Article
Hematology
Tiphaine Belleville-Rolland, Alexandre Leuci, Alexandre Mansour, Benoit Decouture, Fanny Martin, Sonia Poirault-Chassac, Margot Rouaud, Hippolyte Guerineau, Blandine Dizier, Dominique Pidard, Pascale Gaussem, Christilla Bachelot-Loza
Summary: The study found that a small fraction of MRP4 and most inhibitory G-protein Gi were located in lipid rafts; the integrity of lipid rafts is necessary for cAMP signaling regulation, even though MRP4 and most cAMP homeostasis proteins are mainly located outside rafts.
THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Chemistry, Physical
Thomas R. Shaw, Subhadip Ghosh, Sarah L. Veatch
Summary: Lateral organization in the plasma membrane plays a crucial role in biological processes. Recent experimental support suggests that lipid organization is important in modulating membrane heterogeneity. The concept of liquid-liquid phase separation explains the observed heterogeneity and predicts responses to membrane composition perturbations.
ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 72
(2021)
Article
Biochemistry & Molecular Biology
Orsolya Geda, Tamas Tabi, Peter P. Lakatos, Eva Szoko
Summary: This study investigated the effects of DIMEB, HPBCD, RAMEA, and HPACD on ganglioside and cholesterol levels in rat brain synaptosomes. HPBCD showed selective cholesterol depletion capability, while RAMEA and HPACD selectively depleted gangliosides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Giuseppe Miserocchi
Summary: The lung responds promptly to conditions that cause edema through functional adaptations. This review provides evidence for early signaling transduction in endothelial lung cells in two animal models of edema. The role of membrane rafts, such as caveolae and lipid rafts, in signaling transduction is discussed. The changes in lipid composition of the plasma membrane trigger the signaling process in response to changes in the pericellular microenvironment caused by edema.
Review
Pharmacology & Pharmacy
Jeffrey M. Schappi, Mark M. Rasenick
Summary: The relationship between depression, its etiology and therapy, and the cAMP signaling system have been studied for decades. This review focuses on the role of cAMP, G proteins, and adenylyl cyclase in depression and antidepressant action. Both human and animal studies are compared, revealing that cAMP signaling is attenuated in depression and can be reversed by successful antidepressant therapy. The G protein G alpha(s) that activates adenylyl cyclase appears to have limited access to adenylyl cyclase in depression, but this can be rectified by successful antidepressant treatment. However, there is a discrepancy between human and animal studies in linking specific isoforms of adenylyl cyclase to depression or antidepressant action.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Emmanuel Laplantine, Christine Chable-Bessia, Anne Oudin, Jitendryia Swain, Adele Soria, Peggy Merida, Manon Gourdelier, Sarra Mestiri, Indira Besseghe, Erwan Bremaud, Aymeric Neyret, Sebastien Lyonnais, Cyril Favard, Philippe Benaroch, Mathieu Hubert, Olivier Schwartz, Maryse Guerin, Anne Danckaert, Elaine Del Nery, Delphine Muriaux, Robert Weil
Summary: This study highlights the potential of Auranofin in inhibiting NF-kappa B pathway to alleviate inflammation, prevent SARS-CoV-2 infection, and counteract key steps of viral entry into host cells.
Article
Physics, Multidisciplinary
Taras Sych, Ramin Omidvar, Rafael Ostmann, Thomas Schubert, Annette Brandel, Ludovic Richert, Yves Mely, Josef Madl, Winfried Roemer
Summary: The dynamic reorganization of lipid rafts is important in host cell infection by human pathogens. Bacteria induce this reorganization through interactions with glycosphingolipids (GSLs). The authors studied how the bacterial lectin LecA affects the nanometric organization of membranes and found that it causes dispersion of liquid-ordered domains and surface deformation, providing insights into P. aeruginosa infection.
COMMUNICATIONS PHYSICS
(2023)
Article
Plant Sciences
Natalia Ozolina, Irina S. Kapustina, Veronika V. Gurina, Vadim N. Nurminsky
Summary: Variations in the content of tonoplast microdomains induced by osmotic stress may play a role in adaptive mechanisms of plant cells. The lipids of raft-like microdomains in tonoplasts are hypothesized to have a protective function against stress. Under hyperosmotic stress, an increase in sterols and polar lipids stabilizes membrane structure, while hydrocarbons mainly fulfill a protective function under hypoosmotic stress.
Review
Biochemistry & Molecular Biology
Borna Puljko, Mario Stojanovic, Katarina Ilic, Svjetlana Kalanj-Bognar, Kristina Mlinac-Jerkovic
Summary: Gangliosides, through interactions with membrane proteins, affect the activity of Na+/K+-ATPase and may be involved in the pathogenesis of epilepsy.
Article
Multidisciplinary Sciences
Kang-Cheng Liu, Hudson Pace, Elin Larsson, Shakhawath Hossain, Aleksei Kabedev, Ankita Shukla, Vanessa Jerschabek, Jagan Mohan, Christel A. S. Bergstrom, Marta Bally, Christian Schwieger, Madlen Hubert, Richard Lundmark
Summary: Caveolae, important plasma membrane invaginations, are shaped by the coat protein Cavin1. This study reveals the mechanism of Cavin1 assembly at the membrane interface, involving initial PI(4,5)P-2-dependent membrane adsorption, subsequent partial separation and membrane insertion. This intricate mechanism facilitates membrane curvature generation and dynamic assembly-disassembly of Cavin1 at the membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biophysics
Anthony Legrand, Daniel G-Cava, Marie-Dominique Jolivet, Marion Decossas, Olivier Lambert, Vincent Bayle, Yvon Jaillais, Antoine Loquet, Veronique Germain, Marie Boudsocq, Birgit Habenstein, Marisela Velez Tirado, Sebastien Mongrand
Summary: Remorins are a family of plasma membrane phosphoproteins involved in plant interaction mechanisms. Their signaling activity depends on phosphorylation and clustering into membrane domains. This study investigates the role of the intrinsically disordered domain (IDD) in remorin-membrane interaction. The results show that REM1.3 drives the formation of lipid-reorganized nanodomains and the phosphorylation of IDD influences clustering and domain formation.
BIOPHYSICAL JOURNAL
(2023)
Article
Chemistry, Medicinal
Keying Liang, Shengsheng Mei, Xiangzheng Gao, Shanshan Peng, Jinbiao Zhan
Summary: The study has identified the caveolae/lipid-raft mediated endocytosis pathway of T-DM1, demonstrating that modulation of this pathway may improve the therapeutic effect of T-DM1.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Review
Biochemistry & Molecular Biology
Muhammad Arifur Rahman, Ravinder Kumar, Enrique Sanchez, Taras Y. Nazarko
Summary: Originally seen as passive structures for lipid storage, lipid droplets (LDs) have been found to be dynamic organelles with important cellular functions. LDs are degraded through a process called lipophagy, where they are broken down within cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Claudia Roessler, Julia Schumann
Summary: Inflammation is influenced by the adaptation of macrophages and endothelial cells, which can be dysregulated in both acute and chronic diseases. The interaction between these cells and dietary components, such as polyunsaturated fatty acids (PUFA), can impact their differentiation processes. RNA sequencing analysis was used to study the global changes in gene expression during cell differentiation and uncover the molecular mechanisms underlying the effects of PUFA on macrophages and endothelial cells. This dataset provides a valuable resource for studying the transcriptional and post-transcriptional changes associated with inflammation and the modulation by omega-3 and omega-6 fatty acids.
Review
Cell Biology
Claudia Matthaeus, Justin W. Taraska
Summary: Caveolae are plasma membrane invaginations with a diameter of 70-100 nm, abundant in specific cell types and characterized by specific lipid binding proteins. They provide support for proteins involved in cell-specific signaling pathways and play an important role in lipid trafficking and metabolism through their ability to detach from the plasma membrane and move through the cytosol.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)