Article
Genetics & Heredity
Dana Dlouha, Milan Blaha, Pavlina Huckova, Vera Lanska, Jaroslav Alois Hubacek, Vladimir Blaha
Summary: Long-term lipoprotein apheresis treatment has an influence on the dynamic changes of circulating miRNAs, which are involved in the pathogenesis of atherosclerosis. The longer the treatment, the more significant the impact of LA on circulating miRNAs, thereby better reflecting the potential cardiovascular risk.
Article
Genetics & Heredity
Katia Cappelli, Samanta Mecocci, Stefano Capomaccio, Francesca Beccati, Andrea Rosario Palumbo, Alessia Tognoloni, Marco Pepe, Elisabetta Chiaradia
Summary: This study aimed to measure serum miRNA profiles in horses participating in endurance competitions and found that the levels of miRNAs were associated with metabolic conditions, involving various physiological processes. Target and pathway analysis revealed the up regulation of specific miRNAs involved in muscle remodeling, angiogenesis, and gene expression regulation.
Review
Virology
Sara Monosilio, Silvia Prosperi, Maria Rosaria Squeo, Stefano Spataro, Antonio Spataro, Viviana Maestrini
Summary: Cardiovascular involvement after SARS-CoV2 infection is common, especially in the pre-vaccination era and among hospitalized patients or those with severe disease. Acute myocarditis is particularly concerning for athletes due to the risk of malignant arrhythmias during training. Initial studies showed high percentages of CV injuries even in young, healthy athletes with a mild disease course, but subsequent research reported lower prevalence in athletes. Studies on CV adverse events during follow-up periods are now available. This narrative review aims to provide an updated summary of CV involvement after COVID-19, focusing on athletic populations.
Article
Clinical Neurology
Ali Al-Husseini, Anna Gard, Per-Anders Fransson, Yelverton Tegner, Mans Magnusson, Niklas Marklund, Fredrik Tjernstroem
Summary: This study found that sports-related concussions (SRC) can affect postural control and motor learning in athletes, leading to persistent symptoms such as neck and shoulder pain, headache, imbalance, dizziness, and visual disturbances. Athletes with persistent post-concussive symptoms (PPCS) at least 6 months after the incident used more energy during balance perturbations and quiet stance, and had diminished sensorimotor adaptation compared to controls.
FRONTIERS IN NEUROLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xinying Yang, Xiaoyu Du, Ke Ma, Guoqi Li, Zhuohui Liu, Wei Rong, Huangtai Miao, Fuli Zhu, Qinghua Cui, Shaowei Wu, Yulin Li, Jie Du
Summary: This study found that circulating miR-26a-5p, miR-21-5p, and miR-191-5p levels were lower in patients who experienced major adverse cardiovascular events after acute myocardial infarction compared to those who did not. Multivariate conditional logistic regression analysis showed that these miRNAs were significantly inversely associated with incident primary composite outcomes. Combining these miRNAs with B-type natriuretic peptide improved risk scores recommended in the current guidelines.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dong Hoon Lee, Leandro F. M. Rezende, Hee-Kyung Joh, NaNa Keum, Gerson Ferrari, Juan Pablo Rey-Lopez, Eric B. Rimm, Fred K. Tabung, Edward L. Giovannucci
Summary: Engaging in moderate or vigorous physical activities for an appropriate amount of time can reduce the risk of mortality.
Article
Medical Laboratory Technology
Jorge Diaz-Garzon, Pilar Fernandez-Calle, Aasne K. Aarsand, Sverre Sandberg, Abdurrahaman Coskun, Anna Carobene, Niels Jonker, Outi Itkonen, William A. Bartlett, Antonio Buno
Summary: This study aimed to deliver BV estimates of 29 routine laboratory measurands derived from a population of high-endurance athletes. Most BV estimates were similar or slightly higher in athletes compared to the general population, with notable increases observed for specific measurands.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Article
Sport Sciences
Tea Saetereng Fyksen, Paul Vanberg, Knut Gjesdal, Thomas G. von Lueder, Reidar Bjornerheim, Kjetil Steine, Dan Atar, Sigrun Halvorsen
Summary: This study compared the cardiovascular phenotypes of strength-trained men with long-term use of AAS and athletes without AAS use. The results showed that AAS users had higher hematocrit and hemoglobin levels, lower HDL cholesterol levels, slightly lower maximal exercise capacity, thicker intraventricular septum and left ventricular posterior wall, and lower LV ejection fraction compared to non-users. Furthermore, 17% of AAS users showed evidence of coronary artery disease. These findings indicate a divergent cardiovascular profile associated with increased cardiovascular risk among AAS users.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2022)
Article
Urology & Nephrology
Davide Bolignano, Marta Greco, Pierangela Presta, Anila Duni, Caterina Vita, Ethymios Pappas, Maria Mirabelli, Lampros Lakkas, Katerina K. Naka, Antonio Brunetti, Daniela Patrizia Foti, Michele Andreucci, Giuseppe Coppolino, Evangelia Dounousi
Summary: Chronic HD patients with severe cardiac alterations have a higher risk of death and adverse CV outcomes. Imbalanced expression of certain miRNAs is related to pathological cardiac remodeling and worse CV outcomes. In this study, circulating levels of miRNA 30a-5p, 23a-3p, and 451a were found to be lower in HD patients and correlated with the severity of cardiac dysfunction. These miRNAs may serve as predictors of worse clinical outcomes.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Sport Sciences
Adam Runacres, Kelly A. Mackintosh, Melitta A. McNarry
Summary: Overall, athletes tend to live longer and have lower rates of cardiovascular disease and cancer mortality compared to the general population, but there may be different health risks associated with different sports classifications and genders. Further investigation is needed to explore these differences.
Article
Medicine, General & Internal
Vittorio Picchio, Giulio Ferrero, Claudia Cozzolino, Barbara Pardini, Erica Floris, Sonia Tarallo, Xhulio Dhori, Cristina Nocella, Lorenzo Loffredo, Giuseppe Biondi-Zoccai, Roberto Carnevale, Giacomo Frati, Isotta Chimenti, Francesca Pagano
Summary: This study defines for the first time the miRNA profile in the serum of chronic exclusive heat-not-burn cigarette smokers and suggests a significant impact of heat-not-burn cigarettes on circulating miRNAs.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Pediatrics
Panagiota Klentrou, Katherine McKee, Brandon J. McKinlay, Nigel Kurgan, Brian D. Roy, Bareket Falk
Summary: The study showed that short-term high-impact intense training had no direct catabolic impact on bone metabolism, with Greek yogurt providing no additional benefit beyond that of an isocaloric carbohydrate control pudding.
Article
Sport Sciences
Heath M. Burton, Anthony S. Wolfe, Emre Vardarli, Remzi Satiroglu, Edward F. Coyle
Summary: The study found that reducing daily steps can affect acute and short-term adaptations to intense aerobic training, especially showing more pronounced effects on metabolic responses and stress reactions.
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
(2021)
Article
Cardiac & Cardiovascular Systems
Tony G. Dawkins, Bryony A. Curry, Stephen P. Wright, Victoria L. Meah, Zaheer Yousef, Neil D. Eves, Rob E. Shave, Michael Stembridge
Summary: This meta-analysis found that athletes have significantly higher RV pressure, increased tricuspid annular displacement and velocity, as well as increased longitudinal apical strain compared to controls.
CIRCULATION-CARDIOVASCULAR IMAGING
(2021)
Article
Multidisciplinary Sciences
Avik Mukherjee, Jade Ealy, Yanqing Huang, Nina Catherine Benites, Mark Polk, Markus Basan
Summary: Utilizing a combination of experiments and computer simulations, researchers have found that the emergence and persistence of coexistence of multiple ecotypes in Escherichia coli long-term evolution experiment can be explained by two interacting trade-offs rooted in biochemical constraints. Faster growth enabled by higher fermentation and obligate acetate excretion results in longer lag times when utilizing acetate after glucose is depleted, creating an ecological niche for a slower-growing ecotype specialized in switching to acetate. These findings highlight the importance of trade-offs in the evolution of complex microbial communities.
NATURE COMMUNICATIONS
(2023)