Article
Immunology
Shuyue Yang, Dezhi Song, Ziyi Wang, Yuangang Su, Junchun Chen, Yansi Xian, Jian Huang, Jing Li, Jiake Xu, Jinmin Zhao, Qian Liu
Summary: This study found that AZD inhibits the generation, function, and ROS-scavenging enzyme activity of mature osteoclasts, suggesting its potential as a new therapeutic agent for osteoporosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Qian Guo, Honglei Kang, Jia Wang, Yimin Dong, Renpeng Peng, Hongjian Zhao, Wei Wu, Hanfeng Guan, Feng Li
Summary: The research revealed the significant role of ATP-citrate lyase (ACLY) in osteoclast differentiation. Inhibition of ACLY suppresses osteoclast differentiation and function through regulation of histone acetylation, with Rac1 potentially acting as a downstream regulator of ACLY.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Nanoscience & Nanotechnology
Krzysztof Marycz, Agnieszka Smieszek, Klaudia Marcinkowska, Mateusz Sikora, Eliza Turlej, Paulina Sobierajska, Adrian Patej, Alina Bienko, Rafal J. Wiglusz
Summary: The study developed a new nanocomposite nHAp/IO@miR-21/124 and demonstrated its modulatory effects on bone cell metabolism, differentiation, and inflammation in vitro. The results suggest that this fabricated nanocomposite has the potential to impact proper bone regeneration in osteoporosis by restoring the balance between osteoblasts and osteoclasts.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Review
Endocrinology & Metabolism
Na Jiang, Jinyang An, Kuan Yang, Jinjin Liu, Conghui Guan, Chengxu Ma, Xulei Tang
Summary: The NLRP3 inflammasome plays a crucial role in the pathogenesis of osteoporosis by affecting the differentiation of osteoblasts and osteoclasts, resulting in accelerated bone resorption and inhibited bone formation. Abnormal activation of the inflammasome can lead to inflammation, pyroptosis, and dysfunction of osteoblasts, highlighting it as a potential therapeutic target for managing osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Muhamed Lahtif Nor Muhamad, Sophia Ogechi Ekeuku, Sok-Kuan Wong, Kok-Yong Chin
Summary: This systematic review presents the available evidence on the skeletal protective effects of naringenin, a natural compound found in citrus fruits and grapefruit. The findings suggest that naringenin enhances bone formation and inhibits bone resorption through various signaling pathways, making it a potential dietary intervention for preventing bone loss.
Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Xinli Hu, Zheng Wang, Chao Kong, Yu Wang, Weiguo Zhu, Yongjin Li, Wei Wang, Shibao Lu
Summary: This review discusses the role of necroptosis in osteoporosis and its associated mechanisms, including interactions with osteoclasts, osteoblasts, and osteocytes. It also explores the associations between necroptosis and different types of osteoporosis, and highlights experimental medicines capable of modulating necroptosis processes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Rui Wei, Lin Zhang, Wei Hu, Jie Wu, Wei Zhang
Summary: CSTA plays a crucial role in osteoporosis by interacting with the DAP12/TREM2 complex and regulating the differentiation, formation, and bone resorption of osteoclasts. Overexpression of CSTA enhances osteoclast function, while silencing CSTA inhibits osteoclast function.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Chemistry, Multidisciplinary
Hongsen Tian, Chenhui Gu, Wenshuai Li, Tong Tong, Yunsheng Wang, Yang Yang, Haoli Wang, Zhanqiu Dai, Pengfei Chen, Feng Wang, Xianfeng Lin, Liqing Shangguan, Linfeng Wang
Summary: Osteoporosis is a global disease caused by abnormal overactivation of osteoclasts. A novel nanovesicle (Na2HPO4@Lipo-pOCm) was developed to target preosteoclasts and reduce intracellular H+ concentration, thereby inhibiting osteoclasts and ameliorating osteoporosis caused by OVX. In vitro and in vivo experiments confirmed its effectiveness in reducing mitochondrial membrane potential and expression of FOXM1 of Acp5 in osteoclasts.
Review
Nanoscience & Nanotechnology
Helena Rouco, Patricia Garcia-Garcia, Erik Briffault, Patricia Diaz-Rodriguez
Summary: Osteoclasts play a crucial role in the bone resorption process during bone remodeling. Osteoporosis, characterized by decreased bone mass density and altered bone microarchitecture, poses challenges in its treatment due to low patients' adherence to available therapies. Hence, the development of new and safe treatments, such as synthetic and natural nanoparticles, to modulate osteoclasts activity is necessary. Synthetic nanoparticles can carry antiresorptive drugs or regulate osteoclasts gene expression, while natural nanoparticles, known as extracellular vesicles, have been studied for their role in bone homeostasis. By controlling osteoclast activity using nanoparticles, the management of osteoporosis can be improved.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Fujun Jin, Yexuan Zhu, Meijing Liu, Rongze Wang, Yi Cui, Yanting Wu, Gang Liu, Yifei Wang, Xiaogang Wang, Zhe Ren
Summary: In this study, Babam2 was identified as an essential negative regulator of osteoclast formation and bone resorption. It interacts with Hey1 to inhibit Nfatc1 transcription, thus negatively regulating osteoclastogenesis. Targeting Babam2 may be a novel therapeutic approach for osteoclast-related bone diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Review
Endocrinology & Metabolism
Jie Han, Kuan Yang, Jinyang An, Na Jiang, Songbo Fu, Xulei Tang
Summary: Bone metabolism is closely related to oxidative stress, and NRF2, as a core regulatory factor, plays a complex and controversial role in bone homeostasis. Moderate activation of NRF2 promotes increased bone mass, while hyperactivation may cause damage to bone formation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
So Young Eun, Yoon-Hee Cheon, Gyeong Do Park, Chong Hyuk Chung, Chang Hoon Lee, Ju-Young Kim, Myeung Su Lee
Summary: Vigeo, a mixture of fermented extracts, showed protective effects against inflammatory bone loss and osteoclastogenesis induced by LPS and RANKL, respectively, by inhibiting various signaling pathways and gene expressions.
Article
Endocrinology & Metabolism
Hui Zhang, Yuxuan Li, Lin Yuan, Lutian Yao, Jie Yang, Liping Xia, Hui Shen, Jing Lu
Summary: The study demonstrated the immunosuppressive function of IL-35 on RANKL and M-CSF-induced osteoclastogenesis and angiogenesis through Th17/IL-17 axis. Utilizing IL-35 as a therapeutic approach may serve as a novel treatment option for osteoporosis by suppressing bone resorption and angiogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ning Li, Xiaoping Li, Kai Zheng, Jiaxiang Bai, Weicheng Zhang, Houyi Sun, Gaoran Ge, Wei Wang, Zhen Wang, Ye Gu, Yi Xue, Yaozeng Xu, Dechun Geng, Jun Zhou
Summary: Inhibition of SIRT3 can reduce titanium particle-induced osteolysis and bone loss, potentially through decreasing osteoclast differentiation and phosphorylation levels of JNK and ERK.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Cell & Tissue Engineering
Yuanhao Xie, Chenqi Tang, Zizhan Huang, Sicheng Zhou, Yuwei Yang, Zi Yin, Boon Chin Heng, Weishan Chen, Xiao Chen, Weiliang Shen
Summary: In vitro extracellular matrix (ECM) remodeling is critical for maintaining stem cell (SC) function. This review summarizes how cells remodel ECM and the significance of ECM remodeling in ex vivo SC culture, as well as outlines the shortcomings of current research and future directions.
TISSUE ENGINEERING PART B-REVIEWS
(2022)
Article
Engineering, Biomedical
Li Wang, Xiaolei Guo, Jiaqing Chen, Zhen Zhen, Bin Cao, Wenqian Wan, Yuandong Dou, Haobo Pan, Feng Xu, Zepu Zhang, Jianmei Wang, Daisong Li, Quanyi Guo, Qing Jiang, Yanan Du, Jiakuo Yu, Boon Chin Heng, Qianqian Han, Zigang Ge
Summary: With the interdisciplinary convergence of biology, medicine, and materials science, there is a growing need to bridge the gap between applied basic research and translational products in the field of biomaterials. This article critically examines the developmental pipeline of biodegradable biomaterials and proposes ideas to integrate different mindsets to guide research and translation, reducing unnecessary research efforts and funding.
BIOACTIVE MATERIALS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Mei Zhuang, Wuwen Zhang, Nuo Cheng, Ling Zhou, Dan Liu, Hua Yan, Ge Fang, Boon Chin Heng, Yan Sun, Guoqing Tong
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Engineering, Biomedical
Ting Zou, Shan Jiang, Baicheng Yi, Qixin Chen, Boon Chin Heng, Chengfei Zhang
Summary: The study demonstrated that SCAPs induced in BDNF-GelMA with small molecule cocktail showed significant upregulation of neural markers, exhibiting morphological characteristics similar to neuronal cells, which may provide a therapeutic platform for neurological disorders.
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
(2022)
Article
Cell Biology
Jiabei Yang, Xuewei Zhang, Jiaqing Chen, Boon Chin Heng, Yangzi Jiang, Xiaoyu Hu, Zigang Ge
Summary: The study highlights the important role of macrophages in cartilage regeneration, showing that they promote regeneration by modulating proliferation and apoptosis. Exogeneous macrophages have therapeutic potential in promoting cartilage regeneration by regulating stem cells. Only M2c macrophages are able to promote regeneration of both cartilage tissues and subchondral bone.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Endocrinology & Metabolism
Jaydeep Roy, Kan Yin Wong, Luca Aquili, Md. Sahab Uddin, Boon Chin Heng, George Lim Tipoe, Kah Hui Wong, Man Lung Fung, Lee Wei Lim
Summary: In this review, the developmental trends and neuroprotective mechanisms of melatonin therapies for Alzheimer's disease (AD) are examined. Melatonin has been shown to alleviate various pathological processes in AD and beneficially affect behavior in animal models. Clinical studies demonstrate positive effects of melatonin on sleep, cognition, behavior, and psychiatric symptoms in AD patients.
FRONTIERS IN NEUROENDOCRINOLOGY
(2022)
Article
Chemistry, Physical
Ruyuan Ding, Yajun Liu, Dawei Cheng, Gang Yang, Wenjing Wu, Haoran Du, Xin Jin, Yihan Chen, Yuanyin Wang, Boon Chin Heng, Qing Yang, Jianguang Xu
Summary: The incorporation of pro-osteogenic growth factors into bone graft materials to enhance bone regeneration is a key research area. The combination of gene therapy and tissue engineering through gene-activated matrix (GAM) provides a solution to overcome the limitations of growth factors degradation. In this study, a novel GAM system with superior bone regeneration capacity was prepared, and in vitro experiments demonstrated excellent biocompatibility and sustained release of therapeutic genes.
Review
Dentistry, Oral Surgery & Medicine
Boon Chin Heng, Yunyang Bai, Xiaochan Li, Xuehui Zhang, Xuliang Deng
Summary: Dental and oral-derived stem cells have high potential for neurogenesis. Using electroactive or electroconductive tissue engineering scaffolds may enhance their neurogenesis. However, there is limited research on these cells, with most scientific information coming from studies on other mesenchymal stem cell lineages.
INTERNATIONAL JOURNAL OF ORAL SCIENCE
(2022)
Article
Cell & Tissue Engineering
Zhenggang Wang, Zhiyi He, Weikai Zhang, Shuang Liang, Kun Chen, Shimeng Xu, Ying Zhang, Peng Cheng
Summary: Our study found that GSK-3β can inhibit chondrogenesis of IL-1β-impaired BMSCs through disrupting metabolic balance and promoting cell apoptosis, regulating chondrogenesis via the NF-κB and Wnt/β-catenin signaling pathways. GSK-3β may mediate the cross-reaction between NF-κB and β-catenin in the nucleus.
STEM CELLS INTERNATIONAL
(2022)
Article
Pharmacology & Pharmacy
Kun Chen, Xianzuo Zhang, Zhi Li, Xingshi Yuan, Daijie Fu, Kerong Wu, Xifu Shang, Zhe Ni
Summary: Osteoarthritis, a common joint disease among middle-aged and elderly people, has diverse pathogenesis, poor prognosis, and high recurrence rate, which significantly affects patients' physical and mental health, reducing their quality of life. The pathogenesis of osteoarthritis is not completely understood, and current treatment plans focus on symptom relief and ensuring basic quality of life, making it urgent to explore the pathogenesis of the disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yangmengfan Chen, Chao Lu, Xifu Shang, Kerong Wu, Kun Chen
Summary: Primary cilia play a crucial role in receiving and transducing signals in cells, and the mechanisms underlying the positive effects of electromagnetic field (EMF) treatment for bone fractures remain unclear. This review provides a comprehensive understanding of bone healing, the structure and function of primary cilia, and the application and mechanism of EMF in fracture healing. It also highlights the limitations in EMF-related research and offers an outlook for future studies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Engineering, Biomedical
Fangyuan Bao, Junzhi Yi, Yixiao Liu, Yuliang Zhong, Hui Zhang, Zhonglin Wu, Boon Chin Heng, Ying Wang, Ziyang Wang, Lizi Xiao, Hua Liu, Hongwei Ouyang, Jing Zhou
Summary: This study investigates the optimal applied form and underlying mechanisms of nano-hydroxyapatite (nHAP) in bone repair. The results suggest that when nHAP is applied in the fixed state in a 3D form, it can induce optimal osteogenesis and increased bone volume through upregulation of the PI3K-AKT signaling pathway and ITGA7-mediated mechanisms, contrary to the results observed with free nHAP.
BIOACTIVE MATERIALS
(2022)
Article
Engineering, Biomedical
Xiaochan Li, Boon Chin Heng, Yunyang Bai, Qianqian Wang, Min Gao, Ying He, Xinwen Zhang, Xuliang Deng, Xuehui Zhang
Summary: The study confirms the dose-response effect of surface electrical charge on SHED neural differentiation and provides insights into the underlying molecular mechanisms and signaling pathways involved.
BIOACTIVE MATERIALS
(2023)
Article
Endocrinology & Metabolism
Xingshi Yuan, Kerong Wu, Zhi Li, Xiaodong Ling, Zhengliang Luo, Daijie Fu, Xiaoqi Zhang, Kun Chen, Xifu Shang
Summary: This study aimed to investigate the pharmacological action and mechanism of Micheliolide (MCL) in the treatment of osteoarthritis (OA). The results showed that MCL can inhibit IL-1β-induced chondrocyte inflammation by blocking the MAPK pathway. These findings provide new data support for the application of MCL in the treatment of OA.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2023)
Article
Biochemistry & Molecular Biology
Kun Chen, Xi Chen, Chuandong Lang, Xingshi Yuan, Junming Huang, Zhi Li, Mingyou Xu, Kerong Wu, Chenhe Zhou, Qidong Li, Chen Zhu, Lianxin Liu, Xifu Shang
Summary: circFam190a is identified as a critical regulator of osteoclast differentiation and function, enhancing osteoclast formation and function by enhancing the binding of AKT1 and HSP90 ss and promoting AKT1 stability. Targeting circFam190a might be a promising therapeutic strategy for treating pathological bone loss.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2023)