. Through retrospective data analysis from ICU patients admitted to ten hospitals in the Netherlands between January 2010 and September 2019, it was found that DDI-ADEs have a high preventability and severity rate.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Pediatrics
Jeong-Rim Lee, Jae Hoon Lee, Hye-Mi Lee, Nayeon Kim, Myoung Hwa Kim
Summary: This study identified the risk factors for respiratory complications related to pediatric sedation, including cardiac and neurologic comorbidities, crying before sedation, a history of snoring or upper respiratory infection, and prolonged duration of sedation. Proactive management before sedation is critical to prevent adverse respiratory events in children undergoing propofol-based sedation.
EUROPEAN JOURNAL OF PEDIATRICS
(2021)
Article
Public, Environmental & Occupational Health
Susan Park, So Hyun Choi, Yun-Kyoung Song, Jin-Won Kwon
Summary: This study explored new adverse events (AEs) related to tramadol use using both social media and conventional pharmacovigilance data. The results identified several novel AEs associated with tramadol use, some of which were not listed on the drug label. Vascular disorders and tramadol-induced pain were found to be potentially serious AEs.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2022)
Article
Public, Environmental & Occupational Health
Lisa M. Kalisch Ellett, Gerel Dorj, Andre Q. Andrade, Rebecca L. Bilton, Debra Rowett, Joseph Whitehouse, Renly Lim, Nicole L. Pratt, Thu-Lan Kelly, Nibu Parameswaran Nair, Luke Bereznicki, Imaina Widagdo, Elizabeth E. Roughead
Summary: This study examined the prevalence and preventability of adverse medicine events among aged care residents in Australia. The results showed that 62% of residents experienced a medicine-related adverse event, and 54% of these events were preventable within a 12-month period.
Article
Surgery
Laure Taher Mansour, Sean Brien, Jessica Reid, Guy J. Maddern
Summary: This study identified preventable clinical management issues related to mortality in cholecystectomy patients, with a focus on post-operative management and communication within the multidisciplinary team. Preventive measures should be implemented to reduce adverse events and peri-operative mortality.
WORLD JOURNAL OF SURGERY
(2021)
Review
Pharmacology & Pharmacy
Jaroslaw Woron, Adrian Andrzej Chrobak, Daniel Slezak, Marcin Siwek
Summary: This study systematically evaluated the prevalence and clinical characteristics of adverse effects of antidepressants and over-the-counter drugs interactions through a retrospective chart review. The results showed that the simultaneous use of antidepressants and other drugs could lead to adverse events. Some over-the-counter drugs were found to have pharmacokinetic interactions with antidepressants, resulting in categorized side effects. The study suggested monitoring the use of over-the-counter drugs by patients as they may increase the severity of side effects of antidepressants.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Ariane Cristina Barboza Zanetti, Bruna Moreno Dias, Andrea Bernardes, Helaine Carneiro Capucho, Alexandre Pazetto Balsanelli, Andre Almeida de Moura, Rodrigo Soato, Carmen Silvia Gabriel
Summary: This study analyzed the incidence and preventability of adverse events related to healthcare in adult patients at a Brazilian teaching hospital. The incidence rate of adverse events was 33.7%, with common types including general care, medications, and nosocomial infections. A portion of the events were found to be preventable, and patient's length of hospital stay was identified as a risk factor for the occurrence of adverse events.
Article
Psychiatry
Qin Zhou, Zhiqiang Du, Kankan Qu, Yuan Shen, Ying Jiang, Haohao Zhu, Xiuhong Zhang
Summary: This study analyzed adverse events data related to Epidiolex and found that most real-world reactions align with those mentioned in the drug's leaflet. However, some potential new side effects emerged, highlighting the need for further research on drug safety.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Multidisciplinary Sciences
Edmundo Vazquez-Cornejo, Olga Morales-Rios, Gabriela Hernandez-Pliego, Carlo Cicero-Oneto, Juan Garduno-Espinosa
Summary: This study aimed to describe the incidence, types, severity, and preventability of adverse events occurring in pediatric patients with acute lymphoblastic leukemia during the remission induction phase in a tertiary care pediatric hospital in Mexico. The results showed that improving the safety and quality of care processes is possible.
Article
Pediatrics
Wayessa Olika Tola, Tsegaye Melaku, Diriba Fufa, Tadesse Sheleme
Summary: The study aimed to assess the incidence and contributing factors of adverse drug events (ADEs) among pediatric cancer patients at Jimma university medical center in Ethiopia. The results showed that ADEs were common in the pediatric oncology ward, and children receiving multiple chemotherapy drugs and those with comorbid conditions were at a higher risk for ADEs.
Article
Emergency Medicine
Jonathan A. Summerlin, Nicholas Scaturo, Jeremy A. Lund, Kellie M. Wang, Marshall A. Frank
Summary: This study aimed to assess the adverse events associated with the rapid administration of undiluted IV levetiracetam. The study found that the rapid administration of undiluted IV levetiracetam in emergency department patients was associated with few adverse events.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2023)
Review
Pharmacology & Pharmacy
William Hao Syuen Ng, Saxon D. D. Smith
Summary: Laser-assisted drug delivery (LADD) is a growingly studied and applied methodology for drug delivery. This systematic review aimed to assess the safety outcomes of LADD and found that it can lead to adverse effects such as erythema, oedema, pain, and crusting. However, no life-threatening adverse effects were reported. Further research is needed to quantitatively determine the risks.
Article
Dermatology
Anusuya Kawsar, Charlotte Edwards, Pooja Patel, Richard M. Heywood, Aakriti Gupta, Jasmine Mann, Christopher Harland, Kara Heelan, James Larkin, Paul Lorigan, Catherine A. Harwood, Rubeta N. Matin, Louise Fearfield
Summary: This multicentre observational study investigates the incidence and characteristics of bullous cutaneous immune-related adverse events (irAEs) associated with checkpoint inhibitor (CPI) therapy. The study finds that these irAEs are rare but can occur after cessation of treatment, and discontinuation of CPIs may be necessary for management. Prompt recognition and referral to dermatology are crucial for optimal management and patient outcomes.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Pharmacology & Pharmacy
Huaqiao Jiang, Yanhua Lin, Weifang Ren, Zhonghong Fang, Yujuan Liu, Xiaofang Tan, Xiaoqun Lv, Ning Zhang
Summary: This study analyzed the pattern of adverse drug reactions (ADRs) in detail and obtained clinical evidence about ADRs associated with actual drug-drug interactions (DDIs). Antimicrobial agents were the most common implicated pharmacological group, with the gastrointestinal system being the most frequently affected.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ettore Marconi, Giada Crescioli, Roberto Bonaiuti, Lavinia Pugliese, Raffaella Santi, Gabriella Nesi, Elisabetta Cerbai, Alfredo Vannacci, Niccolo Lombardi
Summary: This article describes a case of appendicitis after COVID-19 vaccination, suggesting a possible association between COVID-19 vaccines and appendicitis. In pediatric vaccination campaigns, close monitoring of gastrointestinal adverse events associated with COVID-19 vaccines and prompt management of potential complications are recommended.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Andrea Zovi, Francesco Ferrara, Sarah Sorrentino, Roberto Langella, Ugo Trama, Mariarosaria Boccellino, Antonio Vitiello
Summary: Modern research focuses on new viruses and the re-emergence of past microbes. Overcoming the infection depends on vaccination, which has proven to minimize hospitalizations and severe syndromes.
PHARMACEUTICAL RESEARCH
(2023)
Review
Immunology
Antonio Vitiello, Francesco Ferrara, Andrea Zovi
Summary: The human microbiota, consisting of symbiotic microorganisms, plays a crucial role in human physiological functions. While the impact of an altered microbiota on diseases like chronic inflammatory diseases and psychiatric diseases is well-studied, its role in the host immune response to bacterial and viral infections is still not fully understood. Recent evidence highlights the alterations in the microbiota of patients with viral infections such as post-acute COVID-19 syndrome (PACS). This review emphasizes the biological and clinical significance of the associations between the microbiota and COVID-19 infection and how microbiota-produced metabolites modulate immune responses to COVID-19 infection.
INFLAMMOPHARMACOLOGY
(2023)
Article
Ophthalmology
A. N. D. R. E. A. Spini, S. A. B. R. I. N. A. Giometto, S. A. N. D. R. A. Donnini, M. A. T. T. E. O. Posarelli, F. R. A. N. C. E. S. C. O. Dotta, M. A. R. I. N. A. Ziche, Gian Marco Tosi, A. N. N. A. Girardi, E. R. S. I. L. I. A. Lucenteforte, R. O. S. A. Gini, M. A. H. Y. A. R. Etminan, G. I. A. N. N. I. Virgili
Summary: This study aimed to evaluate the risk of intraocular pressure increase (IOPi) among nondiabetic patients using bevacizumab, aflibercept, and ranibizumab. The results showed that compared with aflibercept, bevacizumab and ranibizumab users had a higher risk of IOPi.
AMERICAN JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Immunology
Michela Sabbatucci, Antonio Vitiello, Salvatore Clemente, Andrea Zovi, Mariarosaria Boccellino, Francesco Ferrara, Carla Cimmino, Roberto Langella, Annarita Ponzo, Paola Stefanelli, Giovanni Rezza
Summary: The SARS-CoV-2 virus responsible for the COVID-19 pandemic has caused nearly 760 million cases and 7 million deaths worldwide as of February 2023. Multiple variants, such as Alpha, Beta, Gamma, Delta, and Omicron, have emerged with increased transmissibility and immune evasion capabilities. The most recent variant, Centaurus BA.2.75.2, shows a higher affinity for ACE-2 receptors and potential resistance to vaccines and antiviral treatments.
INFLAMMOPHARMACOLOGY
(2023)
Review
Medicine, General & Internal
Eugenia Piragine, Davide Petri, Alma Martelli, Vincenzo Calderone, Ersilia Lucenteforte
Summary: Poor adherence to oral antidiabetic drugs (OADs) in patients with type 2 diabetes (T2D) can lead to therapy failure and risk of complications. This study aimed to determine the adherence to OADs in patients with T2D and estimate the association between good adherence and glycemic control. The systematic review and meta-analysis included 156 studies and showed that the proportion of adherent patients was 54%. There was a significant association between good glycemic control and good adherence, indicating that improving adherence could reduce the risk of complications.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Antonio Vitiello, Francesco Ferrara, Mariarosaria Boccellino, Annarita Ponzo, Carla Cimmino, Emilio Comberiati, Andrea Zovi, Salvatore Clemente, Michela Sabbatucci
Summary: Fungal infections, especially drug-resistant forms like Candida and Aspergillus spp., are increasing in prevalence and causing severe diseases. This is primarily due to the growing number of immunocompromised patients and the emergence of resistant strains. Unlike bacterial infections which have a wide array of antimicrobial drugs, there are only a few classes of antifungal drugs available, leading to a limited therapeutic armamentarium. This review provides a comprehensive overview of systemic mycosis, current antifungal drug compounds, and the molecular mechanisms of antifungal resistance.
Letter
Medicine, General & Internal
Alfredo Vannacci, Roberto Bonaiuti, Claudia Ravaldi
JAMA INTERNAL MEDICINE
(2023)
Review
Immunology
Samina Sana, Elisa Fabbro, Andrea Zovi, Antonio Vitiello, Toluwani Ola-Ajayi, Ziad Zahoui, Bukola Salami, Michela Sabbatucci
Summary: In the aftermath of the COVID-19 pandemic, asylum seekers, refugees, and foreign-born migrants are more likely to suffer from physical, mental, and socioeconomic consequences owing to their existing vulnerabilities and worsening conditions in refugee camps around the world. It is critical to educate migrants and newcomers about immunization to achieve health equity worldwide. However, it is unclear whether government vaccination policies prioritize the health information needs of migrants globally.
Meeting Abstract
Toxicology
Valentina Brilli, Giada Crescioli, Francesco Gambassi, Andrea Missanelli, Alessandra Ieri, Cecilia Lanzi, Alessandra Pistelli, Arianna Totti, Alfredo Vannacci, Guido Mannaioni, Niccolo Lombardi
CLINICAL TOXICOLOGY
(2023)
Article
Medicine, General & Internal
Anna Bombelli, Greta Guarnieri, Niccolo Lombardi, Maria Giuseppa Sullo, Edoardo Spina, Giada Crescioli, Concetta Rafaniello, Giuseppe Cicala, Veronica Marangon, Rachele Folchino, Silvia Vecchio, Giulia Mosini, Sonia Radice, Emilio Clementi
Summary: Awareness of the risk/benefit profile of therapies used in paediatric and elderly patients is limited. The MEAP 3.0 study collected and analyzed evidence of adverse drug reactions (ADRs) and drug-drug interactions (DDIs) in frail populations under polypharmacy in a real-world setting, revealing the most frequently implicated pharmacological classes in these patient groups.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Sabrina Giometto, Marco Finocchietti, Olga Paoletti, Niccolo Lombardi, Maria Grazia Celani, Francesco Sciancalepore, Ersilia Lucenteforte, Ursula Kirchmayer
Summary: The study evaluated adherence to riluzole in ALS patients during the first year of use and identified two main clusters: adherent patients and patients who discontinued therapy. Most patients adhered to therapy, with early therapy discontinuation associated with greater fragility and mortality.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
