Article
Clinical Neurology
Finja Schweitzer, Yasemin Goereci, Christiana Franke, Steffi Silling, Fabian Bosl, Franziska Maier, Eva Heger, Birgit Deiman, Harald Pruss, Oezguer A. Onur, Florian Klein, Gereon R. Fink, Veronica Di Cristanziano, Clemens Warnke
Summary: The study found no evidence of SARS-CoV-2 in cerebrospinal fluid, and intrathecally produced anti-SARS-CoV-2 antibodies were not detected in post-COVID-19 syndrome patients. This suggests that a persistent central nervous system infection is unlikely to be the cause of neurological or neuropsychiatric post-COVID-19 syndrome.
ANNALS OF NEUROLOGY
(2022)
Article
Infectious Diseases
Guirong Wang, Ruixia Liang, Qing Sun, Xinlei Liao, Chenqian Wang, Hairong Huang
Summary: This study evaluated different methods for diagnosing central nervous system (CNS) involvement in patients with military tuberculosis (TB). The results showed that MRI had superior sensitivity and could be used as an initial diagnostic approach.
BMC INFECTIOUS DISEASES
(2022)
Article
Emergency Medicine
Ping Wang, Li-Ying Lin, Yuan-Qiang Lu
Summary: This article reports a case of diquat poisoning and highlights the importance of being aware of the development of pulmonary symptoms and neurological complications in patients. Interestingly, the study also found a correlation between the concentration of diquat in the cerebrospinal fluid and both the intracranial pressure and the severity of cerebral edema.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2024)
Article
Biotechnology & Applied Microbiology
Ying Liu, Weiwei Zhu, Mengfan Jiao, Wenhu Guo, Yonggang Luo
Summary: The clinical value of metagenomic next-generation sequencing (mNGS) in central nervous system (CNS) infections was evaluated in this study. mNGS and routine examination of cerebrospinal fluid (CSF) samples were retrospectively analyzed and compared with clinical diagnosis. The results showed that mNGS had a higher detection rate and identified additional pathogens compared to conventional methods. The sensitivity and specificity of mNGS in the diagnosis of CNS infections were 89.5% and 44%, respectively.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Huixin Xu, Ryann M. Fame, Cameron Sadegh, Jason Sutin, Christopher Naranjo, Della Syau, Jin Cui, Frederick B. Shipley, Amanda Vernon, Fan Gao, Yong Zhang, Michael J. Holtzman, Myriam Heiman, Benjamin C. Warf, Pei-Yi Lin, Maria K. Lehtinen
Summary: NKCC1 regulates the clearance of both CSF K+ and fluid volume through the choroid plexus during postnatal development in mice, implicating NKCC1 in regulating CSF clearance in the critical period during postnatal neurodevelopment.
NATURE COMMUNICATIONS
(2021)
Article
Pharmacology & Pharmacy
Yaqian Li, Wenpeng Lu, Xuecheng Zheng, Linhui Zhang, Weichong Dong, Xiaoxiao Zhao, Zongmao Zhao, Zhiqing Zhang
Summary: This study demonstrates that combined intravenous and intrathecal administration can significantly shorten the treatment time of MRSA ventriculitis and increase the exposure of the drug in cerebrospinal fluid without an increased risk of adverse reactions.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Immunology
Ronald J. Ellis, Scott Peterson, Mariana Cherner, Erin Morgan, Rachel Schrier, Bin Tang, Martin Hoenigl, Scott Letendre, Jenny Iudicello
Summary: This study suggests that cannabis may have a beneficial impact on HIV-associated blood-brain barrier (BBB) injury, with worse BBB index values correlated with higher levels of neural injury in cerebrospinal fluid (CSF). The findings support a potential therapeutic role of cannabis among people living with HIV (PWH) and may have important treatment implications for antiretroviral therapy (ART) effectiveness and toxicity.
CLINICAL INFECTIOUS DISEASES
(2021)
Review
Biochemistry & Molecular Biology
Maria Thastrup, Hanne Vibeke Marquart, Kjeld Schmiegelow
Summary: Despite the good prognosis of acute lymphoblastic lymphoma in children and adolescents, involvement of the central nervous system (CNS) remains a therapeutic challenge. The current method for detecting CNS involvement has low sensitivity, while flow cytometric analysis of cerebrospinal fluid (CSF) offers a novel and sensitive approach. Prospective studies have shown that flow cytometry detects CNS involvement at a higher rate than conventional methods and is particularly sensitive in detecting low-level CNS disease. Flow cytometry-detected CNS involvement is linked to a higher risk of relapse and poor outcomes in childhood ALL.
Article
Oncology
Jiayan Gu, Xin Huang, Yi Zhang, Chenhui Bao, Ziyang Zhou, Hongyan Tong, Jie Jin
Summary: This study evaluated the correlation between cerebrospinal fluid (CSF) cytokine levels and central nervous system (CNS) involvement in adult acute myeloid leukemia (AML). The results showed that CSF IL-6 is a promising marker for the diagnosis of adult AML with CNS involvement and is also associated with therapeutic response.
FRONTIERS IN ONCOLOGY
(2022)
Review
Medicine, General & Internal
Xue Chen, Min Huang, Zhenyuan Zhang, Huilan Jing, Yueli Zou, Hui Bu
Summary: This article reports a rare case of primary meningeal central nervous system lymphoma. The patient presented with progressive lower extremity motor dysfunction and blurred vision. Diagnosis was confirmed through cytology, immunohistochemistry, and flow cytometry of the cerebrospinal fluid. After treatment, the patient showed significant improvement and could walk and take care of herself after a 2-year follow-up.
Article
Clinical Neurology
Fereshte Sheybani, Diederik van de Beek, Matthijs C. Brouwer
Summary: Half of the patients with suspected CNS infections are diagnosed with a CNS infection, and this was not related to CD4 counts. The best predictor for CNS infections was the CSF leukocyte count.
FRONTIERS IN NEUROLOGY
(2021)
Article
Microbiology
Yunqi Zhu, Wenxuan Zhao, Xihong Yang, Yuanyuan Zhang, Xiaoling Lin, Xing Weng, Yali Wang, Cong Cheng, Yun Chi, Hongxia Wei, Zhihang Peng, Zhiliang Hu
Summary: This study found that mNGS has a high sensitivity for detecting common opportunistic CNS pathogens in HIV-infected patients, although its performance in CNS tuberculosis is unsatisfactory. EBV and CMV are commonly detected by CSF mNGS, but the threshold for clinically significant detection still needs to be defined.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Oncology
Soeren Buesker, Walter Jaeger, Stefan Poschner, Lisa Mayr, Valentin Al Jalali, Johannes Gojo, Amedeo A. Azizi, Sami Ullah, Muhammad Bilal, Lobna El Tabei, Uwe Fuhr, Andreas Peyrl
Summary: This study aimed to investigate the penetration of temozolomide into cerebrospinal fluid (CSF) in pediatric patients. The results showed that metronomic oral temozolomide could penetrate into CSF in pediatric patients, with even higher concentration levels compared to adults.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2022)
Article
Medical Laboratory Technology
Yao Hu, Jin Xiang, Xiao Luo, Meijuan Lu, Dongwen Xu, Bobin Chen, Ming Guan
Summary: This study assessed the potential application of CSF FLC ratios in diagnosing PCNSL and monitoring treatment efficacy, and found that CSF FLC is a novel biomarker for diagnosis and chemotherapy efficacy monitoring in PCNSL.
CLINICA CHIMICA ACTA
(2022)
Article
Immunology
Shanshan Zhang, Gang Wu, Yuru Shi, Ting Liu, Liangfei Xu, Yuanyuan Dai, Wenjiao Chang, Xiaoling Ma
Summary: In this study, metagenomic next-generation sequencing (mNGS) identified a wide variety of pathogens in CA-CNS infections, many of which were undetectable by conventional methods.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)