Unveiling the Role of Ecto-5′-Nucleotidase/CD73 in Astrocyte Migration by Using Pharmacological Tools

Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro

(2016) Marija Adzic et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Inhibition of CD73 AMP hydrolysis by a therapeutic antibody with a dual, non-competitive mechanism of action

(2016) James C. Geoghegan et al.   mAbs

Insights into Ecto-5’-Nucleotidase as a New Target for Cancer Therapy: A Medicinal Chemistry Study

(2015) Patricia Corbelini et al.   CURRENT MEDICINAL CHEMISTRY

Extracellular ATP Selectively Upregulates Ecto-Nucleoside Triphosphate Diphosphohydrolase 2 and Ecto-5′-Nucleotidase by Rat Cortical Astrocytes In Vitro

(2015) Dusica Brisevac et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Role of tenascins in the ECM of gliomas

(2015) Nicole Brösicke et al.   Cell Adhesion & Migration

Ecto-5’-Nucleotidase Overexpression Reduces Tumor Growth in a Xenograph Medulloblastoma Model

(2015) Angélica R. Cappellari et al.   PLoS One

Enzymes involved in metabolism of extracellular nucleotides and nucleosides: Functional implications and measurement of activities

(2014) Gennady G. Yegutkin   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Expression of a Second Ecto-5′-Nucleotidase Variant Besides the Usual Protein in Symptomatic Phase of Experimental Autoimmune Encephalomyelitis

(2014) Irena Lavrnja et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Developmental Increase in Ecto-5′-Nucleotidase Activity Overlaps with Appearance of Two Immunologically Distinct Enzyme Isoforms in Rat Hippocampal Synaptic Plasma Membranes

(2014) Ivana Grkovic et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

The Roles of CD73 in Cancer

(2014) Zhao-wei Gao et al.   Biomed Research International

Anti-Human CD73 Monoclonal Antibody Inhibits Metastasis Formation in Human Breast Cancer by Inducing Clustering and Internalization of CD73 Expressed on the Surface of Cancer Cells

(2013) M. G. Terp et al.   JOURNAL OF IMMUNOLOGY

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Synergy between the ectoenzymes CD39 and CD73 contributes to adenosinergic immunosuppression in human malignant gliomas

(2013) Shuo Xu et al.   NEURO-ONCOLOGY

CD39 and CD73 in immunity and inflammation

(2013) Luca Antonioli et al.   TRENDS IN MOLECULAR MEDICINE

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes

(2013) Alberto L Horenstein et al.   OncoImmunology

Crystal Structure of a Soluble Form of Human CD73 with Ecto-5′-Nucleotidase Activity

(2012) Dominic P. H. M. Heuts et al.   CHEMBIOCHEM

Ectonucleotidases and Nucleotide/Nucleoside Transporters as Pharmacological Targets for Neurological Disorders

(2012) Carla D. Bonan   CNS & Neurological Disorders-Drug Targets

Production of Adenosine by Ectonucleotidases: A Key Factor in Tumor Immunoescape

(2012) François Ghiringhelli et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Regulation of ecto-5′-nucleotidase (CD73) in cultured cortical astrocytes by different inflammatory factors

(2012) Dusica Brisevac et al.   NEUROCHEMISTRY INTERNATIONAL

Neuromodulation by Extracellular ATP and P2X Receptors in the CNS

(2012) Baljit S. Khakh et al.   NEURON

Characterization of Ectonucleotidases in Human Medulloblastoma Cell Lines: ecto-5′NT/CD73 in Metastasis as Potential Prognostic Factor

(2012) Angélica Regina Cappellari et al.   PLoS One

Cellular function and molecular structure of ecto-nucleotidases

(2012) Herbert Zimmermann et al.   Purinergic Signalling

Crystal Structure of the Human Ecto-5′-Nucleotidase (CD73): Insights into the Regulation of Purinergic Signaling

(2012) Karen Knapp et al.   STRUCTURE

Astrocytes as a Source for Extracellular Matrix Molecules and Cytokines

(2012) Stefan Wiese et al.   Frontiers in Pharmacology

Ecto-5′-nucleotidase/CD73 knockdown increases cell migration and mRNA level of collagen I in a hepatic stellate cell line

(2011) Cláudia M. B. Andrade et al.   CELL AND TISSUE RESEARCH

Ontogenetic profile of ecto-5′-nucleotidase in rat brain synaptic plasma membranes

(2011) Ivana Stanojević et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Dynamic changes in the expression pattern of ecto-5′-nucleotidase in the rat model of cortical stab injury

(2011) Ivana Bjelobaba et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Review: NAD + : A modulator of immune functions

(2010) Andreas Grahnert et al.   Innate Immunity

Extracellular ATP and the P2X7 receptor in astrocyte-mediated motor neuron death: implications for amyotrophic lateral sclerosis

(2010) Mandi Gandelman et al.   Journal of Neuroinflammation

Time-course changes in ectonucleotidase activities during experimental autoimmune encephalomyelitis

(2009) Irena Lavrnja et al.   NEUROCHEMISTRY INTERNATIONAL

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade

(2008) Gennady G. Yegutkin   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Adenosine A1 and A3 receptors protect astrocytes from hypoxic damage

(2008) Olga Björklund et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Loss of Astrocytic Domain Organization in the Epileptic Brain

(2008) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

The role of ecto-5′-nucleotidase/CD73 in glioma cell line proliferation

(2008) Luci Bavaresco et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Tenascin C interacts with Ecto-5′-nucleotidase (eN) and regulates adenosine generation in cancer cells

(2007) Rafal Sadej et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE