A Novel EphA2 Inhibitor Exerts Beneficial Effects in PI-IBS in Vivo and in Vitro Models via Nrf2 and NF-κB Signaling Pathways

An in vitro inflammation model to study the Nrf2 and NF-κB crosstalk in presence of ferulic acid as modulator

(2018) Nadia Lampiasi et al.   IMMUNOBIOLOGY

Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling

(2017) Ravikanth Velagapudi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Bifunctional role of ephrin A1-Eph system in stimulating cell proliferation and protecting cells from cell death through the attenuation of ER stress and inflammatory responses in bovine mammary epithelial cells

(2017) Minkyung Kang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Small extracellular vesicles secreted from senescent cells promote cancer cell proliferation through EphA2

(2017) Masaki Takasugi et al.   Nature Communications

Oxidative Modification in the Salivary Glands of High Fat-Diet Induced Insulin Resistant Rats

(2017) Urszula Kołodziej et al.   Frontiers in Physiology

Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism

(2016) Agnieszka Loboda et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibition of EphA2/EphrinA1 signal attenuates lipopolysaccharide-induced lung injury

(2016) J. Y. Hong et al.   CLINICAL SCIENCE

Sa2085 MLCK Regulates Intestinal Permeability Through Tight Junctions in PI-IBS Mouse Model Inducing Visceral Hypersensitivity

(2016) Yanqin Long et al.   GASTROENTEROLOGY

Anti-inflammatory activity of IL-37 in asthmatic children: Correlation with inflammatory cytokines TNF-α, IL-β, IL-6 and IL-17A

(2016) Rihab Charrad et al.   IMMUNOBIOLOGY

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

The impact of abuse and mood on bowel symptoms and health-related quality of life in irritable bowel syndrome (IBS)

(2016) N. Kanuri et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Changes of excitatory and inhibitory neurotransmitters in the colon of rats underwent to the wrap partial restraint stress

(2016) C. Traini et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Nitric oxide-induced oxidative stress impairs pacemaker function of murine interstitial cells of Cajal during inflammation

(2016) Noriyuki Kaji et al.   PHARMACOLOGICAL RESEARCH

KSHV Entry and Trafficking in Target Cells—Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics

(2016) Binod Kumar et al.   Viruses-Basel

NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

(2016) Shenglan Yang et al.   RSC Advances

An inhibitor of the Keap1-Nrf2 protein-protein interaction protects NCM460 colonic cells and alleviates experimental colitis

(2016) Meng-Chen Lu et al.   Scientific Reports

Eph Receptors and Ephrins: Therapeutic Opportunities

(2015) Antonio Barquilla et al.   Annual Review of Pharmacology and Toxicology

Changes of cytokine levels in a mouse model of post-infectious irritable bowel syndrome

(2015) Bo Yang et al.   BMC GASTROENTEROLOGY

Eph as a Target in Inflammation

(2015) Katsuaki Ieguchi   Endocrine Metabolic & Immune Disorders-Drug Targets

Identification of Novel Small Molecule Inhibitors of Oncogenic RET Kinase

(2015) Marialuisa Moccia et al.   PLoS One

Cytokine Response after Stimulation with Key Commensal Bacteria Differ in Post-Infectious Irritable Bowel Syndrome (PI-IBS) Patients Compared to Healthy Controls

(2015) Johanna Sundin et al.   PLoS One

Transcription Factors NRF2 and NF-κB Are Coordinated Effectors of the Rho Family, GTP-binding Protein RAC1 during Inflammation

(2014) Antonio Cuadrado et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic and pharmacologic inhibition of EPHA2 promotes apoptosis in NSCLC

(2014) Katherine R. Amato et al.   JOURNAL OF CLINICAL INVESTIGATION

EphB/ephrinB Signaling in Cell Adhesion and Migration

(2014) Inji Park et al.   MOLECULES AND CELLS

Motility response to colonic distention is increased in postinfectious irritable bowel syndrome (PI-IBS)

(2014) M. Kanazawa et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Eph/Ephrin Signaling in Injury and Inflammation

(2012) Mark G. Coulthard et al.   AMERICAN JOURNAL OF PATHOLOGY

EphA2 Activation Promotes the Endothelial Cell Inflammatory Response

(2012) Steven Daniel Funk et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Eph-A2 Promotes Permeability and Inflammatory Responses to Bleomycin-Induced Lung Injury

(2011) Todd C. Carpenter et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Antioxidants in patients receiving total parenteral nutrition after gastrointestinal cancer surgery

(2011) Maria Szpetnar et al.   CELL BIOCHEMISTRY AND FUNCTION

Eph/ephrin signaling in cell-cell and cell-substrate adhesion

(2011) Arvinder Singh   Frontiers in Bioscience-Landmark

Capillary Defects and Exaggerated Inflammatory Response in the Airways of EphA2-Deficient Mice

(2009) Tatsuma Okazaki et al.   AMERICAN JOURNAL OF PATHOLOGY

Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro

(2008) Barden Chan et al.   THROMBOSIS RESEARCH