期刊
JOURNAL OF CO2 UTILIZATION
卷 25, 期 -, 页码 338-345出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.jcou.2018.01.022
关键词
Carbon dioxide fixation; Copper(I) complex; Cyclization; Homogeneous catalysis; Synthetic methods
资金
- National Natural Science Foundation of China [21472103, 21421062, 21672119]
- National Key Research and Development Program [2016YFA0602900]
- Natural Science Foundation of Tianjin [16JCZDJC39900]
- 12th Five-Year National Science and Technology Support Plan [2015BAD15B07]
Efficient CuI/1,10-phen-catalyzed three-component cascade reaction of propargylic alcohols, CO2, and 2-aminoethanols has been firstly developed for the thermodynamically favourable preparation of 2-oxazolidinones. In the presence of commercially available CuI, 1,10-phen (1,10-phenanthroline) and t-BuOK,the cascade reaction afforded the desired products in good to excellent yields with a broad substrate scope (14 examples). The predicted copper complex Cu2I2(phen)(2) in situ formed from CuI and 1,10-phen could activate the triple bond through coordination. The isolation of alpha-alkylidene cyclic carbonate as the reaction intermediate suggests that the carboxylative cyclization of propargylic alcohol with CO2, followed by ring-opening reaction, is involved in the one-pot three-component cascade reaction.
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