Article
Neurosciences
Christopher R. Madan
Summary: A study found that cortical gyrification decreases with aging, potentially due to changes in sulcal morphology with age. This suggests a different underlying mechanism compared to age effects on cortical thickness.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Xi Wang, Lu Lu, Meng Liao, Hong Wei, Xiaohang Chen, Xiaoqi Huang, Longqian Liu, Qiyong Gong
Summary: This study investigated the cortical differences between children with intermittent exotropia (IXT) and healthy controls (HCs) using high-resolution magnetic resonance imaging (MRI). The results showed significant alterations in surface area and cortical thickness in specific brain regions of IXT patients, as well as differences in age-related cortical differences and structural covariance compared to HCs.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Medicine, General & Internal
Chengwei Shen, Qi Jiang, Yan Luo, Ji Long, Xiujuan Tai, Shuqing Liu
Summary: Previous studies have found inhibitory deficits in dyslexic children, with differences in brain activation patterns between dyslexic and non-dyslexic children during the Stroop color-word test. Dyslexic children have poorer inhibitory function which may be related to their abnormal brain activation patterns.
Review
Multidisciplinary Sciences
Bartosz M. Radtke, Urszula Sajewicz-Radtke, Lucja Bieleninik, Malgorzata Lipowska
Summary: Developmental learning disorder (DLD) is a neurodevelopmental disorder that results from the developmental neurodiversity of the brain. Genetics is the main cause of DLD, but environmental factors such as inadequate oxygen supply during pregnancy or labor are also considered.
Article
Psychology, Multidisciplinary
Emanuele Casani, Mila Vulchanova, Anna Cardinaletti
Summary: Morphosyntactic competence influences reading accuracy in Italian children, both with and without developmental dyslexia (DD). Children with DD exhibit lower accuracy and speed in reading, while decoding function words and morphologically complex words have a significant impact on reading accuracy.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Valentina Borghesani, Cheng Wang, Christa Watson, Florence Bouhali, Eduardo Caverzasi, Giovanni Battistella, Rian Bogley, Nicole A. Yabut, Jessica Deleon, Zachary A. Miller, Fumiko Hoeft, Maria Luisa Mandelli, Maria Luisa Gorno-Tempini
Summary: This study compared structural and functional MRI data of children with dyslexia and typically developing readers and found significant differences in both measures. Children with dyslexia showed lack of selectivity for words in the left vOT, which was associated with increased neurite dispersion heterogeneity. This study provides new insights into the neurobiology of word tuning in dyslexia.
JOURNAL OF NEUROIMAGING
(2021)
Article
Chemistry, Multidisciplinary
Guodong Hong, Xiaolong Fu, Xin Chen, Liyan Zhang, Xuan Han, Shuqin Ding, Ziyi Liu, Xiuli Bi, Wen Li, Miao Chang, Ruifeng Qiao, Siwei Guo, Hailong Tu, Renjie Chai
Summary: This study finds that knockout of the Dyslexia susceptibility 1 candidate 1 (Dyx1c1) gene in mice results in severe hearing loss, making it a good model for studying the mechanism of Dyslexia-related hearing loss (DRHL). The study reveals that Dyx1c1 gene is highly expressed in the mouse cochlea and the electrical activity of inner hair cells and type I spiral ganglion neurons is altered in Dyx1c1(-/-) mice. Additionally, the study shows that Dyx1c1(-/-) mice exhibit phenotypes related to primary ciliary dyskinesia, such as situs inversus and disrupted ciliary structure. In conclusion, this study provides new insights into the mechanism of DRHL and suggests Dyx1c1 as a potential target for clinical diagnosis of DRHL.
Article
Neurosciences
Martina Hedenius, Jonas Persson
Summary: This study aimed to test the impact of the striatum on developmental dyslexia (DD), and found that the DD group showed less activation of the striatum during the processing of sequential statistical regularities. Additionally, hippocampal activity and caudate nucleus volume played different roles in sequence learning between the typically developing (TD) group and the DD group.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Xinyi Xu, Cong Sun, Jiwei Sun, Wen Shi, Yao Shen, Ruoke Zhao, Wanrong Luo, Mingyang Li, Guangbin Wang, Dan Wu
Summary: This study established a spatiotemporal atlas of normal fetal brain development in the Chinese population using in utero MRI, revealing various cortical morphology indices and developmental patterns. The findings showed different developmental trajectories of cortical thickness, curvature, sulcal depth, and surface area, as well as developmental gradients among cortical regions.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Theresa C. Sutherland, Arthur Sefiani, Darijana Horvat, Taylor E. Huntington, Yuanjiu Lei, A. Phillip West, Cedric G. Geoffroy
Summary: The age of incidence of spinal cord injury is increasing, and the average age of people living with SCI is also rising. However, research on SCI has mainly focused on young animals, making it difficult to translate findings to clinical applications. Aging neurons show dysfunctional mitochondria, which may be associated with age-dependent reduction in neurite growth. This presents a challenge for the aging SCI population, as both normal aging and traumatic injury are linked to mitochondrial dysfunction.
Article
Neurosciences
Chunhong Cao, Yongquan Li, Lele Zhang, Fang Hu, Xieping Gao
Summary: This paper aims to develop a deep network model for fast identification of the Cortical 3-Hinges Folding Pattern based on cortical morphological and structural features. The proposed model achieves better performance in terms of time consumption, and it reveals the critical role of cortical sulcus information and the supplementary information provided by cortical thickness, surface area, and volume characteristics in 3-Hinges identification. Additionally, significant structural differences on 3-Hinges among adolescent gender are discovered.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Marvin Petersen, Felix L. Naegele, Carola Mayer, Maximilian Schell, D. Leander Rimmele, Elina Petersen, Simone Kuehn, Juergen Gallinat, Uta Hanning, Jens Fiehler, Raphael Twerenbold, Christian Gerloff, Goetz Thomalla, Bastian Cheng
Summary: The study identified a pattern of age-related cortical thickness differences, particularly with pronounced age effects in sensorimotor areas, showing strong correlations with connectivity profiles of functional and structural brain networks. Additionally, the identified difference pattern significantly covaried with cognitive and motor performance.
Article
Neurosciences
Zhengyan Liu, Junjun Li, Hong-Yan Bi, Min Xu, Yang Yang
Summary: This study examined the functional brain networks associated with handwriting in Chinese children with developmental dyslexia. The results showed reduced network connectivity between the sensory-motor network and the visual network, and between the default mode network and the ventral attention network in dyslexic children during handwriting. The strength of these networks was correlated with handwriting speed, reading, and working memory.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yusi Zhang, Jiayang Huang, Li Huang, Lixin Peng, Xiuxiu Wang, Qingqing Zhang, Yi Zeng, Junchao Yang, Zuanfang Li, Xi Sun, Shengxiang Liang
Summary: This study found that individuals with DD have atypical structural connectivity in brain regions related to visual attention and memory, which may impact the information input and integration needed for reading and spelling.
NEUROLOGICAL SCIENCES
(2023)
Article
Neurosciences
Flaminia Reda, Maurizio Gorgoni, Aurora D'Atri, Serena Scarpelli, Matteo Carpi, Erica Di Cola, Deny Menghini, Stefano Vicari, Giacomo Stella, Luigi De Gennaro
Summary: Sleep plays a crucial role in memory processes, and maturational changes in sleep electrophysiology are involved in cognitive development. A study compared sleep topography and associated sleep-related declarative memory consolidation in participants with Developmental Dyslexia (DD) and normal readers (NR). The results showed specific alterations in local sleep EEG (i.e., sleep spindles) and in sleep-dependent memory consolidation processes in DD, calling for a topographical approach to shed light on potential alterations in regional cortical oscillation dynamics in DD.
Article
Neuroimaging
Carmen Tur, Francesco Grussu, Floriana De Angelis, Ferran Prados, Baris Kanber, Alberto Calvi, Arman Eshaghi, Thalis Charalambous, Rosa Cortese, Declan T. Chard, Jeremy Chataway, Alan J. Thompson, Olga Ciccarelli, Claudia A. M. Gandini Wheeler-Kingshott
Summary: Predicting disability in progressive multiple sclerosis (MS) is challenging due to the lack of established quantitative metrics characterizing spatial distribution of white matter (WM) lesions. A novel approach, SPACE-MS, was introduced to quantitatively characterize spatial distributional features of brain MS lesions, showing that lesions in lower parts of the brain and more isotropic spreading of lesions are associated with clinical deterioration in progressive MS. This approach may be applicable to other conditions with brain WM lesions.
NEUROIMAGE-CLINICAL
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julien Cohen-Adad, Eva Alonso-Ortiz, Stephanie Alley, Maria Marcella Lagana, Francesca Baglio, Signe Johanna Vannesjo, Haleh Karbasforoushan, Maryam Seif, Alan C. Seifert, Junqian Xu, Joo-Won Kim, Rene Labounek, Lubomir Vojtisek, Marek Dostal, Jan Valosek, Rebecca S. Samson, Francesco Grussu, Marco Battiston, Claudia A. M. Gandini Wheeler-Kingshott, Marios C. Yiannakas, Guillaume Gilbert, Torben Schneider, Brian Johnson, Ferran Prados
Summary: This study compared different MRI protocols (1.5 T, 3 T, and 7 T) for visualizing spinal cord gray matter. Qualitative assessments indicated comparable image quality for 3 T and 7 T scans, while 1.5 T scans had moderate to low image quality. The proposed evaluation criteria and metrics can serve as a benchmark for optimizing spinal cord gray matter imaging protocols in the future.
MAGNETIC RESONANCE IN MEDICINE
(2022)
Article
Clinical Neurology
Alberto Calvi, Ferran Prados Carrasco, Carmen Tur, Declan T. Chard, Jonathan Stutters, Floriana De Angelis, Nevin John, Thomas Williams, Anisha Doshi, Rebecca S. Samson, David MacManus, Claudia A. Gandini Wheeler-Kingshott, Olga Ciccarelli, Jeremy Chataway, Frederik Barkhof
Summary: This study found that slowly expanding lesions (SELs) make up a significant proportion of T2 lesions in secondary progressive multiple sclerosis (SPMS). These lesions are associated with neurodegenerative MRI markers and clinical worsening, suggesting that they may contribute to disease progression and be a new target for therapeutic interventions.
Article
Clinical Neurology
Anna Nigri, Stefania Ferraro, Claudia A. M. Gandini Wheeler-Kingshott, Michela Tosetti, Alberto Redolfi, Gianluigi Forloni, Egidio D'Angelo, Domenico Aquino, Laura Biagi, Paolo Bosco, Irene Carne, Silvia De Francesco, Greta Demichelis, Ruben Gianeri, Maria Marcella Lagana, Edoardo Micotti, Antonio Napolitano, Fulvia Palesi, Alice Pirastru, Giovanni Savini, Elisa Alberici, Carmelo Amato, Filippo Arrigoni, Francesca Baglio, Marco Bozzali, Antonella Castellano, Carlo Cavaliere, Valeria Elisa Contarino, Giulio Ferrazzi, Simona Gaudino, Silvia Marino, Vittorio Manzo, Luigi Pavone, Letterio S. Politi, Luca Roccatagliata, Elisa Rognone, Andrea Rossi, Caterina Tonon, Raffaele Lodi, Fabrizio Tagliavini, Maria Grazia Bruzzone
Summary: Neuroimaging studies often lack reproducibility. To address this issue, the RIN-Neuroimaging Network, a national consortium, was established to identify neuroimaging biomarkers of various neurological conditions. Through the establishment of standard procedures and a web-based infrastructure, this network aims to enhance data collection and sharing across multiple institutes.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cell Biology
Giuseppe Gagliano, Anita Monteverdi, Stefano Casali, Umberto Laforenza, Claudia A. M. Gandini Wheeler-Kingshott, Egidio D'Angelo, Lisa Mapelli
Summary: This study investigates the relationship between neurovascular coupling (NVC) and neuronal activity (NA) using acute mouse cerebellar slices. The findings suggest that NVC involves a balance between the NMDAR-NO pathway and the mGluRs-20HETE pathway, with the latter playing a role at intermediate frequencies. This has important implications for interpreting fMRI signals.
Review
Neurosciences
Alberto Redolfi, Damiano Archetti, Silvia De Francesco, Claudio Crema, Fabrizio Tagliavini, Raffaele Lodi, Roberta Ghidoni, Claudia A. M. Gandini Wheeler-Kingshott, Daniel C. Alexander, Egidio D'Angelo
Summary: Neuroinformatics is a research field that focuses on software tools for identifying, analyzing, modeling, organizing, and sharing neuroscience data. With the emergence of big data, neuroinformatics has experienced rapid growth in the past two decades, enabling neuroscientists to acquire and process data faster and more cost-effectively. To address this, neuroimaging-focused neuroinformatics platforms have been developed, aiming to archive and organize data, develop data-driven models, and provide computational and storage resources.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Marta Lancione, Paolo Bosco, Mauro Costagli, Anna Nigri, Domenico Aquino, Irene Carne, Stefania Ferraro, Giovanni Giulietti, Antonio Napolitano, Fulvia Palesi, Luigi Pavone, Alice Pirastru, Giovanni Savini, Fabrizio Tagliavini, Maria Grazia Bruzzone, Claudia A. M. Gandini Wheeler-Kingshott, Michela Tosetti, Laura Biagi
Summary: Quantitative Susceptibility Mapping (QSM) is a technique in MRI that quantifies iron content and myelination in the brain. The RIN - Neuroimaging Network established an optimized protocol for QSM across multiple sites with 3T MRI systems, showing good reproducibility. This protocol can be used as a quantitative biomarker in multicentric studies.
PHYSICA MEDICA-EUROPEAN JOURNAL OF MEDICAL PHYSICS
(2022)
Article
Clinical Neurology
Gilbert Thomas-Black, Daniel R. Altmann, Harry Crook, Nita Solanky, Ferran Prados Carrasco, Marco Battiston, Francesco Grussu, Marios C. Yiannakas, Baris Kanber, Jasleen K. Jolly, Jon Brett, Susan M. Downes, Marni Moran, Ping K. Chan, Emmanuel Adewunmi, Claudia A. M. Gandini Wheeler-Kingshott, Andrea H. Nemeth, Richard Festenstein, Fion Bremner, Paola Giunti
Summary: This study comprehensively evaluated the degeneration of the retina in FRDA patients and found heterogeneity in different retinal sectors. The thickness of the retinal nerve fiber layer was associated with frataxin levels. These findings have implications for future clinical trial design.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Wallace J. Brownlee, Carmen Tur, Andreea Manole, Arman Eshaghi, Ferran Prados, Katherine A. Miszkiel, Claudia A. M. Gandini Wheeler-Kingshott, Henry Houlden, Olga Ciccarelli
Summary: This study found that HLA-DRB1*1501 is associated with the severity of multiple sclerosis (MS), as indicated by long-term disability worsening and greater extent of inflammatory disease activity and tissue loss. HLA-DRB1*1501 may provide useful information for prognosis and treatment decisions in early relapse-onset MS.
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Clinical Neurology
Iris J. Broce, Eduardo Caverzasi, Simone Sacco, Ryan Michael Nillo, Matteo Paoletti, Rahul S. Desikan, Michael Geschwind, Leo P. Sugrue
Summary: This study investigated the relationship between regional PRNP expression in healthy brain tissue and diffusion abnormalities and atrophy patterns in patients with sporadic Creutzfeldt-Jakob disease (sCJD). PRNP microarray data from healthy brains and T1-weighted and diffusion-weighted MRIs from sCJD patients and healthy controls were used to examine correlations between PRNP expression, diffusion measures, cortical morphology, and local gyrification index. The results showed that regional patterns of PRNP expression were associated with diffusion abnormalities and atrophy in sCJD, with the local gyrification index exhibiting the strongest correlation. These findings suggest that the genetic and molecular environment influence the vulnerability of different brain regions to misfolding of the prion protein, which is reflected in imaging findings in sCJD. Larger studies are needed to validate these regional imaging patterns as reliable markers for distinct disease subtypes.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
Eduardo Caverzasi, Nico Papinutto, Christian Cordano, Gina Kirkish, Tristan J. Gundel, Alyssa Zhu, Amit Vijay Akula, W. John Boscardin, Heiko Neeb, Roland G. Henry, Jonah R. Chan, Ari J. Green
Summary: This study demonstrates that clemastine can induce myelin repair in patients with MS, and proposes myelin water fraction within the normal-appearing white matter of fibers as an imaging biomarker for assessing myelin restoration.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Clinical Neurology
Alberto Calvi, Zoe Mendelsohn, Weaam Hamed, Declan Chard, Carmen Tur, Jon Stutters, David MacManus, Baris Kanber, Claudia A. M. Gandini Wheeler-Kingshott, Frederik Barkhof, Ferran Prados
Summary: This study retrospectively analyzed a fingolimod trial in patients with primary progressive MS (PPMS) and found that newly appearing lesions are common and can develop into chronic active lesions. Treatment can reduce the number of these lesions.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rebecca R. Baker, Vivek Muthurangu, Marilena Rega, Javier Montalt-Tordera, Samuel Rot, Bhavana S. Solanky, Claudia A. M. Gandini Wheeler-Kingshott, Stephen B. Walsh, Jennifer A. Steeden
Summary: This study validated the use of 2D sodium MRI with half-sinc excitation and compressed sensing (CS) for quantifying tissue sodium concentration (TSC) with a resolution of 2.25 x 2.25 mm(2) and scan times of <= 5 mins.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Neuroimaging
Nicola De Stefano, Marco Battaglini, Deborah Pareto, Rosa Cortese, Jian Zhang, Niels Oesingmann, Ferran Prados, Maria A. Rocca, Paola Valsasina, Hugo Vrenken, Claudia A. M. Gandini Wheeler-Kingshott, Massimo Filippi, Frederik Barkhof, Alex Rovira
Summary: There is an increasing need to share harmonized data from large, cooperative studies for the development of new diagnostic and prognostic biomarkers. In the field of multiple sclerosis (MS), the harmonization of acquisition, analysis, and storage of large-scale multicentre MRI data is of paramount importance. Despite the advances made, further research and specialized resources are required to address the complexity of these tasks.
NEUROIMAGE-CLINICAL
(2022)
Article
Clinical Neurology
Boon Lead Tee, Christa Watson, Sladjana Lukic, Lynn P. Bajorek, Isabel Elaine Allen, Zachary A. Miller, Kaitlin B. Casaletto, Bruce L. Miller, Maria Luisa Gorno-Tempini
Summary: This study investigates the diagnostic utility of visuospatial profiles in primary progressive aphasia (PPA) and examines their neural basis. It finds that different PPA variants have distinct visuospatial cognitive profiles that correspond with changes in grey matter volume.
BRAIN COMMUNICATIONS
(2022)