Article
Ophthalmology
Bilal Haj Najeeb, Gabor G. Deak, Georgios Mylonas, Stefan Sacu, Bianca S. Gerendas, Ursula Schmidt-Erfurth
Summary: This study found that retinal-choroidal anastomosis (RCA) is an exclusive clinical feature of macular neovascularization Type 3 (MNV3), and the incidence of fibrosis in MNV3 has significantly decreased.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Samuel D. Relton, Gloria C. Chi, Andrew J. Lotery, Robert M. West, Martin McKibbin
Summary: This study aimed to investigate non-persistence with treatment for neovascular age-related macular degeneration (NvAMD) and explore associations with baseline characteristics and variation between sites. An analysis of anonymised demographic and clinical data from National Health Service (NHS) Trusts in the UK showed that non-persistence with treatment was common, especially in the first year, and was often associated with decreased visual acuity. Factors such as treatment site, baseline visual acuity, and age were found to be strong predictors of treatment non-persistence. Understanding and addressing the reasons for non-persistence are crucial to ensure cost-effective use of expensive treatments and to maintain visual acuity.
Article
Ophthalmology
Ulrich Meyer-Bothling, Oliver Meyer-Bothling, Marika Pinney
Summary: The real-world observational study showed positive effects of enhanced patient interaction with the Noctura 400 sleep mask in patients with diabetic retinopathy and diabetic macular oedema. High patient compliance and significant improvements in maculopathy and visual acuity were maintained, even during disruptions caused by COVID-19.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Medicine, General & Internal
Hao Hu, Jiang Liu, Duolao Wang, Shanhu Qiu, Yang Yuan, Fenghua Wang, Liang Wen, Qi Song, Zi-lin Sun
Summary: Calcium dobesilate (CaD) has been used in the treatment of diabetic retinopathy (DR) due to its potential in protecting against retinal vascular damage. This study aims to evaluate whether CaD could prevent DR progression into an advanced stage among Chinese patients with mild-to-moderate non-proliferative DR (NPDR). The study is a single-blind, multicentre, cluster-randomised, controlled superiority trial with 1272 patients enrolled.
Article
Ophthalmology
Christophe Morel, John Conrath, Bruno Morin, Eric Parrat, Eleonora Zito, Catherine Desoudain, Anne Pernot, Guy Chauvet, Christian Hajjar, Stephanie Lemaitre, Pascale Billiard, Pierre Saint Blanquat, Jean Louis Uzel, Dominique Bezeaud, Frederic Villeroy, Patrick N'Guyen, Francois Devin, Frederic Matonti
Summary: The study confirmed the efficacy of intravitreal treatment of diabetic macular edema with aflibercept in the French overseas territories. However, a proportion of patients did not respond well to the treatment, highlighting the importance of patient education and collaboration with referring physicians for improved outcomes.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Susan P. Mollan, Dun Jack Fu, Ching-Yi Chuo, Jacqueline G. Gannon, Wen Hwa Lee, J. Jill Hopkins, Cian Hughes, Alastair K. Denniston, Pearse A. Keane, Ronald Cantrell
Summary: By combining data from a national digital health data repository with historical clinical trial data, we demonstrate an enhanced predictive modeling in nAMD. The detrimental effects of prolonged treatment delay should motivate healthcare providers to support nAMD patients in accessing care in safe environments.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Krishna M. Gokhale, Nicola J. Adderley, Anuradhaa Subramanian, Wen Hwa Lee, Diana Han, Jesse Coker, Tasanee Braithwaite, Alastair K. Denniston, Pearse A. Keane, Krishnarajah Nirantharakumar
Summary: This study aimed to explore the relationship between metformin use and the development of AMD in patients with type 2 diabetes in the UK. The results showed that there was no association between the use of metformin and the risk of developing AMD, regardless of whether other antidiabetic medications were also used.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Katie Etherton, Jugnoo S. Rahi, Harry Petrushkin, Andrew D. Dick, Saira Akbarali, Reshma Pattani, Scott Hau, Sandrine Lacassagne, Xiaoxuan Liu, Alastair K. Denniston, Ameenat Lola Solebo
Summary: The study suggests that OCT-based imaging has great potential in pediatric ophthalmic diseases, providing deeper understanding of diseases, improving patient experience, and more precise monitoring of disease activity, leading to improved treatment outcomes. However, further refinement of imaging and analysis protocols is needed.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
H. D. J. Hogg, L. Low, J. E. Self, J. S. Rahi
Summary: The COVID-19 pandemic has negatively impacted the research activities of UK ophthalmologists, resulting in loss of research time, research delays, and funding shortfalls. A substantial proportion of UK ophthalmologists are research active, but 20.4% of those surveyed felt that the pandemic had made research less attractive.
Editorial Material
Ophthalmology
Varun Chaudhary
Review
Ophthalmology
Thibaud Mathis, Frank G. Holz, Sobha Sivaprasad, Young Hee Yoon, Nicole Eter, Lee-Jen Chen, Adrian Koh, Eduardo Cunha de Souza, Giovanni Staurenghi
Summary: This review aims to identify the common characteristics and prognoses of different subtypes of neovascular age-related macular degeneration (nAMD) and propose recommendations for tailored treatments. Multimodal imaging facilitates accurate determination of subtypes and optimizes patient management.
Editorial Material
Ophthalmology
Oliver Zeitz, Sobha Sivaprasad, Antonia M. Joussen, Andrzej Grzybowski
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Editorial Material
Ophthalmology
Imran H. H. Yusuf, Christin Henein, Sobha Sivaprasad
Editorial Material
Ophthalmology
Imran H. H. Yusuf, Christin Henein, Sobha Sivaprasad
Editorial Material
Ophthalmology
Imran H. Yusuf, Christin Henein, Sobha Sivaprasad
Editorial Material
Ophthalmology
Imran H. Yusuf, Christin Henein, Sobha Sivaprasad
Article
Biochemistry & Molecular Biology
Shruti Chandra, Manjot K. Grewal, Sarega Gurudas, Rajan Sondh, Alan Bird, Glen Jeffery, Victor Chong, Sobha Sivaprasad
Summary: The qAF8 levels in patients with non-neovascular AMD were found to be significantly lower compared to age-matched controls, indicating a early and sustained loss of function of the retinal pigment epithelium in AMD.
Article
Substance Abuse
Felix Naughton, Aimie Hope, Chloe Siegele-Brown, Kelly Grant, Garry Barton, Caitlin Notley, Cecilia Mascolo, Tim Coleman, Lee Shepstone, Stephen Sutton, A. Toby Prevost, David Crane, Felix Greaves, Juliet High
Summary: This study aimed to evaluate the feasibility and effectiveness of the Quit Sense smartphone app, which helps smokers identify smoking cues and provides real-time support for quitting. The results showed that participants using Quit Sense had a sustained abstinence rate of 11.5% at 6 months, compared to 2.9% for those using usual care. The findings suggest that Quit Sense may be an effective smoking cessation tool.
NICOTINE & TOBACCO RESEARCH
(2023)
Article
Health Care Sciences & Services
Joanne Bayly, Hilde Hjelmeland Ahmedzai, Maria Grazia Blandini, Barbara Bressi, Augusto Tommaso Caraceni, Joana Carvalho Vasconcelos, Stefania Costi, Stefania Fugazzaro, Monica Guberti, Mai-Britt Guldin, May Hauken, Irene Higginson, Barry J. A. Laird, Julie Ling, Charles Normand, Lise Nottelmann, Line Oldervoll, Cathy Payne, A. Toby Prevost, Guro B. Stene, Elisa Vanzulli, Eduardo Veber, Guillaume Economos, Matthew Maddocks
Summary: This multinational trial aims to test the clinical and cost-effectiveness of a short-term palliative rehabilitation intervention for people with incurable cancer. Through comparative analysis, mixed-method evaluation, evidence synthesis, and Delphi consensus, the trial will contribute to the development of an international framework for palliative rehabilitation practice and policy.
PALLIATIVE CARE & SOCIAL PRACTICE
(2023)
Review
Ophthalmology
Stela Vujosevic, Emily Chew, Leanne Labriola, Sobha Sivaprasad, Ecosse Lamoureux
Summary: This narrative review assessed the available PROMs used in research on diabetic retinal diseases and highlighted areas for improvement. The most commonly used PROM is NEI VFQ-25, but it lacks the ideal psychometric, responsiveness, and clinical setting digital administration requirements for inclusion in an updated DRD staging system.
OPHTHALMOLOGY SCIENCE
(2024)