Article
Biochemical Research Methods
Johanna Breuer, Andreas Thomas, Philippe Delahaut, Wilhelm Schaenzer, Hans Geyer, Mario Thevis
Summary: Potential scenarios of the origin of banned substances in doping control samples have been widely discussed, including the controversial scenario of female athletes' urine being contaminated with ejaculate containing doping agents and/or their metabolites. In this study, a method using LC-HRMS was established to investigate the concentration and metabolite profiles of stanozolol and LGD-4033 in blood plasma and seminal fluid samples. The developed assays were able to detect the target substances with detection limits between 10 and 40 pg/mL, and metabolites from different metabolic pathways were identified in both fluids.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2023)
Article
Sport Sciences
Andreas Breenfeldt Andersen, Jonathan Graae, Jacob Bejder, Thomas C. Bonne, Soren Seier, Maren Debertin, Kasper Eibye, Morten Hostrup, Nikolai B. Nordsborg
Summary: The effects of recombinant human erythropoietin (rHuEPO) on exercise endurance, maximal aerobic performance, and total hemoglobin mass (tHb) were investigated in this study. The results showed that frequent, small intravenous injections of epoetin beta can improve time trial performance, peak oxygen uptake (VO2peak), and tHb in both males and females. This study provides insights into the effects of microdoses of intravenous rHuEPO on athletic performance and offers training recommendations for athletes.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemical Research Methods
Katja Walpurgis, Johannes Agricola, Andreas Thomas, Mario Thevis
Summary: Protein precipitation and liquid chromatography high-resolution tandem mass spectrometry (LC-HRMS/MS) were used to develop a method for detecting six novel MSTN inhibitory peptides from doping control serum samples. The method was found to allow for specific detection down to concentrations of 3-9 ng/mL. Potential metabolites of the drug candidates DF-3, DF-25, and Peptide 7 were identified as valuable targets for doping control analytical assays. Overall, the data obtained can be used to implement MSTN inhibitory peptides into routine sports drug testing.
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemical Research Methods
Eduard Bezuglov, Oleg Talibov, Artemii Lazarev, Zbigniew Waskiewicz, Sergei Iljukov
Summary: Studies show that the effects of new anti-doping measures on elite athletes' performance are limited. However, the implementation of these measures can lead to a decrease in performance in sports where banned substances are widely used. A study found that the performance of athletes from Country A, which was accused of systematic doping, decreased in 8 out of 10 disciplines after the implementation of new anti-doping methods. In contrast, the performance of athletes from Country B, their competitors, did not significantly change.
DRUG TESTING AND ANALYSIS
(2023)
Article
Sport Sciences
Andrea De Giorgio, Enzo Iuliano, Anthony Turner, Carlo Millevolte, Drazen Cular, Luca P. Ardigo, Johnny Padulo
Summary: The study examined the validity and reliability of a light-based electronic target system for testing response time in fencers. Results showed that the system was highly reliable and could be used as a further measure of performance for fencing athletes. Elite fencers responded faster than novice fencers for all attack types, indicating a higher level of skill and training among elite athletes.
JOURNAL OF STRENGTH AND CONDITIONING RESEARCH
(2021)
Article
Sport Sciences
Andreas Breenfeldt Andersen, Nikolai Baastrup Nordsborg, Thomas Christian Bonne, Jacob Bejder
Summary: This article evaluates the performance-enhancing effects of blood doping, specifically recombinant human erythropoietin (rhEpo) treatment and blood transfusions, with a special emphasis on micro-dosing. Studies show that micro-doses of blood doping can significantly improve endurance performance by increasing the oxygen-carrying capacity and oxygen extraction in muscles. However, detecting micro-dosing poses a challenge, although novel biomarkers such as immature reticulocytes or iron regulatory hormones may provide additional value for detection.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Chemistry, Multidisciplinary
Hsuan Huang, Wei-Yang Huang, Cheng-En Wu
Summary: The aim of this study was to assess the performance of elite basketball players in terms of speed, agility, and explosive strength after an 8-week plyometric training program. Fifteen elite male college basketball players in Taiwan participated in the study. The results showed that the plyometric training program significantly reduced body mass index and body fat percentage, increased skeletal muscle mass, and improved speed and agility. The participants also exhibited increased rate of force development and shorter jumping time, indicating enhanced explosive strength.
APPLIED SCIENCES-BASEL
(2023)
Article
Psychology, Multidisciplinary
Erdem Ayyildiz, Hamza Kayabesler, Mehmet Gulu, Fatma Hilal Yagin, Monira I. Aldhahi, Elena Garcia-Grimau, Sameer Badri Al-Mhanna
Summary: Introduction: There is a lack of studies on attitudes toward the use of prohibited substances in Turkish athletes. This study aims to investigate the effect of doping-related education (DRE) and the status of being a national athlete (NA) on athlete mindfulness and moral disengagement in doping (MDD). The results suggest that being a NA and receiving anti-doping education affect moral disengagement in doping and athletes' mindfulness.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Giscard Lima, Alexander Kolliari-Turner, Fernanda Rossell Malinsky, Fergus M. Guppy, Renan Paulo Martin, Guan Wang, Sven Christian Voss, Costas Georgakopoulos, Paolo Borrione, Fabio Pigozzi, Yannis Pitsiladis
Summary: The study showed that whole blood in long-term and short-term storage without RNA preservation can still be used for gene expression analysis, indicating that transcriptomic analysis of anti-doping samples collected or biobanked without RNA preservation is feasible.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Review
Sport Sciences
Rosa Ventura, Peter Daley-Yates, Irene Mazzoni, Katia Collomp, Martial Saugy, Frank Buttgereit, Olivier Rabin, Mark Stuart
Summary: This review assesses the current regulations on GCs in anti-doping, proposes a new approach to define permitted and prohibited use in sports based on performance enhancement and health risks. It also presents performance-enhancing doses in cortisol-equivalent terms and revised laboratory reporting values to differentiate between prohibited and permitted use effectively. Additionally, washout periods are suggested to allow safe prescription of GCs by clinicians and prevent athletes from testing positive in doping tests.
BRITISH JOURNAL OF SPORTS MEDICINE
(2021)
Article
Nutrition & Dietetics
Alejandro Martinez-Rodriguez, Javier Sanchez-Sanchez, Maria Martinez-Olcina, Manuel Vicente-Martinez, Rodrigo Yanez-Sepulveda, Guillermo Cortes-Roco, Juan Antonio Vazquez-Diz, Juan Antonio Sanchez-Saez
Summary: This study evaluated the body composition, maturation, performance outcomes, and adherence to the Mediterranean diet of professional beach handball players. The results showed that senior players had better performance outcomes, and there is room for improvement in adherence to the Mediterranean diet.
Review
Nutrition & Dietetics
Moriah Mallick, Chloe Briana Camacho, Jana Daher, Dalia El Khoury
Summary: Dietary supplements are commonly used by athletes for health and performance enhancement, but they may unknowingly consume prohibited substances due to contamination. Athletes often rely on unreliable sources of information and lack knowledge of supplement regulations.
Article
Biochemical Research Methods
Hiu Wing Cheung, Kin-Sing Wong, Venus Y. C. Lin, Adrian F. Farrington, Amanda J. Bond, Terence S. M. Wan, Emmie N. M. Ho
Summary: This study optimized a method for routine testing of regulatory samples by using an automated DNA extraction system, reducing the concentration of internal control primers and hydrolysis probe, and validating the spike-in of an exogenous internal control. Four duplex qPCR assays have been developed for the detection of transgenes, which have been successfully applied to the screening of official racehorse samples.
DRUG TESTING AND ANALYSIS
(2022)
Article
Engineering, Aerospace
Hao Li, Yuping Li, Zhongliang Zhao, Xiaobing Wang, Haiyong Yang, Shang Ma
Summary: Studying serious nonlinear coupling problems among aerodynamics, flight mechanics, and flight control during high maneuvers. Developed a virtual flight testing platform that can simulate real maneuvers, investigate coupling characteristics, evaluate flight performance, and verify flight control laws.
Article
Sport Sciences
Roula Kotsifaki, Vasileios Sideris, Enda King, Roald Bahr, Rod Whiteley
Summary: This study aimed to investigate the status of athletes during vertical jump testing at return to sport after ACL reconstruction (ACLR). The results showed that athletes still presented significant asymmetries during all vertical jump tests at the time of return to sport, especially in the concentric impulse. Clinicians should focus on restoring symmetry and improving absolute performance metrics to reduce injury risk and enhance overall athletic performance.
BRITISH JOURNAL OF SPORTS MEDICINE
(2023)
Article
Physiology
Sergei Iljukov, Yorck O. Schumacher
FRONTIERS IN PHYSIOLOGY
(2017)
Editorial Material
Physiology
James Hopker, Yorck O. Schumacher, Matthew Fedoruk, Jakob Morkeberg, Stephane Bermon, Sergei Iljukov, Reid Aikin, Pierre-Edouard Sottas
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Biochemical Research Methods
James Hopker, Jim Griffin, James Brookhouse, John Peters, Yorck Olaf Schumacher, Sergei Iljukov
DRUG TESTING AND ANALYSIS
(2020)
Article
Biochemical Research Methods
Eduard Bezuglov, Oleg Talibov, Artemii Lazarev, Zbigniew Waskiewicz, Sergei Iljukov
Summary: Studies show that the effects of new anti-doping measures on elite athletes' performance are limited. However, the implementation of these measures can lead to a decrease in performance in sports where banned substances are widely used. A study found that the performance of athletes from Country A, which was accused of systematic doping, decreased in 8 out of 10 disciplines after the implementation of new anti-doping methods. In contrast, the performance of athletes from Country B, their competitors, did not significantly change.
DRUG TESTING AND ANALYSIS
(2023)