Article
Microbiology
Jiaqi Cheng, Jun Yan, Zeferino Reyna, Matt Slarve, Peggy Lu, Brad Spellberg, Brian Luna
Summary: The study found that rifabutin and colistin showed synergistic effects in combating Acinetobacter baumannii, with low-dose colistin significantly suppressing the emergence of rifabutin resistance. This combination presents a promising therapeutic option for highly resistant A. baumannii infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Immunology
Xiaoqing Wang, Belinda Loh, Fernando Gordillo Altamirano, Yunsong Yu, Xiaoting Hua, Sebastian Leptihn
Summary: Multidrug-resistant bacterial infections are on the rise, leading to the search for new therapeutic approaches. Phage therapy is gaining attention as an alternative treatment strategy, but faces the challenge of phage-resistant bacteria. This study aims to understand the mechanisms of phage resistance in Acinetobacter baumannii and identifies potential strategies that could be exploited in clinical settings.
EMERGING MICROBES & INFECTIONS
(2021)
Review
Immunology
Chunli Sun, Yunsong Yu, Xiaoting Hua
Summary: Acinetobacter baumannii is a common pathogen causing various infectious diseases and has a high drug resistance rate, severely limiting antibiotic treatment options. Tigecycline and polymyxins are considered the last line of defense against multidrug resistant A. baumannii. This review focuses on the mechanisms of tigecycline resistance in A. baumannii and highlights the need for further investigation and development of new antibiotics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Infectious Diseases
Hector Olmeda-Lopez, Andres Corral-Lugo, Michael J. McConnell
Summary: This study explores previously uncharacterized aspects regarding the acquisition of colistin resistance through insertional activation in LOS biosynthesis genes in A. baumannii. The findings suggest that subinhibitory concentrations of tetracycline significantly increase ISAba11 insertion, and rifampicin completely inhibits the emergence of colistin resistance due to ISAba11 inactivation of lpxC. Sequencing of ISAba11 insertion sites within the lpxC gene demonstrates a hotspot for insertion between nucleotides 382 and 618, with a semi-conserved AT-rich consensus sequence upstream of the insertion site.
Article
Microbiology
Deepak Kumar, Chaitali Singhal, Manisha Yadav, Pooja Joshi, Priyanka Patra, Subhash Tanwar, Amitava Das, Sumit Kumar Pramanik, Susmita Chaudhuri
Summary: A novel nano-formulation, AD-L@Ag(0), has been developed to sensitize Acinetobacter baumannii to colistin. This formulation shows potential in enhancing the efficacy of colistin against multidrug resistant bacteria. The study demonstrates that AD-L@Ag(0) can potentiate the antimicrobial activity of colistin, offering an alternative strategy to combat colistin-resistant AB infections.
FRONTIERS IN MICROBIOLOGY
(2023)
Editorial Material
Microbiology
Santiago Castillo-Ramirez
Summary: A recent study published in mBio sequenced the genomes of 313 carbapenem-resistant A. baumannii isolates from over 100 hospitals in almost 50 countries, providing an updated view of the global distribution of major international clones and their carbapenemase genes. Future global genomic epidemiology studies can be enhanced by considering both human and non-human isolates and their antibiotic resistance profiles.
Article
Biochemistry & Molecular Biology
Jovana Kabic, Katarina Novovic, Dusan Kekic, Anika Trudic, Natasa Opavski, Ivica Dimkic, Branko Jovcic, Ina Gajic
Summary: This study aimed to investigate the prevalence and resistance mechanisms of colistin-resistant Acinetobacter baumannii (ColRAB) isolates in Serbia, assess their genetic relatedness to other circulating A. baumannii isolates in the neighbouring European countries, and analyse the global genomic epidemiology of ColRAB isolates. The findings reveal the central role of the twocomponent regulating system, PmrAB, and increased expression of the pmrC gene in colistin resistance in A. baumannii. The study also highlights the global dissemination of several high-risk clonal lineages of ColRAB isolates.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Infectious Diseases
Filomena Sannio, Antonella Brizzi, Rosita Del Prete, Marialuce Avigliano, Tiziana Simone, Carlotta Pagli, Teresa Ferraro, Filomena De Luca, Marco Paolino, Federico Corelli, Claudia Mugnaini, Jean-Denis Docquier
Summary: The diffusion of antibiotic-resistant Gram-negative pathogens is a global public health issue. Acinetobacter baumannii, despite causing fewer infections, often shows multidrug-resistance, including carbapenem resistance. In this study, a new series of pyrazole compounds was synthesized, some of which showed direct-acting antibacterial activity on Gram-positive organisms. Additionally, two highly active compounds against multidrug-resistant A. baumannii, including colistin-resistant isolates, were identified as potential antibiotic adjuvants. This work highlights the significance of pyrazole amides in developing synergistic antibacterial compounds against antibiotic-resistant Gram-negative pathogens.
Article
Microbiology
Greater Kayode Oyejobi, Sunday Olabode Olaniyan, Nana-Aishat Yusuf, Deborah Adepeju Ojewande, Mobolaji Johnson Awopetu, Goodness Opeyemi Oyeniran, Fazal Mehmood Khan, Peter Alabi Dare, Maryam Kikelomo Adegbite-Badmus
Summary: Acinetobacter baumannii is an important nosocomial and opportunistic pathogen with high antibiotic resistance. New treatment approaches like the use of bacteriophage, phage-antibiotic combinations, and resistance-driven fitness losses are crucial for controlling its infections.
MICROBIOLOGICAL RESEARCH
(2022)
Article
Immunology
Reza Khoshbakht, Susan Panahi, Alireza Neshani, Mahdis Ghavidel, Kiarash Ghazvini
Summary: Acinetobacter baumannii is becoming increasingly resistant to antibiotics, including carbapenems. Colistin is currently used as a last resort against resistant strains, but reports of Colistin-resistant phenotypes are emerging. Quorum quenching, which disrupts bacteria's communication and biofilm formation, shows promise as an alternative method to combat resistance in A. baumannii.
MICROBIAL PATHOGENESIS
(2023)
Article
Immunology
Michael J. McConnell, Antonio J. Martin-Galiano
Summary: This study utilized proteomic and computational data to identify a larger number of potentially immunogenic proteins in the Acinetobacter baumannii panproteome. The study found that certain antigens showed potential cross-reactivity with human proteins and were associated with different infection types. The integration of multi-omic data and knowledge of drug-resistant bacteria can aid in the development of effective multi-antigen vaccines against challenging infections.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Aminul Islam, Luis A. Actis, Timothy J. Wilson
Summary: This study reveals that natural antibodies (NAbs) enhance the host's immune response against A. baumannii infection, potentially leading to the development of effective therapies for human infections caused by antibiotic-resistant A. baumannii.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Microbiology
Marco Falcone, Giusy Tiseo, Alessandro Leonildi, Leonardo Della Sala, Alessandra Vecchione, Simona Barnini, Alessio Farcomeni, Francesco Menichetti
Summary: Cefiderocol appears to be a promising therapeutic option for carbapenem-resistant Acinetobacter baumannii (CRAB) infections, with a potential protective effect on 30-day mortality. However, further studies are needed to address the issue of microbiological failure.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Federica Sacco, Camilla Bitossi, Bruno Casciaro, Maria Rosa Loffredo, Guendalina Fabiano, Luisa Torrini, Flavia Raponi, Giammarco Raponi, Maria Luisa Mangoni
Summary: Multidrug-resistant microbial infections and the scarcity of new antibiotics pose a serious threat to global health security. In this study, we found that a combination of a frog-skin antimicrobial peptide, Esc(1-21), and colistin exhibited synergistic effects against colistin-resistant Acinetobacter baumannii clinical isolates, suggesting a potential clinical application of this combination therapy.
Article
Infectious Diseases
Ye Tao, Sebastien Acket, Emma Beaumont, Henri Galez, Luminita Duma, Yannick Rossez
Summary: The study conducted a detailed analysis of the lipidomics of multidrug-resistant Acinetobacter baumannii, revealing significant changes in lipid content in susceptible and resistant strains at colistin concentrations, highlighting the plasma membrane plasticity used by this gram-negative bacterium to cope with colistin treatment.