Review
Biotechnology & Applied Microbiology
Sang-Woo Han, Jong-Shik Shin
Summary: Aromatic L-amino acid decarboxylases (AADCs) catalyze the conversion of aromatic L-amino acids into aromatic monoamines. Microbial AADCs have limited distribution but hold significant potential for biomedical applications.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Stanislav Kotlyarov
Summary: Atherosclerosis is a prevalent disease that is closely associated with cardiovascular diseases. Endothelial cells play a crucial role in the development of atherosclerosis, and a better understanding of their functions and interactions can improve early diagnosis and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Elena Kotsyuba, Vyacheslav Dyachuk
Summary: Mollusks, as one of the largest phyla of marine invertebrates, play key roles in various habitats due to their diversity, mobility, and behavioral strategies. They have developed adaptive strategies to tolerate environmental stresses, including hypoxia, through behavioral, physiological, biochemical, and molecular defenses. The neuroendocrine system and signaling molecules are crucial in regulating physiological and behavioral processes in mollusks, and may also affect hypoxia tolerance. This review summarizes the current knowledge about the involvement of the neuroendocrine system in the hypoxia stress response and the potential contributions of signaling molecules, providing insights into the molecular mechanisms underlying hypoxic stress in mollusks and comparisons with other species.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Hongyuan Zhang, Zhiqiang Zhao, Shengnan Sun, Sen Zhang, Yuequan Wang, Xuanbo Zhang, Jin Sun, Zhonggui He, Shenwu Zhang, Cong Luo
Summary: In this study, the authors developed a self-propelling nano-penetrator assembled with a photothermal photosensitizer and a photothermal-activable NO donor. The nano-penetrator showed advantages in terms of NO productivity and autonomous motion under laser irradiation. In animal models, it successfully navigated to thrombus, penetrated deep into the clot, and achieved effective thrombolysis and prevention of thrombosis recurrence and ischemic stroke.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Liqin Chen, Yueling Bi, Tong Xu, Xiaohuan Li, Zhongze Fang
Summary: This article introduces two different pretreatment methods for the determination of biogenic monoamines and metabolites in plasma using high performance liquid chromatography. The online PFSPE method stands out due to its greener character and high-throughput compared to the offline PFSPE method.
Article
Engineering, Environmental
Seung-Woon Baek, Da-Seul Kim, Jun-Kyu Lee, Jun Hyuk Kim, Semi Lee, Jeong Min Park, So-Yeon Park, Duck Hyun Song, Chun Gwon Park, Dong Keun Han
Summary: A novel nanoparticle with enhanced nitric oxide (NO) generating ability was synthesized to improve the biodegradable vascular scaffold (BVS) intervention for coronary artery diseases. The BVS containing the synthesized nanoparticles demonstrated potent functional recovery ability of unhealthy vessels by inhibiting platelet adhesion and activation, increasing endothelial cell proliferation, and decreasing smooth muscle cell proliferation. The BVS also showed scavenging ability of reactive oxygen species and inhibition of toxic NO production, with suppressed inflammatory response and induced healthy blood vessel formation when implanted in mice. This offers a new tool for designing cardiovascular stents and various biological applications.
CHEMICAL ENGINEERING JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Rosaria Melis, Antonio Argiolas
Summary: Nitric oxide plays a crucial role in the central nervous system, regulating erectile function and sexual behavior by interacting with neurotransmitters. It acts not only in specific areas of the hypothalamus, but also in extrahypothalamic brain regions, contributing to a neural circuit controlling both consummatory and appetitive components of sexual behavior through interplay with various neurotransmitters.
Article
Biochemistry & Molecular Biology
John Ukeri, Michael T. Wilson, Brandon J. Reeder
Summary: Cytoglobin has physiological roles that are not clearly understood, but may include regulation of nitric oxide, oxygen sensing, and protection against oxidative stress. Specific mutations can affect the nitric oxide binding and metabolism activities of cytoglobin, helping to understand its precise role under physiological and pathophysiological conditions.
Article
Environmental Sciences
Weihua Chen, Alex B. Guenther, Shiguo Jia, Jingying Mao, Fenghua Yan, Xuemei Wang, Min Shao
Summary: The synergistic effects of BVOC and SNO emissions on O-3 formation can impede ground-level O-3 regulation and require stricter control of anthropogenic precursor emissions.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Multidisciplinary
Yanwen Zhang, Zefeng Wang, Mei Li, Can Xu, Ning Gao, Zhuping Yin, Kemin Wang, Stephen Mann, Jianbo Liu
Summary: The design and construction of synthetic protocells capable of stimuli response and homeostatic regulation is an important challenge for synthetic protobiology. In this study, we demonstrate a reconfigurable model protocell based on osmotic reconfiguration of lipid-coated coacervate droplets into multicompartmentalized coacervate vesicles that can exhibit hypotonic stress-induced volume response and enhance enzyme reactions. The increased nitric oxide (NO) within the swollen vesicles can induce blood vessel vasodilation, showing potential applications in biomedicine, cellular diagnostics, and bioengineering.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Biochemistry & Molecular Biology
Heba M. Fahmy, Fatmaalzahraa A. Aboalasaad, Ayman S. Mohamed, Fathi A. Elhusseiny, Yasser A. Khadrawy, Ahmed Elmekawy
Summary: In this study, the antidepressant effects of free curcumin, zinc oxide nanoparticles, and curcumin-conjugated zinc oxide nanoparticles were evaluated. The results showed that curcumin-conjugated zinc oxide nanoparticles exhibited superior efficacy in ameliorating depressive-like behavior and neurochemical effects compared to the other two forms of curcumin.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2023)
Article
Medicine, Research & Experimental
Joao Victor Silva-Silva, Carla J. Moragas-Tellis, Maria S. S. Chagas, Paulo Victor R. Souza, Davyson L. Moreira, Celeste S. F. de Souza, Kerolain F. Teixeira, Arthur R. Cenci, Aldo S. de Oliveira, Fernando Almeida-Souza, Maria D. Behrens, Katia S. Calabrese
Summary: This study evaluated the leishmanicidal activity of a crude extract and anthocyanidin-rich fractions from Arrabidaea chica, as well as three isolated anthocyanidins. The results showed promising anti-leishmanial effects of these compounds, indicating their potential as therapeutic agents for leishmaniasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Henry Jay Forman
Summary: This invited paper addresses the question of whether the superoxide radical can exert deleterious effects independently of its participation with H2O2 in the production of the hydroxyl radical. The author, Irwin Fridovich, provides a correct affirmative answer, although subsequent research on peroxynitrite has added more complexity.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Review
Biochemistry & Molecular Biology
Jinghua Chen, Lulu Liu, Weiwei Wang, Haichun Gao
Summary: This article discusses the important role of nitric oxide in the microbe-driven nitrogen biogeochemical cycle, as well as its significance in medicine and the biological sciences. The article explores the importance of nitric oxide in early energy generation and its effects on various biological processes within bacterial physiology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Agronomy
El-Sayed H. Shaurub, Jorge R. Paredes-Montero, Judith K. Brown, Haggag S. Zein, Amr A. Mohamed
Summary: This study evaluated resistance levels of the whitefly Bemisia tabaci in Egyptian cotton to three organophosphate insecticides and detoxification enzymatic activities, providing important baseline data for future monitoring. Enzymatic activities varied among governorates, and phylogenetic analysis identified field-collected B. tabaci as the B mitotype.
Article
Infectious Diseases
Moataza Dorrah, Chaima Bensaoud, Amr A. Mohamed, Daniel Sojka, Taha T. M. Bassal, Michail Kotsyfakis
Summary: This study examines the hemolytic activity, lytic cycles, characteristics, and nature of hemolytic factors in the mosquito Culex pipiens and the fowl tick A. persicus. The findings provide new insights into the distinct digestive processes in both species, enhancing our understanding of the basic biology of arthropod vectors. The researchers conclude that midgut hemolysins in C. pipiens and A. persicus control blood lysis to ensure efficient blood digestion.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Multidisciplinary Sciences
Mostafa R. Sharaf, Amr A. Mohamed, Brendon E. Boudinot, James K. Wetterer, Francisco Hita Garcia, Hathal M. Al Dhafer, Abdulrahman S. Aldawood
Summary: This study presents a revised and updated synoptic list of 44 Arabian Monomorium species, introducing two new species and proposing several new synonyms. Distribution maps, illustrations, ecological and biological notes are provided, showing the majority of Arabian species are endemic to the peninsula. The Arabian Peninsula is considered a biogeographical crossroads between the Afrotropical and Palearctic regions, with one species of Indomalayan origin recorded for the first time.
Review
Cell Biology
Wei Zhang, Gianluca Tettamanti, Taha Bassal, Christa Heryanto, Ioannis Eleftherianos, Amr Mohamed
Summary: Insects have an innate immune system that can directly eliminate or neutralize pathogenic microorganisms, providing insights into the regulation mechanisms of the immune system. Studying the insect immune system has shed light on how to combat infectious diseases in humans.
CELLULAR SIGNALLING
(2021)
Review
Immunology
Ioannis Eleftherianos, Ghada Tafesh-Edwards, Amr Mohamed
Summary: Recent studies have shown that insect tissues and organs play a crucial role in the natural infection routes of parasites and microbial pathogens. This article summarizes the different types of parasites that infect insects through distinct routes and examines the relationship between infection routes and insect immune response. The findings suggest that understanding the association between infection routes and insect host defense can help in designing strategies for managing agricultural pests and disease vectors.
IMMUNOLOGY LETTERS
(2022)
Article
Immunology
Hadeer Mamdouh Ahmed Eldeeb, Mona F. Ali, Maisa M. A. Mansour, Maha Ahmed Ali Ahmed, Mohamed Z. M. Salem
Summary: This study focused on isolating and identifying fungi from old albumen prints and evaluating their ability to cause deterioration. Four fungal species were identified, and it was found that some of them can cause hydrolysis and oxidation to the prints.
MICROBIAL PATHOGENESIS
(2022)
Article
Environmental Sciences
David Renault, Abdo Elfiky, Amr Mohamed
Summary: This study used in silico techniques to detect sequence polymorphisms in the ace1 gene of naturally occurring B. tabaci variants. The researchers identified several point mutations that could potentially influence insecticide resistance. Homology modeling and molecular docking analyses indicated that these mutations could alter the structure of the enzyme and potentially affect its sensitivity to insecticides.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Entomology
Daniele Bruno, Aurora Montali, Marzia Gariboldi, Anna Katarzyna Wronska, Agata Kaczmarek, Amr Mohamed, Ling Tian, Morena Casartelli, Gianluca Tettamanti
Summary: This study provides the first detailed characterization of black soldier fly hemocytes and reveals new insights into the cell-mediated immune response of this insect. The study identifies five hemocyte types involved in the immune response in the larva and analyzes their behavior, role, and morphofunctional changes. The results demonstrate that circulating phagocytes in black soldier fly larvae are plasmatocytes, which participate in nodulation and encapsulation with granulocytes and lamellocyte-like cells.
Article
Biochemistry & Molecular Biology
Chen Jia, Amr Mohamed, Alberto Maria Cattaneo, Xiaohua Huang, Nemat O. O. Keyhani, Maiqun Gu, Liansheng Zang, Wei Zhang
Summary: Spodoptera frugiperda is a worldwide generalist pest with remarkable adaptations to environments and stresses, including diverse feeding preferences, mate seeking, and pesticide resistance. This study identified and analyzed the expression patterns of odorant-binding proteins (OBPs) and chemosensory proteins (CSPs) in S. frugiperda across developmental stages and sexes. The results revealed correlations between gene expression patterns and phylogenic trees, and suggested the potential function of SfruOBP31 in food, mate seeking, and pesticide resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Entomology
Norimitsu Izawa, Susumu Hiragaki, Amr A. Mohamed, Azza M. Elgendy, Takeshi Ohtani, Makio Takeda
Summary: Two AANAT genes in honey bees were found to be associated with the regulation of social behavior, with expression being controlled by circadian rhythms and linked to the transition in honey bee lifestyles.
Article
Entomology
Wei Zhang, Chen Jia, Lian-Sheng Zang, Maiqun Gu, Rui Zhang, Ioannis Eleftherianos, Amr A. Mohamed
Summary: There are complex interactions between insects and microbes, and the roles of disease-related microbial-derived metabolites in regulating host innate immunity and gut microbial community composition are still not well understood. This study found that the entomopathogenic fungus Metarhizium anisopliae produces various metabolites during growth in locusts, which can modify the expression of host genes involved in innate immune processes. These metabolites also suppress the locust gut microbial composition. Overall, this study highlights the important functions of entomopathogenic fungal-derived metabolites in manipulating the insect host innate immunity and gut microbiota composition.
JOURNAL OF PEST SCIENCE
(2023)
Article
Archaeology
M. Ali, H. Kalil, M. Mohamed
Summary: This study presents the results of various analytical techniques applied to a painted wooden stela in the Egyptian Museum in Cairo. The analysis revealed the composition of the stela, including its wooden support, prepared layer, and pigments. The study also focused on the presence of active fungi on the wood, as well as the use of a tempera technique and the specific pigments used.
EGYPTIAN JOURNAL OF ARCHAEOLOGICAL AND RESTORATION STUDIES
(2022)
Article
Art
Rasha Shaheen, Abdelrahman M. Elserogy, Shaaban Abd Elaa, Mona Ali, Abdelrahman Metwaly, Mohamed Eida, Ahmed Gad
Summary: This paper presents the identification of microentities growing on gelatin photograph prints and discusses the study of using Nanomaterials to treat microbiological damage on gelatin photographs. UV photography and USB microscope were used to study the distribution and appearance of biological damage on the image surface. Additionally, the growth requirements of these microorganisms were determined and recommendations were made to control temperature and humidity to prevent their growth.
INTERNATIONAL JOURNAL OF CONSERVATION SCIENCE
(2022)
Article
Archaeology
M. Ali, M. Abdel-Ghani, N. Abou Seif
Summary: The poor storage conditions in the basement of the Egyptian Museum resulted in severe damage to a multi-piece mummy cartonnage from the Late Period. The research paper examined and analyzed the layers' structure of the cartonnage, revealing the use of different canvas supports and pigments.
EGYPTIAN JOURNAL OF ARCHAEOLOGICAL AND RESTORATION STUDIES
(2022)
Article
Archaeology
H. Eldeeb, M. Ali, M. Mansour
Summary: Albumen prints, the most important photographic prints of the late 19th century, are facing threats to their permanence due to various factors. In this study, a private collection of albumen prints dating back to 1890 was analyzed. The results showed cracks and chemical degradation in the albumen layer, as well as oxidation and hydrolysis in the secondary supports. Based on these findings, conservation procedures including disinfection, dry cleaning, tear mending, retouching, and rehousing were conducted.
EGYPTIAN JOURNAL OF ARCHAEOLOGICAL AND RESTORATION STUDIES
(2022)
