Review
Oncology
Jerry Polesel, Anna Menegaldo, Giancarlo Tirelli, Vittorio Giacomarra, Roberto Guerrieri, Lorena Baboci, Mariateresa Casarotto, Valentina Lupato, Giuseppe Fanetti, Paolo Boscolo-Rizzo, Elisabetta Fratta
Summary: The expression of PD-L1 in OPSCC is associated with improved survival, particularly benefiting HPV-positive OPSCC patients compared to their negative counterparts. PD-L1 may serve as a valuable biomarker to stratify prognosis in OPSCC alongside HPV status.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Kawita Atipas, Natthawadee Laokulrath, Janjira Petsuksiri, Narin Ratanaprasert, Warut Pongsapich
Summary: This study explored the expression of p16, CD8+ TIL, and PD-L1 and their value as prognostic indicators for overall survival (OS) in patients with oropharyngeal squamous cell carcinoma (OPSCC). The results showed that the positivity of p16 and the density of CD8+ TIL were associated with better OS, while the status of PD-L1 was not significantly related to OS. Among the four types of tumor microenvironments (TME), OPSCCs with type I TME (PD-L1+/TIL+) had the best survival outcome.
Article
Biochemistry & Molecular Biology
Rocio Garcia-Marin, Sara Reda, Cristina Riobello, Virginia N. Cabal, Laura Suarez-Fernandez, Blanca Vivanco, Cesar Alvarez-Marcos, Fernando Lopez, Jose L. Llorente, Mario A. Hermsen
Summary: Sinonasal squamous cell carcinoma (SNSCC) is an aggressive tumor with a poor prognosis. Immunotherapy may be a new therapeutic option for SNSCC patients, especially for the subgroup with high CD8(+) TILs and PD-L1 positivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sebastian Blatt, Maximilian Krueger, Constantin Rump, Stefanie Zimmer, Keyvan Sagheb, Julian Kuenzel
Summary: PD-L1 expression varies between oral and oropharyngeal squamous cell carcinoma, but does not affect patient survival. The status of p16 is also unrelated to PD-L1 expression.
Article
Oncology
Tao Zhang, Qin Liu, Yingfan Zhu, Songfa Zhang, Qiaohua Peng, Amanda Louise Strickland, Wenxin Zheng, Feng Zhou
Summary: The study evaluated the expression and predictive value of PD-L1 in endometrial serous carcinoma (ESC), finding that PD-L1 positivity was associated with unfavorable outcomes in ESC and may serve as a potential therapeutic target for these tumors.
CANCER MANAGEMENT AND RESEARCH
(2021)
Article
Immunology
Sheng-ming Xu, Chao-ji Shi, Rong-hui Xia, Li-zhen Wang, Zhen Tian, Wei-min Ye, Liu Liu, Shu-li Liu, Chun-ye Zhang, Yu-hua Hu, Rong Zhou, Yong Han, Yu Wang, Zhi-yuan Zhang, Jiang Li
Summary: This study aimed to investigate the clinicopathological, tumor immune microenvironmental, and molecular features of HPV(+)OPSCC based on PD-L1 expression. The results showed that high PD-L1 expression was associated with higher tumor mutation burden, CD8(+) T cell infiltration, and immune-related genomic alterations. This study provides valuable insights into the immune features of HPV(+)OPSCC.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Morgan Guenole, Paolo Benigni, Vincent Bourbonne, Francois Lucia, Delphine Legoupil, Olivier Pradier, Laurent Misery, Arnaud Uguen, Ulrike Schick
Summary: In this study focusing on non-metastatic Merkel cell carcinoma patients, it was found that PD-L1 expression by immune cells and tumor cells significantly correlated with improved outcomes. Adjuvant radiotherapy was shown to enhance distant metastasis-free survival and overall survival rates. Additionally, there was a correlation between MCPyV positivity and the expression of PD-L1 on immune and tumor cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wei-Chung Chen, Chun-Chieh Wu, Yi-Hsun Chen, Jui-Ying Lee, Yao-Kuang Wang, Nian-Siou Wu, Ming-Tsang Wu, I-Chen Wu
Summary: This study aimed to investigate the expression of PD-L1 in esophageal squamous cell carcinoma (ESCC) tissues before and after concurrent chemoradiation therapy (CCRT). The results showed a decrease in PD-L1 expression after CCRT, and high pre-CCRT PD-L1 expression was associated with poor prognosis.
Article
Multidisciplinary Sciences
Haruto Nishida, Yoshihiko Kondo, Takahiro Kusaba, Kazuhiro Kawamura, Yuzo Oyama, Tsutomu Daa
Summary: In recent years, several immune checkpoint inhibitors targeting programmed death-ligand 1 (PD-L1) or PD-1 have been developed for cancer therapy. The genetic background of tumors and factors that influence PD-L1 expression in tumor tissues are not yet elucidated in cutaneous squamous cell carcinoma (cSCC).
Article
Otorhinolaryngology
Benedikt Schmidl, Kim-Aylin Vossenkaemper, Leonhard Stark, Melanie Boxberg, Fabian Stoegbauer, Katharina Feigl, Christof Winter, Anja Pickhard, Barbara Wollenberg, Markus Wirth
Summary: In this study, we found immunological differences between squamous cell cancer of unknown primary (SCCUP) and oropharyngeal squamous cell carcinoma (OPSCC). SCCUP exhibited higher expression of PD-L1, which could potentially facilitate further evaluation of checkpoint inhibitor therapy.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Review
Medicine, Research & Experimental
R. Baudouin, S. Hans, Q. Lisan, B. Morin, Y. Adimi, J. Martin, J. R. Lechien, E. Tartour, C. Badoual
Summary: This systematic review provides comprehensive information on the immune microenvironment of HPV+OPSCCs, revealing associations between tumor-infiltrating lymphocytes and PD-L1 expression with favorable clinical outcomes. Higher densities of B cells, CD8+ cells, and resident memory cells are observed in HPV+OPSCCs. The importance of myeloid lineages remains a subject of debate and further research is needed.
Article
Oncology
Qigen Fang, Yao Wu, Wei Du, Xu Zhang, Defeng Chen
Summary: The expression of PD-L1 in high-grade salivary gland carcinomas was significantly associated with tumor stage, and a tumor proportion score (TPS) of >= 1% was common in 43.1% of patients, with significant differences in 5-year disease-free survival and overall survival rates.
FRONTIERS IN ONCOLOGY
(2021)
Review
Immunology
Qian Li, Jingjing Han, Yonglin Yang, Yu Chen
Summary: Hepatocellular carcinoma (HCC) has a high prevalence and mortality rate worldwide. In recent years, immunotherapy using immune checkpoint inhibitors, particularly targeting the PD-1/PD-L1 axis, has brought fundamental changes to the treatment of advanced HCC. However, challenges remain and combination therapy may be a better option to improve the low remission rate.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
I-Tsang Chiang, Yuan-Hao Lee, Zhao-Lin Tan, Fei-Ting Hsu, Hsi-Feng Tu
Summary: Combination therapy with regorafenib and anti-PD-L1 can enhance anti-tumor immune response and suppress immunosuppression in oral squamous cell carcinoma (OSCC). This finding contributes to the development of more effective treatment strategies for OSCC.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Enrico Munari, Marcella Marconi, Giulia Querzoli, Gianluigi Lunardi, Pietro Bertoglio, Francesco Ciompi, Alice Tosadori, Albino Eccher, Nicola Tumino, Linda Quatrini, Paola Vacca, Giulio Rossi, Alberto Cavazza, Guido Martignoni, Matteo Brunelli, George J. Netto, Lorenzo Moretta, Giuseppe Zamboni, Giuseppe Bogina
Summary: This study aimed to clarify the significance and impact of PD-L1 and PD-1 expression on the prognostic value of CD8(+) tumor infiltrating lymphocytes in patients with primary resected non-small cell lung cancer. The results showed a strong prognostic value of CD8(+) cells, especially in PD-L1 negative tumors lacking PD-1(+) TILs, and the importance of assessing and quantifying the immune contexture in cancer for prognostic and possibly predictive purposes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Oncology
Elizabeth Ahern, Ben J. Solomon, Rina Hui, Nick Pavlakis, Ken O'Byrne, Brett G. M. Hughes
Summary: Neoadjuvant therapies, including immune checkpoint inhibitors, show promise in the treatment of non-small cell lung cancer (NSCLC); however, challenges remain in defining optimal treatment combinations, validating biomarkers, and timing of surgery.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Sai-Hong Ou, Benjamin J. Solomon, Alice T. Shaw, Shirish M. Gadgeel, Benjamin Besse, Ross A. Soo, Antonello Abbattista, Francesca Toffalorio, Robin Wiltshire, Alessandra Bearz
Summary: This study retrospectively analyzed the clinical benefit of continuing Lorlatinib beyond progressive disease in patients with ALK-positive NSCLC. The results showed that continuing LBPD can be a viable treatment strategy for these patients.
JOURNAL OF THORACIC ONCOLOGY
(2022)
Article
Oncology
D. S-W. Tan, M. Thomas, D-W. Kim, S. Szpakowski, P. Urban, R. Mehra, L. Q. M. Chow, S. Sharma, B. J. Solomon, E. Felip, D. R. Camidge, J. Vansteenkiste, L. Petruzzelli, S. Pantano, A. T. Shaw
Summary: An exploratory analysis was conducted to understand the genetic determinants of response to ceritinib in ALK+ NSCLC patients. The study revealed the potential role of next-generation sequencing (NGS) in improving our understanding of response and resistance to ceritinib. It also demonstrated the efficacy of ceritinib against almost all ALK resistance mutations found in ALKi-pretreated patients.
Article
Oncology
B. J. Solomon, H. H. Loong, Y. Summers, Z. M. Thomas, P. French, B. K. Lin, A. Sashegyi, J. Wolf, J. C-H Yang, A. Drilon
Summary: This study identified a strong correlation between the treatment effects on ORR and PFS in randomized clinical trials targeting oncogene-addicted tumors, while a weaker correlation was observed between ORR and OS.
Article
Oncology
Lavinia Tan, Ben Tran, Jeanne Tie, Ben Markman, Sumi Ananda, Niall C. Tebbutt, Michael Michael, Emma Link, Stephen Q. Wong, Sushma Chandrashekar, Jerick Guinto, David Ritchie, Rachel Koldej, Benjamin J. Solomon, Grant A. McArthur, Rodney J. Hicks, Peter Gibbs, Sarah-Jane Dawson, Jayesh Desai
Summary: BRAF V600E mutant metastatic colorectal cancer is a significant clinical problem. Combination therapy with vemurafenib and small-molecule EGFR inhibitors has shown effectiveness in pre-clinical studies, but clinical investigation is lacking.
CLINICAL CANCER RESEARCH
(2023)
Editorial Material
Oncology
Benjamin J. Solomon, Todd M. Bauer, Tony S. K. Mok, Geoffrey Liu, Julien Mazieres, Filippo de Marinis, Yasushi Goto, Dong-Wan Kim, Yi-Long Wu, Jacek Jassem, Froylan Lopez Lopez, Ross A. Soo, Alice T. Shaw, Anna Polli, Rossella Messina, Laura Iadeluca, Francesca Toffalorio, Enriqueta Felip
Editorial Material
Oncology
Trudy C. Wu, Annalise Stube, Carol Felix, Denise Oseguera, Tahmineh Romero, Jonathan Goldman, Edward B. Garon, Jay M. Lee, John Glaspy, Aaron E. Lisberg, Chad G. Rusthoven, D. Ross Camidge, Shankar Siva, Benjamin Solomon, Alan Lee, Stephen E. Tenn, Narek Shaverdian, Michael L. Steinberg, Ann C. Raldow, Percy Lee
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Letter
Oncology
Nicolas Girard, Marina C. Garassino, Benjamin Solomon
JOURNAL OF THORACIC ONCOLOGY
(2023)
Letter
Oncology
Nicolas Girard, Marina C. Garassino, Benjamin Solomon
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Oncology
Ross A. Soo, Jean-Francois Martini, Anthonie J. van der Wekken, Shunsuke Teraoka, Roberto Ferrara, Alice T. Shaw, Deborah Shepard, Anna Maria Calella, Anna Polli, Francesca Toffalorio, Pascale Tomasini, Chao-Hua Chiu, Dariusz M. Kowalski, Hye Ryun Kim, Benjamin J. Solomon
Summary: In treatment-naive patients with advanced ALK-positive NSCLC, ctDNA can be used as a biomarker to predict the efficacy of lorlatinib treatment.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Medicine, General & Internal
Adrianus Johannes de Langen, Melissa L. Johnson, Julien Mazieres, Anne -Marie C. Dingemans, Giannis Mountzios, Miklos Pless, Jurgen Wolf, Martin Schuler, Herve Lena, Ferdinandos Skoulidis, Yasuto Yoneshima, Sang-We Kim, Helena Linardou, Silvia Novello, Anthonie J. van der Wekken, Yuanbin Chen, Solange Peters, Enriqueta Felip, Benjamin J. Solomon, Suresh S. Ramalingam, Christophe Dooms, Colin R. Lindsay, Carlos Gil Ferreira, Normand Blais, Cynthia C. Obiozor, Yang Wang, Bhakti Mehta, Tracy Varrieur, Gataree Ngarmchamnanrith, Bjorn Stollenwerk, David Waterhouse, Luis Paz-Ares
Summary: This study compared the efficacy and safety of Sotorasib with standard-of-care treatment in patients with non-small-cell lung cancer (NSCLC) with the KRASG12C mutation. The results showed that compared to docetaxel, Sotorasib significantly increased progression-free survival and had a more favorable safety profile.
Review
Oncology
Grace Chazan, Benjamin J. Solomon
Summary: First-line treatment options for patients with advanced non-small cell lung cancer (NSCLC) whose tumors harbour anaplastic lymphoma kinase (ALK) gene rearrangements have evolved rapidly. Although newer generation ALK inhibitors have demonstrated superiority to crizotinib, head-to-head clinical trials comparing these inhibitors are lacking. Decisions on optimal first-line treatment must be based on analysis of relevant trials and consideration of various factors.
TRANSLATIONAL LUNG CANCER RESEARCH
(2023)
Review
Medicine, General & Internal
L. B. Cameron, N. Hitchen, E. Chandran, T. Morris, R. Manser, B. J. Solomon, V Jordan
Summary: This study evaluated the safety and efficacy of ALK inhibitors as monotherapy for advanced ALK-rearranged NSCLC. The results showed that ALK inhibitors are effective in improving progression-free survival, overall survival, and overall response rate, with minimal adverse events compared to chemotherapy. Next-generation ALK inhibitors are more effective and safe than first-generation ALK inhibitors. However, further research is needed to compare different next-generation ALK inhibitors.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2022)
Article
Endocrinology & Metabolism
Ray Wang, Benjamin Solomon, Stephen J. Luen, Owen W. J. Prall, Christine Khoo, Anthony J. Gill, Jeremy Lewin, Nirupa Sachithanandan
Summary: Adrenocortical carcinoma is a rare disease with significant clinical heterogeneity, presenting a diagnostic challenge to clinicians. Specialist multidisciplinary team input and genomics play vital roles in diagnosis and prognosis of adrenocortical carcinoma.
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS
(2022)
Article
Oncology
Luke S. McLean, Wasek Faisal, Sagun Parakh, Steven C. Kao, Craig R. Lewis, Melvin T. Chin, Mark Voskoboynik, Malinda J. Itchins, Ross R. Jennens, Adam R. Broad, Tessa A. Morris, Benjamin J. Solomon
Summary: This study focused on the outcomes of patients with EGFR-mutated non-small-cell lung cancer who developed leptomeningeal disease and were subsequently treated with osimertinib. The results indicated that osimertinib at a dose of 80 mg daily is an effective therapeutic option for these patients with limited treatment options.
JCO PRECISION ONCOLOGY
(2021)