Identification of a Novel Protein Arginine Methyltransferase 5 Inhibitor in Non-small Cell Lung Cancer by Structure-Based Virtual Screening

Discovery of New SIRT2 Inhibitors by Utilizing a Consensus Docking/Scoring Strategy and Structure–Activity Relationship Analysis

(2017) Shenzhen Huang et al.   Journal of Chemical Information and Modeling

Potent, Selective, and Cell Active Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor Developed by Structure-Based Virtual Screening and Hit Optimization

(2017) Ruifeng Mao et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective inhibition mechanism of RVX-208 to the second bromodomain of bromo and extraterminal proteins: insight from microsecond molecular dynamics simulations

(2017) Qianqian Wang et al.   Scientific Reports

Protein arginine methyltransferase 5 regulates multiple signaling pathways to promote lung cancer cell proliferation

(2016) Xiumei Sheng et al.   BMC CANCER

Discovery of selective protein arginine methyltransferase 5 inhibitors and biological evaluations

(2016) Sen Ji et al.   Chemical Biology & Drug Design

FGFR Signaling as a Target for Lung Cancer Therapy

(2016) Arpita Desai et al.   Journal of Thoracic Oncology

A TGFβ-PRMT5-MEP50 axis regulates cancer cell invasion through histone H3 and H4 arginine methylation coupled transcriptional activation and repression

(2016) H Chen et al.   ONCOGENE

Selective inhibition of protein arginine methyltransferase 5 blocks initiation and maintenance of B-cell transformation

(2015) L. Alinari et al.   BLOOD

The PRMT5 arginine methyltransferase: many roles in development, cancer and beyond

(2015) Nicole Stopa et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Discovery and Optimization of Novel, Selective Histone Methyltransferase SET7 Inhibitors by Pharmacophore- and Docking-Based Virtual Screening

(2015) Fanwang Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

(2015) Elayne Chan-Penebre et al.   Nature Chemical Biology

Structure and Property Guided Design in the Identification of PRMT5 Tool Compound EPZ015666

(2015) Kenneth W. Duncan et al.   ACS Medicinal Chemistry Letters

Discovery of a Dual PRMT5–PRMT7 Inhibitor

(2015) David Smil et al.   ACS Medicinal Chemistry Letters

PRMT5 Is Required for Lymphomagenesis Triggered by Multiple Oncogenic Drivers

(2015) Y. Li et al.   Cancer Discovery

Targeting protein arginine methyltransferase 5 inhibits colorectal cancer growth by decreasing arginine methylation of eIF4E and FGFR3

(2015) Baolai Zhang et al.   Oncotarget

Molecular features of interaction between VEGFA and anti-angiogenic drugs used in retinal diseases: a computational approach

(2015) Chiara B. M. Platania et al.   Frontiers in Pharmacology

PRMT5 is essential for the eIF4E-mediated 5′-cap dependent translation

(2014) Ji-Hong Lim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic Validation of the Protein Arginine Methyltransferase PRMT5 as a Candidate Therapeutic Target in Glioblastoma

(2014) Fengting Yan et al.   CANCER RESEARCH

Expression of PRMT5 in lung adenocarcinoma and its significance in epithelial-mesenchymal transition

(2014) Reem Ibrahim et al.   HUMAN PATHOLOGY

Tuning the smooth particle mesh Ewald sum: Application on ionic solutions and dipolar fluids

(2014) Björn Linse et al.   JOURNAL OF CHEMICAL PHYSICS

KDM4B as a Target for Prostate Cancer: Structural Analysis and Selective Inhibition by a Novel Inhibitor

(2014) Chia-Han Chu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enzyme meets a surprise target

(2014) Marian M. Deuker et al.   NATURE

Cellular localization of protein arginine methyltransferase-5 correlates with grade of lung tumors

(2013) Konstantin Shilo et al.   Diagnostic Pathology

PRMT5 dimethylates R30 of the p65 subunit to activate NF- B

(2013) H. Wei et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein arginine methyltransferase 5 is essential for growth of lung cancer cells

(2012) Zhongping Gu et al.   BIOCHEMICAL JOURNAL

Protein arginine methyltransferase 5 is a potential oncoprotein that upregulates G1 cyclins/cyclin-dependent kinases and the phosphoinositide 3-kinase/AKT signaling cascade

(2012) Tong-You W. Wei et al.   CANCER SCIENCE

Directory of Useful Decoys, Enhanced (DUD-E): Better Ligands and Decoys for Better Benchmarking

(2012) Michael M. Mysinger et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Oncogene eIF4E Reprograms the Nuclear Pore Complex to Promote mRNA Export and Oncogenic Transformation

(2012) Biljana Culjkovic-Kraljacic et al.   Cell Reports

JAK2V617F-Mediated Phosphorylation of PRMT5 Downregulates Its Methyltransferase Activity and Promotes Myeloproliferation

(2011) Fan Liu et al.   CANCER CELL

FGFR3 mutation affects cell growth, apoptosis and attachment in keratinocytes

(2010) Christian Hafner et al.   EXPERIMENTAL CELL RESEARCH

Assessing the Performance of the MM/PBSA and MM/GBSA Methods. 1. The Accuracy of Binding Free Energy Calculations Based on Molecular Dynamics Simulations

(2010) Tingjun Hou et al.   Journal of Chemical Information and Modeling

New Substructure Filters for Removal of Pan Assay Interference Compounds (PAINS) from Screening Libraries and for Their Exclusion in Bioassays

(2010) Jonathan B. Baell et al.   JOURNAL OF MEDICINAL CHEMISTRY

Protein Arginine Methylation in Mammals: Who, What, and Why

(2009) Mark T. Bedford et al.   MOLECULAR CELL

PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing

(2009) Quan Zhao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY