期刊
ACS BIOMATERIALS SCIENCE & ENGINEERING
卷 4, 期 3, 页码 1083-1091出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsbiomaterials.7b00901
关键词
Au-PLGA hybrid nanoparticles; photoacoustic imaging; catalase-mimicking activity chemo/photothermal therapy
资金
- National Natural Science Foundation of China [21703198]
- Interdisciplinary Subject Construction Foundation of Yangzhou University [jcxk 2015-19]
- University Natural Science Foundation of Jiangsu Province [16KJD150004]
- Social Development Project of Yangzhou City [YZ2016074]
- Priority Academic Program Development of Jiangsu Higher Education Institutions
- Top-notch Academic Programs Project of Jiangsu Higher Education Institutions
Imaging-guided diagnosis and therapy has been highlighted in the area of nanomedicines. However, integrating multiple functions with high performance in one theranostic (all-in-one) still presents considerable challenges. Here, all-in-one nanoparticles with drug-loading capacity, catalase-mimetic activity, photoacoustic (PA) imaging ability and photothermal properties were prepared by decorating Au nanoparticles on doxorubicin (DOX) encapsulated poly(lactic-co-glycolic acid) (PLGA) vehicle. The results revealed that the as-prepared Au-PLGA hybrid nanoparticles possessed high photothermal conversion efficiency of up to approximately 69.0%, meanwhile their strong acoustic generation endowed them with efficient PA signal sensing for cancer diagnosis. On an 808 nm laser irradiation, the O-2 generation, DOX release profile and reactive oxygen species (ROS) level were all improved, which were beneficial to relieving tumor hypoxia and enhanced the cancer chemo/PTT combined therapy. Overall, the multifunctional Au-PLGA hybrid nanoparticles with these integrated advantages shows promise in PA imaging-guided diagnosis and synergistic tumor ablation.
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