Review
Geriatrics & Gerontology
Madu N. Soares, Moritz Eggelbusch, Elie Naddaf, Karin H. L. Gerrits, Marike van der Schaaf, Bram van den Borst, W. Joost Wiersinga, Michele van Vugt, Peter J. M. Weijs, Andrew J. Murray, Rob C. I. Wust
Summary: Skeletal muscle-related symptoms, including weakness and exercise intolerance, are common in acute Covid-19 and PASC. Severe cases show muscle fibre atrophy, metabolic alterations, and immune cell infiltration. Contributing factors to weakness and fatigue include systemic inflammation, disuse, hypoxemia, and malnutrition. The mechanisms underlying muscle issues in PASC are more complex and may be related to direct viral infiltration or aberrant immune response. Further research is needed to understand the similarities with chronic fatigue syndrome.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Review
Biochemistry & Molecular Biology
Eduardo Antuna, Cristina Cachan-Vega, Juan Carlos Bermejo-Millo, Yaiza Potes, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes, Claudia Garcia-Gonzalez
Summary: In a world where life expectancy is increasing, understanding and promoting healthy aging has become a contemporary demand. Inflammaging, a chronic and low-grade systemic inflammation in the elderly, is linked with many age-associated diseases. There are correlations between sarcopenia, the loss of strength and mass in skeletal muscle related to aging, and inflammaging. Inflammatory signals from chronic diseases negatively affect skeletal muscle, and autophagic mechanisms play a role in inflammation. Strategies such as using melatonin or senotherapeutic compounds could counteract inflammation in the muscle. This review aims to present the factors regulating skeletal muscle inflammaging and their implications in sarcopenia.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Sebastiaan Dalle, Evelien Van Roie, Charlotte Hiroux, Mathias Vanmunster, Walter Coudyzer, Frank Suhr, Stijn Bogaerts, Ruud Van Thienen, Katrien Koppo
Summary: The study found that while Ω-3 fatty acids contribute to increased muscle strength in older adults, they do not improve beneficial catabolic or inflammatory adaptations induced by resistance exercise. Changes in muscle quality, rather than muscle volume, might explain the gains in strength.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2021)
Review
Respiratory System
Harry R. Gosker, Ramon C. Langen, Sami O. Simons
Summary: This report reviews the impact of AECOPD on muscle dysfunction in COPD, highlighting the negative effects of AECOPD on muscle function and its underlying mechanisms. Novel treatment options should focus on the enhanced drivers of muscle dysfunction during AECOPD.
EXPERT REVIEW OF RESPIRATORY MEDICINE
(2021)
Review
Geriatrics & Gerontology
Hawley E. Kunz, Ian R. Lanza
Summary: Aging is associated with various changes in skeletal muscle, including muscle mass loss, local inflammation, and reduced response to exercise. The chronic inflammation associated with aging, known as inflammaging, may contribute to these age-related muscle impairments. Inflammation and exercise have a complex relationship, as exercise can induce acute inflammation necessary for muscle repair, while chronic inflammation in aging may hinder this response. However, exercise training has anti-inflammatory effects and can target the underlying causes of inflammaging. This review explores the interplay between inflammation and exercise in aging and discusses potential therapeutic targets for enhancing exercise responsiveness in older adults.
EXPERIMENTAL GERONTOLOGY
(2023)
Article
Physiology
Alfredo Mijares, Paul D. Allen, Jose R. Lopez
Summary: The study demonstrates that normal aging is associated with increased intracellular Ca2+ and Na+ concentrations, as well as elevated ROS production in skeletal muscle fibers. Treatment with flufenamic acid can reduce these changes, lower levels of plasma interleukin 6 and tumor necrosis factor-alpha, and decrease muscle damage.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Kai Wang, Stephen H. H. Smith, Hirotaka Iijima, Zachary R. R. Hettinger, Adarsh Mallepally, Sanjeev G. G. Shroff, Fabrisia Ambrosio
Summary: Understanding the cell-autonomous changes in skeletal muscle during aging, regeneration, and intervention is crucial for improving functional recovery in the elderly. However, traditional biological aging models have limitations. To overcome these limitations, a 3D muscle aging system was created and it was found that old muscle constructs (OMC) exhibit a sarcopenic phenotype and impaired regenerative capacity. Enhanced expression of complement component 4b (C4b) in aging muscle was identified as a contributing factor to impaired muscle regeneration, but inhibition of C4b improved regeneration in vitro and in vivo, suggesting a novel approach to enhance aged muscle repair.
ADVANCED MATERIALS
(2023)
Article
Geriatrics & Gerontology
James G. Tidball, Ivan Flores, Steven S. Welc, Michelle Wehling-Henricks, Eisuke Ochi
Summary: The regeneration of skeletal muscle following acute injury is influenced by interactions with immune cells, particularly myeloid cells and lymphoid cells. Aging leads to a decline in the regenerative capacity of muscle, with age-related changes in the immune system affecting the process. Aging immune cells alter their expression of factors that impact the function of muscle stem cells, contributing to defects in muscle regeneration.
EXPERIMENTAL GERONTOLOGY
(2021)
Review
Cell Biology
Mingming Chen, Yiyi Wang, Shoulong Deng, Zhengxing Lian, Kun Yu
Summary: This article discusses the relationship between aging and skeletal muscle atrophy, focusing on the key role of oxidative stress and oxidative damage in muscle atrophy during aging. It also explores the excessive production of reactive oxygen species in aging skeletal muscle and its potential molecular mechanism of ROS-mediated mitochondrial dysfunction. Furthermore, potential antioxidant and anti-inflammatory strategies for the treatment of sarcopenia during aging are summarized.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yann S. Gallot, Kyle R. Bohnert
Summary: Skeletal muscle is a highly plastic tissue capable of adapting to various stimuli, with ER stress and activation of the unfolded protein response (UPR) being induced under conditions such as exercise, hypoxia, and calcium imbalances. The UPR in skeletal muscle is still being elucidated, as evidence suggests its involvement in various catabolic stimuli and potential roles in maintaining homeostasis or driving atrophy. Continued investigations into the individual molecules of this complex pathway are crucial for a full understanding of the mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Public, Environmental & Occupational Health
Barbara Morawin, Anna Tylutka, Filip Bielewicz, Agnieszka Zembron-Lacny
Summary: This study aimed to investigate the relationship between inflammation and sarcopenia and evaluate the impact of lifestyle on inflammatory markers. The results showed significantly higher levels of C-reactive protein and inflammatory markers (IL-1β, cfDNA, and bilirubin) in the sarcopenia group compared to the no sarcopenia group. Gait speed was negatively correlated with cfDNA and IL-1β. Furthermore, the study revealed a link between inflammation and fitness level in older adults, suggesting that lifestyle exercise is a key therapeutic strategy for sarcopenia prevention.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Geriatrics & Gerontology
Gibran Pedraza-Vazquez, Beatriz Mena-Montes, David Hernandez-Alvarez, Juan Carlos Gomez-Verjan, Rafael Toledo-Perez, Miriam T. Lopez-Teros, Mina Konigsberg, Luis E. Gomez-Quiroz, Armando Luna-Lopez
Summary: Osteosarcopenic obesity is associated with immobility, fractures, and other dysfunctions, but its cause is still unknown. Sedentarism, fat gain, and epigenetic regulators play critical roles in its development. Exercise is an effective intervention for preventing and treating OSO. miRNA expression and inflammatory profiles are implicated in this process, suggesting their involvement in immune regulation and preventing OSO.
ARCHIVES OF GERONTOLOGY AND GERIATRICS
(2023)
Article
Nutrition & Dietetics
Alberto Caballero-Garcia, Jorge Pascual-Fernandez, David Cesar Noriega-Gonzalez, Hugo J. Bello, Antoni Pons-Biescas, Enrique Roche, Alfredo Cordova-Martinez
Summary: The study found that citrulline supplementation significantly improved walking speed in elderly participants engaged in physical activity, with no significant differences in strength and endurance improvement. After supplementation, markers of muscle damage and hormone levels showed a tendency to improve compared to the placebo group.
Article
Cell Biology
Wenlan Li, Jennifer Trieu, Ronnie Blazev, Benjamin L. Parker, Kate T. Murphy, Kristy Swiderski, Gordon S. Lynch
Summary: Cancer cachexia is a common condition in cancer patients, where loss of skeletal muscle mass affects treatment response and quality of life. Sulforaphane (SFN), a natural antioxidant found in cruciferous vegetables, has been shown to decrease oxidative stress. This study investigated whether SFN could attenuate muscle wasting induced by cancer cells and chemotherapy, and found that SFN was able to prevent muscle atrophy and activate antioxidant signaling pathways.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2023)
Article
Cell Biology
Zachary A. Graham, Kaleen M. Lavin, Samia M. O'Bryan, Anna E. Thalacker-Mercer, Thomas W. Buford, Kenneth M. Ford, Timothy J. Broderick, Marcas M. Bamman
Summary: Skeletal muscle is the most abundant tissue in healthy individuals and plays important roles in health beyond voluntary movement. Exercise training helps skeletal muscle adapt to repetitive overload and prevents or slows muscle wasting, improving or maintaining its health and function.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Review
Urology & Nephrology
Paul G. Shiels, Dagmara McGuinness, Maria Eriksson, Jeroen P. Kooman, Peter Stenvinkel
NATURE REVIEWS NEPHROLOGY
(2017)
Article
Cell Biology
Dagmara McGuinness, Suhaib Mohammed, Laura Monaghan, Paul A. Wilson, David B. Kingsmore, Oliver Shapter, Karen S. Stevenson, Shana M. Coley, Luke Devey, Robert B. Kirkpatrick, Paul G. Shiels
Article
Surgery
Michele J. de Kok, Dagmara McGuinness, Paul G. Shiels, Dorottya K. de Vries, Joanne B. Tutein Nolthenius, Leonie G. Wijermars, Ton J. Rabelink, Lars Verschuren, Karen S. Stevenson, David B. Kingsmore, Martin McBride, Rutger J. Ploeg, Esther Bastiaannet, Alexander F. Schaapherder, Jan H. Lindeman
Review
Pathology
Christopher A. Moxon, Matthew P. Gibbins, Dagmara McGuinness, Danny A. Milner, Matthias Marti
ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 15, 2020
(2020)
Article
Hematology
Christopher A. Moxon, Yasir Alhamdi, Janet Storm, Julien M. H. Toh, Dagmara McGuinness, Joo Yeon Ko, George Murphy, Steven Lane, Terrie E. Taylor, Karl B. Seydel, Sam Kampondeni, Michael Potchen, James S. O'Donnell, Niamh O'Regan, Guozheng Wang, Guillermo Garcia-Cardena, Malcolm Molyneux, Alister G. Craig, Simon T. Abrams, Cheng-Hock Toh
Article
Cell Biology
Lorna Mulvey, Stephen E. Wilkie, Gillian Borland, Kate Griffiths, Amy Sinclair, Dagmara McGuinness, David G. Watson, Colin Selman
Summary: Genetic background plays a role in how organisms respond to interventions like caloric restriction, impacting parameters such as body weight, adipose tissue mass, glucose tolerance, and insulin levels. Metabolomic analysis revealed specific metabolic differences between different mouse strains under the same caloric restriction, highlighting the importance of how fat depots dynamically respond to caloric restriction in influencing lifespan.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Article
Multidisciplinary Sciences
Hannah Craven, Dagmara McGuinness, Sarah Buchanan, Norman Galbraith, David H. McGuinness, Brian Jones, Emilie Combet, Denise Mafra, Peter Bergman, Anne Ellaway, Peter Stenvinkel, Umer Z. Ijaz, Paul G. Shiels
Summary: The study reveals a correlation between the composition of blood microbiota and an individual's biological age. Individuals with a higher biological age have a higher abundance of pathogenic bacteria in their circulation, while those with a lower biological age possess more bacteria beneficial to human health. In individuals with lower socioeconomic status, lower betaine levels indicate poorer dietary habits and health conditions.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Nikolaos Panagiotou, Dagmara McGuinness, Armand M. G. Jaminon, Barend Mees, Colin Selman, Leon Schurgers, Paul G. Shiels
Summary: Extracellular vesicles (EVs) secreted by cells play a role in repairing cellular and tissue damage. Microvesicles (MVs) from stem cell regulatory cells have been found to enhance the repair of human dermal fibroblasts (HDFs) and mesenchymal stem cells (MSCs) under stress, but this effect is age and stress specific. These findings provide insights into the roles of EVs in tissue repair and ageing.
Meeting Abstract
Biochemistry & Molecular Biology
G. Revechon, H. Helgadottir, N. Viceconte, A. Witasp, A. Sola Carvajal, D. Whisenant, D. McGuinness, G. Artiach, E. Wallen Arzt, A. Thorell, A. Babler, S. Ziegler, R. Kramann, M. Back, P. G. Shiels, A. Wernerson, P. Stenvinkel, M. Eriksson
EUROPEAN JOURNAL OF HUMAN GENETICS
(2020)
Meeting Abstract
Surgery
Oliver Shapter, Dagmara McGuinness, Karen Stevenson, David Kingsmore, Paul Shiels
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
M. Eriksson, H. T. Helgadottir, N. Viceconte, A. Witasp, E. Wallen Arzt, A. Sola Carvajal, G. Revechon, A. Thorell, D. McGuinness, P. G. Shiels, A. Wernerson, P. Stenvinkel
EUROPEAN JOURNAL OF HUMAN GENETICS
(2019)
Article
Cell Biology
Peter Stenvinkel, Karin Luttropp, Dagmara McGuinness, Anna Witasp, Abdul Rashid Qureshi, Annika Wernerson, Louise Nordfors, Martin Schalling, Jonaz Ripsweden, Lars Wennberg, Magnus Soderberg, Peter Barany, Hannes Olauson, Paul G. Shiels
Article
Medical Laboratory Technology
Paul G. Shiels, Peter Stenvinkel, Jeroen P. Kooman, Dagmara McGuinness
PRACTICAL LABORATORY MEDICINE
(2017)
Meeting Abstract
Critical Care Medicine
R. Lakhdar, D. McGuinness, L. Monaghan, E. Drost, P. Sheils, B. MacNee, R. Rabinovich
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2016)