期刊
FRONTIERS IN PHYSIOLOGY
卷 9, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fphys.2018.00522
关键词
bioinformatics; databases; IncRNAs; miRNAs; RNA-seq; RNA editing; RNA modifications
类别
资金
- V. V. Cooke Foundation (Kentucky, U.S.A.)
- University of Louisville School of Medicine
- EVPRI Internal Research Grant from the Office of the Executive Vice President for Research and Innovation at the University of Louisville
- University of Louisville 21st Century University Initiative on Big Data in Medicine
- Mansbach Family
- Gheens Foundation
In recent years, the role of RNA has expanded to the extent that protein-coding RNAs are now the minority with a variety of non-coding RNAs (ncRNAs) now comprising the majority of RNAs in higher organisms. A major contributor to this shift in understanding is RNA sequencing (RNA-seq), which allows a largely unconstrained method for monitoring the status of RNA from whole organisms down to a single cell. This observational power presents both challenges and new opportunities, which require specialized bioinformatics tools to extract knowledge from the data and the ability to reuse data for multiple studies. In this review, we summarize the current status of long non-coding RNA (IncRNA) research in endothelial biology. Then, we will cover computational methods for identifying, annotating, and characterizing IncRNAs in the heart, especially endothelial cells.
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