Article
Chemistry, Medicinal
Yongliang Yuan, Zhiming Yan, Qifang Lao, Neng Jiang, Shuangmin Wu, Qinpei Lu, Jing Han, Songfeng Zhao
Summary: The development of a unimolecular triple agonist peptide targeting GLP-1, glucagon, and Y2 receptors shows great potential as a novel anti-obesity and anti-diabetic agent. This peptide, 3b, demonstrated potent activity in reducing food intake without causing nausea and had better effects on lipid metabolism, body weight, and glycemic control compared to other agonist counterparts. Targeting GLP-1R, GCGR, and Y2R with a unimolecular triple agonist peptide offers a promising route for developing new treatments for obesity and T2DM.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Neurosciences
Zhenbo Huang, Roberta Tatti, Ashley M. Loeven, Daniel R. Landi Conde, Debra Ann Fadool
Summary: Neuromodulation in the olfactory bulb regulates intrinsic firing activity, synaptic communication, and voltage-dependent channels, allowing the olfactory system to integrate sensory inputs and provide behavioral flexibility. Central serotonergic and cholinergic inputs modulate glomerular activity to facilitate odor investigation and learning. The complex interplay of metabolic signaling molecules and neuromodulators fine-tune neuronal microcircuits, with little known about the specific control mechanisms on neuronal subpopulations.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Review
Endocrinology & Metabolism
Neil Tanday, Peter R. Flatt, Nigel Irwin
Summary: GLP-1 receptor agonists have significant effects on treating diabetes and obesity, but their efficacy is limited when compared to bariatric surgery. Augmenting GLP-1's biological actions with other hormones, steroids, and compounds can enhance therapeutic effects for diabetes and obesity.
Article
Chemistry, Medicinal
Qimeng Yang, Feng Zhou, Xuelin Tang, Jialing Wang, Hui Feng, Wen Jiang, Luofan Jin, Neng Jiang, Yongliang Yuan, Jing Han, Zhiming Yan
Summary: The combined use of gastrointestinal hormones for treating metabolic diseases is receiving increasing attention. A study reported a series of novel GLP-1R/CCK-1R co-agonists and showed that they exerted improved effects on metabolic improvements in obese rodents. These findings suggest a promising combination therapy strategy for treating metabolic disorders.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biology
Claudio Perez-Leighton, Bredford Kerr, Philipp E. Scherer, Rene Baudrand, Victor Cortes
Summary: Nutritional, endocrine, and neurological signals converge in the brain to regulate feeding behavior and energy balance. The leptin, glucocorticoid, and GLP1 systems play important roles in this process. Leptin is crucial for controlling appetite, while glucocorticoids regulate energy balance adaptation to stress and excessive adiposity. GLP1 regulates insulin secretion and satiety through central and peripheral signaling systems. This review explores the interactions between these hormone systems at the central and peripheral levels and their roles in dysregulated intake, obesity, lipodystrophy, and eating behavior disorders.
BIOLOGICAL REVIEWS
(2023)
Article
Endocrinology & Metabolism
Brandon B. Boland, Rhianna C. Laker, Siobhan O'Brien, Sadichha Sitaula, Isabelle Sermadiras, Jens Christian Nielsen, Pernille Barkholt, Urmas Roostalu, Jacob Hecksher-Sorensen, Sara Rubek Sejthen, Ditte Dencker Thorbek, Arthur Suckow, Nicole Burmeister, Stephanie Oldham, Sarah Will, Victor G. Howard, Benji M. Gill, Philip Newton, Jacqueline Naylor, David C. Hornigold, Jotham Austin, Louise Lantier, Owen P. McGuinness, James L. Trevaskis, Joseph S. Grimsby, Christopher J. Rhodes
Summary: The co-administration of long-acting analogues of GLP-1 and PYY3-36 resulted in significant weight loss and improved glucose homeostasis in obese T2D mouse models. This combined therapy improved insulin sensitivity and restored endogenous beta-cell function, highlighting a potential association with the gut-brain axis in controlling metabolic homeostasis.
MOLECULAR METABOLISM
(2022)
Review
Endocrinology & Metabolism
Zhuqing Meng, Min Yang, Haibo Wen, Su Zhou, Chuan Xiong, Yu Wang
Summary: In this systematic review, tirzepatide was found to have a safety profile similar to GLP-1 RAs, but high doses (10mg or higher) may increase the risk of hypoglycemia and discontinuation. Dose escalation did not increase the occurrence rates of overall, severe gastrointestinal adverse events and hypoglycemia, but 10mg and 15mg doses were associated with more frequent nausea, discontinuation, and injection-site reaction. Vomiting and diarrhea rates were dose-dependent.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Zhixiong Ying, Robin van Eenige, Xiaoke Ge, Christy van Marwijk, Joost M. Lambooij, Bruno Guigas, Martin Giera, Jan Freark de Boer, Tamer Coskun, Hongchang Qu, Yanan Wang, Mariette R. Boon, Patrick C. N. Rensen, Sander Kooijman
Summary: This study investigated the effects of combined glucose-dependent insulinotropic polypeptide receptor (GIPR) and glucagon-like peptide-1 receptor (GLP1R) agonism on nonalcoholic fatty liver disease (NAFLD) development. The results showed that combined GIPR/GLP1R agonism can reduce body weight, lower plasma levels of glucose, triglycerides, and total cholesterol. Additionally, it can also reduce hepatic lipid accumulation and inflammation. This study suggests that combined GIPR/GLP1R agonism may be a promising approach to attenuate NAFLD progression in humans.
Article
Oncology
Melek Tunc-Ata, Zeynep Mine Altunay, Aysel Alphan, Vural Kucukatay
Summary: This study investigates the effects of insulin on the expression and protein levels of IR and GLP1-R in mouse hippocampal cells, revealing dose and time-dependent effects. These findings provide insights for future research targeting IR isoforms and GLP1-R, as well as determining the optimal dose and duration of insulin stimulation in insulin signaling research.
Article
Nutrition & Dietetics
Manal Ali Ahmad, Mirey Karavetian, Carole Ayoub Moubareck, Gabi Wazz, Tarek Mahdy, Koen Venema
Summary: This study aims to explore the association between peptide hormones and body weight and glucose homeostasis. The results show significant differences in peptide hormone levels between obese and lean adults, and GLP-1 levels are independently associated with markers of obesity and insulin resistance.
Article
Agriculture, Dairy & Animal Science
Maximiliano Muller, Elout Van Liefferinge, Marta Navarro, Elisabet Garcia-Puig, Alan Tilbrook, Robert van Barneveld, Eugeni Roura
Summary: The individual impact of the 20 proteinogenic amino acids on the secretion of anorexigenic gut hormones in pigs was studied using a small intestine ex vivo model. The results suggest that both essential and nonessential amino acids play a key role in appetite control in pigs.
JOURNAL OF ANIMAL SCIENCE
(2022)
Article
Surgery
Fulya Calikoglu, Umut Barbaros, Ayse Kubat Uzum, Yildiz Tutuncu, Ilhan Satman
Summary: The study evaluated the effectiveness of early use of pre-probiotics after Roux-en-Y gastric bypass (RYGB). It was found that early postoperative use of pre-probiotics enhanced insulin, GLP-1, and PYY secretion, but negatively affected anthropometric measurements and appetite ratings. Further research is needed to determine if late postoperative use of pre-probiotics may be more effective for patients with weak insulin and incretin response.
Article
Endocrinology & Metabolism
Ulrich Dischinger, Julia Hasinger, Malina Koenigsrainer, Carolin Corteville, Christoph Otto, Martin Fassnacht, Mohamed Hankir, Florian Johannes David Seyfried
Summary: The combination therapy of PYY3-36 and liraglutide shows similar weight loss effects to RYGB in obese rats, and outperforms the monotherapy of PYY3-36 and liraglutide. Additionally, this combination therapy reduces overall food intake and high-fat preference in the experimental setting.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Katarina T. Borer, Po-Ju Lin, Elizabeth Wuorinen
Summary: This study investigated the effects of changing the timing of exercise on human appetite, finding that moderate-intensity exercise performed after meals can effectively reduce insulin resistance.
Article
Pharmacology & Pharmacy
Chen Wang, Binbin Gong, Qianqian Zhu, Jing Han, Lidan Sun
Summary: In recent years, GLP-1 and its metabolites have gained significant attention for the treatment of type 2 diabetes. This study developed a series of GLP-1-derived hybrid peptides and identified a novel hybrid peptide with biological activity, providing a new perspective in the development of new drugs from peptide metabolites.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Letter
Oncology
Lindsay Brandon, Pip Youl, Peter Baade, Eliza Whiteside, Michael Kimlin
Article
Biochemistry & Molecular Biology
Charrlotte Seib, Eliza Whiteside, Joanne Voisey, Kathryn Lee, Kimberley Alexander, Janice Humphreys, Lisa Chopin, Debra Anderson
GENETIC TESTING AND MOLECULAR BIOMARKERS
(2016)
Article
Public, Environmental & Occupational Health
Charrlotte Seib, Eliza Whiteside, Janice Humphreys, Kathryn Lee, Patrick Thomas, Lisa Chopin, Gabrielle Crisp, Angela O'Keeffe, Michael Kimlin, Andrew Stacey, Debra Anderson
Meeting Abstract
Oncology
Patrick B. Thomas, Penny L. Jeffery, Gahete D. Manuel, Eliza J. Whiteside, Michelle Maugham, Carina Walpole, Jennifer H. Gunter, Elizabeth D. Williams, Colleen C. Nelson, Adrian C. Herington, Raul M. Luque, Rakesh N. Veedu, Lisa K. Chopin, Inge Seim
Article
Oncology
Patrick B. Thomas, Inge Seim, Penny L. Jeffery, Manuel D. Gahete, Michelle Maugham, Gabrielle J. Crisp, Andrew Stacey, Esha T. Shah, Carina Walpole, Eliza J. Whiteside, Colleen C. Nelson, Adrian C. Herington, Raul M. Luque, Rakesh N. Veedu, Lisa K. Chopin
INTERNATIONAL JOURNAL OF ONCOLOGY
(2019)
Article
Multidisciplinary Sciences
Patrick B. Thomas, Penny Jeffery, Manuel D. Gahete, Eliza Whiteside, Carina Walpole, Michelle Maugham, Lidija Jovanovic, Jennifer Gunter, Elizabeth Williams, Colleen Nelson, Adrian Herington, Raul M. Luque, Rakesh Veedu, Lisa K. Chopin, Inge Seim
Summary: GHSROS, an upregulated lncRNA in prostate cancer, alters the expression of cancer-associated genes and promotes tumor cell growth, migration, survival, and resistance to drugs. It modulates the expression of PPP2R2C, potentially driving the progression of a subset of prostate tumors and representing a potential therapeutic target.
Meeting Abstract
Endocrinology & Metabolism
Patrick Thomas, Penny Jeffery, Manuel Gahete, Eliza Whiteside, Carina Maree Walpole, Michelle Maugham, Jennifer Gunter, Colleen Nelson, Adrian Herington, Raul Luque, Rakesh Veedu, Lisa Chopin, Inge Seim
CLINICAL ENDOCRINOLOGY
(2018)
Meeting Abstract
Oncology
Patrick B. Thomas, Penny L. Jeffery, Eliza Whiteside, Carina Walpole, Michelle Maugham, Lidija Jovanovic, Jennifer H. Gunter, Colleen C. Nelson, Adrian C. Herington, Rakesh Veedu, Lisa K. Chopin, Inge Seim
Meeting Abstract
Endocrinology & Metabolism
Patrick Thomas, Carina Maree Walpole, Penny Jeffery, Lidija Jovanovic, Adrian Herington, Colleen Nelson, Eliza Whiteside, Rakesh Veedu, Inge Seim, Lisa Chopin
CLINICAL ENDOCRINOLOGY
(2017)
Meeting Abstract
Urology & Nephrology
Patrick B. Thomas, Carina M. Walpole, Penny L. Jeffery, Lidija Jovanovic, Adrian C. Herington, Colleen C. Nelson, Eliza J. Whiteside, Rakesh N. Veedu, Inge Seim, Lisa K. Chopin
Article
Endocrinology & Metabolism
Inge Seim, Penny L. Jeffery, Patrick B. Thomas, Carina M. Walpole, Michelle Maugham, Jenny N. T. Fung, Pei-Yi Yap, Angela J. O'Keeffe, John Lai, Eliza J. Whiteside, Adrian C. Herington, Lisa K. Chopin
Meeting Abstract
Urology & Nephrology
Patrick Thomas, Carina M. Walpole, Penny L. Jeffery, Lidija Jovanovic, Adrian C. Herington, Colleen C. Nelson, Eliza J. Whiteside, Rakesh N. Veedu, Inge Seim, Lisa K. Chopin
Article
Public, Environmental & Occupational Health
Charrlotte Seib, Eliza Whiteside, Kathryn Lee, Janice Humphreys, Tiet Hanh Dao Tran, Lisa Chopin, Debra Anderson
WOMENS HEALTH ISSUES
(2014)
Meeting Abstract
Endocrinology & Metabolism
Inge Seim, Patrick Thomas, Penny Jeffery, Carina Walpole, Adrian C. Herington, Colleen Nelson, Lidija Jovanovic, Eliza Whiteside, Lisa Kerstin Chopin