Article
Multidisciplinary Sciences
Jiefeng Jiang, Joel Bruss, Woo-Tek Lee, Daniel Tranel, Aaron D. Boes
Summary: Cognitive control is crucial for adaptive behavior and is modulated by distributed neural computations. However, little is known about the anatomy of white matter tracts that coordinate these computations. In this study, the authors found that lesions in white matter connecting left frontoparietal regions reliably predicted deficits in cognitive control performance. These findings improve our understanding of the white matter correlates of cognitive control and provide a method for predicting deficits after lesions through network disconnection.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Bonnie Yin Ka Lam, Brian Yiu, Encarnita Ampil, Christopher Li-Hsian Chen, Yustiani Dikot, Jacqueline C. Dominguez, Patel Vishal Ganeshbhai, Saima Hilal, Nagaendran Kandiah, SangYun Kim, Jun-Young Lee, Anam Paulus Ong, Vorapun Senanarong, Kam Tat Leung, Huali Wang, Yuan-Han Yang, Tingting Yong, Faheem Arshad, Suvarna Alladi, Samuel Wong, Ho Ko, Alexander Yuk Lun Lau, Vincent Chung Tong Mok
Summary: This study aimed to investigate the burden of WML and its associated risk factors in different Asian societies. The prevalence of moderate-to-severe WML was highest in stroke/TIA patients, with Bandung Indonesia showing the highest prevalence. Hypertension and hyperlipidemia were significant risk factors for WML, which was negatively associated with cognitive performance in all groups.
SCIENTIFIC REPORTS
(2021)
Article
Clinical Neurology
Vincent Planche, Boris Mansencal, Jose V. Manjon, Thomas Tourdias, Gwenalle Catheline, Pierrick Coupe
Summary: This study describes the long-term anatomical progression of the three clinical variants of frontotemporal dementia (bvFTD, semantic dementia, and PNFA) using MRI data. The results show that subcortical atrophy precedes focal cortical atrophy in specific behavioral and/or language networks, with a radiological prodromal phase lasting 8-10 years.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Mark Bowren, Joel Bruss, Kenneth Manzel, Dylan Edwards, Charles Liu, Maurizio Corbetta, Daniel Tranel, Aaron D. Boes
Summary: Predicting chronic post-stroke outcomes is challenging due to individual variability and reliance on clinical heuristics. This study explores the use of lesion-behaviour mapping and structural and functional lesion networks to improve prediction of 12-month cognitive and motor outcomes in stroke patients. The results show that both methods can significantly predict variance in outcomes, with variations in performance for specific deficits.
Article
Clinical Neurology
Christoph Sperber, Laura Gallucci, Roza Umarova
Summary: For years, dissociation studies on neurological single-case patients with brain lesions were used to infer cognitive functions in neuropsychology, but the association between deficits was considered of less value. In contrast, computational methods such as principal component analysis became popular for identifying cognitive functions in stroke patients. However, the anatomy of stroke lesions alone influenced the dimensionality of data and limited the interpretability of cognitive deficits and insights into human cognitive architecture. It is suggested to use qualitative criteria and dissociation patterns to refine estimates and optimize interpretation strategies in cognitive deficit studies.
Article
Neuroimaging
Yoonhye Na, JeYoung Jung, Christopher R. Tench, Dorothee P. Auer, Sung-Bom Pyun
Summary: This study provides a comprehensive overview of the neuroanatomical basis in post-stroke aphasia by analyzing lesion-symptom mapping studies. The results reveal that different patterns of lesions are associated with different language functions and tasks. Damage to the insular-motor areas impairs speech production while preserving comprehension, while damage in the frontal area severely impairs speaking with relatively better comprehension. Lesions in the posterior superior temporal gyrus result in repetition-selective deficits, and damage in the anterior-to-posterior temporal cortex is associated with semantic deficits.
NEUROIMAGE-CLINICAL
(2022)
Article
Anatomy & Morphology
Nicholas E. Souter, Xiuyi Wang, Hannah Thompson, Katya Krieger-Redwood, Ajay D. Halai, Matthew A. Lambon Ralph, Michel Thiebaut de Schotten, Elizabeth Jefferies
Summary: Patients with semantic aphasia following left hemisphere stroke often have impaired control of semantic retrieval and executive dysfunction. This study found that the deficits in semantic cognition were associated with infarctions in distributed left-hemisphere regions, while executive dysfunction was linked to adjacent but distinct left frontoparietal clusters. Furthermore, performance on executive tasks was related to interhemispheric structural disconnection, while poor semantic cognition was associated with left-lateralized structurally disconnected clusters.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Clinical Neurology
Vincent Planche, Vincent Bouteloup, Jean-Francois Mangin, Bruno Dubois, Julien Delrieu, Florence Pasquier, Frederic Blanc, Claire Paquet, Olivier Hanon, Audrey Gabelle, Matthieu Ceccaldi, Cedric Annweiler, Pierre Krolak-Salmon, Marie-Odile Habert, Clara Fischer, Marie Chupin, Yannick Bejot, Olivier Godefroy, David Wallon, Mathilde Sauvee, Isabelle Bourdel-Marchasson, Isabelle Jalenques, Francois Tison, Genevieve Chene, Carole Dufouil
Summary: In individuals attending memory clinics, categorization of atrophy subtypes predicted different patterns of cognitive decline and rates of conversion to distinct etiologies of dementia.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Lingling Ding, Hao Liu, Jing Jing, Yong Jiang, Xia Meng, Yaojing Chen, Xingquan Zhao, Haijun Niu, Tao Liu, Yongjun Wang, Zixiao Li
Summary: In this study, a comprehensive map of strategic lesion network localizations for neurological deficits in acute ischemic stroke (AIS) patients was created. Prognostic neuroimaging biomarkers were identified to aid in the early detection of high-risk patients with poor functional outcomes.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Nick A. A. Weaver, Muhammad Hasnain Mamdani, Jae-Sung Lim, Johannes Matthijs Biesbroek, Geert Jan Biessels, Irene M. C. Huenges Wajer, Yeonwook Kang, Beom Joon Kim, Byung-Chul Lee, Keon-Joo Lee, Kyung-Ho Yu, Hee-Joon Bae, Danilo Bzdok, Hugo J. J. Kuijf
Summary: Studies in patients with brain lesions are important for understanding the brain's functional anatomy. Current lesion-symptom mapping approaches have limitations in evaluating multiple cognitive outcomes simultaneously. This study used canonical correlation analysis to improve the identification of infarct locations associated with deficits in verbal memory functions. The findings demonstrated that CCA can complement single-outcome LSM techniques in understanding cognitive functions and their neuroanatomical correlates.
HUMAN BRAIN MAPPING
(2023)
Article
Behavioral Sciences
Olivier Godefroy, Ardalan Aarabi, Flore Dorchies, Melanie Barbay, Daniela Andriuta, Momar Diouf, Michel Thiebaut de Schotten, Rania Kassir, Sophie Tasseel-Ponche, Martine Roussel, RECogVASC Study Grp
Summary: The study examined the functional organization and anatomy of executive functions using a verbal fluency task. A model of verbal fluency was proposed and supported by testing patients and controls. Lesion-symptom mapping and disconnectome analysis identified brain regions associated with fluency, but did not find specific regions for lexico-phonological search processes.
Article
Clinical Neurology
Antoine Weihs, Stefan Frenzel, Katharina Wittfeld, Anne Obst, Beate Stubbe, Mohamad Habes, Andras Szentkiralyi, Klaus Berger, Ingo Fietze, Thomas Penzel, Norbert Hosten, Ralf Ewert, Henry Voelzke, Helena U. Zacharias, Hans J. Grabe
Summary: Sleep disorders like obstructive sleep apnea (OSA) are linked to advanced brain aging, with indices AHI and ODI showing positive associations. This relationship is partially mediated by white blood cell count, indicating a subclinical inflammation process.
Article
Geriatrics & Gerontology
Yi Chen, Qingze Zeng, Yunyun Wang, Xiao Luo, Yan Sun, Lumi Zhang, Xiaoyan Liu, Kaicheng Li, Minming Zhang, Guoping Peng
Summary: Patients with PCA and SD show global cognitive impairment, with distinct patterns of abnormal FC in language, visual, and salience networks. The FC changes are related to cognitive deficits in both syndromes.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Multidisciplinary Sciences
Aaron Sathyanesan, Panagiotis Kratimenos, Vittorio Gallo
Summary: The study suggests that perinatal cerebellar injury can result in maladaptive changes in activity-dependent maturation of the cerebellar cortex, which can be replicated by inhibiting neonatal Purkinje cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Neurosciences
Hulya Ulugut, Anke A. Dijkstra, Marta Scarioni, Netherlands Brain Bank, Frederik Barkhof, Philip Scheltens, Annemieke J. M. Rozemuller, Yolande A. L. Pijnenburg
Summary: Despite being considered a right-sided variant of svPPA, rtvFTD may demonstrate either frontotemporal or temporal evolution. The most common underlying pathology is FTLD-TDP type C, but other pathologies such as Tau-MAPT and FTLD-TDP type A and B are also present in a significant percentage of rtvFTD cases. Additionally, motor neuron or corticospinal tract degeneration was observed in a portion of rtvFTD patients.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
