Article
Biochemistry & Molecular Biology
Janko Gospocic, Karl M. Glastad, Lihong Sheng, Emily J. Shields, Shelley L. Berger, Roberto Bonasio
Summary: Kr-h1 is a transcription factor that maintains distinct brain states in Harpegnathos saltator ants, established in response to socially regulated hormones, influencing the characteristic behaviors between workers and gamergates.
Review
Physiology
Qianyu He, Yuanxi Zhang
Summary: The insect life cycle is regulated by hormones and their downstream effectors. Kruppel homolog1 (Kr-h1) is an important effector that mediates the actions of juvenile hormone (JH) and 20-hydroxyecdysone (20E) in insects. The expression of Kr-h1 fluctuates during insect development and is closely linked to its function in different stages of the insect's life, including antimetamorphic effects, promotion of ovarian development and vitellogenesis, regulation of behavioral plasticity and caste identity, neuronal morphogenesis, maturation of sexual behavior, embryogenesis, and metabolic homeostasis.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Xiaoshuai Zhang, Sheng Li, Suning Liu
Summary: JH, produced by the endocrine gland corpus allatum, plays a critical role in regulating developmental and physiological processes in insects. The fruit fly Drosophila melanogaster is a key model for studying JH.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Entomology
Karol Giejdasz, Monika Fliszkiewicz, Oskar Wasielewski
Summary: The study found that injecting methoprene into Osmia rufa L. nests significantly reduced the emergence time of adult bees in winter, with a more pronounced effect in females. Additionally, methoprene treatment improved reproductive traits of Osmia rufa L. bees.
Article
Agronomy
Qiao Gao, Bei Li, Zhong Tian, Arnold De Loof, Jia-Lu Wang, Xiao-Ping Wang, Wen Liu
Summary: Our study reveals that in the Asian lady beetle Harmonia axyridis, the absence of juvenile hormone (JH) triggers reproductive diapause, as indicated by JH measurements and the knockdown of the intracellular JH receptor methoprene-tolerant (Met). Furthermore, we demonstrate that JH biosynthesis, rather than the degradation pathway, determines the reduction of JH titer in diapausing females.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
H. -Y. Ma, Y. -Y. Li, L. Li, Y. Tan, B. -P. Pang
Summary: The study discovered that topical application of the JH analogue methoprene induced the expression of GdMet in 3-day-old and 5-day-old adults of Galeruca daurica. Silencing GdMet through RNAi inhibited the expression of JHBP, JHE, Kr-h1, and Vg, while promoting FAS2 expression, leading to enhanced lipid accumulation and fat body development, ultimately inducing the adults into diapause ahead of schedule.
INSECT MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qianyu He, Xiaochun Fan, Shunxin Wang, Shanshan Chen, Jinxia Chen
Summary: This study found that the JH primary response gene Kruppel homologue 1 (Kr-h1) plays a vital role in the repression of adult cuticle formation through the mediation of JH action. It inhibits the transcription of Acp65A by directly binding to the consensus Kr-h1 binding site (KBS) within the Acp65A promoter region. Moreover, the DNA methyltransferase Dnmt2 was shown to interact with Kr-h1, combined with the KBS to promote the DNA methylation of sequences around the KBS, in turn inhibiting the transcription of Acp65A.
INSECT MOLECULAR BIOLOGY
(2023)
Article
Entomology
Hui Han, ZhaoYang Feng, ShiPeng Han, Jie Chen, Da Wang, YunZhuan He
Summary: This study identified and analyzed the Met and Kr-h1 genes in Harmonia axyridis and found that they play important roles in female reproduction. Knockdown of these genes significantly reduced yolk protein deposition and fecundity. The findings provide a basis for the application or control of H. axyridis.
JOURNAL OF ECONOMIC ENTOMOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Edmundo Gassias, Annick Maria, Philippe Couzi, Elodie Demondion, Nicolas Durand, Francoise Bozzolan, Paleo Aguilar, Stephane Debernard
Summary: This study investigates the effects of juvenile hormone on the development and secretory activity of the accessory glands in Agrotis ipsilon, revealing the crucial role of the JH-Met-Kr-h1 signaling pathway in this process.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bin-Bin Yang, Shi-Yuan Miao, Yu-Jie Lu, Sui-Sui Wang, Zheng-Yan Wang, Ya-Ru Zhao
Summary: In this study, the roles of Methoprene-tolerant (Met) and Kruppel-homolog 1 (Kr-h1) in the reproduction of Liposcelis entomophila were investigated. Knockdown of Met and Kr-h1 resulted in decreased vitellogenesis and ovarian development, leading to a decline in fecundity. Moreover, the expression of other hormone factors, such as FoxO, was also affected. These findings highlight the importance of JH signaling in female reproduction of psocids and suggest that RNAi-mediated knockdown of Met or Kr-h1 could be a potential pest control strategy.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Entomology
Hong-Yue Ma, Yan-Yan Li, Ling Li, Yao Tan, Bao-Ping Pang
Summary: Juvenile hormone (JH) signaling has been proven to play a significant role in regulating reproductive diapause in insects. Topical application of a JH analog delayed entry into diapause and inhibited lipid accumulation in G. daurica.
Article
Agronomy
Xue-Ming Ren, Yi-Shi Yang, Ru-Xin Guo, Hao-Ran Wang, Xue-Wei Qi, Shuai Cao, Yan-Nan Lai, Gui-Jian Zhang, Changying Niu
Summary: This study found that after oviposition by B. minax, the yeast P. kluyveri translocated to and proliferated inside the citrus fruit, resulting in a significant increase in d-limonene release. This attracted B. dorsalis females to oviposit, but also reduced the survival rate and pupal weight of B. dorsalis larvae. This suggests that B. minax occupies a dominant position in the interspecific interaction.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Jie Luo, Sheng Liu, Jiangan Hou, Lichao Chen, Honghong Li, Shucheng Liao, Qimei Tan, Taiyi Yang, Guoqiang Yi, Fu Zhang, Xuesheng Li
Summary: The study showed that different JHAs treatments on honey bee larvae led to varying changes in gene transcription and pathway enrichment, with fenoxycarb affecting the most genes and pathways. Furthermore, the treatments with different JHAs resulted in different levels of impact on the JH titers in the honey bee.
Article
Biochemistry & Molecular Biology
Shengfeng Zhang, Junfei Xie, Rengang Luo, Hongyu Zhang, Weiwei Zheng
Summary: In this study, a microRNA, miR-2b-2-5p, was identified in the highly invasive agricultural pest Bactrocera dorsalis. Knockdown of miR-2b-2-5p impaired ovarian development, reduced fecundity, and decreased triglyceride storage. Overexpression of miR-2b-2-5p caused similar reproductive defects but increased triglyceride storage. miR-2b-2-5p regulates cyclic AMP response element (CRE)-binding protein (CREB) expression to maintain metabolic and reproductive homeostasis.
Article
Biochemistry & Molecular Biology
Matej Milacek, Lenka Bittova, Sarka Tumova, Ondrej Luksan, Robert Hanus, Pavlina Kyjakova, Ales Machara, Ales Marek, Marek Jindra
Summary: Juvenile hormone controls insect reproduction and development through a receptor complex consisting of Met and Tai proteins, affecting vitellogenesis in cockroaches and caste polyphenism in termites. Studies show high-affinity binding of JH III by Met proteins in cockroaches and termites, with evidence of JH receptor agonist binding in hemimetabolous species.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2021)