Article
Biochemistry & Molecular Biology
Han Gao, Xing Fan, Qi-Chun Wu, Chuan Chen, Fei Xiao, Kun Wu
Summary: This study characterized the promoter of SHP in a teleost fish and found that zinc reduces hepatic lipid deposition by activating the FXR/SHP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jianping Pan, Xilin Ouyang, Qi Jin, Wei Wang, Jiali Xie, Baoming Yu, Zhijie Ling, Qizhen Wu, Baoping Zheng
Summary: This study found that ethanol extract from Chimonanthus nitens Oliv. leaf (COE) can improve liver function and lipid metabolism, and alleviate hyperlipidemia by activating the leptin/Janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) pathway.
MOLECULAR MEDICINE
(2022)
Article
Food Science & Technology
Maria Helena Araujo de Vasconcelos, Renata Leite Tavares, Emanuel Ubaldino Torres Junior, Victor Augusto Mathias Dorand, Kamila Sabino Batista, Lydiane Tavares Toscano, Alexandre Sergio Silva, Angela Maria Tribuzy de Magalhaes Cordeiro, Bruno Ranieri Lins de Albuquerque Meireles, Rubens da Silva Araujo, Adriano Francisco Alves, Jailane de Souza Aquino
Summary: This study investigated the anti-adiposity effect of extra virgin coconut oil (E-VCO) on obese rats and found that E-VCO reduced body mass and adiposity index, improved hormonal parameters, and decreased liver fat accumulation. E-VCO also had positive effects on metabolic parameters.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Immunology
Meiyu Wu, Lu Wang, Haijing Wu, Ming Yang, Zhenghao He, Yiran Chen, Huiming Zhang
Summary: This study found that Leptin can promote the progression of vitiligo by enhancing the cytotoxic function of CD8(+) T cells. This suggests that Leptin may become a new target for vitiligo treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Ji Hyeon Kang, Hyung Sik Kim, Seon Hyang Park, Ye Seon Kim, Yoe-Sik Bae
Summary: Obesity is a metabolic disorder caused by an imbalance of energy intake and consumption, and its chronic inflammation can lead to various complications. This study investigates the effects of WKYMVm, an anti-inflammatory agent, against obesity. The results show that WKYMVm attenuates body weight gain, improves insulin sensitivity, ameliorates hepatic steatosis and adipose tissue hypertrophy induced by a high fat diet. WKYMVm also improves lipid metabolism and leptin signaling, suggesting its potential as an anti-obesity agent.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Zsolt Szekeres, Barbara Sandor, Zita Bognar, Fadi H. J. Ramadan, Anita Palfi, Beata Bodis, Kalman Toth, Eszter Szabados
Summary: Obesity is a global public health issue associated with various diseases, particularly type 2 diabetes. Leptin plays a crucial role in regulating food intake and metabolism. Sodium glucose co-transport 2 inhibitors have beneficial effects and can be potent antihyperglycemic drugs. This study aimed to investigate the metabolic state and leptin level among obese and type 2 diabetic patients, as well as the impact of empagliflozin treatment. The results showed that empagliflozin treatment led to lower body mass index, body fat, visceral fat, and leptin levels compared to conventional antidiabetic treatments. Leptin levels were increased in both obese and type 2 diabetic patients. Empagliflozin treatment also resulted in lower body mass index, body fat, and visceral fat percentages, while preserving renal function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Liyun Wu, Hongyan Li, Wenjie Xu, Bo Dong, Junyan Jin, Dong Han, Xiaoming Zhu, Yunxia Yang, Haokun Liu, Shouqi Xie
Summary: Leptin regulates glucose and lipid metabolism in gibel carp through different signaling pathways, leading to strain-specific differences. Strain A exhibited stronger activation of the PI3K-AKT signaling pathway in muscle tissue, while other signaling pathways and metabolic activities varied between tissues and strains.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Environmental Sciences
Liwei Yang, Zikai Song, Yang Pan, Tianyang Zhao, Yanbin Shi, Jiqiang Xing, Aipeng Ju, Liting Zhou, Lin Ye
Summary: This study showed that exposure to PM2.5 could lead to abnormal lipid metabolism and inflammatory responses in macrophages, with inhibition of the JAK2/STAT3 signaling pathway. Activation of STAT3 could reverse these effects.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Cell Biology
Haibi Su, Chen Meng, Jie Xu, Zhenghua Su, Chenxi Xiao, Di Yang
Summary: The study reveals that Smyd2 plays an important regulatory role in adipogenesis and adipocyte differentiation. Inhibition of Smyd2 can hinder adipocyte differentiation, thereby slowing down the occurrence and development of obesity.
CELL DEATH & DISEASE
(2022)
Article
Environmental Sciences
Ross M. Reid, Andrea L. Reid, David A. Lovejoy, Peggy R. Biga
Summary: This study investigated the expression of tcap-3 and its role as a regulator of metabolism in zebrafish across different life stages. The results showed that rtTCAP-3 enhanced metabolic activity in larvae and adults through mitochondrial uncoupling. Additionally, rtTCAP-3 protected larval fish from reduced metabolic activity induced by low temperatures and increased metabolic output in adult zebrafish subjected to accelerated swimming speeds.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Cell Biology
Vicente Barrios, Elena Lopez-Villar, Laura M. Frago, Sandra Canelles, Francisca Diaz-Gonzalez, Emma Burgos-Ramos, Gema Fruehbeck, Julie A. Chowen, Jesus Argente
Summary: The central actions of leptin and insulin on hepatic lipid metabolism may be opposing, with the GH axis playing an important role in these effects. Leptin treatment led to an increase in hepatic lipolysis and a decrease in serum NEFA and triglyceride levels, while insulin treatment normalized these levels through activation of the GH axis.
Article
Biochemistry & Molecular Biology
Pingping Chen, Bin Wang, Meng Li, Chunxue Cui, Fei Liu, Yonggang Gao
Summary: Celastrol has been found to reverse the proliferation and migration of breast cancer cells induced by Leptin. Transcriptomic analysis revealed celastrol's effects on lipid metabolism and the endocrine system in breast cancer cells. Additionally, celastrol exerts its anticancer effects by binding to the Leptin receptor and partially inhibiting the activation of the PI3K/AKT pathway.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Fisheries
Zhixia Zhou, Yanxin He, Shoushi Wang, Yin Wang, Peipei Shan, Peifeng Li
Summary: Autophagy is a conserved cellular process essential for maintaining metabolism and energy balance, with implications in various physiological functions and clinical diseases. However, little is known about autophagy in teleost fish. This review provides an overview of the current knowledge of autophagy in teleosts, focusing on its physiological and pathological regulation in different processes. The potential options for targeting autophagy in teleosts for domestication, farming, or therapeutic strategies are also explored.
Article
Nutrition & Dietetics
Joe Eun Son, Jay-Young Jo, San Kim, Min Ju Park, Yerin Lee, Seong Shil Park, Shin Young Park, Su Myung Jung, Sung Keun Jung, Ji Yeon Kim, Sanguine Byun
Summary: Rice bran, a by-product of rice milling, is rich in bioactive molecules and has health-promoting properties in improving metabolic conditions. This study aimed to optimize the extraction conditions of rice bran extract (RBE) and validate its impact on lipid metabolism. The optimized RBE showed significant benefits in reducing weight gain, hyperlipidemia, and hepatosteatosis in mouse models. The study also discovered that the administration of optimized RBE activated AMPK and inhibited STAT3, crucial players in liver lipid metabolism. Overall, optimized RBE holds promise as a dietary intervention against hyperlipidemia and hepatosteatosis.
Article
Plant Sciences
QinMei Sun, Xin Wang, Xin Xin, ZiMing An, YiYang Hu, Qin Feng
Summary: The study showed that Qushi Huayu decoction could attenuate lipid accumulation by increasing the fatty acid beta-oxidation (FAO) dependent on the JAK2/STAT3/CPT-1A pathway, providing a scientific basis for its clinical application in the treatment of non-alcoholic steatohepatits.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Genetics & Heredity
Guang-Hui Chen, Tao Zhao, Xiao-Lei Wei, Dian-Guang Zhang, Mei-Qin Zhuo, Zhi Luo
Article
Biochemistry & Molecular Biology
Fang Chen, Chong-Chao Zhong, Chang-Chun Song, Shu-Wei Chen, Yang He, Xiao-Ying Tan
Summary: The study characterized the cDNA and promoter sequences of TSPO and SMAD4 genes in yellow catfish, explored their mRNA tissue expression, and deciphered their promoter regions. It also identified several transcription factors that influence the promoter activity of TSPO and SMAD4.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Shu-Wei Chen, Wu-Hong Lv, Kun Wu, Guang-Hui Chen, Fang Chen, Chang-Chun Song, Zhi Luo
Summary: This study investigated the molecular mechanism of nano-ZnO absorption and its effects on lipid metabolism in the intestinal tissues of yellow catfish. Results showed that dietary nano-ZnO increased intestinal Zn contents, altered mRNA expression levels of zinc transporters and lipogenic genes, and led to increased triglyceride content and lipogenic enzyme activities. Nano-ZnO absorption via endocytosis in intestinal epithelial cells was associated with TG deposition and lipogenesis, potentially regulated by the MTF-1-SHP pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Yi-Chuang Xu, Hua Zheng, Jia-Cheng Guo, Xiao-Ying Tan, Tao Zhao, Yu-Feng Song, Xiao-Lei Wei, Zhi Luo
Summary: This research investigated the effects of different dietary zinc sources on the growth performance, zinc metabolism, antioxidant capacity, endoplasmic reticulum stress, and intestinal tight junctions in grass carp. The findings showed that organic zinc sources (Zn-Lac and Zn-Gly) were more beneficial for intestinal health, improving zinc transport activity, intestinal histology, and expression of tight junction-related genes.