期刊
CANCER MEDICINE
卷 7, 期 4, 页码 1019-1029出版社
WILEY
DOI: 10.1002/cam4.1315
关键词
ceRNA network; cutaneous melanoma; lncRNA; progression
类别
资金
- National Natural Science Foundation of China [81472939, 81673132]
- Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University [2017EME002]
- PUMC Youth Fund [3332016106]
- Fundamental Research Funds for the Central Universities
Cutaneous melanoma (CM) is the most malignant tumor of skin cancers because of its rapid development and high mortality rate. Long noncoding RNAs (lncRNAs), which play essential roles in the tumorigenesis and metastasis of CM and interplay with microRNAs (miRNAs) and mRNAs, are hopefully considered to be efficient biomarkers to detect deterioration during the progression of CM to improve the prognosis. Bioinformatics analysis was fully applied to predict the vital lncRNAs and the associated miRNAs and mRNAs, which eventually constructed the competing endogenous RNA (ceRNA) network to explain the RNA expression patterns in the progression of CM. Further statistical analysis emphasized the importance of these key genes, which were statistically significantly related to one or few clinical features from the ceRNA network. The results showed the lncRNAs MGC12926 and LINC00937 were verified to be strongly connected with the prognosis of CM patients.
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