Article
Materials Science, Multidisciplinary
Manuel J. Freire, Jesus Tornero, Ricardo Marques
Summary: This work demonstrates the use of metamaterial lenses to improve the signal-to-noise ratio of magnetic resonance imaging coils in low-field magnetic resonance imaging systems. The dominant source of noise in the signal-to-noise ratio in low-field magnetic resonance imaging systems is the metallization of the coil, while the contribution of noise sample or tissue can be neglected, unlike in high-field magnetic resonance imaging systems. A metamaterial lens composed of a three-dimensional array of capacitively loaded split rings was fabricated and tested on a 0.3 T MRI system. The experiment showed that the metamaterial lens was far enough from the coil to introduce negligible additional losses and tissue losses.
RESULTS IN PHYSICS
(2023)
Article
Chemistry, Multidisciplinary
Aihui Sun, Yaoyao Ji, Yaxi Li, Wenhui Xie, Zhihe Liu, Tingting Li, Tian Jin, Weizhi Qi, Kai Li, Changfeng Wu, Lei Xi
Summary: PAI, with OR-PAM as a submodality, has high lateral resolution and optical contrast, showing potential in visualizing cellular structures. The proposed multicolor 3D photoacoustic microscopy with improved axial resolution allows visualization of subcellular structures efficiently.
Article
Chemistry, Analytical
Tian Jin, Chen Zhang, Fei Liu, Xingxing Chen, Guangru Liang, Fei Ren, Suzi Liang, Chaolong Song, Jianbing Shi, Weibao Qiu, Xingyu Jiang, Kai Li, Lei Xi
Summary: On-chip photoacoustic imaging flow cytometry (PAIFC) combines multicolor high-speed photoacoustic microscopy and microfluidics for cell imaging, utilizing a multicolor strategy to measure and image cells, capable of detecting melanoma cells in whole blood with high sensitivity and specificity.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Qi Wu, Xiaoyu Wang, Peiyan Sun, Zhen Wang, Jian Chen, Zhigang Chen, Ge Song, Chenglong Liu, Xinyang Mu, Shan Cong, Zhigang Zhao
Summary: The newly demonstrated multilayered metal-dielectric metamaterials (MMDMs) serve as a new family of inorganics-based EC materials to achieve dynamic alternation among multicolors with high contrast and high color purity. This is achieved by significantly enhancing the confinement of the incident light in specific optical frequencies.
Article
Biochemistry & Molecular Biology
Alison G. Tebo, Benjamien Moeyaert, Marion Thauvin, Irene Carlon-Andres, Dorothea Boken, Michel Volovitch, Sergi Padilla-Parra, Peter Dedecker, Sophie Vriz, Arnaud Gautier
Summary: Spectrally separated fluorophores enable the observation of multiple targets in living cells simultaneously for a deeper understanding of cell functions. Engineered fluorogen-activating tags based on the FAST system offer orthogonality in recognition and spectral properties, allowing efficient multicolor imaging of proteins in live cells.
NATURE CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Irene Lim, Eric Yu Lin, Joseph Garcia, Shang Jia, Robert E. Sommerhalter, Subrata K. Ghosh, John A. Gladysz, Ellen M. Sletten
Summary: Developing chemical tools to detect and influence biological processes is important in chemical biology. In this study, we combined perfluorocarbons and multiplexed shortwave infrared fluorescence imaging to visualize nanoemulsions in real time in living mice. We prepared two fluorous-soluble chromenylium polymethine dyes that emit shortwave infrared light and successfully tracked the biodistribution of perfluorocarbon nanoemulsions in vivo. Our findings provided insight into the significance of size and surfactant identity on biodistribution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Lacey A. Birnbaum, Emily C. Sullivan, Priscilla Do, Biaggio Uricoli, Sunil S. Raikar, Christopher C. Porter, Curtis J. Henry, Erik C. Dreaden
Summary: Cytokines play an important role in the human immune system and can effectively treat autoimmune diseases, tissue damage, and cancer. However, controlling the immune response mediated by recombinant cytokines is difficult due to their systemic administration and localized action. Researchers have developed a strategy to reversibly inactivate recombinant cytokines using photo-labile polymers that respond to visible LED light.
Article
Optics
Edoardo Vicentini, Wiwat Nuansing, Iris Niehues, Iban Amenabar, Alexander Bittner, Rainer Hillernbrand, Martin Schnell
Summary: We have developed a detection technique for scattering-type scanning near-field optical microscopy (s-SNOM) that enables simultaneous near-field amplitude and phase imaging at different wavelengths. This technique, called multispectral pseudoheterodyne (PSH) interferometry, combines infrared lasers to form a beam with multiple laser lines and utilizes a time-multiplexing scheme with a single infrared detector. We have demonstrated the implementation of multispectral PSH in a commercial s-SNOM instrument and its application in real-time correction of negative phase contrast (NPC) for reliable imaging of weak IR absorption at the nanoscale. This technique shows potential in improving data throughput, reducing sample and interferometer drift, and establishing multicolor s-SNOM imaging as a regular imaging modality.
Article
Chemistry, Multidisciplinary
Wenbo Zhao, Yong Wang, Kaikai Liu, Rui Zhou, Chongxin Shan
Summary: Biomass-based carbon nanodots (CNDs) have been prepared using natural biomass as precursors through an ultrasonic-assisted method at room temperature. The multicolor CNDs can be prepared within a short time and ultrasound contributes to the polymerization of biomolecules into nanodots. The CNDs show emission in the blue to red region and have demonstrated applications in bacterial imaging.
CHINESE CHEMICAL LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Yeon Ui Lee, Clara Posner, Junxiang Zhao, Jin Zhang, Zhaowei Liu
Summary: This study presents an application of metamaterial-assisted photobleaching microscopy (MAPM) with high-axial resolution to characterize morphological properties of living cells, providing quantitative imaging of changes in cell morphology through topographic and statistical analysis. The time-lapse topography image obtained using metamaterial-induced photostability offers insights into growth factor induced changes in cell morphology with high-axial resolution.
Article
Physics, Applied
Chengbo Hu, Jingkai Weng, Yujiang Ding, Bin Liang, Jing Yang, Jianchun Cheng
Summary: This study theoretically proposes and experimentally demonstrates a 3D acoustic hyperlens capable of producing super-resolution imaging for broadband airborne sound. The simple nonresonant metamaterial design ensures tessellation of the curved surface and deep-subwavelength resolution, converting evanescent waves into radially propagating modes based on positive extreme anisotropy. The effectiveness of the mechanism is shown through numerical and experimental results, allowing for 3D magnifying super-resolution imaging of small objects containing subwavelength patterns across a wide frequency range. This research opens up possibilities for designing acoustic super-resolution imaging devices and their application in diverse scenarios.
APPLIED PHYSICS LETTERS
(2021)
Article
Chemistry, Analytical
Yeeun Roh, Sang-Hun Lee, Jisung Kwak, Hyun Seok Song, Seulgi Shin, Yun Kyung Kim, Jeong Weon Wu, Byeong-Kwon Ju, Boyoung Kang, Minah Seo
Summary: This report introduces a highly improved THz imaging technology by comparing complementary metamaterials based on Babinet's principle, showing significant potential applications in producing clear contrast images in biological samples.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Physics, Applied
Chuanjie Hu, Shuwen Xue, Yuhang Yin, Zhanlei Hao, Yangyang Zhou, Huanyang Chen
Summary: In this Letter, the acoustic imaging properties of a three-dimensional Maxwell's fish-eye lens (3D-MFEL) based on the solid immersion mechanism are explored. The results show that the 3D-MFEL can achieve super-resolution imaging without chromatic aberration. Furthermore, the introduction of vortex waves into the 3D-MFEL allows for the exploration of super-resolution imaging properties in reconstructing vortex waves.
APPLIED PHYSICS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Do-Hyeon Kim, Yeonho Chang, Soyeon Park, Min Gyu Jeong, Yonghoon Kwon, Kai Zhou, Jungeun Noh, Yun-Kyu Choi, Triet Minh Hong, Young-Tae Chang, Sung Ho Ryu
Summary: Multicolor fluorescence imaging is a powerful tool for visualizing the spatiotemporal relationship among biomolecules. However, commonly employed organic dyes exhibit a blue-conversion phenomenon which can lead to severe multicolor image artifacts, particularly in localization-based superresolution microscopy. Therefore, practical guidelines for the use of organic dyes in multicolor imaging have been provided to prevent artifacts caused by blue-conversion.
Article
Chemistry, Applied
Zhong Lin, Heru Pan, Yong Tian, Jia Tang, Chonghua Zhang, Peisheng Zhang, Heping Yang, Jian Chen
Summary: This paper reports the fabrication of novel photo-pH dual stimuli-responsive multicolor fluorescent polymeric nanoparticles (SMFPNs) through combination of one-pot miniemulsion polymerization and surface modification, which can achieve multi-color transformation of blue, green, and red under changing pH and illumination conditions.
Review
Neurosciences
Rui-Zhe Zheng, Zeng-Xin Qi, Zhe Wang, Ze-Yu Xu, Xue-Hai Wu, Ying Mao
Summary: Significant progress has been made in identifying and managing disorders of consciousness in patients with acquired brain injury. Advanced technology and tools have improved diagnostic accuracy, but there are still challenges in clinical treatment and a lack of effective management protocols.
NEUROSCIENCE BULLETIN
(2023)
Review
Neurosciences
Qiyuan Zhuang, Hui Yang, Ying Mao
Summary: Glioma, the most common and lethal primary brain tumor, is highly heterogeneous and its cell state, including glioma stem cells, microglia, neurons, and immune cells, play crucial roles in tumor initiation, progression, and response to therapy.
NEUROSCIENCE BULLETIN
(2023)
Article
Chemistry, Multidisciplinary
Xinzhong Chen, Suheng Xu, Sara Shabani, Yueqi Zhao, Matthew Fu, Andrew J. Millis, Michael M. Fogler, Abhay N. Pasupathy, Mengkun Liu, D. N. Basov
Summary: The ability to perform nanometer-scale optical imaging and spectroscopy is crucial for decoding low-energy effects in quantum materials, as well as identifying vibrational fingerprints in planetary and extraterrestrial particles, catalytic substances, and aqueous biological samples. The scattering-type scanning near-field optical microscopy (s-SNOM) technique, along with artificial intelligence (AI) and machine learning (ML) algorithms, can greatly enhance the efficiency, accuracy, and intelligence of scanning probe optical nanoscopy.
ADVANCED MATERIALS
(2023)
Article
Optics
Ziping Li, Xuhong Ma, Kang Zhou, Binbin Liu, Chenjie Wang, Xiaoyu Liao, Wen Guan, Shumin Wu, Han Liu, Zhenzhen Zhang, J. C. Cao, Min Li, Ming Yan, Heping Zeng, Hua Li
Summary: Dual-comb source offers unique advantages in various applications. A self-reference method is proposed to improve the long-term stability of a terahertz quantum cascade laser dual-comb source.
LASER & PHOTONICS REVIEWS
(2023)
Review
Neurosciences
Lijuan Zhang, Yafei Wang, Taohui Liu, Ying Mao, Bo Peng
Summary: Microglia, as immune cells in the central nervous system, play a crucial role in monitoring the environment and protecting neurons to maintain brain homeostasis. In diseased brains, microglia are important mediators of neuroinflammation and have been extensively studied for their involvement in neurodegeneration. This review summarizes the multifunctional contributions of microglia to homeostasis and their potential as therapeutic targets in neurodegenerative diseases, with a particular focus on microglial replacement therapy.
NEUROSCIENCE BULLETIN
(2023)
Article
Computer Science, Information Systems
Renping Yu, Han Zhang, Xuehai Wu, Xuan Fei, Qing Yang, Zhiwei Ma, Zengxin Qi, Di Zang, Weijun Tang, Ying Mao, Dinggang Shen
Summary: This study aims to predict the outcome of unconscious acquired brain injury patients and differentiate consciousness levels using brain functional imaging and machine learning techniques. The researchers construct functional networks based on resting-state fMRI and use connection strengths as features for outcome prediction and consciousness level differentiation. The study achieves improved classification accuracy for consciousness levels (84.78%) and recovery outcome prediction (89.74%) compared to other methods, and identifies contributive connections across the entire brain. These findings provide potential biomarkers for understanding consciousness and developing diagnostic, prognostic, and therapeutic guidelines for ABI patients.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Multidisciplinary Sciences
Fushun Wang, Wei Wang, Simeng Gu, Dan Qi, Nathan A. Smith, Weiguo Peng, Wei Dong, Jiajin Yuan, Binbin Zhao, Ying Mao, Peng Cao, Qing Richard Lu, Lee A. Shapiro, S. Stephen Yi, Erxi Wu, Jason H. Huang
Summary: The researchers discovered two distinct astrocytic Ca2+ signals in the mouse barrel cortex, which play different roles in modulating sensory transmission during sleep and arousal states.
NATURE COMMUNICATIONS
(2023)
Correction
Neurosciences
Lijuan Zhang, Yafei Wang, Taohui Liu, Ying Mao, Bo Peng
NEUROSCIENCE BULLETIN
(2023)
Article
Physics, Multidisciplinary
Andrea Buccellato, Yasir Catal, Patrizia Bisiacchi, Di Zang, Federico Zilio, Zhe Wang, Zengxin Qi, Ruizhe Zheng, Zeyu Xu, Xuehai Wu, Alessandra Del Felice, Ying Mao, Georg Northoff
Summary: In this study, the use of permutation entropy (PE) is proposed to estimate time delays from neural time series, which is a more robust alternative to autocorrelation window (ACW). The validity of this approach is demonstrated on synthetic neural data and hd-EEG human data, suggesting its potential use for characterizing conscious states.
Article
Acoustics
Shaoyuan Yan, Jiajun Shou, Junjin Yu, Jianping Song, Ying Mao, Kailiang Xu
Summary: The study developed an ultrafast ultrasound vector Doppler (ultrafast UVD) method for small vasculature hemodynamic imaging by combining multiangle vector Doppler strategy and ultrafast sequencing. The validity of the technique was demonstrated through experiments on a rotational phantom, rat brain, human brain, and human spinal cord. Compared with the widely accepted accurate flow velocimetry technique ultrasound localization microscopy (ULM), the rat brain experiment showed that the average relative error (ARE) of the velocity magnitude estimated by ultrafast UVD was approximately 16.2%, with a root-mean-square error (RMSE) of the velocity direction of 26.7°. The results demonstrated that ultrafast UVD is a promising tool for accurate blood flow velocity measurement, especially for organs with vasculature typically exhibiting tendential alignment of vascular trees, such as the brain and spinal cord.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2023)
Article
Chemistry, Physical
Mengqi Liu, Shuang Xia, Wenjian Wan, Jun Qin, Hua Li, Changying Zhao, Lei Bi, Cheng-Wei Qiu
Summary: Using doped InAs multilayers under moderate external magnetic fields with gradient epsilon-near-zero frequencies, broadband non-reciprocal absorption that can be tailored within the mid-infrared spectral region has been demonstrated. The study of magneto-optical absorption has stimulated diverse energy-technology-related explorations, showing potential in breaking the current theoretical efficiency limits of energy devices compared with reciprocal counterparts. However, experimentally realizing strong infrared non-reciprocal absorption remains an open challenge, and existing proposals of non-reciprocal absorbers are restricted to a narrow working waveband.
Article
Optics
Mengyu Yang, Xin Shen, Ziping Li, Zhongquan Wen, Gang Chen, Zhihai Zhang, Gaofeng Liang, Hua Li, Zhengguo Shang
Summary: A method is introduced to design a hybrid metalens at terahertz frequency, achieving a large numerical aperture and high focusing efficiency. Experimental results demonstrate significantly increased focusing efficiency and promising application prospects in complex optical systems.
Article
Nanoscience & Nanotechnology
Xiaohong Li, Peng Bai, Siheng Huang, Wenjun Song, Xinran Lian, Cheng Hu, Zhiwen Shi, Wenzhong Shen, Zhanglong Fu, Dixiang Shao, Zhiyong Tan, Juncheng Cao, Cheng Tan, Gangyi Xu, Yueheng Zhang
Summary: Ultra-broadband detection and imaging devices with highspeed,high bandwidth, and high sensitivity are in great demand. An ultra-broadband high-speed device, called HIWIP-photodiode, is realized using a p-GaAs homojunction interfacial work function internal photoemission detector. This device achieves dual-band response from terahertz to short-wavelength-infrared (SWIR) and visible/near-infrared regions simultaneously. It also demonstrates high-resolution pixelless imaging for the mid-infrared spot. The HIWIP-photodiode shows unique characteristics that make it a strong contender for miniaturized and monolithic optoelectronic systems, providing an alternative strategy for photon-type ultra-broadband detection.
Article
Engineering, Electrical & Electronic
Zhengnan Fu, Zhanglong Fu, Zhiyong Tan, Juncheng Cao
Summary: This letter presents a pixel-level, high-dynamic-range, low-power, digital-readout-integrated circuit (DROIC) for infrared focal-plane array (IRFPA). It employs nonfeedback-reset pulse-frequency-modulation (PFM) technology to improve linearity and reduce power consumption. The DROIC is designed and simulated using a 180-nm one-poly six-metal CMOS process, with pixel pitch of 15 μm, effective number of 15.93 bits, linearity up to 99.60%, power consumption of 1.303 μW, and dynamic range of 100.2 dB.
IEEE SENSORS LETTERS
(2023)
Article
Materials Science, Multidisciplinary
Ran Jing, Rocco A. Vitalone, Suheng Xu, Chiu Fan Bowen Lo, Zaiyao Fei, Elliott Runburg, Yinming Shao, Xinzhong Chen, Fabian Mooshammer, Alexander S. Mcleod, Mengkun Liu, Michael M. Fogler, David H. Cobden, Xiaodong Xu, D. N. Basov
Summary: In this study, the real-space features of the plasmonic response of few-layer WTe2 were visualized and evaluated using time-domain THz nanoimaging technique combined with scattering amplitude experiments.
