期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 11, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2018.00189
关键词
metabolic syndrome; miRs; ncRNAs; sepsis; SNPs
资金
- European Research Council [321501]
- Israeli Ministry of Science, Technology and Space [53140]
- Legacy Heritage Science Initiative (LHSI) of The Israel Science Foundation [817/13]
- Austrian Research Promotion Agency (FFG Bridge1 project
- Osterreichische Forschungsforderungsgesellschaft) [853294]
- Edmond and Lily Safra Center for Brain Sciences (ELSC)
- Howard and Diana Wendy pre-doctoral fellowship
- Israel I-Core Center of Excellence for Mass Trauma [817/13]
Sepsis and metabolic syndrome (MetS) are both inflammation-related entities with high impact for human health and the consequences of concussions Both represent imbalanced parasympathetic/cholinergic response to insulting triggers and variably uncontrolled inflammation that indicates shared upstream regulators, including short microRNAs (miRs) and long non-coding RNAs (IncRNAs). These may cross talk across multiple systems, leading to complex molecular and clinical outcomes. Notably, biomedical and RNA-sequencing based analyses both highlight new links between the acquired and inherited pathogenic, cardiac and inflammatory traits of sepsis/MetS. Those include the HOTAIR and MIAT IncRNAs and their targets, such as miR-122, -150, -155, -182, -197, -375, -608 and HLA-DRA. Implicating non-coding RNA regulators in sepsis and MetS may delineate novel high-value biomarkers and targets for intervention.
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