Article
Integrative & Complementary Medicine
Li Wang, Xixi Yu, Hongju Li, Dahong He, Su Zeng, Zheng Xiang
Summary: Rhein can delay the progression of chronic nephropathy by affecting metabolic pathways and NF-kappa B and MAPK signaling pathways, providing a basis for its further development and clinical application.
Article
Multidisciplinary Sciences
Lucia Pappalardo
Summary: Pomegranate is a valuable source of nutrition with medicinal benefits. As the demand for pomegranate fresh fruit juices increases, the issue of adulteration becomes a concern. This study utilized UV-visible spectroscopy and multivariate statistical analysis to detect adulteration of pomegranate juice with apple juice concentrate.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Yue Sun, Lin Zhou, Xiao Shan, Tiantian Zhao, Meirong Cui, Wenqian Hao, Binbin Wei
Summary: Using UPLC-QTOF/MS and plasma untargeted metabolomics analysis, this study revealed the changes in components and metabolic fluctuations of polygonatum under different processing times. The results showed that processed polygonatum exhibited changes in protein, fat, polysaccharide, flavonoids, saponins, and isoflavones. Additionally, four types of Lysophosphatidylcholines were found to be highly expressed in the plasma of rats in the SAD-9 group. Through network pharmacological analysis, it was determined that liquiritigenin and 4',5-dihydroxyflavone activated PLA2 type enzymes, promoting the production of lysophosphatidylcholine, and the SAD-9 processing method facilitated the effects of these two components.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Agriculture, Multidisciplinary
Shangguang Du, Yali Cai, Shengrong Qiu, Yingbin Hao, Kaili Tian, Zhengrong Zou, Liping Luo
Summary: This study found that low temperature stress induces different metabolic changes in rice, with significant differences between Qiutianxiaoting and 93-11. Qiutianxiaoting maintains cellular homeostasis through starch and sucrose metabolism, aminoacyl-tRNA biosynthesis, and phenylpropanoid biosynthesis. 93-11 responds to chilling stress through aminoacyl-tRNA biosynthesis and antioxidation metabolism, but experiences metabolic and transcriptomic disorders during the recovery stage.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Food Science & Technology
Dahye Yoon, Woo-Cheol Shin, Seon-Min Oh, Bo-Ram Choi, Dae Young Lee
Summary: This study compared the metabolic profiles of Korean, Chinese, and Japanese ginseng, revealing significant differences depending on the cultivation environment. Different types of ginsenosides were found to be predominant in ginseng cultivated in each country, indicating the importance of considering origin when using ginseng for medicinal purposes. The results provide valuable insights for future ginseng research.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
Yanna Zhang, Bin Wang, Penghui Zhao, Fan He, Wei Xiao, Jingbo Zhu, Yan Ding
Summary: This study successfully identified characteristic markers of sulfur-fumigated ginseng and revealed the chemical transformation mechanism during the fumigation process. The findings showed that sulfur fumigation significantly altered the chemical profile of ginseng and provided insights into the sulfates transformation mechanism of ginsenosides during the fumigation process.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Jinlin Fan, Zheng Xiao, Wanwei Qiu, Chao Zhao, Chao Yi, Dongmei Lin, Zhanxi Lin
Summary: This study used GC-QTOF-MS metabolomics and multivariate statistical analysis to investigate the dynamic changes of metabolites during the fermentation of JUNCAO wine. It identified key metabolic pathways and differential metabolites, providing a comprehensive overview of metabolite changes during fermentation.
Article
Biochemistry & Molecular Biology
Yan Cheng, Xiaofang Ma, Qi Zhao, Chunyan Wang, Dongmei Yan, Fei Li
Summary: In this study, the metabolic characterizations of three C-PYCs, including MH, ISM, and MER, were determined using UPLC-ESI-QTOF-MS, revealing major metabolic pathways of hydroxylation, dehydrogenation, demethylation, and conjugation. MH exhibited lower metabolic rate compared to ISM and MER, impacting their bioactivities. Recombinant CYP screening implicated CYP1A1, 2B6, 3A4, and 3A5 as major metabolic enzymes involved in the formation of metabolites, which all showed anti-inflammatory activity.
Article
Biochemistry & Molecular Biology
Haotian Pei, Wenyu Su, Meng Gui, Mingjie Dou, Yingxin Zhang, Cuizhu Wang, Dan Lu
Summary: Advanced technology was used to detect and characterize 171 compounds from the six parts of lotus, identifying 23 robust biomarkers. These findings can be utilized to enhance the quality control methods of herbal medicines.
Article
Plant Sciences
Noga Sikron-Persi, Gila Granot, Albert Batushansky, David Toubiana, Gideon Grafi, Aaron Fait
Summary: A study on the petioles of perennial desert shrub Zygophyllum dumosum Boiss revealed a consistent seasonal pattern in petiole metabolism, involving organic acids, polyols, phenylpropanoids, sulfate conjugates, and piperazines. The metabolic changes were primarily related to the plant's development stage and its interaction with the environment, rather than specific environmental conditions.
Article
Endocrinology & Metabolism
Asmaa M. Otify, Osama G. Mohamed, Yasser A. El-Amier, Fatema R. Saber, Ashootosh Tripathi, Inas Y. Younis
Summary: This study found that extracts from several Cassia plants have allelopathic activity, inhibiting weed germination and growth. The extracts were found to contain various compounds, such as flavonoids, coumarins, anthraquinones, phenolic acids, lipids, and fatty acid derivatives. Further evaluation of the potential of Cassia extracts as allelopathic compounds in agricultural systems is therefore recommended.
Article
Medical Laboratory Technology
Zheng Zhong, Yukai Huang, Qidang Huang, Shaoling Zheng, Zhixiang Huang, Weiming Deng, Tianwang Li
Summary: This study investigated the serum metabolic profiling of gout patients compared to healthy controls using UPLC-Q-TOF/MS, revealing significant differences in metabolites between the two groups. Bilirubin was identified as a potential biomarker for gout, and primary bile acid biosynthesis was suggested as a novel metabolic pathway.
CLINICA CHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Ruifeng Ji, Thomas Avery Garran, Yilu Luo, Meng Cheng, Mengyue Ren, Xiuteng Zhou
Summary: An integrated strategy of combining UPLC-QTOF-MS and chemometrics was developed to profile identification markers for differentiating five species of ginseng. This study is critical for ensuring the appropriate use of these ginseng species. A total of 38 robust biomarkers, mainly composed of saponins with small amounts of amino acids and fatty acids, were identified.
Article
Plant Sciences
Shiqin Jiang, Xiuting Shen, Shenxin Xuan, Bao Yang, Qingfeng Ruan, Hui Cui, Zhongxiang Zhao, Jing Jin
Summary: Croton crassifolius Geisel (CCG) extract has shown therapeutic potential against ulcerative colitis (UC) by modulating metabolic pathways and reducing inflammation, offering a new strategy for UC management.
Article
Food Science & Technology
Shufeng Wang, Xin Yang, Feng Liu, Xinzheng Wang, Xuemin Zhang, Kun He, Hongxia Wang
Summary: A comprehensive non-targeted metabolomic study on Hep3B cells exposed to AFB1 revealed dynamic metabolic reprogramming, including pathways such as purine and pyrimidine metabolism, hexosamine pathway and sialylation. The metabolomic strategy employed in this study showed high sensitivity and resolution, providing new insights into potential drug targets for therapeutic intervention in carcinogen-induced cancer.
Article
Biochemistry & Molecular Biology
He Su, Yang Chu, Junqi Bai, Lu Gong, Juan Huang, Wen Xu, Jing Zhang, Xiaohui Qiu, Jiang Xu, Zhihai Huang
Article
Plant Sciences
Jianyong Qi, Yafang Tan, Dancai Fan, Wenjun Pan, Juan Yu, Wen Xu, Jiashin Wu, Minzhou Zhang
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Agriculture, Multidisciplinary
Jing Zhang, Xiaofang Wu, Jiaqi Qu, Liang Zhang, Yating Zhang, Xiaohui Qu, Zhihai Huang, Wen Xu
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Pharmacology & Pharmacy
Xiaofang Wu, Yating Zhang, Jiaqi Qiu, Ya Xu, Jing Zhang, Juan Huang, Junqi Bai, Zhihai Huang, Xiaohui Qiu, Wen Xu
FRONTIERS IN PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Junqi Bai, He Su, Youling Liang, Xuhua Shi, Juan Huang, Wen Xu, Jing Zhang, Lu Gong, Zhihai Huang, Xiaohui Qiu
Summary: In this study, a comprehensive identification method based on metabolomics using UHPLC-Q-Exactive plus orbitrap MS/MS technology was established to find quality markers to distinguish raw Reynoutria multiflora (RRM) and processed Reynoutria multiflora (PRM) with different processing times. Twenty potential markers were identified, with tetrahydroxystilbene-O-hexoside-O-galloyl and sucrose being able to distinguish PRM processed for 24 hours. This approach has wide application prospects and could serve as an important control technology for the processing of Reynoutria multiflora.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Ya Xu, Pu-Lin Liang, Xue-Lian Chen, Ming-Jiong Gong, Liang Zhang, Xiao-Hui Qiu, Jing Zhang, Zhi-Hai Huang, Wen Xu
Summary: This study comprehensively investigated the chemical changes in pu-erh tea after cofermented with Citrus peel using advanced technology, revealing significant chemical profile disparities between Ganpu tea and raw pu-erh tea. The cofermentation process with Citrus peel greatly impacted the content and types of compounds in the tea.
FRONTIERS IN NUTRITION
(2021)
Article
Chemistry, Multidisciplinary
Jiaqi Qiu, Xuelian Chen, Pulin Liang, Liang Zhang, Ya Xu, Mingjiong Gong, Xiaohui Qiu, Jing Zhang, Wen Xu
Summary: This study identified new bioactive constituents with antioxidant and anti-inflammatory properties in Syzygium brachythyrsum, including a large number of bergenin derivatives and phenolic compounds, some of which were discovered for the first time in the genus. This indicates the potential of Syzygium brachythyrsum as a promising functional and medicinal resource.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Mei Yang, Zongde Jiang, Mingchun Wen, Zhenfeng Wu, Minyu Zha, Wen Xu, Liang Zhang
Summary: This study compared the effects of storage years on the chemical composition and bioactivity of Citrus reticulata Chachi peel. The content of hesperidin decreased, while nobiletin, 3,5,6,7,8,3 ',4 '-heptamethoxyflavone, and tangeretin increased with the increase of storage time. The antioxidant activity of the peel was enhanced. Phenolic acids, flavonol glycosides, fatty acids, and alkyl glycosides were marker compounds for distinguishing the storage time of the peel.
FRONTIERS IN NUTRITION
(2022)
Article
Chemistry, Applied
Jing Zhang, Ya Xu, Chi-Tang Ho, Jia-Qi Qiu, Xiao-Hui Qiu, Zhi-Hai Huang, Liang Zhang, Wen Xu
Summary: This study comprehensively characterized the components of Medog lemon, a wild citron species native to southeastern Tibet, using advanced analytical techniques. The analysis identified numerous new phytochemicals in Medog lemon and revealed its distinct chemical composition compared to cultivated citron and fingered citron. The unique morphological and chemical characteristics, along with its strong antioxidant properties, suggest that Medog lemon could potentially serve as a beneficial new food resource for human health.
Article
Chemistry, Applied
Yiyu Ren, Yan Hou, Daniel Granato, Minyu Zha, Wen Xu, Liang Zhang
Summary: This study investigated the key astringency compounds of Crude Pu-erh tea (CPET) during storage using metabolomics integrated with sensory evaluation. The results showed that the hydrolysis of galloylated catechins was the key reason for astringency decrease, while flavonol glycosides had a lower contribution to astringency.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2022)
Article
Pharmacology & Pharmacy
Junqi Bai, Wanting Chen, Juan Huang, He Su, Danchun Zhang, Wen Xu, Jing Zhang, Zhihai Huang, Xiaohui Qiu
Summary: This study utilized ultra high performance liquid chromatography tandem quadrupole/electrostatic field orbitrap high-resolution mass spectrometry to investigate the changes in stilbene glycosides during the processing of Reynoutria multiflora. The content and quantity of stilbene glycosides were found to undergo significant changes, with the detection of potential new compounds. The results provide a basis for further research on the pharmacodynamics and toxicity mechanisms of processed R. multiflora.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Juan Huang, Shuyi Huang, Jing Zhang, Youling Liang, Junqi Bai, Wen Xu, Lu Gong, He Su, Zhihai Huang, Xiaohui Qiu
Summary: A comprehensive analytical strategy was developed to characterize the metabolites of THSG in vivo using UHPLC-Q Exactive-Orbitrap MS. The results showed that the major metabolic pathways of THSG included glucoside hydrolysis, hydrogenation, hydroxylation, glucuronide conjugation, and sulfate conjugation.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Plant Sciences
Pu-Lin Liang, Xue-Lian Chen, Ming-Jiong Gong, Ya Xu, Hai-Sheng Tu, Liang Zhang, Bao-sheng Liao, Xiao-Hui Qiu, Jing Zhang, Zhi-Hai Huang, Wen Xu
Summary: The dried pericarp of Citrus reticulata Blanco, specifically the cultivar Guang Chen Pi (GCP), has high medicinal and dietary value. It is traditionally used to regulate Qi, promote blood circulation, and treat diseases related to the digestive, respiratory, and cardiovascular systems. This study demonstrated that GCP can inhibit foam cell formation and inflammation in macrophages, suggesting its potential as a treatment for atherosclerosis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chunyin Qin, Li Lian, Wen Xu, Zongde Jiang, Mingchun Wen, Zisheng Han, Liang Zhang
Summary: A comparative study was conducted on the supernatant and cream of black tea infusion, revealing that the cream contained higher levels of polyphenols and some important elements, and exhibited better antioxidant, anti-inflammatory, and enzyme inhibitory activities. Additionally, metabolomics analysis revealed chemical composition differences between the supernatant and cream.
Article
Chemistry, Multidisciplinary
Peng Wang, Jing Zhang, Yating Zhang, He Su, Xiaohui Qiu, Lu Gong, Juan Huang, Junqi Bai, Zhihai Huang, Wen Xu