Asiatic Acid Prevents Oxidative Stress and Apoptosis by Inhibiting the Translocation of α-Synuclein Into Mitochondria

Mechanism of α-synuclein translocation through a VDAC nanopore revealed by energy landscape modeling of escape time distributions

(2017) David P. Hoogerheide et al.   Nanoscale

Lewy Bodies and the Mechanisms of Neuronal Cell Death in Parkinson's Disease and Dementia with Lewy Bodies

(2016) John H. T. Power et al.   BRAIN PATHOLOGY

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

(2012) Min-fang Xu et al.   ACTA PHARMACOLOGICA SINICA

Asiatic acid protects primary neurons against C2-ceramide-induced apoptosis

(2012) Xiangnan Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Asiatic Acid Attenuates Infarct Volume, Mitochondrial Dysfunction, and Matrix Metalloproteinase-9 Induction After Focal Cerebral Ischemia

(2012) Ki Yong Lee et al.   STROKE

The role of α-synuclein in neurodegeneration — An update

(2012) Kurt Jellinger   Translational Neuroscience

Elevated tauopathy and alpha-synuclein pathology in postmortem Parkinson's disease brains with and without dementia

(2010) Jonathan Wills et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein induced membrane depolarization and loss of phosphorylation capacity of isolated rat brain mitochondria: Implications in Parkinson's disease

(2010) Kalpita Banerjee et al.   FEBS LETTERS

Huperzine A protects isolated rat brain mitochondria against β-amyloid peptide

(2009) Xin Gao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Asiatic acid, a pentacyclic triterpene fromCentella asiatica, is neuroprotective in a mouse model of focal cerebral ischemia

(2009) Rajanikant G. Krishnamurthy et al.   JOURNAL OF NEUROSCIENCE RESEARCH

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

Grape Extract Protects Mitochondria from Oxidative Damage and Improves Locomotor Dysfunction and Extends Lifespan in a Drosophila Parkinson's Disease Model

(2009) Jiangang Long et al.   REJUVENATION RESEARCH

Dimeric structures of α-synuclein bind preferentially to lipid membranes

(2008) Eleni Giannakis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High doses of nicotinamide prevent oxidative mitochondrial dysfunction in a cellular model and improve motor deficit in aDrosophilamodel of Parkinson's disease

(2008) Haiqun Jia et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Protective Effects of Asiatic Acid on Rotenone- or H2O2-Induced Injury in SH-SY5Y Cells

(2008) Yuyun Xiong et al.   NEUROCHEMICAL RESEARCH

Mitochondrial localization of alpha-synuclein protein in alpha-synuclein overexpressing cells

(2008) Shaik Shavali et al.   NEUROSCIENCE LETTERS