Article
Multidisciplinary Sciences
Christian A. Unger, Ahmed K. Aladhami, Marion C. Hope, Sahar Pourhoseini, Mitzi Nagarkatti, Owen P. McGuinness, E. Angela Murphy, Kandy T. Velazquez, Reilly T. Enos
Summary: Research suggests that women are less susceptible to type II diabetes than men due to the protective effects of estrogen. However, epidemiological data shows that men are more prone to developing diabetes after menopause compared to women. This study aims to investigate if adiponectin serves as a protective factor for women.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Qi Guo, Shicheng Cao, Xiaohong Wang
Summary: Exercise can improve the pathogenic changes in adiponectin and betatrophin levels in insulin-resistant mice. This effect is achieved by increasing adiponectin levels and reducing betatrophin levels through exercise.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Klaudia Dopytalska, Malgorzata Kalisz, Anna Litwiniuk, Irena Walecka, Wojciech Bik, Agnieszka Baranowska-Bik
Summary: Systemic sclerosis (SSc) is a connective tissue disease characterized by fibrosis in the skin and internal organs. This study examined the levels of omentin-1 and adiponectin in SSc patients to understand their role in the development of the disease. The results showed that omentin-1 levels were significantly higher in SSc patients, especially in those with longer disease duration, suggesting its involvement in the pathogenesis of SSc.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Daniel Antonio de Luis Roman, David Primo, Olatz IZaola, Emilia Gomez, Juan Jose Lopez
Summary: The ADIPOQ gene variant rs3774261 combined with a high polyunsaturated fat hypocaloric diet is associated with a significant increase in serum adiponectin levels and adiponectin/leptin ratio, as well as a decrease in lipid profile and C-reactive protein concentration.
Article
Neurosciences
Wanling Xu, Junfeng Li, Chang Ji, Danwei Fang, Lulu Yao, Nenggui Xu, Wei Yi
Summary: This study provides mechanistic insights into how electroacupuncture (EA) improves insulin resistance (IR) through the response of Pro-opiomelanocortin (POMC) neurons to adiponectin (Adipo).
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Maria Lorena Orostica, Isis Astorga, Francisca Plaza-Parrochia, Cristian Poblete, Rodrigo Carvajal, Victor Garcia, Carmen Romero, Margarita Vega
Summary: PCOS is an endocrine/metabolic disorder associated with insulin resistance and obesity. This study found that MTF can improve insulin and adiponectin signaling in endometrial tissues, independent of PCOS. This suggests that MTF may help improve insulin action and reproductive issues in women with obesity/PCOS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Endocrinology & Metabolism
Romulo Sperduto Dezonne, Claudia Maria Pereira, Cyro Jose de Moraes Martins, Virginia Genelhu de Abreu, Emilio Antonio Francischetti
Summary: Dementia, including Alzheimer's Disease, is a global public health problem related to metabolic dysfunction. Adiponectin plays an important and contradictory role in the development of Alzheimer's Disease, known as the adiponectin paradox. Alzheimer's Disease and type 2 diabetes mellitus share common features, including brain insulin resistance. The evolvability of amyloidogenic proteins is also important in the development of Alzheimer's Disease.
METABOLIC BRAIN DISEASE
(2023)
Review
Pharmacology & Pharmacy
Pitchai Balakumar, Kumar Venkatesan, Noohu Abdulla Khan, N. M. Raghavendra, Vijayan Venugopal, D. R. Bharathi, Neeraj K. Fuloria
Summary: The prevalence of type 2 diabetes mellitus (T2DM) has rapidly increased in the past few decades. Current management strategies for insulin resistance are not effective enough and additional therapeutic options are needed. Curcumin has shown potential beneficial effects on insulin resistance and scientific evidence supports its potential applications against the disease. Curcumin combats insulin resistance through various mechanisms, such as increasing the levels of circulating irisin and adiponectin, activating PPARc, suppressing Notch1 signaling, and regulating SREBP target genes. This review provides a comprehensive understanding of the potential benefits of curcumin on insulin resistance, associated mechanistic insights, and new therapeutic possibilities.
DRUG DISCOVERY TODAY
(2023)
Article
Biochemistry & Molecular Biology
Roy Chun-Laam Ng, Min Jian, Oscar Ka-Fai Ma, Myriam Bunting, Jason Shing-Cheong Kwan, Guang-Jie Zhou, Krishnamoorthi Senthilkumar, Ashok Iyaswamy, Ping-Kei Chan, Min Li, Kenneth Mei-Yee Leung, Siva-Sundara Kumar Durairajan, Karen Siu-Ling Lam, Leung-Wing Chu, Richard Festenstein, Sookja Kim Chung, Koon-Ho Chan
Summary: The decrease in circulating adiponectin levels is associated with neurodegeneration, neuroinflammation, and Alzheimer's disease pathologies. Increasing adiponectin through treatments like adipoRon can improve neuronal insulin signaling, memory functions, and reduce amyloid levels in Alzheimer's disease models.
MOLECULAR PSYCHIATRY
(2021)
Article
Veterinary Sciences
Susan Gottlieb, Jacquie S. Rand, Katsumi Ishioka, Daniel A. Dias, Berin A. Boughton, Ute Roessner, Ziad Ramadan, Stephen T. Anderson
Summary: This study compared insulin, adiponectin, leptin, and measures of insulin sensitivity between diabetic cats in remission and healthy control cats, and investigated their associations with serum metabolites. The results showed that insulin resistance persists in diabetic remission cats, indicating the importance of managing insulin resistance in cats in remission.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Endocrinology & Metabolism
Yaxin Guan, Fan Zuo, Juan Zhao, Xin Nian, Li Shi, Yushan Xu, Jingshan Huang, Tsutomu Kazumi, Bin Wu
Summary: This study aims to compare the differences in circulating adiponectin levels and their relationships to regional adiposity, insulin resistance, serum lipid, and inflammatory factors in young, healthy Japanese women with different physical activity statuses. The results suggest that regardless of insulin sensitivity and physical activity status, adiponectin is primarily associated with regional adiposity and HDL-C.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Pediatrics
Doaa El Amrousy, Dalia El-Afify, Shaimaa Salah
Summary: This study found that insulin resistance and leptin levels increase in hypothyroid children and adolescents, especially those with obesity. Insulin resistance is positively correlated with TSH and BMI, but inversely correlated with fT3 and fT4 in hypothyroid children. There is no correlation between insulin resistance and leptin or adiponectin levels in children with hypothyroidism.
Article
Medicine, General & Internal
Jelena Nesic, Biljana Ljujic, Vesna Rosic, Aleksandar Djukic, Milenko Rosic, Ivica Petrovic, Nenad Zornic, Ivan P. Jovanovic, Sara Petrovic, Svetlana Djukic
Summary: Adiponectin and interleukin-33 are associated in patients with metabolic syndrome, with adiponectin potentially serving as an early marker and interleukin-33 being a potential predictor of inflammatory status in the early stage.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Xiaojing Huang, Olivia A. Maguire, Jeanne M. Walker, Caroline S. Jiang, Thomas S. Carroll, Ji-Dung Luo, Emily Tonorezos, Danielle Novetsky Friedman, Paul Cohen
Summary: The study shows that childhood cancer survivors exposed to abdominal radiotherapy or total body irradiation exhibit signs of chronic subcutaneous adipose tissue dysfunction, characterized by dysregulated adipokine secretion which may negatively impact their systemic metabolic health.
Editorial Material
Cardiac & Cardiovascular Systems
Roberta Gualtierotti, Massimiliano Ruscica
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Environmental Sciences
Chiara Macchi, Cesare R. Sirtori, Alberto Corsini, Pier Mannuccio Mannucci, Massimiliano Ruscica
Summary: According to the WHO, the entire global population is exposed to air pollution levels higher than recommended for health preservation. Air pollution, a complex mixture of particles and gases, poses a major global threat to public health. Particulate matter PM2.5 has been identified as a causal factor for cardiovascular diseases such as hypertension, coronary artery disease, stroke, heart failure, arrhythmias, and cardiovascular mortality. This review explores the proatherogenic effects of PM2.5, including endothelial dysfunction, chronic inflammation, reactive oxygen species, mitochondrial dysfunction, and arterial plaque instability.
ENVIRONMENT INTERNATIONAL
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Miron Sopic, Georgios Kararigas, Yvan Devaux, Paolo Magni
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Nicola Ferri, Alberto Corsini, Massimiliano Ruscica
Summary: The knowledge that a significant proportion of ACS survivors are at risk of recurrent ischemic cardiovascular events highlights the importance of lipid-lowering strategies in secondary prevention. Statin treatment has been shown to improve clinical outcomes. This review critically discusses the use of statin and non-statin lipid-lowering approaches, including PCSK9 inhibitors, in early management of ACS patients. Cost is a major barrier to the widespread prescription of non-statin agents in this field.
EUROPEAN HEART JOURNAL SUPPLEMENTS
(2023)
Article
Cell Biology
Paolo Magni
Summary: Cardiovascular diseases are the leading cause of morbidity, mortality, and disability across the globe. The interaction between sex/gender and age has been proven to have a significant impact on the pathophysiology and clinical presentation of atherosclerosis. To address the gaps in knowledge in this area, more research involving women as participants in clinical studies is necessary. Age-related discrimination, or ageism, must also be addressed to ensure equal access to healthcare for older individuals of both genders. Diagnostic and prevention protocols for managing cardiovascular diseases should be improved based on these factors, alongside innovative biomedical and communication strategies.
MECHANISMS OF AGEING AND DEVELOPMENT
(2023)
Article
Pharmacology & Pharmacy
Manfredi Rizzo, Alessandro Colletti, Peter E. Penson, Niki Katsiki, Dimitri P. Mikhailidis, Peter P. Toth, Ioanna Gouni-Berthold, John Mancini, David Marais, Patrick Moriarty, Massimiliano Ruscica, Amirhossein Sahebkar, Dragos Vinereanu, Arrigo Francesco Giuseppe Cicero, Maciej Banach
Summary: Non-Alcoholic Fatty Liver Disease (NAFLD) is a common condition with a high prevalence in adults, children, and individuals with type 2 diabetes mellitus. It is a leading cause of liver-related morbidity and cardiovascular mortality. The use of nutraceuticals in managing NAFLD has been suggested, but there is currently insufficient evidence to support their routine use. Further rigorous trials are needed to evaluate their efficacy and safety.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Elisa Mattavelli, Elena Olmastroni, Manuela Casula, Liliana Grigore, Fabio Pellegatta, Andrea Baragetti, Paolo Magni, Alberico L. Catapano
Summary: Recent epidemiological studies have shown a decrease in adherence to the Mediterranean diet (MedDiet). A prospective cohort study was conducted to evaluate changes in individual determinants of MedDiet adherence over time. The study reveals an overall decrease in MedDiet adherence, highlighting the need for better dietary interventions.
Article
Biochemistry & Molecular Biology
Achille Parfait Nwakiban Atchan, Orissa Charlene Monthe, Armelle Deutou Tchamgoue, Yeshvanthi Singh, Shilpa Talkad Shivashankara, Moorthy Karthika Selvi, Gabriel Agbor Agbor, Paolo Magni, Stefano Piazza, Uma Venkateswaran Manjappara, Jules-Roger Kuiate, Mario Dell'Agli
Summary: This study characterized four Cameroonian spice extracts and investigated their antioxidant and synergistic anti-inflammatory activities in human gastric adenocarcinoma cells. The extracts showed high amounts of phenolic and flavonoid compounds with antioxidant properties, and their combination exerted synergistic effects on inflammatory markers in gastric epithelial cells.
Review
Cardiac & Cardiovascular Systems
Erica Gianazza, Chiara Macchi, Cristina Banfi, Massimiliano Ruscica
Summary: Proprotein convertase subtilisin/kexin type 9 (PCSK9), as a key regulator of low-density lipoprotein receptor (LDLR), can directly contribute to atheroma development. Recent studies have revealed non-cholesterol-related processes mediated by PCSK9, and advancements in proteomics and lipidomics have helped identify novel lipids and proteins associated with PCSK9. These findings have the potential to develop new statistical models for cardiovascular disease (CVD) risk prediction. Furthermore, PCSK9 has been found to impact extracellular vesicles (EVs) composition, which could contribute to a prothrombotic state in CVD patients and may be targeted to counteract atherosclerosis progression.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Nutrition & Dietetics
Laura Manna, Eleonora Rizzi, Eleonora Bafile, Andrea Cappelleri, Massimiliano Ruscica, Chiara Macchi, Michele Podaliri Vulpiani, Romolo Salini, Emanuela Rossi, Concetta Panebianco, Francesco Perri, Valerio Pazienza, Federica Federici
Summary: Inflammatory bowel diseases (IBD) are chronic inflammatory conditions that have a significant impact on patients' quality of life. This study aimed to evaluate the effects of oral administration of Lentilactobacillus kefiri SGL 13 and Andrographis paniculata on DSS-treated mice.
FRONTIERS IN NUTRITION
(2023)
Article
Cell Biology
Silvia Pelucchi, Chiara Macchi, Laura D'Andrea, Paolo Dionigi Rossi, Michela Carola Speciani, Ramona Stringhi, Massimiliano Ruscica, Beatrice Arosio, Monica Di Luca, Matteo Cesari, Valeria Edefonti, Elena Marcello
Summary: Frailty is a geriatric syndrome resulting from age-associated accumulation of deficits. The study found a significant inverse association between circulating CAP2 concentration and frailty index in older adults. This suggests that CAP2 may serve as a biomarker for age-related deficits, highlighting its potential for personalized care.
Article
Medicine, General & Internal
Luca Mircoli, Niccolo Baca, Barbara Antonelli, Lucio Caccamo, Emanuele Cattaneo, Federico Colombo, Clara Dibenedetto, Livia Diehl, Maria Francesca Donato, Andrea Faggiano, Massimo Alberto Iavarone, Pietro Lampertico, Cristina Marenghi, Federico Polli, Edoardo Quarenghi, Fabiola B. Sozzi, Cristina Spaziani, Giulia Tosetti, Carlo Valsecchi, Pierluigi Vicardi, Marco Vicenzi, Arianna Zefelippo, Massimiliano Ruscica, Stefano Carugo
Summary: Stress echocardiography and coronary computed tomography angiography can detect coronary artery disease in end-stage liver disease patients without previous evidence of heart disease. The prevalence of CAD is low in high-risk end-stage liver disease patients, and screening helps reduce the incidence of post-liver transplantation acute coronary events without impacting mid-term survival.
ANNALS OF MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Alyssa J. J. Paganoni, Rossella Cannarella, Roberto Oleari, Federica Amoruso, Renata Antal, Marco Ruzza, Chiara Olivieri, Rosita A. Condorelli, Sandro La Vignera, Fationa Tolaj, Anna Cariboni, Aldo E. Calogero, Paolo Magni
Summary: Gonadotropin-releasing hormone (GnRH) neurons play a crucial role in regulating reproduction. AMH, GH, and IGF1 were found to enhance the migration and function of GnRH neurons in vitro. However, their involvement in the development and function of GnRH neurons in vivo remains unknown. This study evaluated the expression of AMHR2, GHR, and IGF1R during different developmental stages in mice, revealing differential protein expression patterns.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Miron Sopic, Baiba Vilne, Eva Gerdts, Fabio Trindade, Shizuka Uchida, Soliman Khatib, Stephanie Bezzina Wettinger, Yvan Devaux, Paolo Magni
Summary: Multiomics studies offer accurate strategies for ASCVD, and AI and ML can integrate multiple datasets for personalized approaches. Challenges in data quality and privacy need to be addressed.
TRENDS IN MOLECULAR MEDICINE
(2023)
Article
Medicine, General & Internal
Giuseppe Locatelli, Luca Donisi, Luca Mircoli, Federico Colombo, Lucia Barbieri, Gabriele Tumminello, Stefano Carugo, Massimiliano Ruscica, Marco Vicenzi
Summary: Antecubital access for right heart catheterization (RHC) has advantages over proximal vein access, including shorter fluoroscopy time, reduced radiation dose, and fewer guidewires used. A retrospective study of patients who underwent RHC showed that antecubital access resulted in lower fluoroscopy time (6 vs. 3 min) and radiation exposure (61 vs. 30 cGy/m(2)). The number of patients requiring guidewires was also lower in the antecubital access group (55% vs. 43%).
JOURNAL OF CLINICAL MEDICINE
(2023)